Talk:Methaqualone/Archive 1

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Archive 1


Long term effects

It would be useful to have a section on the long-term effects of the drug. I remember there being rumours in SA that it made your hair curly and messed up your nails --Mostyn 11:48, 21 April 2008 (UTC) — Preceding unsigned comment added by Fishwristwatch (talk • contribs) 11:48, 21 April 2008 (UTC) and modified in — Preceding unsigned comment added by Fishwristwatch (talk • contribs) 11:48, 21 April 2008 (UTC)

Gujiral

Is there any reference about Gujiral being the discoverer of methaqualone in 1955? I always thought it was discovered during wwII when Japan cut of Quinin supplies. There also is an article about methaqualone in an 1951 article in the "Journal of the Indian Chemical Society" according to the Merck Index --82.207.200.229 21:08, 20 January 2006 (UTC)

question re dopewars

Do you think it would be worthwhile to add a reference to ludes and the game dopewars(drug wars), in which they are one of the drugs you can deal? Perhaps this methaqualone is more commonly known as ludes, anyway I added a redirect for those of us wondering what ludes are. ~ --Haruki 08:33, 1 Oct 2004 (UTC)

No it is not usefeul to add this --81.244.91.27 09:56, 5 Jun 2005 (UTC)


forum

It is a shame this drug is no longer around. In the early 70's it was my fave. The effects on me were EXACTLY like drinking alot, but without any side effects. None what so ever. Most females reacted that way. As a non gay male who always thought I didn't have enough testosterone (my voice never deepened enought), I have wondered for years why most abuse of this drug was male. I know a few folk who could not hold their drugs any better than their alcohol. They are born again now, and still exhibit that same addictive personality thing.— Preceding unsigned comment added by 66.214.233.241 (talk • contribs) 03:42, 13 June 2005 (UTC)

Blues name

These pills were heavily abused in the southern US under the name Blues. Along with T's they were used intraveinously, most times in combination with T's. — Preceding unsigned comment added by 67.138.183.57 (talk • contribs) 20:03, 17 February 2006 (UTC)

"Blues" have absolutely nothing to do with methaqualone. T's and Blues is one in a long line of heavily abused opioid-antihistamine combinations. On the issue of whether it was heavily abused in the South by the name "Blues," I cannot, say, but I'm not aware of a blue methaqualone pill. — Preceding unsigned comment added by 209.94.169.232 (talk • contribs) 04:35, 1 August 2009 (UTC)

mandrax 1

This drug is apparently known as "Mandrax" in South Africa.— Preceding unsigned comment added by 209.149.58.156 (talk • contribs) 03:01, 15 November 2004 (UTC)

Methaqualone is known as mandrax in South Africa however on the street it is commonly refered to as Buttons. Explosive steve 11:15, 24 October 2006 (UTC)

freddie prinze

Maybe it's relevant to mention that this drug's side effects are probably what led actor Freddie Prinze to suicide. — Preceding unsigned comment added by 200.195.79.132 (talk • contribs) 20:46, 17 February 2005 (UTC)


Scientology

What is that stuff added about the Church of Scientology? Is that true? I added a citation needed tag, because I don't know Djohnsto77 03:12, 31 January 2007 (UTC)

history

I am really so new to writing anything in Wikipedia I have not even visited this for about a year. I am the writer or editor that did the extensive research behind methaqualone's history. Someone asked and inserted "citation needed" so forgive me for such a slow response. Once I can figure out "how to add the citation" I will. I promise to get with the program here on Wikipedia. I do write for WikiHow but obviously there are far more stringent guidelines to learn here with a steeper learning curve. Apparently I need to start an account or my own page. I did so under my companies name, even made a financial donation, but caught hell from the editors. I admit I never bothered reading the guidelines or link policies. But certainly I had no ill intentions, sure hope they don't continue to hold it against me.--76.166.149.103 (talk) 08:51, 5 October 2010 (UTC) —Preceding unsigned comment added by 76.166.149.103 (talk) 08:35, 5 October 2010 (UTC)

Errors

The article characterizes methaqualone as an "antianxiolytic." This would literally mean a drug that antagonizes the relief of anxiety. The correct term is simply "anxiolytic."

It is mentioned in the discussion that methaqualone was used intravenously as "Blues," in the combination "Ts and Blues." This is incorrect. "Blues" were the antihistamine triplenenamine, which, when used with Tylenol with Codeine ("Ts") was said to create an opioid-like high. — Preceding unsigned comment added by EatonTFores (talk • contribs) 14:42, 24 April 2006 (UTC)

  • T's were not codeine either. T's were Talwin, or pentazocine. It's a benzomorphan opioid. Talwin + Tripplenamine (correct spelling) was extremely popular, which resulted in Talwin NX being brought to market, containing naloxone to prevent injection of this product. — Preceding unsigned comment added by 209.94.169.232 (talk • contribs) 04:35, 1 August 2009 (UTC)
  • The actual adult dosage was 300mg not 75mg. 70.161.213.63 (talk) 15:51, 9 July 2015 (UTC)

"Depression"

I edited the effects heading. Originally it said that high doses could result in depression, among other things, and linked to the clinical depression page, which redirects to Major Depressive Disorder. This results from a stupid belief among lay and otherwise pharm illiterate folk that CNS depressants produce depressed affect, which isn't true at all. I'm sure many here have heard that "of course long term high dose alcoholism results in depressed drunks" or something to that effect. It's nonsense. Anyone who's ever drank ought to know that a CNS depressant doesn't automatically produce depression, that's the result of sobering up and being an addict.

Methaqualone is a CNS depressant and high doses will cause depression of the respiratory drive, but regarding mood, it's a strong mood elevator.— Preceding unsigned comment added by 209.94.169.232 (talk • contribs) 04:35, 1 August 2009 (UTC)

Street names (Chris Morris)?

Jessop Jessop Jessop Jessop Jessop ? Clarky Cat ?

Someone's having a laugh. — Preceding unsigned comment added by 195.75.240.254 (talk • contribs) 13:46, 5 September 2007 (UTC)

Meh. I think I'll remove the section completely. Talk about irrelevant bloat.Ticklemygrits 16:55, 19 October 2007 (UTC)
I think we need at least a brief mention of other names, as the article starts with methaqualone, but later refers to quaaludes and 'ludes. I'd add it myself, but I'm not really knowledgeable on this subject. --Pyrochem (talk) 19:27, 20 December 2007 (UTC)
Methaqualone was manufactured in the United States by the pharmaceutical giants "Rorer" and "Lemmon" with the numbers 714 stamped on the tablet, later to be refered to on the streets as 714's, also as simply "lemons". Underground labs in Mexico continued manufacture of Qualudes all through the 1980's, continuing the "714" stamp, until their popularity waned in the early 1990's.
Other lesser known names include: Disco Biscuits, Down And Dirtys, Fuckers, Joe Fridays,Lennons, Lovers, Ludes, Mandies, Mandrake, Q, qua, quaa, quack, Quad, Qualudes, Soaper, Supper, Vitamin Q, The Love Drug, Wallbangers, Whore Pills,... — Preceding unsigned comment added by 76.166.149.103 (talk • contribs) 00:11, 13 February 2009 (UTC)

Anti-drug bias in article?

Consider this sentence in the article: "Mandrax has become a major problem and is one of the most commonly abused hard drugs in South Africa." The statement presumes that drug use for fun is a 'problem' and that it is 'abuse'. Perhaps this statement was written by a law enforcement officer? I doubt that the users in South Africa would agree with this statement. —Preceding unsigned comment added by 63.193.144.79 (talk) 12:31, 15 April 2008 (UTC)

removed language about 'clearly addictive', based on no supporting cites and personal knowledge of former users. removed 'problem drug abuse' as point of view. article also mentions it as a 'hard' drug; while acknowledging it may strong, i think this description is vague. which drugs are 'soft'? —Preceding unsigned comment added by 63.193.144.79 (talk) 00:21, 17 June 2008 (UTC)

Drug of abuse

Apparently still prescribed in 3rd world but sceduled by the DEA in the US. Back then it had the numbers "624" inscribed on them, like in the song "25 or 6 to 4". Oft given to those on "bad trips" to come down. Twas a popular drug to get your date "in the mood". Shjacks45 (talk) 14:28, 25 May 2008 (UTC)

10cc

I've removed the unsourced reference to 10cc's "I'm Mandy Fly Me" being a song about Mandrax. Unless you've got a source that can quote 10cc themselves giving this (rather far-fetched and unlikely) interpretation of the song, the band themselves in a couple of interviews claimed the inspiration for the song was a famous ad campaign for United Airlines, and that the song describes a fantasy of an eventful plane journey with a stewardess named Mandy. (And is a quasi-sequel to another song they wrote about an eventful plane trip called "Clockwork Creep", which recounted a potential airborne terrorist bombing.) 172.166.107.107 (talk) 20:55, 28 May 2008 (UTC)

Pop culture section

Collapsed above is the removed pop culture section. The most famous examples (one or two, perhaps three at the most) should be cited, if possible, and perhaps returned to the article in prose (not list) format. Avruch T 21:14, 10 January 2009 (UTC)

Removed 'misuse' paragraph as POV

Perhaps the writer intended to say 'illegal' or 'not medically recognized'. —Preceding unsigned comment added by Ykral (talk • contribs) 18:15, 16 January 2009 (UTC)

additional reference by the butthole surfers i added. feel free to edit it correctly. —Preceding unsigned comment added by 70.30.80.254 (talk) 02:48, 30 May 2009 (UTC)

Ethnocentric poop

I'm removing the following crap:

"Methaqualone is no longer legally produced, so methaqualone for the South African market is manufactured either in India or in South Africa itself — or in other African countries.[7]"

"Legal" WHERE? It's no longer legally produced in the USA, but it's perfectly legal in many other jurisdictions. This is ethnocentric crap. 70.185.226.203 (talk) 06:42, 8 January 2010 (UTC)

714 (disambiguation)

Not generic methaqualone, but the famous brand by the name "Quaalude" was made by 'William H Rorer Inc.' as per the 714 disambiguation page, this deserves mention in the article as notable. 184.76.53.217 (talk) 10:47, 2 April 2010 (UTC)

Use for insomnia

When I was attending speical forces medical training in the 1970's my physician-teacher explained that this drug was considered a break through in sleep therapy since its effects did not eliminate REM sleep and the patient awoke as refreshed as most people would from normal sleep. It is a shame that this drug has been scheduled out of prescription use, since there doesn't seem to be a replacement drug that is as safe to use. —Preceding unsigned comment added by 173.79.43.207 (talk) 04:51, 15 August 2010 (UTC)

Photophobia

Someone had some fun with the definition of photophobia --- "photophobia (the fear of being photographed)."

75.66.160.11 (talk) 03:13, 8 January 2011 (UTC)

Moved from article

The following list of references was appended to the article, but they do not appear to be used to support any of the current article content. I'm moving them here in case anyone would like to use them to expand the article. -- Ed (Edgar181) 15:52, 5 January 2012 (UTC)

  • Smyth RD, Lee JK, Polk A, Chemburkar PB, Savacool AM (1973). "Bioavailability of methaqualone". J Clin Pharmacol. 13 (10): 391–400. PMID 4490663. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  • Nayak RK, Smyth RD, Chamberlain JH; et al. (1974). "Methaqualone pharmacokinetics after single- and multiple-dose administration in man". J Pharmacokinet Biopharm. 2 (2): 107–21. doi:10.1007/BF01061503. PMID 4427217. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  • Chemburkar PB, Smyth RD, Buehler JD; et al. (1976). "Correlation between dissolution characteristics and absorption of methaqualone from solid dosage forms". J Pharm Sci. 65 (4): 529–33. doi:10.1002/jps.2600650413. PMID 1271252. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

pharmacological and/or chemical information

This article needs some more scientific information. What is the exact mechanism of action? What makes it different from benzodiazepines or barbiturates? Is it in its own class of drugs? Or it simply another barbiturate? Is it an agonist? An antagonist? A partial agonist? An inverse agonist?

I couldn't find anything from a quick google search. Maybe someone with access to scientific literature could take a look? Charles35 (talk) 18:27, 9 February 2013 (UTC)

Statement not supported by the authority cited

In section 2.2 of the Article, with the title ==Recreational== the final sentence is not supported by the referenced authority.

The sentence reads:
The drug's price of R 90[citation needed] (about US$8) together with readily available cheap, low-grade cannabis, makes methaqualone one of the preferred drugs of the lower-income, mid and upper sections of South African society.

The citation, which is "cite web|url=http://www.drugaware.co.za/mandrax.html%7Ctitle=Mandrax%7Cyear=2003%7Cwork=DrugAware%7Cpublisher=Reality Media|accessdate=2009-08-13}} McCarthy G, Myers B, Siegfried N" makes no such statement and there is nothing at the cited page which could be stretched far enough to support the conclusion in the sentence. -- Komowkwa (talk) 04:51, 8 January 2014 (UTC)

safety comparison to alcohol would be nice

given that alcohol is legal (even 151-proof rum!), it would be nice to see the safety of 300 mg compared to 2 shots of vodka. my understanding is that the drug was banned mostly because of a few irresponsible teenagers, and that it was not truly addictive. — Preceding unsigned comment added by 76.176.108.8 (talk • contribs) 11:39, 23 January 2014 (UTC)

"World govts shut down Q production," vs "still used in SAfrica"

DEA worker is quoted as saying world govts shut down Q production around 2007, but article says Q is popular in South Africa. Could someone clarify if production there is clandestine? 74.60.161.158 (talk) 00:06, 8 March 2014 (UTC)

Yes it is made in South Africa and in India, but still illegal in both countries. — Preceding unsigned comment added by 76.176.108.8 (talk) 19:58, 30 March 2014 (UTC)

page protection

i am going to request page protection with all the driveby vandalism. Jytdog (talk) 16:07, 8 July 2015 (UTC)

don't let all the current Bill Cosby stuff tarnish the hard earned reputation of Roman Polanski he was droppin ludes on 13yr olds 40 years ago — Preceding unsigned comment added by 207.81.248.125 (talk) 10:16, 13 July 2015 (UTC)

Mandrax

Aside from the UK someone said on YT comment they are also called Mandrax in South Africa. Inclined to believe. What other nations should we mention un intro? 05:03, 16 July 2015 (UTC) — Preceding unsigned comment added by 64.228.89.160 (talk)

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smoking methaqualone

Smoking is a common practice in South Africa but I am unaware of any sources that show the drug was smoked in the united states, all the info in the entry about smoking in the US and the physical dangers of smoking the tablets was totally unsourced and a search on google scholar and pubmed did not reveal any references describing methaqualone smoke induced emphysema nor any information re toxicity of smoked binders. I don't doubt these things may be true, but without any citation and without any indication these phenomena have been studied medically and toxicologically I feel this may not only be OR but a totally unsupported inference. The offending passage is pasted below, feel free to reintroduce if someone finds a reference:

"Smoking methaqualone, either by itself or as an adulterant added to various legal and illegal smoking mixtures, gained popularity in the US for a few years during the mid-1970s. Because the various binders and inert ingredients that were contained in the pill form were toxic when smoked, this practice was roundly decried by the medical community as a serious health risk. Smoking methaqualone pills can lead to emphysema and other chronic lung disorders, most notably talcosis."

-- Glucuronide (talk) 19:22, 14 May 2016 (UTC)

In Popular culture section needed

In Popular culture section needed — Preceding unsigned comment added by 169.0.4.169 (talk) 13:43, 20 March 2017 (UTC)

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2=2

"Methaqualone was initially placed in Schedule II as defined by the UN Convention of Psychotropic Substances, but was moved to Schedule II in 1979" Huh? Are my eyes bad or does this really say it changed from Schedule II (whatever that is -- it is not explained, and only linked in a sidebar) to Schedule II. 5.34.25.102 (talk) 07:18, 10 September 2017 (UTC)

Repeated information

The information in the third paragraph is reproduced almost verbatim at the start of the "Recreational" section. I won't presume to decide which version is better, or which is the best location for the information, but whoever wrote this should perhaps re-read the whole thing.89.212.50.177 (talk) 12:35, 21 December 2017 (UTC)

In general, the opening section of the article should be a summary of the main text below, so it's fine to have some redundancy is that sense. Word-for-word repetition isn't ideal though. -- Ed (Edgar181) 12:42, 21 December 2017 (UTC)

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1715 year

In 1715-1716 the word ludes was used in an old nursery rhyme, but it has some how lost that era meaning. Mseasly48 (talk) 09:10, 24 August 2018 (UTC)

Mechanism of action?

While it's understandable that there isn't a "Synthesis" section for this Schedule I drug, I find it surprising that there is as yet no description of its mechanism of action. Would anyone like to add such a section? See "A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)(2015)"-Quisqualis (talk) 06:44, 7 February 2019 (UTC)

Overdose section

A newspaper article is a poor source for a lethal dosage. Most scientific sources don't speak of lethal dose in terms of absolutes, they talk about an LD50. --A Shortfall Of Gravitas (talk) 09:30, 10 March 2020 (UTC)

'Common' date-rape drug?

The citation given for this statement says no such thing anywhere I can see. The closest seems to be where it says 'the increasing prevalence of predators using Benadryl to incapacitate their victims', which is both about a different drug (diphenhydramine) and only says use is 'increasing', not that it is 'common'. Should I just go ahead and remove the claim, or remove the citation and note it as un-cited for now? -Joey- (talk) 00:39, 25 February 2020 (UTC)

You are correct, I'd say remove. I don't know of anyone claiming that quaaludes are common, let alone their use in rapes in modern times. --A Shortfall Of Gravitas (talk) 11:42, 10 March 2020 (UTC)

Methaqualone uses

Where and for what could this medication be obtained 2600:8807:C4A:1A00:78F9:165E:176:EAEA (talk) 17:23, 23 November 2022 (UTC)

Reference 16 does not belong on this page

Reference number 16, which appears as:

"The Meth Epidemic – Haislip discusses parallels to current Methamphetamine epidemic". Frontline. Boston: WGBH Educational Foundation.

Is very clearly about methamphetamine, not methaqualone. I was unable to find any references to methaqualone when I followed the link to the Frontline new report.

The reference should be removed and every subsequent reference moved back by one number, but I do not have enough experience editing to know how to remove a reference. I would appreciate some help on this, either by informing me how to delete a reference myself or by someone else just going ahead and deleting it. Nmetkn (talk) 10:25, 4 February 2023 (UTC)

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