Flavin adenine dinucleotide synthetase 1

FLAD1
Identifiers
Aliases	FLAD1, FAD1, FADS, PP591, flavin adenine dinucleotide synthetase 1, LSMFLAD
External IDs	OMIM: 610595 MGI: 2443030 HomoloGene: 115598 GeneCards: FLAD1
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 154,983,338 bp End 154,993,111 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 89,401,004 bp End 89,411,870 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen gastrocnemius muscle right lobe of thyroid gland right lobe of liver ganglionic eminence body of stomach left lobe of thyroid gland left ventricle spleen right uterine tube Top expressed in interventricular septum extraocular muscle left lobe of liver digastric muscle temporal muscle sternocleidomastoid muscle triceps brachii muscle right ventricle brown adipose tissue myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity protein binding catalytic activity ATP binding FMN adenylyltransferase activity Cellular component mitochondrial matrix plasma membrane mitochondrion cytoplasm cytosol Biological process riboflavin metabolic process metabolism FAD biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80308 319945 Ensembl ENSG00000160688 ENSMUSG00000042642 UniProt Q8NFF5 Q8R123 RefSeq (mRNA) NM_001184891 NM_001184892 NM_025207 NM_201398 NM_177041 RefSeq (protein) NP_001171820 NP_001171821 NP_079483 NP_958800 NP_796015 NP_001349304 NP_001349305 Location (UCSC) Chr 1: 154.98 – 154.99 Mb Chr 3: 89.4 – 89.41 Mb PubMed search
Wikidata
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Flavin adenine dinucleotide synthetase 1 is a protein that in humans is encoded by the FLAD1 gene.

Function

This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.