C11orf53

POU2AF2
Identifiers
Aliases	POU2AF2, chromosome 11 open reading frame 53, POU class 2 homeobox associating factor 2, C11orf53
External IDs	MGI: 1917059 HomoloGene: 18881 GeneCards: POU2AF2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,286,401 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	51,240,224 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gallbladder; ; body of stomach; ; gastrocnemius muscle; ; tibial nerve; ; rectum; ; fundus; ; skeletal muscle tissue; ; placenta; ; subcutaneous adipose tissue;
	Top expressed in
	jejunum; ; yolk sac; ; duodenum; ; left lobe of liver; ; secondary oocyte; ; spleen; ; thymus; ; stomach; ; blood; ; colon;
	More reference expression data
	n/a
Orthologs
	341032
	69809
	ENSG00000150750
	ENSMUSG00000036027
	Q8IXP5
	Q9D8Q6
	NM_198498
	NM_027217; NM_001372554; NM_001372555; NM_001372556; NM_001372557
	NP_940900
	NP_081493; NP_001359483; NP_001359484; NP_001359485; NP_001359486
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene.^[5] Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.^[6] Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.^[7]^[8] C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment.^[9] CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Venetoclax, further supporting a role in cancer predisposition.^[10]^[11]

Additional roles have been proposed.^[12]^[13]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
^ Delgado AP, Brandao P, Chapado MJ, Hamid S, Narayanan R (July 2014). "Open reading frames associated with cancer in the dark matter of the human genome". Cancer Genomics & Proteomics. 11 (4): 201–213. PMID 25048349.
^ Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, et al. (April 2014). "Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1". Human Molecular Genetics. 23 (8): 2198–2209. doi:10.1093/hmg/ddt584. PMC 3959808. PMID 24256810.
^ Closa A, Cordero D, Sanz-Pamplona R, Solé X, Crous-Bou M, Paré-Brunet L, et al. (September 2014). "Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis". Carcinogenesis. 35 (9): 2039–2046. doi:10.1093/carcin/bgu092. PMC 4146415. PMID 24760461.
^ Funato Y, Yoshida A, Hirata Y, Hashizume O, Yamazaki D, Miki H (November 2020). "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis". Developmental Cell. 55 (4): 387–397.e8. doi:10.1016/j.devcel.2020.08.009. PMID 32918875. S2CID 221643438.
^ "C11orf53 CRISPR Screens (Homo sapiens)". orcs.thebiogrid.org.
^ Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, et al. (July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells". Cancer Discovery. 9 (7): 910–925. doi:10.1158/2159-8290.CD-19-0125. PMC 6606338. PMID 31048320.
^ "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
^ Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, et al. (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–34100. doi:10.1074/jbc.M111.243907. PMC 3190826. PMID 21832049.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150750 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.

[6] Delgado AP, Brandao P, Chapado MJ, Hamid S, Narayanan R (July 2014). "Open reading frames associated with cancer in the dark matter of the human genome". Cancer Genomics & Proteomics. 11 (4): 201–213. PMID 25048349.

[7] Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, et al. (April 2014). "Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1". Human Molecular Genetics. 23 (8): 2198–2209. doi:10.1093/hmg/ddt584. PMC 3959808. PMID 24256810.

[8] Closa A, Cordero D, Sanz-Pamplona R, Solé X, Crous-Bou M, Paré-Brunet L, et al. (September 2014). "Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis". Carcinogenesis. 35 (9): 2039–2046. doi:10.1093/carcin/bgu092. PMC 4146415. PMID 24760461.

[9] Funato Y, Yoshida A, Hirata Y, Hashizume O, Yamazaki D, Miki H (November 2020). "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis". Developmental Cell. 55 (4): 387–397.e8. doi:10.1016/j.devcel.2020.08.009. PMID 32918875. S2CID 221643438.

[10] "C11orf53 CRISPR Screens (Homo sapiens)". orcs.thebiogrid.org.

[11] Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, et al. (July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells". Cancer Discovery. 9 (7): 910–925. doi:10.1158/2159-8290.CD-19-0125. PMC 6606338. PMID 31048320.

[12] "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.

[13] Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, et al. (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–34100. doi:10.1074/jbc.M111.243907. PMC 3190826. PMID 21832049.

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