UBE1L

UBA7
Identifiers
Aliases	UBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDs	OMIM: 191325 MGI: 1349462 HomoloGene: 2502 GeneCards: UBA7
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,805,209 bp End 49,813,953 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 59.07 cM Start 107,852,704 bp End 107,861,259 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right uterine tube lymph node appendix duodenum gallbladder right lobe of thyroid gland right coronary artery left lobe of thyroid gland rectum Top expressed in spleen blood duodenum thymus submandibular gland jejunum intestinal villus ileum bone marrow stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding ISG15 activating enzyme activity nucleotide binding ubiquitin-like modifier activating enzyme activity ligase activity protein binding ubiquitin-protein transferase activity ubiquitin activating enzyme activity Cellular component nucleoplasm cytosol cytoplasm nucleus Biological process negative regulation of type I interferon production ISG15-protein conjugation protein ubiquitination modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7318 74153 Ensembl ENSG00000182179 ENSMUSG00000032596 UniProt P41226 n/a RefSeq (mRNA) NM_003335 NM_023738 RefSeq (protein) NP_003326 n/a Location (UCSC) Chr 3: 49.81 – 49.81 Mb Chr 9: 107.85 – 107.86 Mb PubMed search
Wikidata
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Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.

Further reading

• Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.
• Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMC 6134375. PMID 7734949.
• McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
• Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
• Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. Bibcode:2002PNAS...99.3806K. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
• Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.