User talk:EIhannifin/sandbox

selected article Serotonergic cell groups Intend to add about what they do as a whole (more generally) what is their purpose beyond how they are classified. Expand on the categories (hopefully). Adding diagram, some general detail on the function and more specific locations of the groups as a whole. Also working to add more detail about the specific groups, and perhaps diagrams or pathways there as well. proposed sources as follows.

Serotonergic cell groups refer to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter serotonin (5-hydroxytryptamine).[1] Since they are for the most part localized to classical brainstem nuclei, particularly the raphe nuclei, they are more often referred to by the names of those nuclei than by the B1-9 nomenclature.

Body These cells appear to be common across most mammals and has two main regions in which they develop; one forms in the mesencephlon and the rostral pons (find articles/links) and the other in the medulla oblongata and the caudal pons (links).EIhannifin (talk) 19:03, 4 October 2016 (UTC) NEEDS: additional locations, reasons for classification of sections B1-9, function!!....

Nervous system[edit | edit source]

In this drawing of the brain, the serotonergic system is red and the mesolimbic dopamine pathway is blue. There is one collection of serotonergic neurons in the upper brainstem that sends axons upwards to the whole cerebrum, and one collection next to the cerebellum that sends axons downward to the spinal cord. Slightly forward the upper serotonergic neurons is the ventral tegmental area (VTA), which contains dopaminergic neurons. These neurons' axons then connect to the nucleus accumbens, hippocampus and the frontal cortex. Over the VTA is another collection of dopaminergic cells, the substansia nigra, which send axons to the striatum.

Serotonin system, contrasted with the dopamine system The neurons of the raphe nuclei are the principal source of 5-HT release in the brain.[25] There are nine raphe nuclei, designated B1-B9, which contain the majority of serotonin-containing neurons (some scientists chose to group the nuclei raphes lineares into one nucleus), all of which are located along the midline of the brainstem, and centered on the reticular formation.[26][27] Axons from the neurons of the raphe nuclei form a neurotransmitter system reaching almost every part of the central nervous system. Axons of neurons in the lower raphe nuclei terminate in the cerebellum and spinal cord, while the axons of the higher nuclei spread out in the entire brain. WORKING ON THIS---> Add about the cell groups. things from body into this

Pharmacology can add about marijuana (classification of marijuana?) the pathway perhaps? \

History needs expanding here, look for papers. EIhannifin (talk) 00:48, 10 October 2016 (UTC)

Serotonin transporter and Brodmann's area 25---- look for paper/book. High in serotonin transporteres in BA25, link to the cell groups? Link transporters as well. EIhannifin (talk) 13:38, 10 October 2016 (UTC)

Peer Review

Hey, good start on this topic. The current wiki page for this is pretty bare, so it seems like you have a lot of ways you could move forward with this one. I was glad to see that you could categorize some of the different cell groups together (ie B1-B9) by similarities, I think it will add fluency and understanding to the article. Are you planning on writing about each cell group like the current wiki is set up as, or just focusing on the ones that have to do with the marijuana pathway. It may help to narrow it down a little bit to make research and writing easier. Looks like you have reliable sources, the nature review paper on serotonin’s role on development seems interesting.

Have you been able to find a diagram that you want to use for your wiki? Also, don’t forget that you will be able to minimize some work and space by linking vocab and other important concepts to already established wiki pages such as the Central Nervous System or even the BA25. This way you won’t have to spend time explaining these aspects, and just spend time and energy on describing how the serotogenic cell groups are related.

It’s also cool that you are going to be able to talk about marijuana again, you’re probably somewhat prepared from your paper last semester. Skd17 (talk) 18:48, 15 October 2016 (UTC)

Hi, I like what you are adding to the page on Serotonergic cells. Are they found in different mammalian systems? Have certain drugs been found to act on them in similar and different ways depending on the species? I’m a little confused about what you want to add about marijuana because I don’t know the subject well enough! But I hope you find same information because that could be more of a real-life application. For some grammar things: I would replace “Since they are for the most part localized to classical brainstem nuclei,” with “Majority of cells are localized to ___”… OdessaG (talk) 17:07, 15 October 2016 (UTC) — Preceding unsigned comment added by EIhannifin (talk • contribs)

This looks like a great start and great peer review comments! I'm not sure about hand-drawn schematics, but if that was your best option, another wikipedian might contribute a computer rendering of it! ProfJRL (talk) 22:22, 23 October 2016 (UTC)