From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene .[5] [6]
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000149735 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024784 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ (Jan 2002). "Activation of orphan receptors by the hormone relaxin". Science . 295 (5555): 671–4. Bibcode :2002Sci...295..671H . doi :10.1126/science.1065654 . PMID 11809971 . S2CID 32693420 . ^ a b "Entrez Gene: GPHA2 glycoprotein hormone alpha 2" .
7. Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#
Further reading [ edit ]
Suzuki C, Nagasaki H, Okajima Y, et al. (2007). "The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin". Regul. Pept . 142 (1–2): 60–7. doi :10.1016/j.regpep.2007.01.009 . PMID 17363077 . S2CID 24382046 . Breous E, Wenzel A, Loos U (2006). "Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit". Mol. Cell. Endocrinol . 245 (1–2): 169–80. doi :10.1016/j.mce.2005.11.009 . PMID 16376481 . S2CID 21211666 . Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5" . Endocrinology . 146 (8): 3596–604. doi :10.1210/en.2005-0317 PMID 15890769 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5" . Mol. Endocrinol . 16 (7): 1538–51. doi :10.1210/mend.16.7.0871 PMID 12089349 . Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor" . J. Clin. Invest . 109 (11): 1445–52. doi :10.1172/JCI14340 . PMC 150994 PMID 12045258 .
