Coiled-coil domain containing 88b

CCDC88B
Identifiers
Aliases	CCDC88B, BRLZ, CCDC88, HKRP3, gipie, coiled-coil domain containing 88B
External IDs	OMIM: 611205 MGI: 1925567 HomoloGene: 49992 GeneCards: CCDC88B
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 64,340,204 bp End 64,357,534 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 6,821,991 bp End 6,835,579 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere spleen appendix monocyte bone marrow cells blood lymph node upper lobe of left lung minor salivary glands right lung Top expressed in thymus spermatocyte spermatid bone marrow spleen blood seminiferous tubule visual cortex jejunum subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding dynein light intermediate chain binding Cellular component membrane cytoplasm endoplasmic reticulum Golgi apparatus centrosome cytoskeleton Biological process positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of cytokine production defense response to protozoan cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283234 78317 Ensembl ENSG00000168071 ENSMUSG00000047810 UniProt A6NC98 Q4QRL3 RefSeq (mRNA) NM_032251 NM_001081291 NM_198008 RefSeq (protein) NP_115627 NP_001074760 Location (UCSC) Chr 11: 64.34 – 64.36 Mb Chr 19: 6.82 – 6.84 Mb PubMed search
Wikidata
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Coiled-coil domain containing 88B is a protein that in humans is encoded by the CCDC88B gene.

Function

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009].

Further reading

• Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M (March 2011). "Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells". Mol. Biol. Cell. 22 (6): 736–47. doi:10.1091/mbc.E10-08-0724. PMC 3057699. PMID 21289099.
• Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". Am. J. Respir. Crit. Care Med. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.
• Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD (April 2015). "HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing". J. Immunol. 194 (8): 3984–96. doi:10.4049/jimmunol.1402897. PMC 4390494. PMID 25762780.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.