TMEM123

TMEM123
Identifiers
Aliases	TMEM123, KCT3, PORIMIN, PORMIN, transmembrane protein 123
External IDs	OMIM: 606356 MGI: 1919179 HomoloGene: 14177 GeneCards: TMEM123
Gene location (Human) Chr. Chromosome 11 (human) Band 11q22.2 Start 102,396,332 bp End 102,470,384 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A1 Start 7,764,042 bp End 7,794,334 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva human penis germinal epithelium thymus lymph node ganglionic eminence monocyte endometrium bronchial epithelial cell bone marrow cells Top expressed in spleen seminal vesicula superior surface of tongue conjunctival fornix corneal stroma blood carotid body adrenal gland ascending aorta submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor activity Cellular component integral component of membrane membrane external side of plasma membrane cytoplasmic vesicle Biological process oncosis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114908 71929 Ensembl ENSG00000152558 ENSMUSG00000050912 UniProt Q8N131 Q91Z22 RefSeq (mRNA) NM_052932 NM_133739 RefSeq (protein) NP_443164 NP_598500 Location (UCSC) Chr 11: 102.4 – 102.47 Mb Chr 9: 7.76 – 7.79 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Porimin is a protein that in humans is encoded by the TMEM123 gene.

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.

Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.

Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Further reading

• Dekker J, Rossen JW, Büller HA, Einerhand AW (2002). "The MUC family: an obituary". Trends Biochem. Sci. 27 (3): 126–31. doi:10.1016/S0968-0004(01)02052-7. PMID 11893509.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang C, Xu Y, Gu J, Schlossman SF (1998). "A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6290–5. Bibcode:1998PNAS...95.6290Z. doi:10.1073/pnas.95.11.6290. PMC 27661. PMID 9600958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.