User:Qtcells/sandbox
Norepinephrine is often used as a first-line treatment for hypotensive septic shock because evidence shows that there is a relative deficiency of vasopressin, when shock continues for 24 to 48 hours.[1] In some patients, the required dose of vasopressor needed to increase the mean arterial pressure can become exceedingly high that it becomes toxic.[2] In order to reduce the required dose of vasopressor, epinephrine may be added.[2] Epinephrine is not often used as a first-line treatment for hypotensive shock because it reduces blood flow to the abdominal organs and increases lactate levels.[1]
Dobutamine can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues.[3] Dobutamine is not used as often as epinephrine due to its associate side effects, which include reducing blood flow to the gut.[3] Additionally, dobutamine increases the cardiac output by abnormally increasing the heart rate.[3]
- ^ a b Avni, Tomer; Lador, Adi; Lev, Shaul; Leibovici, Leonard; Paul, Mical; Grossman, Alon (2015-08-03). "Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis". PLOS ONE. 10 (8): e0129305. doi:10.1371/journal.pone.0129305. ISSN 1932-6203.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b Hamzaoui, Olfa; Scheeren, Thomas W.L.; Teboul, Jean-Louis (2017). "Norepinephrine in septic shock". Current Opinion in Critical Care. 23 (4): 342–347. doi:10.1097/mcc.0000000000000418. ISSN 1070-5295.
- ^ a b c Dubin, Arnaldo; Lattanzio, Bernardo; Gatti, Luis (2017). "The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients". Revista Brasileira de Terapia Intensiva. 29 (4). doi:10.5935/0103-507x.20170068. ISSN 0103-507X.
{{cite journal}}: line feed character in|title=at position 80 (help)
Comments[edit]
Thanks for sharing your proposed article improvements. I have a few small notes:
-On Wikipedia we refer to "people" rather than "patients" as per MEDMOS
-Please check and see if this is the first time technical terms and medical terms are used in Sepsis. On the first use, please add a Wikilink to help readers understand.
-Can you re-word your second second sentence to make it a little shorter? e.g.: "Some people with... require near-toxic doses of..." (this is just an example).
-You did a nice job adding references as per WP:MEDRS to each sentence.
If you have any questions please do not hesitate to let me know. I think your group is ready to improve the mainspace article!
Thanks again.