TRAT1

TRAT1
Identifiers
Aliases	TRAT1, TCRIM, TRIM, HSPC062, pp29/30, T cell receptor associated transmembrane adaptor 1, T-cell receptor associated transmembrane adaptor 1
External IDs	OMIM: 604962 MGI: 1924897 HomoloGene: 41130 GeneCards: TRAT1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	108,855,005 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	48,592,384 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; thymus; ; spleen; ; gallbladder; ; bone marrow; ; thymus; ; bone marrow cells; ; rectum;
	Top expressed in
	thymus; ; blood; ; spleen; ; subcutaneous adipose tissue; ; superior frontal gyrus; ; vastus lateralis muscle; ; submandibular gland; ; sternocleidomastoid muscle; ; skin of abdomen; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex;
Biological process	positive regulation of calcium-mediated signaling; adaptive immune response; immune system process; positive regulation of T cell receptor signaling pathway; negative regulation of transport; cellular defense response; T cell receptor signaling pathway; negative regulation of receptor recycling; signal transduction; phosphatidylinositol phosphate biosynthetic process; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	50852
	77647
	ENSG00000163519
	ENSMUSG00000030775
	Q6PIZ9
	Q3UU67
	NM_016388; NM_001317747
	NM_198297
	NP_001304676; NP_057472
	NP_938039
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163519 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030775 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID 10663578. S2CID 43325566.
^ Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC 2212462. PMID 9687533.
^ "Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

Further reading[edit]

Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. S2CID 340034.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163519 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030775 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10663578-5] Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID 10663578. S2CID 43325566.

[pmid9687533-6] Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC 2212462. PMID 9687533.

[entrez-7] "Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

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