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Protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene .[5] [6]
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000168734 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035268 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA" . Biochem J . 349 (Pt 2): 403–7. doi :10.1042/0264-6021:3490403 . PMC 1221161 PMID 10880337 . ^ a b "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma" .
Further reading [ edit ]
Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase" . J. Biol. Chem . 272 (29): 18169–78. doi :10.1074/jbc.272.29.18169 PMID 9218452 . Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20" . Genomics . 76 (1–3): 45–57. doi :10.1006/geno.2001.6584 . PMID 11549316 . Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol . 282 (1): C59–66. doi :10.1152/ajpcell.00256.2001 . PMID 11742798 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res . 99 (2): 145–9. doi :10.1016/S0169-328X(02)00104-3 . PMID 11978406 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol . 38 (12): 2064–73. doi :10.1016/j.biocel.2006.05.015 . PMID 16870489 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
