User:Mr. Ibrahem/Peramivir

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Mr. Ibrahem/Peramivir
Clinical data
Trade namesRapivab
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
Routes of
administration		Intravenous
Drug classNeuraminidase inhibitor[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
Bioavailability100% (IV)
Elimination half-life7.7 to 20.8 hours (in patients with normal renal function)
ExcretionKidney
Identifiers
  • (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-(carbamimidoylamino)-2-hydroxycyclopentanecarboxylic acid
Chemical and physical data
FormulaC15H28N4O4
Molar mass328.413 g·mol−1
3D model (JSmol)
  • CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)NC(=N)N)NC(=O)C
  • InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1 ☒N
  • Key:XRQDFNLINLXZLB-CKIKVBCHSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Peramivir, sold under the brand name Rapivab, is an antiviral used to treat influenza.[1] It should be given within two days of the start of symptoms.[1] Evidence does not support its use for prevention.[1] It is given by gradual injection in to a vein.[2]

Common side effects include low neutrophils, trouble sleeping, and nausea.[2][1] Other side effects may include abnormal behavior.[1] Serious side effects may include anaphylaxis and Stevens-Johnson syndrome.[2] It does not appear to be harmful in pregnancy, but such use has not been well studied.[3] It is a neuraminidase inhibitor that is active against both influenza A and B viruses.[1]

Peramivir was approved for medical use in the United States in 2014.[1] While it was approved in Europe in 2018, this approval was subsequently withdrawn.[4] In the United States it costs about 1,000 USD per dose as of 2021.[5]

References[edit]

  1. ^ a b c d e f g h i j k "Peramivir Monograph for Professionals". Drugs.com. Archived from the original on 7 October 2020. Retrieved 27 October 2021.
  2. ^ a b c d "Alpivab (peramivir)" (PDF). Archived (PDF) from the original on 6 March 2020. Retrieved 27 October 2021.
  3. ^ "Peramivir (Rapivab) Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 27 October 2021.
  4. ^ "Alpivab". Archived from the original on 26 June 2021. Retrieved 27 October 2021.
  5. ^ "Rapivab Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 27 October 2021.
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