SPA17

SPA17
Identifiers
Aliases	SPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17
External IDs	OMIM: 608621 MGI: 1333778 HomoloGene: 7951 GeneCards: SPA17
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.2 Start 124,673,844 bp End 124,697,518 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A4 Start 37,514,586 bp End 37,525,018 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell sperm right uterine tube caput epididymis corpus epididymis islet of Langerhans optic nerve prefrontal cortex anterior pituitary endometrium Top expressed in seminiferous tubule spermatid olfactory epithelium spermatocyte right lung lobe islet of Langerhans choroid plexus lens pituitary gland proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calmodulin binding Cellular component cytoplasm sperm principal piece motile cilium sperm fibrous sheath external side of plasma membrane membrane cilium extracellular region Biological process epithelial cilium movement involved in extracellular fluid movement spermatogenesis single fertilization binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53340 20686 Ensembl ENSG00000064199 ENSMUSG00000001948 UniProt Q15506 Q62252 RefSeq (mRNA) NM_017425 NM_011449 NM_001324545 RefSeq (protein) NP_059121 NP_001311474 NP_035579 Location (UCSC) Chr 11: 124.67 – 124.7 Mb Chr 9: 37.51 – 37.53 Mb PubMed search
Wikidata
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Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.

Further reading

• McLeskey SB, Dowds C, Carballada R, et al. (1997). Molecules involved in mammalian sperm-egg interaction. International Review of Cytology. Vol. 177. pp. 57–113. doi:10.1016/S0074-7696(08)62231-7. ISBN 9780123645814. PMID 9378618. {{cite book}}: |journal= ignored (help)
• Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387.
• Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. doi:10.1095/biolreprod53.3.579. PMID 7578682.
• Fujita A, Nakamura K, Kato T, et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell Sci. 113 (1): 103–12. doi:10.1242/jcs.113.1.103. hdl:2433/181273. PMID 10591629.
• Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. doi:10.1042/0264-6021:3570025. PMC 1221924. PMID 11415432.
• De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. doi:10.1016/S0304-3835(02)00350-6. PMID 12213290.
• Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta. 1578 (1–3): 29–42. doi:10.1016/S0167-4781(02)00478-5. PMID 12393185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction. 124 (6): 767–74. doi:10.1530/rep.0.1240767. PMID 12530914.
• Takeoka Y, Kenny TP, Yago H, et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. doi:10.1080/1044667021000095186. PMC 2276097. PMID 12739786.
• Chiriva-Internati M, Wang Z, Pochopien S, et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer. 107 (5): 863–5. doi:10.1002/ijc.11486. PMID 14566839. S2CID 30452400.
• Straughn JM, Shaw DR, Guerrero A, et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer. 108 (6): 805–11. doi:10.1002/ijc.11617. PMID 14712480. S2CID 20294805.
• Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. doi:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753.
• Wang Z, Zhang Y, Ramsahoye B, et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597–603. doi:10.1038/sj.bjc.6602160. PMC 2409933. PMID 15381930.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gupta G, Sharma R, Chattopadhyay TK, et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer. 120 (8): 1739–47. doi:10.1002/ijc.22463. PMID 17230514. S2CID 31927317.