PELI2

PELI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EGA, 3EGB
Identifiers
Aliases	PELI2, pellino E3 ubiquitin protein ligase family member 2
External IDs	OMIM: 614798 MGI: 1891445 HomoloGene: 41431 GeneCards: PELI2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	56,301,524 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	48,519,032 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; jejunal mucosa; ; monocyte; ; body of pancreas; ; metanephric glomerulus; ; blood; ; sural nerve; ; retinal pigment epithelium; ; kidney tubule;
	Top expressed in
	basilar part of occipital bone; ; spermatid; ; fibula; ; splanchnocranium; ; seminiferous tubule; ; spermatocyte; ; Meckel's cartilage; ; sciatic nerve; ; ascending aorta; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-ubiquitin ligase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytosol;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein phosphorylation; protein ubiquitination; positive regulation of MAPK cascade; protein polyubiquitination; protein phosphorylation; immune response; Toll signaling pathway; interleukin-1-mediated signaling pathway; regulation of Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57161
	93834
	ENSG00000139946
	ENSMUSG00000021846
	Q9HAT8
	Q8BST6
	NM_021255
	NM_033602
	NP_067078
	NP_291080
	Wikidata
View/Edit Human	View/Edit Mouse

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
^ Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.
^ "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

Further reading[edit]

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu Y, Dong W, Chen L, et al. (2004). "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2". J. Biol. Chem. 279 (36): 37436–44. doi:10.1074/jbc.M400241200. PMID 15213237.
Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu KY, Kwon HJ, Norman DA, et al. (2002). "Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling". J. Immunol. 169 (8): 4075–8. doi:10.4049/jimmunol.169.8.4075. PMID 12370331.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11306823-5] Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.

[pmid12860405-6] Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.

[entrez-7] "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

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