User:StevieMichaels14/sandbox

"Motor proteins"

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  The action of myosin along the actin filaments causes the shortening and lengthening of the sarcomere; responsible for muscle contraction and relaxation, respectively.

  

  As motor proteins that move along microtubules, kinesin and dynein have critical roles in cell division. Kinesin at the kinetochore helps in the separation of chromosomes, while cytoplasmic dynein provides the constricting force necessary to create the daughter cells during cytokinesis.

  

  Dynein on a microtubule

  Kinesin, Myosin, and Dynein illustrations :
• ** "Diseases associated with motor protein defects" .. Move this section down to the bottom of the page.

Diseases associated with motor protein defects[edit]

The importance of motor proteins in cells becomes evident when they fail to fulfill their function. For example, kinesin deficiencies have been identified as the cause for Charcot-Marie-Tooth disease and some kidney diseases. Dynein deficiencies can lead to chronic infections of the respiratory tract as cilia fail to function without dynein. Numerous myosin deficiencies are related to disease states and genetic syndromes. Because myosin II is essential for muscle contraction, defects in muscular myosin predictably cause myopathies. Myosin is necessary in the process of hearing because of its role in the growth of stereocilia so defects in myosin protein structure can lead to Usher syndrome and non-syndromic deafness.

https://www.cytoskeleton.com/dynein-neurodegenerative-diseases

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• Connection with "Moleular motor" article --- link ??
• **Remove comment under "Cellular function" that says, "The best prominent example..." in bold below :

Cellular functions[edit]

The best prominent example of a motor protein is the muscle protein myosin which "motors" the contraction of muscle fibers in animals. Motor proteins are the driving force behind most active transport of proteins and vesicles in the cytoplasm. Kinesins and cytoplasmic dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. Axonemal dynein, found in cilia and flagella, is crucial to cell motility, for example in spermatozoa, and fluid transport, for example in trachea.

• ** "Genomic representations" of the microtubule and actin motors. --? Talk topic "Can anybody tell me what is meant by the genomic representations of the microtubule and actin motors?? This is unclear to me. Is it necessary in this article?"