D-lysopine dehydrogenase

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D-lysopine dehydrogenase
Identifiers
EC no.1.5.1.16
CAS no.65187-41-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a D-lysopine dehydrogenase (EC 1.5.1.16) is an enzyme that catalyzes the chemical reaction

N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O L-lysine + pyruvate + NADPH + H+

The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-lysine, NADP+, and H2O, whereas its 4 products are L-lysine, pyruvate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming). Other names in common use include D-lysopine synthase, lysopine dehydrogenase, D(+)-lysopine dehydrogenase, 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine degradation.

References[edit]

  • Otten LA, Vreugdenhil D, Schilperoort RA (1977). "Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue". Biochim. Biophys. Acta. 485 (2): 268–77. doi:10.1016/0005-2744(77)90163-2. PMID 21695.