Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:40, 8 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (7)[edit]
Created (4)[edit]
Manual Inspection (Page not found) (21)[edit]
Protein Status Grid - Date: 23:40, 8 November 2007 (UTC)[edit]
Vebose Log - Date: 23:40, 8 November 2007 (UTC)[edit]
- INFO: Beginning work on AMH... {November 8, 2007 3:05:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:06:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Anti-Mullerian hormone
| HGNCid = 464
| Symbol = AMH
| AltSymbols =; MIF; MIS
| OMIM = 600957
| ECnumber =
| Homologene = 68060
| MGIid = 88006
| GeneAtlas_image1 = PBB_GE_AMH_206516_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001880 |text = Mullerian duct regression}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007506 |text = gonadal mesoderm development}} {{GNF_GO|id=GO:0007530 |text = sex determination}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 268
| Hs_Ensembl = ENSG00000104899
| Hs_RefseqProtein = NP_000470
| Hs_RefseqmRNA = NM_000479
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 2200122
| Hs_GenLoc_end = 2203071
| Hs_Uniprot = P03971
| Mm_EntrezGene = 11705
| Mm_Ensembl = ENSMUSG00000035262
| Mm_RefseqmRNA = NM_007445
| Mm_RefseqProtein = NP_031471
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80208377
| Mm_GenLoc_end = 80210777
| Mm_Uniprot = Q5EC55
}}
}}
'''Anti-Mullerian hormone''', also known as '''AMH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome.<ref>{{cite web | title = Entrez Gene: AMH anti-Mullerian hormone| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=268| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Teixeira J, Donahoe PK |title=Molecular biology of MIS and its receptors. |journal=J. Androl. |volume=17 |issue= 4 |pages= 336-41 |year= 1996 |pmid= 8889695 |doi= }}
*{{cite journal | author=Lane AH, Donahoe PK |title=New insights into mullerian inhibiting substance and its mechanism of action. |journal=J. Endocrinol. |volume=158 |issue= 1 |pages= 1-6 |year= 1998 |pmid= 9713320 |doi= }}
*{{cite journal | author=Josso N, di Clemente N, Gouédard L |title=Anti-Müllerian hormone and its receptors. |journal=Mol. Cell. Endocrinol. |volume=179 |issue= 1-2 |pages= 25-32 |year= 2001 |pmid= 11420127 |doi= }}
*{{cite journal | author=Picard JY, Belville C |title=[Genetics and molecular pathology of anti-Mullerian hormone and its receptor] |journal=J. Soc. Biol. |volume=196 |issue= 3 |pages= 217-21 |year= 2003 |pmid= 12462075 |doi= }}
*{{cite journal | author=Sinisi AA, Pasquali D, Notaro A, Bellastella A |title=Sexual differentiation. |journal=J. Endocrinol. Invest. |volume=26 |issue= 3 Suppl |pages= 23-8 |year= 2004 |pmid= 12834017 |doi= }}
*{{cite journal | author=Josso N, Picard JY, Rey R, di Clemente N |title=Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applications. |journal=Pediatric endocrinology reviews : PER |volume=3 |issue= 4 |pages= 347-58 |year= 2006 |pmid= 16816803 |doi= }}
*{{cite journal | author=Seifer DB, Maclaughlin DT |title=Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. |journal=Fertil. Steril. |volume=88 |issue= 3 |pages= 539-46 |year= 2007 |pmid= 17559842 |doi= 10.1016/j.fertnstert.2007.02.014 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BMPR1A... {November 8, 2007 3:06:01 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BMPR1A image.jpg {November 8, 2007 3:06:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:07:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BMPR1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1es7.
| PDB = {{PDB2|1es7}}, {{PDB2|1rew}}, {{PDB2|2goo}}, {{PDB2|2h62}}, {{PDB2|2h64}}
| Name = Bone morphogenetic protein receptor, type IA
| HGNCid = 1076
| Symbol = BMPR1A
| AltSymbols =; ACVRLK3; ALK3; CD292
| OMIM = 601299
| ECnumber =
| Homologene = 20911
| MGIid = 1338938
| GeneAtlas_image1 = PBB_GE_BMPR1A_213578_at_tn.png
| GeneAtlas_image2 = PBB_GE_BMPR1A_204832_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005024 |text = transforming growth factor beta receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 657
| Hs_Ensembl = ENSG00000107779
| Hs_RefseqProtein = NP_004320
| Hs_RefseqmRNA = NM_004329
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 88506387
| Hs_GenLoc_end = 88674925
| Hs_Uniprot = P36894
| Mm_EntrezGene = 12166
| Mm_Ensembl = ENSMUSG00000021796
| Mm_RefseqmRNA = NM_009758
| Mm_RefseqProtein = NP_033888
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 33240158
| Mm_GenLoc_end = 33331638
| Mm_Uniprot = Q3UP52
}}
}}
'''Bone morphogenetic protein receptor, type IA''', also known as '''BMPR1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.<ref>{{cite web | title = Entrez Gene: BMPR1A bone morphogenetic protein receptor, type IA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=657| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nickel J, Dreyer MK, Kirsch T, Sebald W |title=The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists. |journal=The Journal of bone and joint surgery. American volume |volume=83-A Suppl 1 |issue= Pt 1 |pages= S7-14 |year= 2001 |pmid= 11263668 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAV2... {November 8, 2007 3:07:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:08:13 PM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Caveolin 2
| HGNCid = 1528
| Symbol = CAV2
| AltSymbols =; CAV; MGC12294
| OMIM = 601048
| ECnumber =
| Homologene = 942
| MGIid = 107571
| GeneAtlas_image1 = PBB_GE_CAV2_203323_at_tn.png
| GeneAtlas_image2 = PBB_GE_CAV2_203324_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016599 |text = caveolar membrane}} {{GNF_GO|id=GO:0030133 |text = transport vesicle}} {{GNF_GO|id=GO:0045121 |text = lipid raft}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0001937 |text = negative regulation of endothelial cell proliferation}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 858
| Hs_Ensembl = ENSG00000105971
| Hs_RefseqProtein = NP_001224
| Hs_RefseqmRNA = NM_001233
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 115926680
| Hs_GenLoc_end = 115935830
| Hs_Uniprot = P51636
| Mm_EntrezGene = 12390
| Mm_Ensembl = ENSMUSG00000000058
| Mm_RefseqmRNA = NM_016900
| Mm_RefseqProtein = NP_058596
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 17231310
| Mm_GenLoc_end = 17239004
| Mm_Uniprot = Q924U3
}}
}}
'''Caveolin 2''', also known as '''CAV2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.<ref>{{cite web | title = Entrez Gene: CAV2 caveolin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=858| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Engelman JA, Zhang X, Galbiati F, ''et al.'' |title=Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1578-87 |year= 1999 |pmid= 9837809 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTNNA1... {November 8, 2007 3:10:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CTNNA1 image.jpg {November 8, 2007 3:12:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:12:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTNNA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dov.
| PDB = {{PDB2|1dov}}, {{PDB2|1dow}}, {{PDB2|1h6g}}, {{PDB2|1l7c}}
| Name = Catenin (cadherin-associated protein), alpha 1, 102kDa
| HGNCid = 2509
| Symbol = CTNNA1
| AltSymbols =; CAP102; FLJ36832
| OMIM = 116805
| ECnumber =
| Homologene = 1433
| MGIid = 88274
| GeneAtlas_image1 = PBB_GE_CTNNA1_200764_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CTNNA1_200765_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CTNNA1_210844_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017166 |text = vinculin binding}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0043297 |text = apical junction assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1495
| Hs_Ensembl = ENSG00000044115
| Hs_RefseqProtein = NP_001894
| Hs_RefseqmRNA = NM_001903
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 138117006
| Hs_GenLoc_end = 138298619
| Hs_Uniprot = P35221
| Mm_EntrezGene = 12385
| Mm_Ensembl = ENSMUSG00000037815
| Mm_RefseqmRNA = NM_009818
| Mm_RefseqProtein = NP_033948
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 35244863
| Mm_GenLoc_end = 35380747
| Mm_Uniprot = Q3TGQ3
}}
}}
'''Catenin (cadherin-associated protein), alpha 1, 102kDa''', also known as '''CTNNA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP2B6... {November 8, 2007 3:12:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:14:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 2, subfamily B, polypeptide 6
| HGNCid = 2615
| Symbol = CYP2B6
| AltSymbols =; CYP2B; CPB6; CYPIIB6; IIB1; P450
| OMIM = 123930
| ECnumber =
| Homologene = 73894
| MGIid = 88598
| GeneAtlas_image1 = PBB_GE_CYP2B6_206754_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP2B6_206755_at_tn.png
| GeneAtlas_image3 = PBB_GE_CYP2B6_217133_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1555
| Hs_Ensembl = ENSG00000197408
| Hs_RefseqProtein = NP_000758
| Hs_RefseqmRNA = NM_000767
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46189044
| Hs_GenLoc_end = 46216141
| Hs_Uniprot = P20813
| Mm_EntrezGene = 13088
| Mm_Ensembl = ENSMUSG00000030483
| Mm_RefseqmRNA = NM_009998
| Mm_RefseqProtein = NP_034128
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 25606418
| Mm_GenLoc_end = 25635383
| Mm_Uniprot = Q61461
}}
}}
'''Cytochrome P450, family 2, subfamily B, polypeptide 6''', also known as '''CYP2B6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.<ref>{{cite web | title = Entrez Gene: CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1555| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1-18 |year= 2004 |pmid= 15128046 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ERCC6... {November 8, 2007 3:14:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:14:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Excision repair cross-complementing rodent repair deficiency, complementation group 6
| HGNCid = 3438
| Symbol = ERCC6
| AltSymbols =; CSB; ARMD5; CKN2; COFS; RAD26
| OMIM = 609413
| ECnumber =
| Homologene = 6279
| MGIid = 1100494
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2074
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000115
| Hs_RefseqmRNA = NM_000124
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 319955
| Mm_Ensembl = ENSMUSG00000054051
| Mm_RefseqmRNA = XM_484360
| Mm_RefseqProtein = XP_484360
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 31399142
| Mm_GenLoc_end = 31409248
| Mm_Uniprot =
}}
}}
'''Excision repair cross-complementing rodent repair deficiency, complementation group 6''', also known as '''ERCC6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The ERCC6 protein is a DNA-binding protein important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites.<ref>{{cite web | title = Entrez Gene: ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2074| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cleaver JE, Thompson LH, Richardson AS, States JC |title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. |journal=Hum. Mutat. |volume=14 |issue= 1 |pages= 9-22 |year= 1999 |pmid= 10447254 |doi= 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FANCD2... {November 8, 2007 3:14:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:15:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fanconi anemia, complementation group D2
| HGNCid = 3585
| Symbol = FANCD2
| AltSymbols =; FACD; FAD; FANCD; DKFZp762A223; FA-D2; FA4; FAD2; FLJ23826
| OMIM = 227646
| ECnumber =
| Homologene = 13212
| MGIid = 2448480
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2177
| Hs_Ensembl = ENSG00000144554
| Hs_RefseqProtein = NP_001018125
| Hs_RefseqmRNA = NM_001018115
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 10043113
| Hs_GenLoc_end = 10118614
| Hs_Uniprot = Q9BXW9
| Mm_EntrezGene = 211651
| Mm_Ensembl = ENSMUSG00000034023
| Mm_RefseqmRNA = NM_001033244
| Mm_RefseqProtein = NP_001028416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 113497462
| Mm_GenLoc_end = 113562794
| Mm_Uniprot = Q3TLN3
}}
}}
'''Fanconi anemia, complementation group D2''', also known as '''FANCD2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: FANCD2 Fanconi anemia, complementation group D2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2177| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FCAR... {November 8, 2007 3:15:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FCAR image.jpg {November 8, 2007 3:18:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:18:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FCAR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ovz.
| PDB = {{PDB2|1ovz}}, {{PDB2|1ow0}}, {{PDB2|1uct}}
| Name = Fc fragment of IgA, receptor for
| HGNCid = 3608
| Symbol = FCAR
| AltSymbols =; CD89
| OMIM = 147045
| ECnumber =
| Homologene = 48064
| MGIid =
| GeneAtlas_image1 = PBB_GE_FCAR_211307_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FCAR_211816_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0019862 |text = IgA binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2204
| Hs_Ensembl = ENSG00000186431
| Hs_RefseqProtein = NP_001991
| Hs_RefseqmRNA = NM_002000
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 60077534
| Hs_GenLoc_end = 60095055
| Hs_Uniprot = P24071
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Fc fragment of IgA, receptor for''', also known as '''FCAR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Ten transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: FCAR Fc fragment of IgA, receptor for| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2204| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Morton HC, van Egmond M, van de Winkel JG |title=Structure and function of human IgA Fc receptors (Fc alpha R). |journal=Crit. Rev. Immunol. |volume=16 |issue= 4 |pages= 423-40 |year= 1997 |pmid= 8954257 |doi= }}
*{{cite journal | author=Morton HC, Brandtzaeg P |title=CD89: the human myeloid IgA Fc receptor. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=49 |issue= 3 |pages= 217-29 |year= 2001 |pmid= 11478396 |doi= }}
*{{cite journal | author=Martin AM, Kulski JK, Witt C, ''et al.'' |title=Leukocyte Ig-like receptor complex (LRC) in mice and men. |journal=Trends Immunol. |volume=23 |issue= 2 |pages= 81-8 |year= 2002 |pmid= 11929131 |doi= }}
*{{cite journal | author=Monteiro RC, Van De Winkel JG |title=IgA Fc receptors. |journal=Annu. Rev. Immunol. |volume=21 |issue= |pages= 177-204 |year= 2003 |pmid= 12524384 |doi= 10.1146/annurev.immunol.21.120601.141011 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGF23... {November 8, 2007 3:30:36 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FGF23 image.jpg {November 8, 2007 3:31:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:31:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGF23_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p39.
| PDB = {{PDB2|2p39}}
| Name = Fibroblast growth factor 23
| HGNCid = 3680
| Symbol = FGF23
| AltSymbols =; ADHR; HYPF; HPDR2; PHPTC
| OMIM = 605380
| ECnumber =
| Homologene = 10771
| MGIid = 1891427
| GeneAtlas_image1 = PBB_GE_FGF23_221166_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030500 |text = regulation of bone mineralization}} {{GNF_GO|id=GO:0030643 |text = cellular phosphate ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8074
| Hs_Ensembl = ENSG00000118972
| Hs_RefseqProtein = NP_065689
| Hs_RefseqmRNA = NM_020638
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 4347654
| Hs_GenLoc_end = 4359155
| Hs_Uniprot = Q9GZV9
| Mm_EntrezGene = 64654
| Mm_Ensembl = ENSMUSG00000000182
| Mm_RefseqmRNA = XM_001003443
| Mm_RefseqProtein = XP_001003443
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 127038593
| Mm_GenLoc_end = 127046844
| Mm_Uniprot = Q0VBJ8
}}
}}
'''Fibroblast growth factor 23''', also known as '''FGF23''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.<ref>{{cite web | title = Entrez Gene: FGF23 fibroblast growth factor 23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8074| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Silve C, Beck L |title=Is FGF23 the long sought after phosphaturic factor phosphatonin? |journal=Nephrol. Dial. Transplant. |volume=17 |issue= 6 |pages= 958-61 |year= 2003 |pmid= 12032180 |doi= }}
*{{cite journal | author=Quarles LD |title=FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 1 |pages= E1-9 |year= 2003 |pmid= 12791601 |doi= 10.1152/ajpendo.00016.2003 }}
*{{cite journal | author=Fukagawa M, Nii-Kono T, Kazama JJ |title=Role of fibroblast growth factor 23 in health and in chronic kidney disease. |journal=Curr. Opin. Nephrol. Hypertens. |volume=14 |issue= 4 |pages= 325-9 |year= 2005 |pmid= 15930999 |doi= }}
*{{cite journal | author=Imel EA, Econs MJ |title=Fibroblast growth factor 23: roles in health and disease. |journal=J. Am. Soc. Nephrol. |volume=16 |issue= 9 |pages= 2565-75 |year= 2006 |pmid= 16033853 |doi= 10.1681/ASN.2005050573 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on G6PC... {November 8, 2007 3:18:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:19:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucose-6-phosphatase, catalytic subunit
| HGNCid = 4056
| Symbol = G6PC
| AltSymbols =; G6PT; GSD1a; MGC163350
| OMIM = 232200
| ECnumber =
| Homologene = 20079
| MGIid = 95607
| GeneAtlas_image1 = PBB_GE_G6PC_206952_at_tn.png
| Function = {{GNF_GO|id=GO:0004346 |text = glucose-6-phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0005978 |text = glycogen biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2538
| Hs_Ensembl = ENSG00000131482
| Hs_RefseqProtein = NP_000142
| Hs_RefseqmRNA = NM_000151
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 38306341
| Hs_GenLoc_end = 38318912
| Hs_Uniprot = P35575
| Mm_EntrezGene = 14377
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008061
| Mm_RefseqProtein = NP_032087
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Glucose-6-phosphatase, catalytic subunit''', also known as '''G6PC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).<ref>{{cite web | title = Entrez Gene: G6PC glucose-6-phosphatase, catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2538| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNE... {November 8, 2007 3:31:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:32:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
| HGNCid = 23657
| Symbol = GNE
| AltSymbols =; NM; DMRV; GLCNE; IBM2; Uae1
| OMIM = 603824
| ECnumber =
| Homologene = 3996
| MGIid = 1354951
| GeneAtlas_image1 = PBB_GE_GNE_205042_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004396 |text = hexokinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008761 |text = UDP-N-acetylglucosamine 2-epimerase activity}} {{GNF_GO|id=GO:0009384 |text = N-acylmannosamine kinase activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006047 |text = UDP-N-acetylglucosamine metabolic process}} {{GNF_GO|id=GO:0006054 |text = N-acetylneuraminate metabolic process}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0009103 |text = lipopolysaccharide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10020
| Hs_Ensembl = ENSG00000159921
| Hs_RefseqProtein = NP_005467
| Hs_RefseqmRNA = NM_005476
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 36204430
| Hs_GenLoc_end = 36248450
| Hs_Uniprot = Q9Y223
| Mm_EntrezGene = 50798
| Mm_Ensembl = ENSMUSG00000028479
| Mm_RefseqmRNA = NM_015828
| Mm_RefseqProtein = NP_056643
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 44055175
| Mm_GenLoc_end = 44105277
| Mm_Uniprot = Q3TCI8
}}
}}
'''Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase''', also known as '''GNE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The bifunctional enzyme, UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase/N-acetylmannosamine kinase) regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. UDP-GlcNAc 2-epimerase activity is rate-limiting for the biosynthesis of sialic acid and is required for sialylation in hematopoietic cells. The activity of the enzyme can be controlled at the transcriptional level and can affect the sialylation and function of specific cell surface molecules expressed on B cells and myeloid cells. Modification of cell surface molecules with sialic acid is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Sialuria is a rare inborn error of metabolism characterized by cytoplasmic accumulation and increased urinary excretion of free NeuAc.<ref>{{cite web | title = Entrez Gene: GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10020| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLF6... {November 8, 2007 3:09:16 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 3:10:44 PM PST}
- CREATED: Created new protein page: KLF6 {November 8, 2007 3:10:51 PM PST}
- INFO: Beginning work on MS4A1... {November 8, 2007 3:08:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:09:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Membrane-spanning 4-domains, subfamily A, member 1
| HGNCid = 7315
| Symbol = MS4A1
| AltSymbols =; B1; Bp35; CD20; LEU-16; MGC3969; MS4A2; S7
| OMIM = 112210
| ECnumber =
| Homologene = 7259
| MGIid = 88321
| GeneAtlas_image1 = PBB_GE_MS4A1_210356_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MS4A1_217418_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042113 |text = B cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 931
| Hs_Ensembl = ENSG00000156738
| Hs_RefseqProtein = NP_068769
| Hs_RefseqmRNA = NM_021950
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 59979858
| Hs_GenLoc_end = 59994801
| Hs_Uniprot = P11836
| Mm_EntrezGene = 12482
| Mm_Ensembl = ENSMUSG00000024673
| Mm_RefseqmRNA = NM_007641
| Mm_RefseqProtein = NP_031667
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 11316865
| Mm_GenLoc_end = 11333194
| Mm_Uniprot = Q542S5
}}
}}
'''Membrane-spanning 4-domains, subfamily A, member 1''', also known as '''MS4A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.<ref>{{cite web | title = Entrez Gene: MS4A1 membrane-spanning 4-domains, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=931| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Macardle PJ, Nicholson IC |title=CD20. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 136-8 |year= 2003 |pmid= 12144126 |doi= }}
*{{cite journal | author=Tamayose K, Sato N, Ando J, ''et al.'' |title=CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature. |journal=Am. J. Hematol. |volume=71 |issue= 4 |pages= 331-5 |year= 2002 |pmid= 12447967 |doi= 10.1002/ajh.10224 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NOD1... {November 8, 2007 3:32:08 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NOD1 image.jpg {November 8, 2007 3:32:44 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 3:32:58 PM PST}
- CREATED: Created new protein page: NOD1 {November 8, 2007 3:33:05 PM PST}
- INFO: Beginning work on PAX8... {November 8, 2007 3:28:03 PM PST}
- UPLOAD: Added new Image to wiki: {November 8, 2007 3:30:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:30:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAX8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k78.
| PDB = {{PDB2|1k78}}, {{PDB2|1mdm}}
| Name = Paired box gene 8
| HGNCid = 8622
| Symbol = PAX8
| AltSymbols =;
| OMIM = 167415
| ECnumber =
| Homologene = 2589
| MGIid = 97492
| GeneAtlas_image1 = PBB_GE_PAX8_121_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAX8_207921_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PAX8_207923_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004550 |text = nucleoside diphosphate kinase activity}} {{GNF_GO|id=GO:0004996 |text = thyroid-stimulating hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006183 |text = GTP biosynthetic process}} {{GNF_GO|id=GO:0006228 |text = UTP biosynthetic process}} {{GNF_GO|id=GO:0006241 |text = CTP biosynthetic process}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7849
| Hs_Ensembl = ENSG00000125618
| Hs_RefseqProtein = NP_003457
| Hs_RefseqmRNA = NM_003466
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 113690046
| Hs_GenLoc_end = 113720991
| Hs_Uniprot = Q06710
| Mm_EntrezGene = 18510
| Mm_Ensembl = ENSMUSG00000026976
| Mm_RefseqmRNA = NM_011040
| Mm_RefseqProtein = NP_035170
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 24242560
| Mm_GenLoc_end = 24297608
| Mm_Uniprot = Q6GU20
}}
}}
'''Paired box gene 8''', also known as '''PAX8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: PAX8 paired box gene 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7849| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMA7... {November 8, 2007 3:19:35 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMA7 image.jpg {November 8, 2007 3:20:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:20:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMA7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
| PDB = {{PDB2|1iru}}
| Name = Proteasome (prosome, macropain) subunit, alpha type, 7
| HGNCid = 9536
| Symbol = PSMA7
| AltSymbols =; C6; HSPC; MGC3755; RC6-1; XAPC7
| OMIM = 606607
| ECnumber =
| Homologene = 2086
| MGIid = 1347070
| GeneAtlas_image1 = PBB_GE_PSMA7_216088_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMA7_201114_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5688
| Hs_Ensembl = ENSG00000101182
| Hs_RefseqProtein = NP_002783
| Hs_RefseqmRNA = NM_002792
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 60145186
| Hs_GenLoc_end = 60151881
| Hs_Uniprot = O14818
| Mm_EntrezGene = 26444
| Mm_Ensembl = ENSMUSG00000027566
| Mm_RefseqmRNA = NM_011969
| Mm_RefseqProtein = NP_036099
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 179965784
| Mm_GenLoc_end = 179971816
| Mm_Uniprot = Q3THL2
}}
}}
'''Proteasome (prosome, macropain) subunit, alpha type, 7''', also known as '''PSMA7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.<ref>{{cite web | title = Entrez Gene: PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5688| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMB5... {November 8, 2007 3:20:57 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMB5 image.jpg {November 8, 2007 3:21:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:21:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMB5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
| PDB = {{PDB2|1iru}}
| Name = Proteasome (prosome, macropain) subunit, beta type, 5
| HGNCid = 9542
| Symbol = PSMB5
| AltSymbols =; X; LMPX; MB1; MGC104214
| OMIM = 600306
| ECnumber =
| Homologene = 55690
| MGIid = 1194513
| GeneAtlas_image1 = PBB_GE_PSMB5_208799_at_tn.png
| Function = {{GNF_GO|id=GO:0004263 |text = chymotrypsin activity}} {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5693
| Hs_Ensembl = ENSG00000100804
| Hs_RefseqProtein = NP_002788
| Hs_RefseqmRNA = NM_002797
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 22564900
| Hs_GenLoc_end = 22573949
| Hs_Uniprot = P28074
| Mm_EntrezGene = 19173
| Mm_Ensembl = ENSMUSG00000022193
| Mm_RefseqmRNA = NM_011186
| Mm_RefseqProtein = NP_035316
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 53568325
| Mm_GenLoc_end = 53572219
| Mm_Uniprot = Q3UZI1
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 5''', also known as '''PSMB5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit).<ref>{{cite web | title = Entrez Gene: PSMB5 proteasome (prosome, macropain) subunit, beta type, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5693| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMC1... {November 8, 2007 3:21:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:22:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 1
| HGNCid = 9547
| Symbol = PSMC1
| AltSymbols =; MGC24583; MGC8541; P26S4; S4; p56
| OMIM = 602706
| ECnumber =
| Homologene = 2095
| MGIid = 106054
| GeneAtlas_image1 = PBB_GE_PSMC1_204219_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5700
| Hs_Ensembl = ENSG00000100764
| Hs_RefseqProtein = NP_002793
| Hs_RefseqmRNA = NM_002802
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 89792639
| Hs_GenLoc_end = 89808719
| Hs_Uniprot = P62191
| Mm_EntrezGene = 19179
| Mm_Ensembl = ENSMUSG00000021178
| Mm_RefseqmRNA = NM_008947
| Mm_RefseqProtein = NP_032973
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 100513381
| Mm_GenLoc_end = 100524242
| Mm_Uniprot = Q542I9
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 1''', also known as '''PSMC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.<ref>{{cite web | title = Entrez Gene: PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5700| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100A1... {November 8, 2007 3:22:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein S100A1 image.jpg {November 8, 2007 3:22:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:23:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k2h.
| PDB = {{PDB2|1k2h}}, {{PDB2|1zfs}}
| Name = S100 calcium binding protein A1
| HGNCid = 10486
| Symbol = S100A1
| AltSymbols =; S100; S100-alpha; S100A
| OMIM = 176940
| ECnumber =
| Homologene = 4566
| MGIid = 1338917
| GeneAtlas_image1 = PBB_GE_S100A1_205334_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048154 |text = S100 beta binding}} {{GNF_GO|id=GO:0048155 |text = S100 alpha binding}} {{GNF_GO|id=GO:0051117 |text = ATPase binding}}
| Component = {{GNF_GO|id=GO:0016529 |text = sarcoplasmic reticulum}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6271
| Hs_Ensembl = ENSG00000160678
| Hs_RefseqProtein = NP_006262
| Hs_RefseqmRNA = NM_006271
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151867026
| Hs_GenLoc_end = 151871137
| Hs_Uniprot = P23297
| Mm_EntrezGene = 20193
| Mm_Ensembl = ENSMUSG00000044080
| Mm_RefseqmRNA = NM_011309
| Mm_RefseqProtein = NP_035439
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90596964
| Mm_GenLoc_end = 90600319
| Mm_Uniprot = Q91V77
}}
}}
'''S100 calcium binding protein A1''', also known as '''S100A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.<ref>{{cite web | title = Entrez Gene: S100A1 S100 calcium binding protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6271| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zimmer DB, Cornwall EH, Landar A, Song W |title=The S100 protein family: history, function, and expression. |journal=Brain Res. Bull. |volume=37 |issue= 4 |pages= 417-29 |year= 1995 |pmid= 7620916 |doi= }}
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Garbuglia M, Verzini M, Sorci G, ''et al.'' |title=The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. |journal=Braz. J. Med. Biol. Res. |volume=32 |issue= 10 |pages= 1177-85 |year= 2000 |pmid= 10510252 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SCGB1A1... {November 8, 2007 3:25:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:26:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secretoglobin, family 1A, member 1 (uteroglobin)
| HGNCid = 12523
| Symbol = SCGB1A1
| AltSymbols =; CC10; CC16; CCSP; UGB
| OMIM = 192020
| ECnumber =
| Homologene = 2518
| MGIid = 98919
| GeneAtlas_image1 = PBB_GE_SCGB1A1_205725_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0019834 |text = phospholipase A2 inhibitor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7356
| Hs_Ensembl = ENSG00000149021
| Hs_RefseqProtein = NP_003348
| Hs_RefseqmRNA = NM_003357
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 61943099
| Hs_GenLoc_end = 61947242
| Hs_Uniprot = P11684
| Mm_EntrezGene = 22287
| Mm_Ensembl = ENSMUSG00000024653
| Mm_RefseqmRNA = NM_011681
| Mm_RefseqProtein = NP_035811
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 9150685
| Mm_GenLoc_end = 9154981
| Mm_Uniprot = Q3UKV9
}}
}}
'''Secretoglobin, family 1A, member 1 (uteroglobin)''', also known as '''SCGB1A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on STAR... {November 8, 2007 3:23:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:23:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Steroidogenic acute regulator
| HGNCid = 11359
| Symbol = STAR
| AltSymbols =; STARD1
| OMIM = 600617
| ECnumber =
| Homologene = 297
| MGIid = 102760
| GeneAtlas_image1 = PBB_GE_STAR_204548_at_tn.png
| Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0015485 |text = cholesterol binding}} {{GNF_GO|id=GO:0017127 |text = cholesterol transporter activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006694 |text = steroid biosynthetic process}} {{GNF_GO|id=GO:0006700 |text = C21-steroid hormone biosynthetic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008211 |text = glucocorticoid metabolic process}} {{GNF_GO|id=GO:0044255 |text = cellular lipid metabolic process}} {{GNF_GO|id=GO:0050810 |text = regulation of steroid biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6770
| Hs_Ensembl = ENSG00000147465
| Hs_RefseqProtein = NP_000340
| Hs_RefseqmRNA = NM_000349
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 38119383
| Hs_GenLoc_end = 38127757
| Hs_Uniprot = P49675
| Mm_EntrezGene = 20845
| Mm_Ensembl = ENSMUSG00000031574
| Mm_RefseqmRNA = NM_011485
| Mm_RefseqProtein = NP_035615
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 27274058
| Mm_GenLoc_end = 27281527
| Mm_Uniprot = P51557
}}
}}
'''Steroidogenic acute regulator''', also known as '''STAR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms.<ref>{{cite web | title = Entrez Gene: STAR steroidogenic acute regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6770| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Strauss JF, Kallen CB, Christenson LK, ''et al.'' |title=The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking. |journal=Recent Prog. Horm. Res. |volume=54 |issue= |pages= 369-94; discussion 394-5 |year= 1999 |pmid= 10548884 |doi= }}
*{{cite journal | author=Stocco DM |title=Clinical disorders associated with abnormal cholesterol transport: mutations in the steroidogenic acute regulatory protein. |journal=Mol. Cell. Endocrinol. |volume=191 |issue= 1 |pages= 19-25 |year= 2003 |pmid= 12044915 |doi= }}
*{{cite journal | author=Manna PR, Stocco DM |title=Regulation of the steroidogenic acute regulatory protein expression: functional and physiological consequences. |journal=Curr. Drug Targets Immune Endocr. Metabol. Disord. |volume=5 |issue= 1 |pages= 93-108 |year= 2005 |pmid= 15777208 |doi= }}
*{{cite journal | author=Miller WL |title=Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. |journal=Biochim. Biophys. Acta |volume=1771 |issue= 6 |pages= 663-76 |year= 2007 |pmid= 17433772 |doi= 10.1016/j.bbalip.2007.02.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TGFB1I1... {November 8, 2007 3:23:39 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 3:24:17 PM PST}
- CREATED: Created new protein page: TGFB1I1 {November 8, 2007 3:24:24 PM PST}
- INFO: Beginning work on TNFAIP3... {November 8, 2007 3:24:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:25:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor, alpha-induced protein 3
| HGNCid = 11896
| Symbol = TNFAIP3
| AltSymbols =; A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2
| OMIM = 191163
| ECnumber =
| Homologene = 4582
| MGIid = 1196377
| GeneAtlas_image1 = PBB_GE_TNFAIP3_202644_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNFAIP3_202643_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0043124 |text = negative regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7128
| Hs_Ensembl = ENSG00000118503
| Hs_RefseqProtein = NP_006281
| Hs_RefseqmRNA = NM_006290
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 138230151
| Hs_GenLoc_end = 138246135
| Hs_Uniprot = P21580
| Mm_EntrezGene = 21929
| Mm_Ensembl = ENSMUSG00000019850
| Mm_RefseqmRNA = NM_009397
| Mm_RefseqProtein = NP_033423
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 18690335
| Mm_GenLoc_end = 18704826
| Mm_Uniprot = Q3T9G9
}}
}}
'''Tumor necrosis factor, alpha-induced protein 3''', also known as '''TNFAIP3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.<ref>{{cite web | title = Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7128| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WFS1... {November 8, 2007 3:26:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:27:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Wolfram syndrome 1 (wolframin)
| HGNCid = 12762
| Symbol = WFS1
| AltSymbols =; DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; WOLFRAMIN
| OMIM = 606201
| ECnumber =
| Homologene = 4380
| MGIid = 1328355
| GeneAtlas_image1 = PBB_GE_WFS1_202908_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7466
| Hs_Ensembl = ENSG00000109501
| Hs_RefseqProtein = NP_005996
| Hs_RefseqmRNA = NM_006005
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 6322478
| Hs_GenLoc_end = 6355893
| Hs_Uniprot = O76024
| Mm_EntrezGene = 22393
| Mm_Ensembl = ENSMUSG00000039474
| Mm_RefseqmRNA = NM_011716
| Mm_RefseqProtein = NP_035846
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 37254356
| Mm_GenLoc_end = 37277167
| Mm_Uniprot = Q3TDI2
}}
}}
'''Wolfram syndrome 1 (wolframin)''', also known as '''WFS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transmembrane protein. Mutations in this gene are associated with an autosomal recessive syndrome characterized by insulin-dependent diabetes mellitus and bilateral progressive optic atrophy, usually presenting in childhood or early adult life. Diverse neurologic symptoms, including a predisposition to psychiatric illness, may also be associated with this disorder. A large number and variety of mutations in this gene, particularly in exon 8, can be associated with this syndrome. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38.<ref>{{cite web | title = Entrez Gene: WFS1 Wolfram syndrome 1 (wolframin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7466| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Khanim F, Kirk J, Latif F, Barrett TG |title=WFS1/wolframin mutations, Wolfram syndrome, and associated diseases. |journal=Hum. Mutat. |volume=17 |issue= 5 |pages= 357-67 |year= 2001 |pmid= 11317350 |doi= 10.1002/humu.1110 }}
*{{cite journal | author=Cryns K, Sivakumaran TA, Van den Ouweland JM, ''et al.'' |title=Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. |journal=Hum. Mutat. |volume=22 |issue= 4 |pages= 275-87 |year= 2004 |pmid= 12955714 |doi= 10.1002/humu.10258 }}
*{{cite journal | author=McHugh RK, Friedman RA |title=Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum. |journal=The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology |volume=288 |issue= 4 |pages= 370-81 |year= 2006 |pmid= 16550584 |doi= 10.1002/ar.a.20297 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WNT1... {November 8, 2007 3:27:26 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 3:27:56 PM PST}
- CREATED: Created new protein page: WNT1 {November 8, 2007 3:28:03 PM PST}
end log.
