Glucarate dehydratase
| glucarate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 glucarate dehydratase tetramer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 4.2.1.40 | ||||||||
| CAS no. | 9059-02-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme glucarate dehydratase (EC 4.2.1.40) catalyzes the chemical reaction
- D-glucarate 5-dehydro-4-deoxy-D-glucarate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming). Other names in common use include D-glucarate dehydratase, and D-glucarate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.
Structural studies[edit]
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BQG, 1EC7, 1EC8, 1EC9, 1ECQ, 1JCT, and 1JDF.
References[edit]
- Blumenthal HJ (1966). "D-Glucarate dehydrase". Methods Enzymol. 9: 660–665. doi:10.1016/0076-6879(66)09134-1.
