RO5256390

RO-5256390
Identifiers
	IUPAC name (S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine;
CAS Number	1043495-96-0;
PubChem CID	24963286;
ChemSpider	34959936;
ChEMBL	ChEMBL3684869;
Chemical and physical data
Formula	C13H18N2O
Molar mass	218.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1;
	InChI InChI=1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1; Key:IXDKFUBXESWHSL-JQWIXIFHSA-N;

RO5256390 or RO-5256390 is a drug developed by Hoffmann-La Roche which acts as an agonist for the trace amine associated receptor 1, which has been shown to block compulsive and binge-like eating behavior in rats. For this reason, it is being investigated as a potential drug to treat binge eating disorder.^[1]^[2]

Reference section[edit]

^ Ferragud A, Howell AD, Moore CF, Ta TL, Hoener MC, Sabino V, Cottone P (June 2017). "The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats". Neuropsychopharmacology. 42 (7): 1458–1470. doi:10.1038/npp.2016.233. PMC 5436108. PMID 27711047.
^ "RO5256390". MedChem Express. Retrieved 11 August 2023.

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