Trevor K. Archer

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Trevor K. Archer
Archer 2019 NIEHS photograph
Born
The Bahamas
Alma materQueen's University at Kingston
Scientific career
InstitutionsNational Cancer Institute
University of Western Ontario
ThesisAn analysis of human and non-human primate apolipoprotein biosynthesis : hormonal (1988)

Trevor K. Archer is a Bahamian research scientist who is a National Institutes of Health Distinguished Investigator and deputy director at the National Institute of Environmental Health Sciences. He leads the Chromatin and Gene Expression Group, who investigate chromatin, epigenetics and embryonic stem cells pluripotency.

Early life and education[edit]

Archer was born in The Bahamas.[1] He studied biochemistry at Queen's University at Kingston, and remained there for his doctorate.[2] His doctoral research considered human and non-human primate apolipoprotein biosynthesis.[3] He moved to the National Cancer Institute as a postdoctoral researcher working on chromatin and epigenetics, with a focus on steroid hormone activated transcription.[citation needed]

Research and career[edit]

Archer returned to Canada in 1992, where he was made an Assistant Professor and National Cancer Institute Canada scientist at University of Western Ontario. He received tenure in 1996.[1] In 1999, he was recruited to the National Institute of Environmental Health Sciences.[4] He was promoted to Chief of Molecular Carcinogenesis in 2003, and Chief of Epigenetics and Stem Cell Biology in 2014.[1] He was named as an National Institutes of Health Distinguished Investigator in 2019.[4]

Archer's research uses genomics to study the environmental factors that impact the architecture of chromatin,[5] and how changes to the architecture of chromatin impact gene expression, which affects health and disease.[6][7] Archer showed that steroid hormone signalling can be used to understand how gene expression is controlled.[8]

In an interview with Molecular Cell, Archer said that throughout his career he was underestimated because of his skin color.[1] As a Deputy Director of the National Institute of Environmental Health Sciences, Archer chaired a committee on workplace culture, where he looked to diversify the talent pool, and make the NIEHS more inclusive.[4]

Selected publications[edit]

  • Deborah A Greer Card; Pratibha B Hebbar; Leping Li; Kevin W Trotter; Yoshihiro Komatsu; Yuji Mishina; Trevor K Archer (October 2008). "Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells". Molecular and Cellular Biology. 28 (20): 6426–38. doi:10.1128/MCB.00359-08. ISSN 0270-7306. PMC 2577422. PMID 18710938. Wikidata Q24323720.
  • Fryer CJ; Trevor K Archer (1 May 1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature. 393 (6680): 88–91. Bibcode:1998Natur.393...88F. doi:10.1038/30032. ISSN 1476-4687. PMID 9590696. Wikidata Q28271105.
  • T K Archer; P Lefebvre; R G Wolford; G L Hager (1 March 1992). "Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation". Science. 255 (5051): 1573–1576. Bibcode:1992Sci...255.1573A. doi:10.1126/SCIENCE.1347958. ISSN 0036-8075. PMID 1347958. Wikidata Q67514906.

References[edit]

  1. ^ a b c d "Education, Experience, and Action: An Interview with Dr. Trevor K. Archer". Molecular Cell. 80 (5): 749–751. December 2020. doi:10.1016/j.molcel.2020.11.018. ISSN 1097-2765. PMID 33275883. S2CID 227296049.
  2. ^ "Trevor Archer, Ph.D. | Principal Investigators | NIH Intramural Research Program". irp.nih.gov. Retrieved 2023-06-03.
  3. ^ "An analysis of human and non-human primate apolipoprotein biosynthesis : hormonal regulation of apolipoprotein mRNA levels in the human hepatocarcinoma cell line HepG2 | WorldCat.org". www.worldcat.org. Retrieved 2023-06-03.
  4. ^ a b c "Trevor K. Archer — new Deputy Director of NIEHS — shares his goals, research passion (Environmental Factor, February 2022)". National Institute of Environmental Health Sciences. Retrieved 2023-06-03.
  5. ^ Trotter, Kevin W.; Archer, Trevor K. (2004-04-01). "Reconstitution of Glucocorticoid Receptor-Dependent Transcription In Vivo". Molecular and Cellular Biology. 24 (8): 3347–3358. doi:10.1128/MCB.24.8.3347-3358.2004. ISSN 1098-5549. PMC 381687. PMID 15060156.
  6. ^ Fryer, Christy J.; Archer, Trevor K. (May 1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature. 393 (6680): 88–91. Bibcode:1998Natur.393...88F. doi:10.1038/30032. ISSN 0028-0836. PMID 9590696. S2CID 2208522.
  7. ^ Kinyamu, H. Karimi; Bennett, Brian D.; Bushel, Pierre R.; Archer, Trevor K. (2020-01-31). "Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity". Journal of Biological Chemistry. 295 (5): 1271–1287. doi:10.1074/jbc.RA119.011174. ISSN 0021-9258. PMC 6996893. PMID 31806706.
  8. ^ Hoffman, Jackson A; Trotter, Kevin W; Ward, James M; Archer, Trevor K (2018-05-24). "BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome". eLife. 7. doi:10.7554/eLife.35073. ISSN 2050-084X. PMC 5967868. PMID 29792595.
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