LGSN

LGSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J9I
Identifiers
Aliases	LGSN, GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain
External IDs	OMIM: 611470 MGI: 2672844 HomoloGene: 9569 GeneCards: LGSN
Gene location (Human)
Chr.	Chromosome 6 (human)
End	63,319,983 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	31,243,806 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; placenta; ; bronchial epithelial cell; ; kidney; ; kidney tubule; ; islet of Langerhans; ; muscle tissue; ; metanephros; ; uterine tube; ; smooth muscle tissue;
	Top expressed in
	lens; ; spermatocyte; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	catalytic activity; glutamate-ammonia ligase activity;
Cellular component	plasma membrane; membrane;
Biological process	glutamine biosynthetic process; nitrogen compound metabolic process; nitrogen utilization;
	Sources:Amigo / QuickGO
Orthologs
	51557
	266744
	ENSG00000146166
	ENSMUSG00000050217
	Q5TDP6
	Q8CIX8
	NM_001143940; NM_016571
	NM_153601
	NP_001137412; NP_057655
	NP_705829
	Wikidata
View/Edit Human	View/Edit Mouse

Lengsin is a protein that in humans is encoded by the LGSN gene.

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.^[5] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146166 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G (March 2008). "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry. 283 (10): 6607–15. doi:10.1074/jbc.M709144200. PMC 2911820. PMID 18178558.

External links[edit]

"Q5TDP6 (LGSN_HUMAN)". UniProtKB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146166 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050217 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G (March 2008). "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry. 283 (10): 6607–15. doi:10.1074/jbc.M709144200. PMC 2911820. PMID 18178558.

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