User:Doc James/Sandbox
A Cochrane review from 2008 did not recommend silver sulfadiazine, an ointment containing silver, for burns as it potentially prolongs healing time.[1] It however used to be deemed the "gold standard" in topical treatment.[2] A 2012 review found no advantage when an anti-microbial (silver) hydrocolloid dressing was compared with a standard alginate dressing in diabetic foot ulcers.[3] There is insufficient evidence to support the use ofsilvercontaining dressings.[4]These dressings sometimes result in a slower healing process.[2] The evidence for their use is marred by the poor quality of the trials.[5] Most of the studies have been small and they generally indicated that the treatments did not promote wound healing or prevent wound infections.[6][7]
Silver sulfadiazine cream replaced colloidal silver as the most common delivery system for using silver on the surface of burn wounds to control infection in the 1970s.[8][2] The US Food and Drug Administration has approved topical preparations of silver sulfadiazine for treatment of second- and third-degree burns.[9]
Dressings incorporating nanocrystalline silver or activated silver-impregnated substances are available,[2] which deliver higher concentrations of the active silver ion.[10] As of 2006, more "than 10 dressings containing pure silver" were available.[11] In particular, silver is being used with alginate, a naturally occurring biopolymer derived from seaweed, in a range of products designed to prevent infections as part of wound management procedures, particularly applicable to burn.[11]
Topical silver is regaining popularity in the management of open wounds, “due largely to the spread of methicillin-resistant Staphylococcus aureus and the resultant reduction in first-line antibiotic prescribing”, and “[s]ome silver-based dressings appear to provide an effective alternative to antibiotics in the management of wound infection.”[12] Silver has broad-spectrum antimicrobial activity that includes antibiotic-resistant bacteria, with minimal toxicity toward mammalian cells at low concentrations, and has a less likely tendency than antibiotics to induce resistance due to its activity at multiple bacterial target sites.[13]
- ^ Wasiak J, Cleland H, Campbell F (2008). Wasiak, Jason (ed.). "Dressings for superficial and partial thickness burns". Cochrane Database Syst Rev (4): CD002106. doi:10.1002/14651858.CD002106.pub3. PMID 18843629.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b c d Cite error: The named reference
Burns2007was invoked but never defined (see the help page). - ^ Dumville, J. C.; O'Meara, S.; Deshpande, S.; Speak, K. (2012 Feb 15). "Alginate dressings for healing diabetic foot ulcers". Cochrane Database of Systematic Reviews (Online). 2 (2): CD009110. doi:10.1002/14651858.CD009110.pub2. PMID 22336860.
{{cite journal}}: Check date values in:|date=(help) - ^ Storm-Versloot, Marja N.; Vos, Cornelis G.; Ubbink, Dirk T.; Vermeulen, Hester (2010 Mar 17). "Topical silver for preventing wound infection". Cochrane Database of Systematic Reviews (Online) (3): CD006478. doi:10.1002/14651858.CD006478.pub2. PMID 20238345.
{{cite journal}}: Check date values in:|date=(help) - ^ Lo SF, Hayter M, Chang CJ, Hu WY, Lee LL (2008). "A systematic review of silver-releasing dressings in the management of infected chronic wounds". Journal of Clinical Nursing. 17 (15): 1973–85. doi:10.1111/j.1365-2702.2007.02264.x. PMID 18705778.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Cochrane Collaboration: Topical silver for preventing wound infection, 2009
- ^ Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT (2007). Vermeulen, Hester (ed.). "Topical silver for treating infected wounds". Cochrane Database of Systematic Reviews (1): CD005486. doi:10.1002/14651858.CD005486.pub2. PMID 17253557.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Cite error: The named reference
nccamwas invoked but never defined (see the help page). - ^ "Drugs@FDA". Accessdata.fda.gov. Retrieved 2010-07-10.
- ^ Cite error: The named reference
Lansdown2006was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
Hermans2006was invoked but never defined (see the help page). - ^ Chopra, I. (2007). "The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?". Journal of Antimicrobial Chemotherapy. 59 (4): 587. doi:10.1093/jac/dkm006. PMID 17307768.
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Chopra2007was invoked but never defined (see the help page).