Tagatose-bisphosphate aldolase
| tagatose-bisphosphate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.2.40 | ||||||||
| CAS no. | 39433-95-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme tagatose-bisphosphate aldolase (EC 4.1.2.40) catalyzes the chemical reaction
- D-tagatose 1,6-bisphosphate glycerone phosphate[1] + Dglyceraldehyde 3-phosphate
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.
Structural studies[edit]
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GVF.
References[edit]
- ^ Commonly known as dihydroxyacetone phosphate.
- Anderson RL, Markwell JP (1982). "D-Tagatose-1,6-bisphosphate aldolase (Class II) from Klebsiella pneumoniae". Methods Enzymol. 90: 323–324. doi:10.1016/s0076-6879(82)90131-8. PMID 6759854.
- van Rooijen RJ, van Schalkwijk S, de Vos WM (1991). "Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis". J. Biol. Chem. 266 (11): 7176–81. PMID 1901863.
