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Phosducin-like

From Wikipedia, the free encyclopedia
PDCL
Identifiers
AliasesPDCL, PhLP, Phosducin-like, phosducin like
External IDsOMIM: 604421; MGI: 1914716; HomoloGene: 38043; GeneCards: PDCL; OMA:PDCL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005388

NM_026176

RefSeq (protein)

NP_005379

NP_080452

Location (UCSC)Chr 9: 122.8 – 122.83 MbChr 2: 37.24 – 37.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.[5][6]

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in the retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136940Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009030Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thibault C, Feng Wang J, Charnas R, Mirel D, Barhite S, Miles MF (May 1999). "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization". Biochim Biophys Acta. 1444 (3): 346–54. doi:10.1016/S0167-4781(99)00006-8. PMID 10095058.
  6. ^ a b "Entrez Gene: PDCL phosducin-like".

Further reading

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