User:Yuxuan0831/Capillary electrophoresis
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Article Draft[edit]
Background[edit]
Capillary electrophoresis (CE) is an analytical liquid-based separation technique that uses an applied voltage to separate ions based on their electrophoretic mobility. Capillary electrophoresis was first published in 1937 by Swedish biochemist Arne Tiselius[1]. In the 1980s, scientists improved the technique by introducing less than 100-micrometer fused silica capillaries to make it more efficient and thus became widespread[2].
Capillary electrophoresis (CE) is a family of electrokinetic separation methods performed in submillimeter diameter capillaries and in micro- and nanofluidic channels. Very often, CE refers to capillary zone electrophoresis (CZE), but other electrophoretic techniques including capillary gel electrophoresis (CGE), capillary isoelectric focusing (CIEF), capillary isotachophoresis and micellar electrokinetic chromatography (MEKC) belong also to this class of methods. In CE methods, analytes migrate through electrolyte solutions under the influence of an electric field. Analytes can be separated according to ionic mobility and/or partitioning into an alternate phase via non-covalent interactions. Additionally, analytes may be concentrated or "focused" by means of gradients in conductivity and pH.
Reference[edit]
- ^ Tiselius, Arne (1937). "A new apparatus for electrophoretic analysis of colloidal mixtures". Transactions of the Faraday Society. 33: 524. doi:10.1039/tf9373300524. ISSN 0014-7672.
- ^ "Stellan Hjertén, Uppsala University". The Analyst. 128 (11): 1307–1309. 2003. doi:10.1039/B307798P. ISSN 0003-2654.