Prephenate dehydrogenase (NADP+)
| prephenate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.13 | ||||||||
| CAS no. | 37251-11-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a prephenate dehydrogenase (NADP+) (EC 1.3.1.13) is an enzyme that catalyzes the chemical reaction
- prephenate + NADP+ 4-hydroxyphenylpyruvate + CO2 + NADPH
Thus, the two substrates of this enzyme are prephenate and NADP+, whereas its 3 products are 4-hydroxyphenylpyruvate, CO2, and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is prephenate:NADP+ oxidoreductase (decarboxylating). Other names in common use include prephenate dehydrogenase, prephenate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, and prephenate dehydrogenase (NADP). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.
References[edit]
- Gamborg OL, Keeley FW (1966). "Aromatic metabolism in plants. I. A study of the prephenate dehydrogenase from bean plants". Biochim. Biophys. Acta. 115 (1): 65–72. doi:10.1016/0304-4165(66)90049-3. PMID 4379953.
