Zinc finger protein 516

ZNF516
Identifiers
Aliases	ZNF516, HsT287, zinc finger protein 516
External IDs	OMIM: 615114 MGI: 2443957 HomoloGene: 37122 GeneCards: ZNF516
Gene location (Human) Chr. Chromosome 18 (human) Band 18q23 Start 76,357,682 bp End 76,495,242 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E3 Start 82,928,788 bp End 83,023,439 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium canal of the cervix right uterine tube monocyte left uterine tube seminal vesicula blood myometrium anterior pituitary tibial nerve Top expressed in hand ascending aorta aortic valve islet of Langerhans trigeminal ganglion abdominal wall otolith organ pituitary gland vas deferens utricle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding cis-regulatory region sequence-specific DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development positive regulation of transcription, DNA-templated response to cold adipose tissue development regulation of transcription, DNA-templated transcription by RNA polymerase II signal transduction brown fat cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9658 329003 Ensembl ENSG00000101493 ENSMUSG00000058881 UniProt Q92618 Q7TSH3 RefSeq (mRNA) NM_014643 NM_001177464 NM_183033 RefSeq (protein) NP_055458 NP_001170935 NP_898854 Location (UCSC) Chr 18: 76.36 – 76.5 Mb Chr 18: 82.93 – 83.02 Mb PubMed search
Wikidata
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Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene.

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

Further reading

• Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (January 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449. PMID 23064961.
• Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Lee MG, Wynder C, Cooch N, Shiekhattar R (September 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
• Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
• O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519. S2CID 13087946.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.