Merlin G. Butler

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Merlin G. Butler is an American physician scientist and professor at the University of Kansas Medical Center's Departments of Psychiatry & Behavioral Sciences and Pediatrics.[1] He is board-certified in Clinical Genetics and Clinical Cytogenetics and was inducted into the American College of Medical Genetics and Genomics in 1993 as a founding fellow.[2] He has over 500 publications in peer-reviewed journals, numerous book chapters.[3]

Early life and research[edit]

Merlin G. Butler was born in the sandhills of Nebraska in 1952. After graduating from high school from Stuart, Nebraska, he attended Chadron State College in Nebraska, where he studied biology and earned a Bachelor of Arts in education in 1974 and a Bachelor of Science with a Biology- Pre-Medicine major in 1975. Butler earned his M.D. in 1978 from the University of Nebraska and a Ph.D. in Medical Genetics in 1984 from Indiana University. Between 1980 and 1984, he completed an American Board of Medical Genetics-accredited fellowship in Medical Genetics in Indiana and was named a Diplomate of the American Board of Medical Genetics in 1984.[4][2][5]

Career[edit]

Butler has performed extramurally funded research on several genetic and cytogenetic disorders and conditions including Prader-Willi syndrome, the first recognized human disorder with errors in genomic imprinting which he characterized.[6][7] The study of Angelman, a sister syndrome to Prader-Willi syndrome, as well as fragile X and Burnside- Butler syndromes, both common genetic causes of autism have been focused areas of research through his career expanding more than 40 years.[8][9][10] Besides the study of genetics of rare syndromes, autism and obesity, he has also invested time in the characterization and treatment of genetic illnesses and use of pharmacogenetics for the selection of medications to treat disorders based on the patient's DNA patterns that influence medication use and treatment success.

Butler was a tenured associate professor of Pediatrics and Pathology at Vanderbilt University in Nashville, Tennessee. In 2008, he was appointed Professor of Psychiatry & Behavioral Sciences and Pediatrics at the University of Kansas Medical Center and became the Director of the Division of Research and Genetics and Director of the Genetics Clinic.[11]

Awards[edit]

He served as chair of the Scientific Advisory Board of the Prader-Willi Syndrome Association of the United States of America for 25 years, where he received the 2008 Lifetime Achievement Award. In addition, he was a 1986 recipient of the Distinguished Service Award from Chadron State College in Chadron, Nebraska and 2007 recipient of Indiana University's Distinguished Alumni Award.[12]

Bibliography[edit]

  • Genetics of Developmental Disabilities. ASIN : B00UVA0RYI
  • The Identification of the Genetic Components of Autism Spectrum Disorders 2017. ISBN 978-3038425205
  • Genetics of Prader-Willi Syndrome. ISBN 978-3036550251
  • Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2020. ISBN 978-3036536118
  • Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019. ISBN 978-3036536095
  • Management of Prader-Willi Syndrome. ISBN 978-3030981709

Publication[edit]

  • Epstein LJ, Kristo D, Strollo PJ, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab RJ, Weaver EM, Weinstein. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. Journal of Clinical Sleep Medicine.[13]
  • Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N, Mooser V, Preisig M, Malhotra A, Waeber G, Vollenweider P, Tafti M, Haba-Rubio J. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. The Lancet.[14]
  • Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, pin JL, Peppard PE, Sinha S, Tufik S, Valentine K, Malhotra A. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. The Lancet.[15]
  • Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, and Hu FB. A prospective study of sleep duration and coronary heart disease in women. JAMA Internal Medicine.[16]
  • Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnea. The Lancet.[17]
  • Sitzmann, Adam F.; Hagelstrom, Robert T.; Tassone, Flora; Hagerman, Randi J.; Butler, Merlin G. (January 2018). "Rare FMR1 gene mutations causing fragile X syndrome: A review". American Journal of Medical Genetics Part A. [9]

References[edit]

  1. ^ "Merlin Butler". www.kumc.edu. Retrieved 2023-09-21.
  2. ^ a b "Pioneering geneticist Merlin G. Butler, M.D., Ph.D., keeps pushing the boundaries of science". www.kumc.edu. Retrieved 2023-09-21.
  3. ^ "Scopus preview - Scopus - Search for an author profile". www.scopus.com. Retrieved 2023-09-21.
  4. ^ College, Chadron State. "Dr. Merlin G. & Ranae Butler Endowment for Life Sc". www.csc.edu. Retrieved 2023-09-21.
  5. ^ "Merlin G. Butler, M.D., Ph.D." Retrieved 2023-09-21.
  6. ^ Butler, Merlin G.; Miller, Jennifer L.; Forster, Janice L. (2019). "Prader-Willi Syndrome - Clinical Genetics, Diagnosis and Treatment Approaches: An Update". Current Pediatric Reviews. 15 (4): 207–244. doi:10.2174/1573396315666190716120925. PMC 7040524. PMID 31333129.
  7. ^ Bittel, Douglas C.; Butler, Merlin G. (July 2005). "Prader–Willi syndrome: clinical genetics, cytogenetics and molecular biology". Expert Reviews in Molecular Medicine. 7 (14): 1–20. doi:10.1017/S1462399405009531. ISSN 1462-3994. PMC 6750281. PMID 16038620.
  8. ^ Rafi, Syed K.; Butler, Merlin G. (January 2020). "The 15q11.2 BP1-BP2 Microdeletion (Burnside–Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Disorders". International Journal of Molecular Sciences. 21 (9): 3296. doi:10.3390/ijms21093296. ISSN 1422-0067. PMC 7246448. PMID 32384786.
  9. ^ a b Sitzmann, Adam F.; Hagelstrom, Robert T.; Tassone, Flora; Hagerman, Randi J.; Butler, Merlin G. (January 2018). "Rare FMR1 gene mutations causing fragile X syndrome: A review". American Journal of Medical Genetics Part A. 176 (1): 11–18. doi:10.1002/ajmg.a.38504. ISSN 1552-4825. PMC 6697153. PMID 29178241.
  10. ^ Genovese, Ann; Butler, Merlin G. (January 2020). "Clinical Assessment, Genetics, and Treatment Approaches in Autism Spectrum Disorder (ASD)". International Journal of Molecular Sciences. 21 (13): 4726. doi:10.3390/ijms21134726. ISSN 1422-0067. PMC 7369758. PMID 32630718.
  11. ^ "Merlin Butler". www.kumc.edu. Retrieved 2023-10-17.
  12. ^ "Pioneering geneticist Merlin G. Butler, M.D., Ph.D., keeps pushing the boundaries of science". www.kumc.edu. Retrieved 2023-10-17.
  13. ^ Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine (2009-06-15). "Clinical Guideline for the Evaluation, Management and Long-term Care of Obstructive Sleep Apnea in Adults". Journal of Clinical Sleep Medicine. 05 (3): 263–276. doi:10.5664/jcsm.27497. ISSN 1550-9389.
  14. ^ Heinzer, R.; Vat, S.; Marques-Vidal, P.; Marti-Soler, H.; Andries, D.; Tobback, N.; Mooser, V.; Preisig, M.; Malhotra, A.; Waeber, G.; Vollenweider, P.; Tafti, M.; Haba-Rubio, J. (2015-04-01). "Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study". The Lancet Respiratory Medicine. 3 (4): 310–318. doi:10.1016/S2213-2600(15)00043-0. ISSN 2213-2600. PMC 4404207. PMID 25682233.
  15. ^ Benjafield, Adam V.; Ayas, Najib T.; Eastwood, Peter R.; Heinzer, Raphael; Ip, Mary S. M.; Morrell, Mary J.; Nunez, Carlos M.; Patel, Sanjay R.; Penzel, Thomas; Pépin, Jean-Louis; Peppard, Paul E.; Sinha, Sanjeev; Tufik, Sergio; Valentine, Kate; Malhotra, Atul (2019-08-01). "Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis". The Lancet Respiratory Medicine. 7 (8): 687–698. doi:10.1016/S2213-2600(19)30198-5. ISSN 2213-2600. PMC 7007763. PMID 31300334.
  16. ^ Ayas, Najib T.; White, David P.; Manson, JoAnn E.; Stampfer, Meir J.; Speizer, Frank E.; Malhotra, Atul; Hu, Frank B. (2003-01-27). "A Prospective Study of Sleep Duration and Coronary Heart Disease in Women". Archives of Internal Medicine. 163 (2): 205–209. doi:10.1001/archinte.163.2.205. ISSN 0003-9926. PMID 12546611.
  17. ^ Jordan, Amy S.; McSharry, David G.; Malhotra, Atul (2014-02-22). "Adult obstructive sleep apnoea". The Lancet. 383 (9918): 736–747. doi:10.1016/S0140-6736(13)60734-5. ISSN 0140-6736. PMC 3909558. PMID 23910433.
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