Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 04:03, 10 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (6)[edit]
Redirected Proteins (1)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (13)[edit]
Updated (1)[edit]
Protein Status Grid - Date: 04:03, 10 November 2007 (UTC)[edit]
Vebose Log - Date: 04:03, 10 November 2007 (UTC)[edit]
- INFO: Beginning work on APLP2... {November 9, 2007 7:28:29 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:30:53 PM PST}
- CREATED: Created new protein page: APLP2 {November 9, 2007 7:31:00 PM PST}
- INFO: Beginning work on ASS1... {November 9, 2007 7:31:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ASS1 image.jpg {November 9, 2007 7:31:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:31:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ASS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nz2.
| PDB = {{PDB2|2nz2}}
| Name = Argininosuccinate synthetase 1
| HGNCid = 758
| Symbol = ASS1
| AltSymbols =; ASS; CTLN1
| OMIM = 603470
| ECnumber =
| Homologene = 6899
| MGIid = 88090
| GeneAtlas_image1 = PBB_GE_ASS1_207076_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004055 |text = argininosuccinate synthase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000050 |text = urea cycle}} {{GNF_GO|id=GO:0006526 |text = arginine biosynthetic process}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 445
| Hs_Ensembl = ENSG00000130707
| Hs_RefseqProtein = NP_000041
| Hs_RefseqmRNA = NM_000050
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 132310137
| Hs_GenLoc_end = 132366482
| Hs_Uniprot = P00966
| Mm_EntrezGene = 11898
| Mm_Ensembl = ENSMUSG00000076441
| Mm_RefseqmRNA = NM_007494
| Mm_RefseqProtein = NP_031520
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 31292216
| Mm_GenLoc_end = 31342681
| Mm_Uniprot = Q3UEJ7
}}
}}
'''Argininosuccinate synthetase 1''', also known as '''ASS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: ASS1 argininosuccinate synthetase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=445| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beaudet AL, O'Brien WE, Bock HG, ''et al.'' |title=The human argininosuccinate synthetase locus and citrullinemia. |journal=Adv. Hum. Genet. |volume=15 |issue= |pages= 161-96, 291-2 |year= 1986 |pmid= 3513483 |doi= }}
*{{cite journal | author=Ikeda S |title=[Recent advances of the treatment in metabolic disorders] |journal=Rinsho Shinkeigaku |volume=40 |issue= 12 |pages= 1264-6 |year= 2001 |pmid= 11464474 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GSR... {November 9, 2007 7:31:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GSR image.jpg {November 9, 2007 7:32:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:32:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GSR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bwc.
| PDB = {{PDB2|1bwc}}, {{PDB2|1dnc}}, {{PDB2|1gra}}, {{PDB2|1grb}}, {{PDB2|1gre}}, {{PDB2|1grf}}, {{PDB2|1grg}}, {{PDB2|1grt}}, {{PDB2|1gsn}}, {{PDB2|1k4q}}, {{PDB2|1xan}}, {{PDB2|2aaq}}, {{PDB2|2gh5}}, {{PDB2|2grt}}, {{PDB2|3grs}}, {{PDB2|3grt}}, {{PDB2|4gr1}}, {{PDB2|4grt}}, {{PDB2|5grt}}
| Name = Glutathione reductase
| HGNCid = 4623
| Symbol = GSR
| AltSymbols =; MGC78522
| OMIM = 138300
| ECnumber =
| Homologene = 531
| MGIid = 95804
| GeneAtlas_image1 = PBB_GE_GSR_205770_at_tn.png
| Function = {{GNF_GO|id=GO:0004362 |text = glutathione-disulfide reductase activity}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006749 |text = glutathione metabolic process}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2936
| Hs_Ensembl = ENSG00000104687
| Hs_RefseqProtein = NP_000628
| Hs_RefseqmRNA = NM_000637
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 30656549
| Hs_GenLoc_end = 30704894
| Hs_Uniprot = P00390
| Mm_EntrezGene = 14782
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010344
| Mm_RefseqProtein = NP_034474
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Glutathione reductase''', also known as '''GSR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2F2... {November 9, 2007 7:32:39 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GTF2F2 image.jpg {November 9, 2007 7:32:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:33:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2F2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bby.
| PDB = {{PDB2|1bby}}, {{PDB2|1f3u}}, {{PDB2|2bby}}
| Name = General transcription factor IIF, polypeptide 2, 30kDa
| HGNCid = 4653
| Symbol = GTF2F2
| AltSymbols =; BTF4; TFIIF; RAP30; TF2F2
| OMIM = 189969
| ECnumber =
| Homologene = 37884
| MGIid = 1915955
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005674 |text = transcription factor TFIIF complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006368 |text = RNA elongation from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2963
| Hs_Ensembl = ENSG00000188342
| Hs_RefseqProtein = NP_004119
| Hs_RefseqmRNA = NM_004128
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 44592650
| Hs_GenLoc_end = 44756237
| Hs_Uniprot = P13984
| Mm_EntrezGene = 68705
| Mm_Ensembl = ENSMUSG00000067995
| Mm_RefseqmRNA = NM_026816
| Mm_RefseqProtein = NP_081092
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 74631517
| Mm_GenLoc_end = 74745016
| Mm_Uniprot = Q3UMJ4
}}
}}
'''General transcription factor IIF, polypeptide 2, 30kDa''', also known as '''GTF2F2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HOXB7... {November 9, 2007 7:33:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HOXB7 image.jpg {November 9, 2007 7:34:21 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:34:38 PM PST}
- CREATED: Created new protein page: HOXB7 {November 9, 2007 7:34:46 PM PST}
- INFO: Beginning work on HPX... {November 9, 2007 7:34:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:35:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hemopexin
| HGNCid = 5171
| Symbol = HPX
| AltSymbols =;
| OMIM = 142290
| ECnumber =
| Homologene = 511
| MGIid = 105112
| GeneAtlas_image1 = PBB_GE_HPX_39763_at_tn.png
| GeneAtlas_image2 = PBB_GE_HPX_210013_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0015232 |text = heme transporter activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0015886 |text = heme transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3263
| Hs_Ensembl = ENSG00000110169
| Hs_RefseqProtein = NP_000604
| Hs_RefseqmRNA = NM_000613
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 6408858
| Hs_GenLoc_end = 6418830
| Hs_Uniprot = P02790
| Mm_EntrezGene = 15458
| Mm_Ensembl = ENSMUSG00000030895
| Mm_RefseqmRNA = NM_017371
| Mm_RefseqProtein = NP_059067
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 105465432
| Mm_GenLoc_end = 105473917
| Mm_Uniprot = Q3UKP2
}}
}}
'''Hemopexin''', also known as '''HPX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Piccard H, Van den Steen PE, Opdenakker G |title=Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins. |journal=J. Leukoc. Biol. |volume=81 |issue= 4 |pages= 870-92 |year= 2007 |pmid= 17185359 |doi= 10.1189/jlb.1006629 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1B... {November 9, 2007 7:35:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:36:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1B
| HGNCid = 5287
| Symbol = HTR1B
| AltSymbols =; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
| OMIM = 182131
| ECnumber =
| Homologene = 669
| MGIid = 96274
| GeneAtlas_image1 = PBB_GE_HTR1B_210799_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3351
| Hs_Ensembl = ENSG00000135312
| Hs_RefseqProtein = NP_000854
| Hs_RefseqmRNA = NM_000863
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 78228641
| Hs_GenLoc_end = 78229900
| Hs_Uniprot = P28222
| Mm_EntrezGene = 15551
| Mm_Ensembl = ENSMUSG00000049511
| Mm_RefseqmRNA = NM_010482
| Mm_RefseqProtein = NP_034612
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 81428110
| Mm_GenLoc_end = 81429270
| Mm_Uniprot = Q0VES5
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1B''', also known as '''HTR1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Olivier B, van Oorschot R |title=5-HT1B receptors and aggression: a review. |journal=Eur. J. Pharmacol. |volume=526 |issue= 1-3 |pages= 207-17 |year= 2006 |pmid= 16310769 |doi= 10.1016/j.ejphar.2005.09.066 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IFNA2... {November 9, 2007 7:36:24 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IFNA2 image.jpg {November 9, 2007 7:37:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:37:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IFNA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1itf.
| PDB = {{PDB2|1itf}}, {{PDB2|1rh2}}, {{PDB2|2hym}}
| Name = Interferon, alpha 2
| HGNCid = 5423
| Symbol = IFNA2
| AltSymbols =; IFNA; INFA2; MGC125764; MGC125765
| OMIM = 147562
| ECnumber =
| Homologene = 86655
| MGIid =
| GeneAtlas_image1 = PBB_GE_IFNA2_211338_at_tn.png
| Function = {{GNF_GO|id=GO:0005132 |text = interferon-alpha/beta receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3440
| Hs_Ensembl = ENSG00000188379
| Hs_RefseqProtein = NP_000596
| Hs_RefseqmRNA = NM_000605
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 21374253
| Hs_GenLoc_end = 21375387
| Hs_Uniprot = P01563
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Interferon, alpha 2''', also known as '''IFNA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Conti L, Fantuzzi L, Del Cornò M, ''et al.'' |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1-2 |pages= 99-115 |year= 2005 |pmid= 15481145 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITK... {November 9, 2007 7:37:20 PM PST}
- SEARCH REDIRECT: Control Box Found: ITK (gene) {November 9, 2007 7:37:52 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 9, 2007 7:37:53 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 9, 2007 7:37:53 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 9, 2007 7:37:53 PM PST}
- UPDATED: Updated protein page: ITK (gene) {November 9, 2007 7:37:58 PM PST}
- INFO: Beginning work on KLKB1... {November 9, 2007 7:37:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KLKB1 image.jpg {November 9, 2007 7:38:37 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:38:48 PM PST}
- CREATED: Created new protein page: KLKB1 {November 9, 2007 7:38:56 PM PST}
- INFO: Beginning work on LHB... {November 9, 2007 7:38:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:39:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Luteinizing hormone beta polypeptide
| HGNCid = 6584
| Symbol = LHB
| AltSymbols =; CGB4; LSH-B; hLHB
| OMIM = 152780
| ECnumber =
| Homologene = 81806
| MGIid = 96782
| GeneAtlas_image1 = PBB_GE_LHB_214471_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007530 |text = sex determination}} {{GNF_GO|id=GO:0008584 |text = male gonad development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3972
| Hs_Ensembl = ENSG00000104826
| Hs_RefseqProtein = NP_000885
| Hs_RefseqmRNA = NM_000894
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 54211049
| Hs_GenLoc_end = 54212159
| Hs_Uniprot = P01229
| Mm_EntrezGene = 16866
| Mm_Ensembl = ENSMUSG00000038194
| Mm_RefseqmRNA = NM_008497
| Mm_RefseqProtein = NP_032523
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 45288988
| Mm_GenLoc_end = 45289896
| Mm_Uniprot = Q3UUG9
}}
}}
'''Luteinizing hormone beta polypeptide''', also known as '''LHB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.<ref>{{cite web | title = Entrez Gene: LHB luteinizing hormone beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3972| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAPK10... {November 9, 2007 7:49:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MAPK10 image.jpg {November 9, 2007 7:50:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:50:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MAPK10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jnk.
| PDB = {{PDB2|1jnk}}, {{PDB2|1pmn}}, {{PDB2|1pmq}}, {{PDB2|1pmu}}, {{PDB2|1pmv}}, {{PDB2|1ukh}}, {{PDB2|1uki}}, {{PDB2|2b1p}}, {{PDB2|2exc}}, {{PDB2|2g01}}, {{PDB2|2gmx}}, {{PDB2|2h96}}, {{PDB2|2no3}}, {{PDB2|2o0u}}, {{PDB2|2o2u}}, {{PDB2|2ok1}}
| Name = Mitogen-activated protein kinase 10
| HGNCid = 6872
| Symbol = MAPK10
| AltSymbols =; FLJ12099; FLJ33785; JNK3; JNK3A; MGC50974; PRKM10; p493F12; p54bSAPK
| OMIM = 602897
| ECnumber =
| Homologene = 56439
| MGIid = 1346863
| GeneAtlas_image1 = PBB_GE_MAPK10_204813_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004705 |text = JUN kinase activity}} {{GNF_GO|id=GO:0004707 |text = MAP kinase activity}} {{GNF_GO|id=GO:0004708 |text = MAP kinase kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5602
| Hs_Ensembl = ENSG00000109339
| Hs_RefseqProtein = NP_002744
| Hs_RefseqmRNA = NM_002753
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 87156656
| Hs_GenLoc_end = 87511051
| Hs_Uniprot = P53779
| Mm_EntrezGene = 26414
| Mm_Ensembl = ENSMUSG00000046709
| Mm_RefseqmRNA = NM_176970
| Mm_RefseqProtein = NP_795944
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 103152671
| Mm_GenLoc_end = 103451575
| Mm_Uniprot = Q8C9D4
}}
}}
'''Mitogen-activated protein kinase 10''', also known as '''MAPK10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: MAPK10 mitogen-activated protein kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5602| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Freedman BD, Liu QH, Del Corno M, Collman RG |title=HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. |journal=Immunol. Res. |volume=27 |issue= 2-3 |pages= 261-76 |year= 2004 |pmid= 12857973 |doi= }}
*{{cite journal | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MARCKS... {November 9, 2007 7:39:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:41:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myristoylated alanine-rich protein kinase C substrate
| HGNCid = 6759
| Symbol = MARCKS
| AltSymbols =; 80K-L; FLJ14368; FLJ90045; MACS; MRACKS; PKCSL; PRKCSL
| OMIM = 177061
| ECnumber =
| Homologene = 40623
| MGIid = 96907
| GeneAtlas_image1 = PBB_GE_MARCKS_201669_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MARCKS_201668_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MARCKS_201670_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005938 |text = cell cortex}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0042585 |text = germinal vesicle}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4082
| Hs_Ensembl = ENSG00000155130
| Hs_RefseqProtein = NP_002347
| Hs_RefseqmRNA = NM_002356
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 114285234
| Hs_GenLoc_end = 114291341
| Hs_Uniprot = P29966
| Mm_EntrezGene = 17118
| Mm_Ensembl = ENSMUSG00000069662
| Mm_RefseqmRNA = NM_008538
| Mm_RefseqProtein = NP_032564
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 36824237
| Mm_GenLoc_end = 36828330
| Mm_Uniprot = Q05BL6
}}
}}
'''Myristoylated alanine-rich protein kinase C substrate''', also known as '''MARCKS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.<ref>{{cite web | title = Entrez Gene: MARCKS myristoylated alanine-rich protein kinase C substrate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4082| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blackshear PJ |title=The MARCKS family of cellular protein kinase C substrates. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 1501-4 |year= 1993 |pmid= 8420923 |doi= }}
*{{cite journal | author=Aderem A |title=The MARCKS family of protein kinase-C substrates. |journal=Biochem. Soc. Trans. |volume=23 |issue= 3 |pages= 587-91 |year= 1996 |pmid= 8566422 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MLLT7... {November 9, 2007 7:41:09 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MLLT7 image.jpg {November 9, 2007 7:41:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:42:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MLLT7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e17.
| PDB = {{PDB2|1e17}}
| Name = Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
| HGNCid = 7139
| Symbol = MLLT7
| AltSymbols =; AFX; AFX1; FOXO4; MGC120490
| OMIM = 300033
| ECnumber =
| Homologene = 4342
| MGIid = 1891915
| GeneAtlas_image1 = PBB_GE_MLLT7_205451_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007095 |text = mitotic cell cycle G2/M transition DNA damage checkpoint}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0051151 |text = negative regulation of smooth muscle cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4303
| Hs_Ensembl = ENSG00000184481
| Hs_RefseqProtein = NP_005929
| Hs_RefseqmRNA = NM_005938
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 70232772
| Hs_GenLoc_end = 70240110
| Hs_Uniprot = P98177
| Mm_EntrezGene = 54601
| Mm_Ensembl = ENSMUSG00000042903
| Mm_RefseqmRNA = XM_983128
| Mm_RefseqProtein = XP_988222
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 97457308
| Mm_GenLoc_end = 97461957
| Mm_Uniprot = Q9WVH3
}}
}}
'''Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7''', also known as '''MLLT7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NONO... {November 9, 2007 7:42:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NONO image.jpg {November 9, 2007 7:43:02 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:43:18 PM PST}
- CREATED: Created new protein page: NONO {November 9, 2007 7:43:29 PM PST}
- INFO: Beginning work on NOX4... {November 9, 2007 7:53:23 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:54:04 PM PST}
- CREATED: Created new protein page: NOX4 {November 9, 2007 7:54:13 PM PST}
- INFO: Beginning work on P2RY2... {November 9, 2007 7:45:06 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:45:52 PM PST}
- CREATED: Created new protein page: P2RY2 {November 9, 2007 7:46:00 PM PST}
- INFO: Beginning work on PIAS4... {November 9, 2007 7:54:13 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:55:17 PM PST}
- CREATED: Created new protein page: PIAS4 {November 9, 2007 7:55:25 PM PST}
- INFO: Beginning work on PLA2G1B... {November 9, 2007 7:46:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:46:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phospholipase A2, group IB (pancreas)
| HGNCid = 9030
| Symbol = PLA2G1B
| AltSymbols =; MGC119834; MGC119835; PLA2; PLA2A; PPLA2
| OMIM = 172410
| ECnumber =
| Homologene = 715
| MGIid = 101842
| GeneAtlas_image1 = PBB_GE_PLA2G1B_206311_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004623 |text = phospholipase A2 activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5319
| Hs_Ensembl = ENSG00000170890
| Hs_RefseqProtein = NP_000919
| Hs_RefseqmRNA = NM_000928
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 119244298
| Hs_GenLoc_end = 119249975
| Hs_Uniprot = P04054
| Mm_EntrezGene = 18778
| Mm_Ensembl = ENSMUSG00000029522
| Mm_RefseqmRNA = NM_011107
| Mm_RefseqProtein = NP_035237
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 115727265
| Mm_GenLoc_end = 115735716
| Mm_Uniprot = Q9Z0Y2
}}
}}
'''Phospholipase A2, group IB (pancreas)''', also known as '''PLA2G1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986) .[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PLA2G1B phospholipase A2, group IB (pancreas)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5319| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dennis EA |title=Diversity of group types, regulation, and function of phospholipase A2. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13057-60 |year= 1994 |pmid= 8175726 |doi= }}
*{{cite journal | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi= }}
*{{cite journal | author=Sapirstein A, Bonventre JV |title=Phospholipases A2 in ischemic and toxic brain injury. |journal=Neurochem. Res. |volume=25 |issue= 5 |pages= 745-53 |year= 2000 |pmid= 10905638 |doi= }}
*{{cite journal | author=Svensson CI, Yaksh TL |title=The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 553-83 |year= 2002 |pmid= 11807183 |doi= 10.1146/annurev.pharmtox.42.092401.143905 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPP1CC... {November 9, 2007 7:46:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPP1CC image.jpg {November 9, 2007 7:47:28 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:47:39 PM PST}
- CREATED: Created new protein page: PPP1CC {November 9, 2007 7:47:46 PM PST}
- INFO: Beginning work on PPP5C... {November 9, 2007 7:47:46 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPP5C image.jpg {November 9, 2007 7:48:54 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:49:11 PM PST}
- CREATED: Created new protein page: PPP5C {November 9, 2007 7:49:18 PM PST}
- INFO: Beginning work on PSMB3... {November 9, 2007 7:50:30 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMB3 image.jpg {November 9, 2007 7:51:09 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:51:21 PM PST}
- CREATED: Created new protein page: PSMB3 {November 9, 2007 7:51:29 PM PST}
- INFO: Beginning work on PSMD5... {November 9, 2007 7:51:29 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:52:13 PM PST}
- CREATED: Created new protein page: PSMD5 {November 9, 2007 7:52:21 PM PST}
- INFO: Beginning work on RARG... {November 9, 2007 7:52:21 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 7:53:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:53:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB Protein RARB image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dsz.
| PDB = {{PDB2|1dsz}}, {{PDB2|1exa}}, {{PDB2|1exx}}, {{PDB2|1fcx}}, {{PDB2|1fcy}}, {{PDB2|1fcz}}, {{PDB2|1fd0}}, {{PDB2|1hra}}, {{PDB2|2lbd}}, {{PDB2|3lbd}}, {{PDB2|4lbd}}
| Name = Retinoic acid receptor, gamma
| HGNCid = 9866
| Symbol = RARG
| AltSymbols =; NR1B3; RARC
| OMIM = 180190
| ECnumber =
| Homologene = 20263
| MGIid = 97858
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003708 |text = retinoic acid receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048048 |text = embryonic eye morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5916
| Hs_Ensembl =
| Hs_RefseqProtein = XP_945931
| Hs_RefseqmRNA = XM_940838
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19411
| Mm_Ensembl = ENSMUSG00000001288
| Mm_RefseqmRNA = NM_001042727
| Mm_RefseqProtein = NP_001036192
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 102062974
| Mm_GenLoc_end = 102085313
| Mm_Uniprot = Q3UG86
}}
}}
'''Retinoic acid receptor, gamma''', also known as '''RARG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC11A2... {November 9, 2007 7:43:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:45:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
| HGNCid = 10908
| Symbol = SLC11A2
| AltSymbols =; DMT1; DCT1; FLJ37416; NRAMP2
| OMIM = 600523
| ECnumber =
| Homologene = 55471
| MGIid = 1345279
| GeneAtlas_image1 = PBB_GE_SLC11A2_203123_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC11A2_203124_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC11A2_203125_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005381 |text = iron ion transmembrane transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0015087 |text = cobalt ion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0012505 |text = endomembrane system}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006824 |text = cobalt ion transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4891
| Hs_Ensembl = ENSG00000110911
| Hs_RefseqProtein = NP_000608
| Hs_RefseqmRNA = NM_000617
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 49659585
| Hs_GenLoc_end = 49706434
| Hs_Uniprot = P49281
| Mm_EntrezGene = 18174
| Mm_Ensembl = ENSMUSG00000023030
| Mm_RefseqmRNA = NM_008732
| Mm_RefseqProtein = NP_032758
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 100215936
| Mm_GenLoc_end = 100252189
| Mm_Uniprot = Q3UFV5
}}
}}
'''Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2''', also known as '''SLC11A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
