Draft:Bogdanov, Alexey Alexeevich (Chemist)

Bogdanov, Alexey Alexeevich
Alexey Alexeevich Bogdanov
Born	Alexey Alexeevich Bogdanov (1935-10-11)11 October 1935 Moscow, USSR
Alma mater	Moscow State University (MSU)
Awards	State Prize of the USSR (1986) Order of Honor (1996) Order of Alexander Nevsky (2022)
Scientific career
Fields	Chemistry Bioorganic Chemistry, Molecular Biology
Institutions	Moscow State University (MSU)
Doctoral advisor	M.A. Prokofiev

Alexey Alexeevich Bogdanov (born October 11, 1935, Moscow) is a Soviet and Russian chemist. Academician of the Russian Academy of Sciences (1994; Corresponding Member of the USSR Academy of Sciences since 1984). Professor at the Faculty of Chemistry, Moscow State University (MSU), Chief Researcher of the Department of Chemistry and Biochemistry of Nucleoproteids, and Deputy Director of the A.N. Belozersky Institute of Physico-Chemical Biology.

His main areas of scientific activity are bioorganic chemistry and molecular biology.

Biography

In 1958, he graduated from the Faculty of Chemistry, MGU, and pursued postgraduate studies under the guidance of M.A. Prokofiev. The topic of his defended doctoral dissertation in 1962 was "Peptides Covalently Bound to RNA." In 1973, he defended his doctoral dissertation on the topic of "RNA-Protein Interactions in Ribosomes." During this time, he worked at the Faculty of Chemistry, MGU, where in 1973 he also received the title of professor. In 1985, he became the head of the Department of Chemistry of Natural Compounds at the Faculty of Chemistry. At the same time, from 1969, he worked at the A.N. Belozersky Institute of Physico-Chemical Biology, MGU, where until 2002, he headed the Department of Chemistry and Biochemistry of Nucleoproteids and performed the duties of the deputy director. Since 2001, he has been the chief researcher of the same department.

In 1984, he was elected a corresponding member of the USSR Academy of Sciences, and in 1994, a full member of the Russian Academy of Sciences.

He is a member of the European Academy of Sciences (since 2000) and a foreign member of the Academy of Sciences of Lithuania (since 2002).

Author of more than 180 works.

Deputy Editor-in-Chief of the journal "Biochemistry."

Scientific Achievements

A.A. Bogdanov's research is in the field of biochemistry of nucleic acid-protein complexes. In the 1960s, he proved the existence of natural covalent compounds of nucleic acids with proteins for DNA and high-polymer RNA, laying the foundation for a new direction in biochemistry. A.A. Bogdanov also discovered the unfolding of ribosomes and, together with A.S. Spirin, showed the fundamental possibility of their self-assembly. With his colleagues, Bogdanov conducted a series of studies on the transformation of RNA in ribosomes and proposed a new method for the structural analysis of RNA, allowing the breaking of their chains at arbitrary sites. The developed method is used for the synthesis of recombinant RNA and for the study of their functions. Bogdanov, using photoaffinity chemical modification, revealed the fine structure of the functional centers of the ribosome, in particular, its decoding center. The spatial structure and functions of 5S RNA in the ribosome have been studied.

Teaching Activity

A.A. Bogdanov teaches at the Faculty of Chemistry, MGU. In 1961–1962, he created a laboratory on the chemistry of proteins and nucleic acids. Over the years, he taught courses such as "Fundamentals of Molecular Biology," "Nucleic Acids: Structure and Functions," and "Chemical Foundations of Biological Processes." In 1996, at the Institute of Physico-Chemical Biology, A.A. Bogdanov organized a lecture program on molecular and cellular biology. He participated in the writing of three textbooks on the chemistry of nucleic acids and molecular biology. He gave lectures at the University of Massachusetts in Amherst and other universities worldwide.

Awards

• Order of Alexander Nevsky (May 18, 2022) – for significant contributions to the development of science and many years of conscientious work[1].
• Order of Honor (September 6, 1996) – for merits to the state and significant personal contributions to the development of science[2].
• Laureate of the State Prize of the USSR in Science and Technology (1986) – for the series of works "Structural Foundations of Protein Biosynthesis on Ribosomes" (1962–1984).
• M.V. Lomonosov Prize, 1st degree (MSU, 1997).
• Humboldt Prize (2000).
• M.M. Shemyakin Prize (RAN, 2001) – for the series of works "Structural-Functional Analysis of RNA in Complex Ribonucleoproteins."
• A.N. Belozersky Prize (RAN, 2016, jointly with O.A. Dontsova, P.V. Sergiev) – for the series of works "Ribosome: Functional Centers and Inhibitors."

Major Works

• Nucleic Acid-Protein Interaction." Moscow, 1975 (jointly with R.K. Letneva).
• Shabarova, Z.A., Bogdanov, A.A. "Chemistry of Nucleic Acids and Their Components." Moscow: Khimiya, 1978. 584 p.
• Zoe Shabarova, Alexey Bogdanov. "Advanced Organic Chemistry of Nucleic Acids." Weinheim: VCH, 1994. 588 p. ISBN 3527290214.
• Agol, V.I., Bogdanov, A.A., Gvozdev, V.A. "Molecular Biology. Structure and Biosynthesis of Nucleic Acids." Ed. A.S. Spirin. Moscow: Vysshaya Shkola, 1990. 351 p. ISBN 5060000869.

Links

1. Profile of Alexey Alexeevich Bogdanov on the official website of the Russian Academy of Sciences
2. Personal page on the official website of the Faculty of Chemistry, MSU
3. Photograph of A.A. Bogdanov in the gallery of outstanding scientists at MSU "Portrait of Intellect," created in 2005 for the 250th anniversary of the university (photo by Sergey Novikov)
4. Bogdanov A.A. doctoral dissertation "MOLECULAR VISUALIZATION OF PHYSICO-CHEMICAL PROCESSES IN LIVING SYSTEMS USING BIOCOMPATIBLE PROBES: new APPROACHES"
5. Bogdanov A.A. dissertation "Modification of the liposome surface in order to regulate their interaction with cells"