NAPB

NAPB
Identifiers
Aliases	NAPB, SNAP-BETA, SNSF attachment protein beta
External IDs	OMIM: 611270 MGI: 104562 HomoloGene: 5332 GeneCards: NAPB
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,421,519 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	148,574,387 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; pons; ; superior frontal gyrus; ; cerebellar vermis; ; parietal lobe; ; postcentral gyrus; ; superior vestibular nucleus; ; Brodmann area 46;
	Top expressed in
	pontine nuclei; ; subiculum; ; habenula; ; medial vestibular nucleus; ; ventral tegmental area; ; prefrontal cortex; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; lateral hypothalamus; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; protein binding; soluble NSF attachment protein activity;
Cellular component	SNARE complex; extracellular exosome; membrane; vacuolar membrane; synaptobrevin 2-SNAP-25-syntaxin-1a complex;
Biological process	protein transport; SNARE complex disassembly; membrane fusion; intracellular protein transport; vesicle-mediated transport; transport; regulation of synaptic vesicle priming; synaptic transmission, glutamatergic;
	Sources:Amigo / QuickGO
Orthologs
	63908
	17957
	ENSG00000125814
	ENSMUSG00000027438
	Q9H115
	P28663
	NM_001283018; NM_001283020; NM_001283026; NM_022080
	NM_019632
	NP_001269947; NP_001269949; NP_001269955; NP_071363
	NP_062606
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-soluble NSF attachment protein is a SNAP protein involved in vesicular trafficking and exocytosis which is encoded by the NAPB gene humans is.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125814 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027438 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Whiteheart SW, Griff IC, Brunner M, Clary DO, Mayer T, Buhrow SA, Rothman JE (Apr 1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode:1993Natur.362..353W. doi:10.1038/362353a0. PMID 8455721. S2CID 4341471.
^ "Entrez Gene: NAPB N-ethylmaleimide-sensitive factor attachment protein, beta".

Further reading[edit]

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Prekeris R, Klumperman J, Chen YA, Scheller RH (1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes". J. Cell Biol. 143 (4): 957–71. doi:10.1083/jcb.143.4.957. PMC 2132958. PMID 9817754.
Osten P, Srivastava S, Inman GJ, et al. (1998). "The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs". Neuron. 21 (1): 99–110. doi:10.1016/S0896-6273(00)80518-8. PMID 9697855. S2CID 18569829.
Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027438 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8455721-5] Whiteheart SW, Griff IC, Brunner M, Clary DO, Mayer T, Buhrow SA, Rothman JE (Apr 1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode:1993Natur.362..353W. doi:10.1038/362353a0. PMID 8455721. S2CID 4341471.

[entrez-6] "Entrez Gene: NAPB N-ethylmaleimide-sensitive factor attachment protein, beta".

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