DGCR14

ESS2
Identifiers
Aliases	ESS2, DGCR13, DGS-H, DGS-I, DGSH, DGSI, ES2, Es2el, DGCR14, DiGeorge syndrome critical region gene 14, bis1, ESS-2, ess-2 splicing factor homolog
External IDs	OMIM: 601755 MGI: 107854 HomoloGene: 11184 GeneCards: ESS2
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,729,212 bp
RNA expression pattern
	Top expressed in
	sperm; ; blood; ; skin of abdomen; ; popliteal artery; ; sural nerve; ; oocyte; ; prefrontal cortex; ; gastric mucosa; ; left uterine tube; ; thoracic aorta;
	Top expressed in
	neural tube; ; superior frontal gyrus; ; spermatid; ; secondary oocyte; ; spermatocyte; ; yolk sac; ; seminiferous tubule; ; lip; ; ganglionic eminence; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleus;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	8220
	27886
	n/a
	ENSMUSG00000003527
	Q96DF8
	O70279
	NM_022719
	NM_001081633; NM_022408
	NP_073210
	NP_001075102; NP_071853
	Wikidata
View/Edit Human	View/Edit Mouse

Protein DGCR14 is a protein that in humans is encoded by the DGCR14 gene.^[4]^[5]^[6]

This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.^[6]

References[edit]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003527 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML (Dec 1996). "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11". Hum Mol Genet. 5 (6): 789–800. CiteSeerX 10.1.1.539.9441. doi:10.1093/hmg/5.6.789. PMID 8776594.
^ Gong W, Emanuel BS, Galili N, Kim DH, Roe B, Driscoll DA, Budarf ML (Aug 1997). "Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region". Hum Mol Genet. 6 (2): 267–276. doi:10.1093/hmg/6.2.267. PMID 9063747.
^ ^a ^b "Entrez Gene: DGCR14 DiGeorge syndrome critical region gene 14".

Further reading[edit]

Rizzu P, Lindsay EA, Taylor C, et al. (1996). "Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans". Mamm. Genome. 7 (9): 639–643. doi:10.1007/s003359900197. PMID 8703114. S2CID 31659048.
Lindsay EA, Rizzu P, Antonacci R, et al. (1996). "A transcription map in the CATCH22 critical region: identification, mapping, and ordering of four novel transcripts expressed in heart". Genomics. 32 (1): 104–112. doi:10.1006/geno.1996.0082. PMID 8786095.
Botta A, Lindsay EA, Jurecic V, Baldini A (1998). "Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation". Mamm. Genome. 8 (12): 890–895. doi:10.1007/s003359900606. PMID 9383280. S2CID 11874347.
Puech A, Saint-Jore B, Funke B, et al. (1998). "Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14608–14613. doi:10.1073/pnas.94.26.14608. PMC 25069. PMID 9405660.
Lindsay EA, Harvey EL, Scambler PJ, Baldini A (1998). "ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene". Hum. Mol. Genet. 7 (4): 629–635. doi:10.1093/hmg/7.4.629. PMID 9499415.
Taricani L, Tejada ML, Young PG (2002). "The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein". J. Biol. Chem. 277 (12): 10562–10572. doi:10.1074/jbc.M110686200. PMID 11751918.
Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–439. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000003527 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8776594-4] Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML (Dec 1996). "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11". Hum Mol Genet. 5 (6): 789–800. CiteSeerX 10.1.1.539.9441. doi:10.1093/hmg/5.6.789. PMID 8776594.

[pmid9063747-5] Gong W, Emanuel BS, Galili N, Kim DH, Roe B, Driscoll DA, Budarf ML (Aug 1997). "Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region". Hum Mol Genet. 6 (2): 267–276. doi:10.1093/hmg/6.2.267. PMID 9063747.

[entrez-6] "Entrez Gene: DGCR14 DiGeorge syndrome critical region gene 14".

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