Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 21:28, 10 November 2007 (UTC)[edit]
Proteins without matches (19)[edit]
Proteins with a High Potential Match (6)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (14)[edit]
Protein Status Grid - Date: 21:28, 10 November 2007 (UTC)[edit]
Vebose Log - Date: 21:28, 10 November 2007 (UTC)[edit]
- INFO: Beginning work on ALPP... {November 10, 2007 12:04:40 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ALPP image.jpg {November 10, 2007 12:06:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:06:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ALPP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ew2.
| PDB = {{PDB2|1ew2}}, {{PDB2|1zeb}}, {{PDB2|1zed}}, {{PDB2|1zef}}, {{PDB2|2glq}}
| Name = Alkaline phosphatase, placental (Regan isozyme)
| HGNCid = 439
| Symbol = ALPP
| AltSymbols =; ALP; PLAP; ALPG; ALPPL; GCAP
| OMIM = 171800
| ECnumber =
| Homologene = 55592
| MGIid = 108009
| GeneAtlas_image1 = PBB_GE_ALPP_204664_at_tn.png
| GeneAtlas_image2 = PBB_GE_ALPP_211619_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ALPP_210431_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004035 |text = alkaline phosphatase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0016310 |text = phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 250
| Hs_Ensembl = ENSG00000163283
| Hs_RefseqProtein = NP_001623
| Hs_RefseqmRNA = NM_001632
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 232951627
| Hs_GenLoc_end = 232955832
| Hs_Uniprot = P05187
| Mm_EntrezGene = 11650
| Mm_Ensembl = ENSMUSG00000026246
| Mm_RefseqmRNA = NM_007433
| Mm_RefseqProtein = NP_031459
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 88917861
| Mm_GenLoc_end = 88921082
| Mm_Uniprot = Q3ULC9
}}
}}
'''Alkaline phosphatase, placental (Regan isozyme)''', also known as '''ALPP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.<ref>{{cite web | title = Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=250| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATP6... {November 10, 2007 12:26:07 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:26:25 PM PST}
- CREATED: Created new protein page: ATP6 {November 10, 2007 12:26:34 PM PST}
- INFO: Beginning work on DDX58... {November 10, 2007 1:18:22 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 1:19:18 PM PST}
- CREATED: Created new protein page: DDX58 {November 10, 2007 1:19:28 PM PST}
- INFO: Beginning work on EIF3S6... {November 10, 2007 12:15:13 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:15:55 PM PST}
- CREATED: Created new protein page: EIF3S6 {November 10, 2007 12:16:02 PM PST}
- INFO: Beginning work on EXOSC2... {November 10, 2007 1:17:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EXOSC2 image.jpg {November 10, 2007 1:18:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:18:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EXOSC2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nn6.
| PDB = {{PDB2|2nn6}}
| Name = Exosome component 2
| HGNCid = 17097
| Symbol = EXOSC2
| AltSymbols =; RRP4; Rrp4p; hRrp4p; p7
| OMIM = 602238
| ECnumber =
| Homologene = 6095
| MGIid = 2385133
| GeneAtlas_image1 = PBB_GE_EXOSC2_214507_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXOSC2_209527_at_tn.png
| Function = {{GNF_GO|id=GO:0000175 |text = 3'-5'-exoribonuclease activity}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008312 |text = 7S RNA binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23404
| Hs_Ensembl = ENSG00000130713
| Hs_RefseqProtein = NP_055100
| Hs_RefseqmRNA = NM_014285
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 132558929
| Hs_GenLoc_end = 132570069
| Hs_Uniprot = Q13868
| Mm_EntrezGene = 227715
| Mm_Ensembl = ENSMUSG00000039356
| Mm_RefseqmRNA = XM_979843
| Mm_RefseqProtein = XP_984937
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 31492724
| Mm_GenLoc_end = 31503314
| Mm_Uniprot = Q3TKQ3
}}
}}
'''Exosome component 2''', also known as '''EXOSC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GABPA... {November 10, 2007 12:06:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GABPA image.jpg {November 10, 2007 12:07:08 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:07:28 PM PST}
- CREATED: Created new protein page: GABPA {November 10, 2007 12:07:36 PM PST}
- INFO: Beginning work on GFRA1... {November 10, 2007 12:07:36 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GFRA1 image.jpg {November 10, 2007 12:08:17 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:08:43 PM PST}
- CREATED: Created new protein page: GFRA1 {November 10, 2007 12:08:51 PM PST}
- INFO: Beginning work on GGA2... {November 10, 2007 1:14:06 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GGA2 image.jpg {November 10, 2007 1:16:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:17:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GGA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhq.
| PDB = {{PDB2|1mhq}}
| Name = Golgi associated, gamma adaptin ear containing, ARF binding protein 2
| HGNCid = 16064
| Symbol = GGA2
| AltSymbols =; FLJ20966; KIAA1080; VEAR
| OMIM = 606005
| ECnumber =
| Homologene = 22860
| MGIid = 1921355
| GeneAtlas_image1 = PBB_GE_GGA2_208913_at_tn.png
| GeneAtlas_image2 = PBB_GE_GGA2_208914_at_tn.png
| GeneAtlas_image3 = PBB_GE_GGA2_208915_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030306 |text = ADP-ribosylation factor binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030130 |text = clathrin coat of trans-Golgi network vesicle}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23062
| Hs_Ensembl = ENSG00000103365
| Hs_RefseqProtein = NP_055859
| Hs_RefseqmRNA = NM_015044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 23383145
| Hs_GenLoc_end = 23429309
| Hs_Uniprot = Q9UJY4
| Mm_EntrezGene = 74105
| Mm_Ensembl = ENSMUSG00000030872
| Mm_RefseqmRNA = NM_028758
| Mm_RefseqProtein = NP_083034
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 121777870
| Mm_GenLoc_end = 121812315
| Mm_Uniprot = Q3TVV9
}}
}}
'''Golgi associated, gamma adaptin ear containing, ARF binding protein 2''', also known as '''GGA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.<ref>{{cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GM2A... {November 10, 2007 12:08:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GM2A image.jpg {November 10, 2007 12:10:47 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:10:57 PM PST}
- CREATED: Created new protein page: GM2A {November 10, 2007 12:11:05 PM PST}
- INFO: Beginning work on GP9... {November 10, 2007 12:11:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:11:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glycoprotein IX (platelet)
| HGNCid = 4444
| Symbol = GP9
| AltSymbols =; CD42a; GPIX
| OMIM = 173515
| ECnumber =
| Homologene = 144
| MGIid = 1860137
| GeneAtlas_image1 = PBB_GE_GP9_206883_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2815
| Hs_Ensembl = ENSG00000169704
| Hs_RefseqProtein = NP_000165
| Hs_RefseqmRNA = NM_000174
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 130262300
| Hs_GenLoc_end = 130263941
| Hs_Uniprot = P14770
| Mm_EntrezGene = 54368
| Mm_Ensembl = ENSMUSG00000030054
| Mm_RefseqmRNA = NM_018762
| Mm_RefseqProtein = NP_061232
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 87743777
| Mm_GenLoc_end = 87745403
| Mm_Uniprot =
}}
}}
'''Glycoprotein IX (platelet)''', also known as '''GP9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GP9 glycoprotein IX (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2815| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kunishima S, Kamiya T, Saito H |title=Genetic abnormalities of Bernard-Soulier syndrome. |journal=Int. J. Hematol. |volume=76 |issue= 4 |pages= 319-27 |year= 2003 |pmid= 12463594 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRP... {November 10, 2007 12:11:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:12:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gastrin-releasing peptide
| HGNCid = 4605
| Symbol = GRP
| AltSymbols =; BN; GRP-10; preproGRP; proGRP
| OMIM = 137260
| ECnumber =
| Homologene = 1580
| MGIid = 95833
| GeneAtlas_image1 = PBB_GE_GRP_206326_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2922
| Hs_Ensembl = ENSG00000134443
| Hs_RefseqProtein = NP_001012530
| Hs_RefseqmRNA = NM_001012512
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 55038380
| Hs_GenLoc_end = 55048980
| Hs_Uniprot = P07492
| Mm_EntrezGene = 225642
| Mm_Ensembl = ENSMUSG00000024517
| Mm_RefseqmRNA = NM_175012
| Mm_RefseqProtein = NP_778177
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 65998863
| Mm_GenLoc_end = 66011948
| Mm_Uniprot = Q8R1I2
}}
}}
'''Gastrin-releasing peptide''', also known as '''GRP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: GRP gastrin-releasing peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2922| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Merali Z, McIntosh J, Anisman H |title=Role of bombesin-related peptides in the control of food intake. |journal=Neuropeptides |volume=33 |issue= 5 |pages= 376-86 |year= 2000 |pmid= 10657515 |doi= 10.1054/npep.1999.0054 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HUS1... {November 10, 2007 12:12:27 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:13:44 PM PST}
- CREATED: Created new protein page: HUS1 {November 10, 2007 12:14:03 PM PST}
- INFO: Beginning work on IL10RA... {November 10, 2007 12:14:03 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL10RA image.jpg {November 10, 2007 12:14:46 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:15:06 PM PST}
- CREATED: Created new protein page: IL10RA {November 10, 2007 12:15:13 PM PST}
- INFO: Beginning work on ITGB7... {November 10, 2007 12:16:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ITGB7 image.jpg {November 10, 2007 12:16:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:16:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2brq.
| PDB = {{PDB2|2brq}}
| Name = Integrin, beta 7
| HGNCid = 6162
| Symbol = ITGB7
| AltSymbols =;
| OMIM = 147559
| ECnumber =
| Homologene = 20247
| MGIid = 96616
| GeneAtlas_image1 = PBB_GE_ITGB7_205718_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3695
| Hs_Ensembl = ENSG00000139626
| Hs_RefseqProtein = NP_000880
| Hs_RefseqmRNA = NM_000889
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 51871375
| Hs_GenLoc_end = 51887267
| Hs_Uniprot = P26010
| Mm_EntrezGene = 16421
| Mm_Ensembl = ENSMUSG00000001281
| Mm_RefseqmRNA = NM_013566
| Mm_RefseqProtein = NP_038594
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 102044030
| Mm_GenLoc_end = 102059969
| Mm_Uniprot = P26011
}}
}}
'''Integrin, beta 7''', also known as '''ITGB7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCND2... {November 10, 2007 12:16:43 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KCND2 image.jpg {November 10, 2007 12:16:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:17:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KCND2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nn7.
| PDB = {{PDB2|1nn7}}, {{PDB2|1s6c}}
| Name = Potassium voltage-gated channel, Shal-related subfamily, member 2
| HGNCid = 6238
| Symbol = KCND2
| AltSymbols =; KIAA1044; KV4.2; MGC119702; MGC119703; RK5
| OMIM = 605410
| ECnumber =
| Homologene = 40828
| MGIid = 102663
| Function = {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}}
| Process = {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3751
| Hs_Ensembl = ENSG00000184408
| Hs_RefseqProtein = NP_036413
| Hs_RefseqmRNA = NM_012281
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 119701923
| Hs_GenLoc_end = 120175148
| Hs_Uniprot = Q9NZV8
| Mm_EntrezGene = 16508
| Mm_Ensembl = ENSMUSG00000060882
| Mm_RefseqmRNA = NM_019697
| Mm_RefseqProtein = NP_062671
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 21166300
| Mm_GenLoc_end = 21677343
| Mm_Uniprot = Q9Z0V2
}}
}}
'''Potassium voltage-gated channel, Shal-related subfamily, member 2''', also known as '''KCND2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.<ref>{{cite web | title = Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3751| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT7... {November 10, 2007 12:17:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:17:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 7
| HGNCid = 6445
| Symbol = KRT7
| AltSymbols =; CK7; K2C7; K7; MGC129731; MGC3625; SCL
| OMIM = 148059
| ECnumber =
| Homologene = 4058
| MGIid = 96704
| GeneAtlas_image1 = PBB_GE_KRT7_209016_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3855
| Hs_Ensembl = ENSG00000135480
| Hs_RefseqProtein = NP_005547
| Hs_RefseqmRNA = NM_005556
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50913348
| Hs_GenLoc_end = 50928969
| Hs_Uniprot = P08729
| Mm_EntrezGene = 110310
| Mm_Ensembl = ENSMUSG00000023039
| Mm_RefseqmRNA = NM_033073
| Mm_RefseqProtein = NP_149064
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101240436
| Mm_GenLoc_end = 101255827
| Mm_Uniprot =
}}
}}
'''Keratin 7''', also known as '''KRT7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.<ref>{{cite web | title = Entrez Gene: KRT7 keratin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3855| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bouwens L |title=Cytokeratins and cell differentiation in the pancreas. |journal=J. Pathol. |volume=184 |issue= 3 |pages= 234-9 |year= 1998 |pmid= 9614373 |doi= 10.1002/(SICI)1096-9896(199803)184:3<234::AID-PATH28>3.0.CO;2-D }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LALBA... {November 10, 2007 12:17:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LALBA image.jpg {November 10, 2007 12:18:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:18:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LALBA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4v.
| PDB = {{PDB2|1a4v}}, {{PDB2|1alc}}, {{PDB2|1b9o}}, {{PDB2|1hml}}
| Name = Lactalbumin, alpha-
| HGNCid = 6480
| Symbol = LALBA
| AltSymbols =; MGC138521; MGC138523
| OMIM = 149750
| ECnumber =
| Homologene = 1720
| MGIid = 96742
| GeneAtlas_image1 = PBB_GE_LALBA_207816_at_tn.png
| Function = {{GNF_GO|id=GO:0004461 |text = lactose synthase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005989 |text = lactose biosynthetic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3906
| Hs_Ensembl = ENSG00000167531
| Hs_RefseqProtein = NP_002280
| Hs_RefseqmRNA = NM_002289
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 47247735
| Hs_GenLoc_end = 47250096
| Hs_Uniprot = P00709
| Mm_EntrezGene = 16770
| Mm_Ensembl = ENSMUSG00000022991
| Mm_RefseqmRNA = XM_993980
| Mm_RefseqProtein = XP_999074
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 98308434
| Mm_GenLoc_end = 98310717
| Mm_Uniprot = P29752
}}
}}
'''Lactalbumin, alpha-''', also known as '''LALBA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.<ref>{{cite web | title = Entrez Gene: LALBA lactalbumin, alpha-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3906| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heine WE, Klein PD, Reeds PJ |title=The importance of alpha-lactalbumin in infant nutrition. |journal=J. Nutr. |volume=121 |issue= 3 |pages= 277-83 |year= 1991 |pmid= 2002399 |doi= }}
*{{cite journal | author=Permyakov EA, Berliner LJ |title=alpha-Lactalbumin: structure and function. |journal=FEBS Lett. |volume=473 |issue= 3 |pages= 269-74 |year= 2000 |pmid= 10818224 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LBR... {November 10, 2007 12:18:43 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LBR image.jpg {November 10, 2007 12:19:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:19:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LBR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dig.
| PDB = {{PDB2|2dig}}
| Name = Lamin B receptor
| HGNCid = 6518
| Symbol = LBR
| AltSymbols =; DHCR14B; LMN2R; MGC9041; PHA
| OMIM = 600024
| ECnumber =
| Homologene = 2455
| MGIid = 2138281
| GeneAtlas_image1 = PBB_GE_LBR_201795_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005521 |text = lamin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005639 |text = integral to nuclear inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3930
| Hs_Ensembl = ENSG00000143815
| Hs_RefseqProtein = NP_002287
| Hs_RefseqmRNA = NM_002296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 223655827
| Hs_GenLoc_end = 223683142
| Hs_Uniprot = Q14739
| Mm_EntrezGene = 98386
| Mm_Ensembl = ENSMUSG00000004880
| Mm_RefseqmRNA = NM_133815
| Mm_RefseqProtein = NP_598576
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 183651991
| Mm_GenLoc_end = 183679029
| Mm_Uniprot = Q811V7
}}
}}
'''Lamin B receptor''', also known as '''LBR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.<ref>{{cite web | title = Entrez Gene: LBR lamin B receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3930| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LIG1... {November 10, 2007 12:19:33 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LIG1 image.jpg {November 10, 2007 12:20:10 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:20:22 PM PST}
- CREATED: Created new protein page: LIG1 {November 10, 2007 12:20:30 PM PST}
- INFO: Beginning work on MAGEA1... {November 10, 2007 12:20:31 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:21:27 PM PST}
- CREATED: Created new protein page: MAGEA1 {November 10, 2007 12:21:34 PM PST}
- INFO: Beginning work on MATK... {November 10, 2007 12:21:34 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MATK image.jpg {November 10, 2007 12:22:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:22:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MATK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jwo.
| PDB = {{PDB2|1jwo}}, {{PDB2|1x6g}}
| Name = Megakaryocyte-associated tyrosine kinase
| HGNCid = 6906
| Symbol = MATK
| AltSymbols =; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MGC1708; MGC2101
| OMIM = 600038
| ECnumber =
| Homologene = 48104
| MGIid = 99259
| GeneAtlas_image1 = PBB_GE_MATK_206267_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4145
| Hs_Ensembl = ENSG00000007264
| Hs_RefseqProtein = NP_002369
| Hs_RefseqmRNA = NM_002378
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 3728968
| Hs_GenLoc_end = 3740345
| Hs_Uniprot = P42679
| Mm_EntrezGene = 17179
| Mm_Ensembl = ENSMUSG00000004933
| Mm_RefseqmRNA = NM_010768
| Mm_RefseqProtein = NP_034898
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80660674
| Mm_GenLoc_end = 80666110
| Mm_Uniprot = P70223
}}
}}
'''Megakaryocyte-associated tyrosine kinase''', also known as '''MATK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: MATK megakaryocyte-associated tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4145| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MB... {November 10, 2007 12:22:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MB image.jpg {November 10, 2007 12:23:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:23:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m6c.
| PDB = {{PDB2|1m6c}}, {{PDB2|1m6m}}, {{PDB2|1mdn}}, {{PDB2|1mnh}}, {{PDB2|1mni}}, {{PDB2|1mnj}}, {{PDB2|1mnk}}, {{PDB2|1mno}}, {{PDB2|1mwc}}, {{PDB2|1mwd}}, {{PDB2|1myg}}, {{PDB2|1myh}}, {{PDB2|1myi}}, {{PDB2|1myj}}, {{PDB2|1pmb}}, {{PDB2|1yca}}, {{PDB2|1ycb}}, {{PDB2|2mm1}}
| Name = Myoglobin
| HGNCid = 6915
| Symbol = MB
| AltSymbols =; MGC13548; PVALB
| OMIM = 160000
| ECnumber =
| Homologene = 3916
| MGIid = 96922
| GeneAtlas_image1 = PBB_GE_MB_204179_at_tn.png
| Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}} {{GNF_GO|id=GO:0043353 |text = enucleate erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4151
| Hs_Ensembl = ENSG00000198125
| Hs_RefseqProtein = NP_005359
| Hs_RefseqmRNA = NM_005368
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 34332757
| Hs_GenLoc_end = 34349347
| Hs_Uniprot = P02144
| Mm_EntrezGene = 17189
| Mm_Ensembl = ENSMUSG00000018893
| Mm_RefseqmRNA = NM_013593
| Mm_RefseqProtein = NP_038621
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 76842742
| Mm_GenLoc_end = 76877925
| Mm_Uniprot = Q3UVB1
}}
}}
'''Myoglobin''', also known as '''MB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.<ref>{{cite web | title = Entrez Gene: MB myoglobin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4151| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Suzuki T, Imai K |title=Evolution of myoglobin. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 9 |pages= 979-1004 |year= 1998 |pmid= 9791540 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MCM4... {November 10, 2007 12:23:48 PM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:25:26 PM PST}
- CREATED: Created new protein page: MCM4 {November 10, 2007 12:25:37 PM PST}
- INFO: Beginning work on MT1A... {November 10, 2007 12:25:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MT1A image.jpg {November 10, 2007 12:25:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:26:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MT1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|2mhu}}
| Name = Metallothionein 1A
| HGNCid = 7393
| Symbol = MT1A
| AltSymbols =; MGC32848; MT1; MT1S; MTC
| OMIM = 156350
| ECnumber =
| Homologene = 88733
| MGIid =
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046870 |text = cadmium ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4489
| Hs_Ensembl = ENSG00000205362
| Hs_RefseqProtein = NP_005937
| Hs_RefseqmRNA = NM_005946
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55230152
| Hs_GenLoc_end = 55231363
| Hs_Uniprot = P04731
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Metallothionein 1A''', also known as '''MT1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, ''et al.'' |title=Metallothionein: an overview. |journal=World J. Gastroenterol. |volume=13 |issue= 7 |pages= 993-6 |year= 2007 |pmid= 17373731 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYOG... {November 10, 2007 12:26:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 1:14:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myogenin (myogenic factor 4)
| HGNCid = 7612
| Symbol = MYOG
| AltSymbols =; MYF4; MYOGENIN
| OMIM = 159980
| ECnumber =
| Homologene = 1854
| MGIid = 97276
| GeneAtlas_image1 = PBB_GE_MYOG_207282_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4656
| Hs_Ensembl = ENSG00000122180
| Hs_RefseqProtein = NP_002470
| Hs_RefseqmRNA = NM_002479
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 201318883
| Hs_GenLoc_end = 201321789
| Hs_Uniprot = P15173
| Mm_EntrezGene = 17928
| Mm_Ensembl = ENSMUSG00000026459
| Mm_RefseqmRNA = NM_031189
| Mm_RefseqProtein = NP_112466
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 136106400
| Mm_GenLoc_end = 136108958
| Mm_Uniprot = P12979
}}
}}
'''Myogenin (myogenic factor 4)''', also known as '''MYOG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle.<ref>{{cite web | title = Entrez Gene: MYOG myogenin (myogenic factor 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4656| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weintraub H, Davis R, Tapscott S, ''et al.'' |title=The myoD gene family: nodal point during specification of the muscle cell lineage. |journal=Science |volume=251 |issue= 4995 |pages= 761-6 |year= 1991 |pmid= 1846704 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
