Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 10:12, 9 November 2007 (UTC)
[edit]Proteins without matches (21)
[edit]Proteins with a High Potential Match (4)
[edit]Manual Inspection (Page not found) (16)
[edit]
Protein Status Grid - Date: 10:12, 9 November 2007 (UTC)
[edit]Vebose Log - Date: 10:12, 9 November 2007 (UTC)
[edit]- INFO: Beginning work on CASK... {November 9, 2007 1:58:31 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CASK image.jpg {November 9, 2007 1:59:27 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:59:37 AM PST}
- CREATED: Created new protein page: CASK {November 9, 2007 1:59:48 AM PST}
- INFO: Beginning work on CD27... {November 9, 2007 1:34:17 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:34:56 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD27 molecule
| HGNCid = 11922
| Symbol = CD27
| AltSymbols =; MGC20393; S152; T14; TNFRSF7; Tp55
| OMIM = 186711
| ECnumber =
| Homologene = 74386
| MGIid = 88326
| GeneAtlas_image1 = PBB_GE_CD27_206150_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043027 |text = caspase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0008588 |text = release of cytoplasmic sequestered NF-kappaB}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0042100 |text = B cell proliferation}} {{GNF_GO|id=GO:0045078 |text = positive regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0045579 |text = positive regulation of B cell differentiation}} {{GNF_GO|id=GO:0045582 |text = positive regulation of T cell differentiation}} {{GNF_GO|id=GO:0046330 |text = positive regulation of JNK cascade}} {{GNF_GO|id=GO:0048305 |text = immunoglobulin secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 939
| Hs_Ensembl = ENSG00000139193
| Hs_RefseqProtein = NP_001233
| Hs_RefseqmRNA = NM_001242
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 6424327
| Hs_GenLoc_end = 6431144
| Hs_Uniprot = P26842
| Mm_EntrezGene = 21940
| Mm_Ensembl = ENSMUSG00000030336
| Mm_RefseqmRNA = NM_001033126
| Mm_RefseqProtein = NP_001028298
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 125198242
| Mm_GenLoc_end = 125202629
| Mm_Uniprot = Q3U4X0
}}
}}
'''CD27 molecule''', also known as '''CD27''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.<ref>{{cite web | title = Entrez Gene: CD27 CD27 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=939| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lens SM, de Jong R, Hintzen RQ, ''et al.'' |title=CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth. |journal=Leuk. Lymphoma |volume=18 |issue= 1-2 |pages= 51-9 |year= 1996 |pmid= 8580829 |doi= }}
*{{cite journal | author=Agematsu K |title=Memory B cells and CD27. |journal=Histol. Histopathol. |volume=15 |issue= 2 |pages= 573-6 |year= 2000 |pmid= 10809378 |doi= }}
*{{cite journal | author=van Baarle D, Kostense S, van Oers MH, ''et al.'' |title=Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue. |journal=Trends Immunol. |volume=23 |issue= 12 |pages= 586-91 |year= 2003 |pmid= 12464570 |doi= }}
*{{cite journal | author=Dörner T, Lipsky PE |title=Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus. |journal=Lupus |volume=13 |issue= 5 |pages= 283-9 |year= 2005 |pmid= 15230280 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD274... {November 9, 2007 2:03:35 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:04:04 AM PST}
- CREATED: Created new protein page: CD274 {November 9, 2007 2:04:10 AM PST}
- INFO: Beginning work on CDH13... {November 9, 2007 1:34:56 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:35:48 AM PST}
- CREATED: Created new protein page: CDH13 {November 9, 2007 1:35:55 AM PST}
- INFO: Beginning work on CHI3L1... {November 9, 2007 1:35:55 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CHI3L1 image.jpg {November 9, 2007 1:37:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:37:28 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CHI3L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hjv.
| PDB = {{PDB2|1hjv}}, {{PDB2|1hjw}}, {{PDB2|1hjx}}, {{PDB2|1nwr}}, {{PDB2|1nws}}, {{PDB2|1nwt}}, {{PDB2|1nwu}}
| Name = Chitinase 3-like 1 (cartilage glycoprotein-39)
| HGNCid = 1932
| Symbol = CHI3L1
| AltSymbols =; GP39; HC-gp39; HCGP-3P; YKL40; YYL-40
| OMIM = 601525
| ECnumber =
| Homologene = 55569
| MGIid = 1340899
| GeneAtlas_image1 = PBB_GE_CHI3L1_209396_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CHI3L1_209395_at_tn.png
| GeneAtlas_image3 = PBB_GE_CHI3L1_216546_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004553 |text = hydrolase activity, hydrolyzing O-glycosyl compounds}} {{GNF_GO|id=GO:0004568 |text = chitinase activity}} {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006032 |text = chitin catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1116
| Hs_Ensembl = ENSG00000133048
| Hs_RefseqProtein = NP_001267
| Hs_RefseqmRNA = NM_001276
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 201414553
| Hs_GenLoc_end = 201422500
| Hs_Uniprot = P36222
| Mm_EntrezGene = 12654
| Mm_Ensembl = ENSMUSG00000064246
| Mm_RefseqmRNA = NM_007695
| Mm_RefseqProtein = NP_031721
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 135998875
| Mm_GenLoc_end = 136006439
| Mm_Uniprot = Q3U291
}}
}}
'''Chitinase 3-like 1 (cartilage glycoprotein-39)''', also known as '''CHI3L1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rathcke CN, Vestergaard H |title=YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. |journal=Inflamm. Res. |volume=55 |issue= 6 |pages= 221-7 |year= 2007 |pmid= 16955240 |doi= 10.1007/s00011-006-0076-y }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLDN1... {November 9, 2007 1:59:48 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:00:30 AM PST}
- CREATED: Created new protein page: CLDN1 {November 9, 2007 2:00:38 AM PST}
- INFO: Beginning work on CNR2... {November 9, 2007 1:37:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:38:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cannabinoid receptor 2 (macrophage)
| HGNCid = 2160
| Symbol = CNR2
| AltSymbols =; CB2; CX5
| OMIM = 605051
| ECnumber =
| Homologene = 1389
| MGIid = 104650
| GeneAtlas_image1 = PBB_GE_CNR2_206586_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004949 |text = cannabinoid receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1269
| Hs_Ensembl = ENSG00000188822
| Hs_RefseqProtein = NP_001832
| Hs_RefseqmRNA = NM_001841
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 24069603
| Hs_GenLoc_end = 24112439
| Hs_Uniprot = P34972
| Mm_EntrezGene = 12802
| Mm_Ensembl = ENSMUSG00000062585
| Mm_RefseqmRNA = NM_009924
| Mm_RefseqProtein = NP_034054
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 135167470
| Mm_GenLoc_end = 135192284
| Mm_Uniprot = Q544H5
}}
}}
'''Cannabinoid receptor 2 (macrophage)''', also known as '''CNR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.<ref>{{cite web | title = Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1269| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oddi S, Spagnuolo P, Bari M, ''et al.'' |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. |journal=Int. Rev. Neurobiol. |volume=82 |issue= |pages= 327-37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COPB1... {November 9, 2007 1:38:05 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:39:02 AM PST}
- CREATED: Created new protein page: COPB1 {November 9, 2007 1:39:09 AM PST}
- INFO: Beginning work on CSF2RA... {November 9, 2007 1:39:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:40:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
| HGNCid = 2435
| Symbol = CSF2RA
| AltSymbols =; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; MGC3848; MGC4838
| OMIM = 306250
| ECnumber =
| Homologene = 48406
| MGIid = 1339754
| GeneAtlas_image1 = PBB_GE_CSF2RA_210340_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CSF2RA_207085_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CSF2RA_211286_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004896 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1438
| Hs_Ensembl = ENSG00000198223
| Hs_RefseqProtein = XP_001133962
| Hs_RefseqmRNA = XM_001133962
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 1347693
| Hs_GenLoc_end = 1389274
| Hs_Uniprot = P15509
| Mm_EntrezGene = 12982
| Mm_Ensembl = ENSMUSG00000059326
| Mm_RefseqmRNA = XM_977426
| Mm_RefseqProtein = XP_982520
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 61279667
| Mm_GenLoc_end = 61282028
| Mm_Uniprot = Q00941
}}
}}
'''Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)''', also known as '''CSF2RA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.<ref>{{cite web | title = Entrez Gene: CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1438| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK1A1... {November 9, 2007 1:40:57 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:43:02 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Casein kinase 1, alpha 1
| HGNCid = 2451
| Symbol = CSNK1A1
| AltSymbols =; CK1; HLCDGP1; PRO2975
| OMIM = 600505
| ECnumber =
| Homologene = 37546
| MGIid = 1934950
| GeneAtlas_image1 = PBB_GE_CSNK1A1_206562_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CSNK1A1_213086_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CSNK1A1_208865_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004681 |text = casein kinase I activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1452
| Hs_Ensembl = ENSG00000113712
| Hs_RefseqProtein = NP_001020276
| Hs_RefseqmRNA = NM_001025105
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 148855038
| Hs_GenLoc_end = 148911200
| Hs_Uniprot = P48729
| Mm_EntrezGene = 93687
| Mm_Ensembl = ENSMUSG00000024576
| Mm_RefseqmRNA = NM_146087
| Mm_RefseqProtein = NP_666199
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 61680702
| Mm_GenLoc_end = 61713672
| Mm_Uniprot = Q3TVX1
}}
}}
'''Casein kinase 1, alpha 1''', also known as '''CSNK1A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Veis A, Sfeir C, Wu CB |title=Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. |journal=Crit. Rev. Oral Biol. Med. |volume=8 |issue= 4 |pages= 360-79 |year= 1998 |pmid= 9391750 |doi= }}
*{{cite journal | author=Giaccia AJ, Kastan MB |title=The complexity of p53 modulation: emerging patterns from divergent signals. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2973-83 |year= 1998 |pmid= 9765199 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTAG1B... {November 9, 2007 1:43:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:45:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cancer/testis antigen 1B
| HGNCid = 2491
| Symbol = CTAG1B
| AltSymbols =; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B; NY-ESO-1; CAMEL; ESO2; LAGE-1; LAGE-2b; MGC138724; MGC3803; LAGE2A
| OMIM = 300156
| ECnumber =
| Homologene = 37469
| MGIid =
| GeneAtlas_image1 = PBB_GE_CTAG1B_207337_at_tn.png
| GeneAtlas_image2 = PBB_GE_CTAG1B_210546_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CTAG1B_211674_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1485
| Hs_Ensembl = ENSG00000126890
| Hs_RefseqProtein = NP_001318
| Hs_RefseqmRNA = NM_001327
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153533440
| Hs_GenLoc_end = 153535047
| Hs_Uniprot = O75638
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cancer/testis antigen 1B''', also known as '''CTAG1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Scanlan MJ, Gure AO, Jungbluth AA, ''et al.'' |title=Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. |journal=Immunol. Rev. |volume=188 |issue= |pages= 22-32 |year= 2003 |pmid= 12445278 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DDB1... {November 9, 2007 1:45:10 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DDB1 image.jpg {November 9, 2007 1:45:23 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:45:43 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DDB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b5l.
| PDB = {{PDB2|2b5l}}, {{PDB2|2b5m}}, {{PDB2|2b5n}}, {{PDB2|2hye}}
| Name = Damage-specific DNA binding protein 1, 127kDa
| HGNCid = 2717
| Symbol = DDB1
| AltSymbols =; DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
| OMIM = 600045
| ECnumber =
| Homologene = 1448
| MGIid = 1202384
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1642
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001128974
| Hs_RefseqmRNA = XM_001128974
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13194
| Mm_Ensembl = ENSMUSG00000024740
| Mm_RefseqmRNA = NM_015735
| Mm_RefseqProtein = NP_056550
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 10672670
| Mm_GenLoc_end = 10696867
| Mm_Uniprot =
}}
}}
'''Damage-specific DNA binding protein 1, 127kDa''', also known as '''DDB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.<ref>{{cite web | title = Entrez Gene: DDB1 damage-specific DNA binding protein 1, 127kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1642| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EFNA1... {November 9, 2007 1:45:43 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:46:28 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ephrin-A1
| HGNCid = 3221
| Symbol = EFNA1
| AltSymbols =; B61; ECKLG; EFL1; EPLG1; LERK1; TNFAIP4
| OMIM = 191164
| ECnumber =
| Homologene = 3262
| MGIid = 103236
| GeneAtlas_image1 = PBB_GE_EFNA1_202023_at_tn.png
| Function = {{GNF_GO|id=GO:0046875 |text = ephrin receptor binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0048013 |text = ephrin receptor signaling pathway}} {{GNF_GO|id=GO:0050770 |text = regulation of axonogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1942
| Hs_Ensembl = ENSG00000169242
| Hs_RefseqProtein = NP_004419
| Hs_RefseqmRNA = NM_004428
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 153366560
| Hs_GenLoc_end = 153373957
| Hs_Uniprot = P20827
| Mm_EntrezGene = 13636
| Mm_Ensembl = ENSMUSG00000027954
| Mm_RefseqmRNA = NM_010107
| Mm_RefseqProtein = NP_034237
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 89357663
| Mm_GenLoc_end = 89365568
| Mm_Uniprot = Q9D7K8
}}
}}
'''Ephrin-A1''', also known as '''EFNA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.<ref>{{cite web | title = Entrez Gene: EFNA1 ephrin-A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1942| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pandey A, Lindberg RA, Dixit VM |title=Cell signalling. Receptor orphans find a family. |journal=Curr. Biol. |volume=5 |issue= 9 |pages= 986-9 |year= 1996 |pmid= 8542290 |doi= }}
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi= }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ETS2... {November 9, 2007 1:46:28 AM PST}
- UPLOAD: Added new Image to wiki: {November 9, 2007 1:47:19 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:47:27 AM PST}
- CREATED: Created new protein page: ETS2 {November 9, 2007 1:47:34 AM PST}
- INFO: Beginning work on GAD2... {November 9, 2007 1:47:34 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GAD2 image.jpg {November 9, 2007 1:48:44 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:49:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GAD2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2okk.
| PDB = {{PDB2|2okk}}
| Name = Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
| HGNCid = 4093
| Symbol = GAD2
| AltSymbols =; GAD65; MGC161605; MGC161607
| OMIM = 138275
| ECnumber =
| Homologene = 20223
| MGIid = 95634
| GeneAtlas_image1 = PBB_GE_GAD2_206780_at_tn.png
| GeneAtlas_image2 = PBB_GE_GAD2_211264_at_tn.png
| GeneAtlas_image3 = PBB_GE_GAD2_216651_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004351 |text = glutamate decarboxylase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0016831 |text = carboxy-lyase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006540 |text = glutamate decarboxylation to succinate}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0019752 |text = carboxylic acid metabolic process}} {{GNF_GO|id=GO:0042136 |text = neurotransmitter biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2572
| Hs_Ensembl = ENSG00000136750
| Hs_RefseqProtein = NP_000809
| Hs_RefseqmRNA = NM_000818
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 26545242
| Hs_GenLoc_end = 26633493
| Hs_Uniprot = Q05329
| Mm_EntrezGene = 14417
| Mm_Ensembl = ENSMUSG00000026787
| Mm_RefseqmRNA = NM_008078
| Mm_RefseqProtein = NP_032104
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 22473965
| Mm_GenLoc_end = 22542637
| Mm_Uniprot = Q3URJ3
}}
}}
'''Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)''', also known as '''GAD2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.<ref>{{cite web | title = Entrez Gene: GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2572| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GDI1... {November 9, 2007 1:49:16 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GDI1 image.jpg {November 9, 2007 1:49:49 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:50:14 AM PST}
- CREATED: Created new protein page: GDI1 {November 9, 2007 1:50:21 AM PST}
- INFO: Beginning work on MALT1... {November 9, 2007 2:01:37 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MALT1 image.jpg {November 9, 2007 2:02:47 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:03:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MALT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g7r.
| PDB = {{PDB2|2g7r}}
| Name = Mucosa associated lymphoid tissue lymphoma translocation gene 1
| HGNCid = 6819
| Symbol = MALT1
| AltSymbols =; DKFZp434L132; MLT; MLT1
| OMIM = 604860
| ECnumber =
| Homologene = 4938
| MGIid = 2445027
| GeneAtlas_image1 = PBB_GE_MALT1_210017_at_tn.png
| GeneAtlas_image2 = PBB_GE_MALT1_208309_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MALT1_210018_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0019209 |text = kinase activator activity}} {{GNF_GO|id=GO:0030693 |text = caspase activity}} {{GNF_GO|id=GO:0043621 |text = protein self-association}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0032449 |text = CBM complex}}
| Process = {{GNF_GO|id=GO:0002726 |text = positive regulation of T cell cytokine production}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0050870 |text = positive regulation of T cell activation}} {{GNF_GO|id=GO:0051168 |text = nuclear export}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10892
| Hs_Ensembl = ENSG00000172175
| Hs_RefseqProtein = NP_006776
| Hs_RefseqmRNA = NM_006785
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 54489598
| Hs_GenLoc_end = 54568350
| Hs_Uniprot = Q9UDY8
| Mm_EntrezGene = 240354
| Mm_Ensembl = ENSMUSG00000032688
| Mm_RefseqmRNA = NM_172833
| Mm_RefseqProtein = NP_766421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 65556332
| Mm_GenLoc_end = 65604192
| Mm_Uniprot = Q8BRB5
}}
}}
'''Mucosa associated lymphoid tissue lymphoma translocation gene 1''', also known as '''MALT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10892| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10-3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NEDD4L... {November 9, 2007 2:03:01 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NEDD4L image.jpg {November 9, 2007 2:03:13 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:03:28 AM PST}
- CREATED: Created new protein page: NEDD4L {November 9, 2007 2:03:35 AM PST}
- INFO: Beginning work on OGT... {November 9, 2007 1:56:31 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein OGT image.jpg {November 9, 2007 1:58:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:58:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OGT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w3b.
| PDB = {{PDB2|1w3b}}
| Name = O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
| HGNCid = 8127
| Symbol = OGT
| AltSymbols =; FLJ23071; HRNT1; MGC22921; O-GLCNAC
| OMIM = 300255
| ECnumber =
| Homologene = 9675
| MGIid = 1339639
| GeneAtlas_image1 = PBB_GE_OGT_207563_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OGT_207564_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_OGT_209240_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008375 |text = acetylglucosaminyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006493 |text = protein amino acid O-linked glycosylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8473
| Hs_Ensembl = ENSG00000147162
| Hs_RefseqProtein = NP_858058
| Hs_RefseqmRNA = NM_181672
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 70669658
| Hs_GenLoc_end = 70712472
| Hs_Uniprot = O15294
| Mm_EntrezGene = 108155
| Mm_Ensembl = ENSMUSG00000034160
| Mm_RefseqmRNA = NM_139144
| Mm_RefseqProtein = NP_631883
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 97842783
| Mm_GenLoc_end = 97887068
| Mm_Uniprot =
}}
}}
'''O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)''', also known as '''OGT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: OGT O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8473| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Konrad RJ, Kudlow JE |title=The role of O-linked protein glycosylation in beta-cell dysfunction. |journal=Int. J. Mol. Med. |volume=10 |issue= 5 |pages= 535-9 |year= 2002 |pmid= 12373287 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PLA2G7... {November 9, 2007 1:55:59 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:56:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
| HGNCid = 9040
| Symbol = PLA2G7
| AltSymbols =; PAFAH; LDL-PLA2
| OMIM = 601690
| ECnumber =
| Homologene = 3725
| MGIid = 1351327
| GeneAtlas_image1 = PBB_GE_PLA2G7_206214_at_tn.png
| Function = {{GNF_GO|id=GO:0003847 |text = 1-alkyl-2-acetylglycerophosphocholine esterase activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0008247 |text = 2-acetyl-1-alkylglycerophosphocholine esterase complex}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7941
| Hs_Ensembl = ENSG00000146070
| Hs_RefseqProtein = NP_005075
| Hs_RefseqmRNA = NM_005084
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 46779897
| Hs_GenLoc_end = 46811389
| Hs_Uniprot = Q13093
| Mm_EntrezGene = 27226
| Mm_Ensembl = ENSMUSG00000023913
| Mm_RefseqmRNA = XM_001003905
| Mm_RefseqProtein = XP_001003905
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 43031500
| Mm_GenLoc_end = 43075242
| Mm_Uniprot = Q3U1V7
}}
}}
'''Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)''', also known as '''PLA2G7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The PLA2G7 gene encodes platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7941| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi= }}
*{{cite journal | author=Feng Y, Walsh CA |title=Protein-protein interactions, cytoskeletal regulation and neuronal migration. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 6 |pages= 408-16 |year= 2001 |pmid= 11389474 |doi= 10.1038/35077559 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMF1... {November 9, 2007 2:00:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:01:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
| HGNCid = 9571
| Symbol = PSMF1
| AltSymbols =; PI31
| OMIM =
| ECnumber =
| Homologene = 38231
| MGIid = 1346072
| GeneAtlas_image1 = PBB_GE_PSMF1_201052_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMF1_201053_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008539 |text = proteasome inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9491
| Hs_Ensembl = ENSG00000125818
| Hs_RefseqProtein = NP_006805
| Hs_RefseqmRNA = NM_006814
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 1041939
| Hs_GenLoc_end = 1097022
| Hs_Uniprot = Q92530
| Mm_EntrezGene = 228769
| Mm_Ensembl = ENSMUSG00000032869
| Mm_RefseqmRNA = NM_144889
| Mm_RefseqProtein = NP_659138
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 151407256
| Mm_GenLoc_end = 151432734
| Mm_Uniprot = Q8BHL8
}}
}}
'''Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)''', also known as '''PSMF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9491| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tanahashi N, Kawahara H, Murakami Y, Tanaka K |title=The proteasome-dependent proteolytic system. |journal=Mol. Biol. Rep. |volume=26 |issue= 1-2 |pages= 3-9 |year= 1999 |pmid= 10363639 |doi= }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
*{{cite journal | author=Minghetti L, Visentin S, Patrizio M, ''et al.'' |title=Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. |journal=Neurochem. Res. |volume=29 |issue= 5 |pages= 965-78 |year= 2004 |pmid= 15139295 |doi= }}
*{{cite journal | author=Liou LY, Herrmann CH, Rice AP |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 9 |pages= 1767-75 |year= 2005 |pmid= 15183343 |doi= 10.1016/j.biocel.2004.02.018 }}
*{{cite journal | author=Bannwarth S, Gatignol A |title=HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 61-71 |year= 2005 |pmid= 15638724 |doi= }}
*{{cite journal | author=Gibellini D, Vitone F, Schiavone P, Re MC |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue= 2 |pages= 95-109 |year= 2005 |pmid= 16035254 |doi= }}
*{{cite journal | author=Hetzer C, Dormeyer W, Schnölzer M, Ott M |title=Decoding Tat: the biology of HIV Tat posttranslational modifications. |journal=Microbes Infect. |volume=7 |issue= 13 |pages= 1364-9 |year= 2006 |pmid= 16046164 |doi= 10.1016/j.micinf.2005.06.003 }}
*{{cite journal | author=Peruzzi F |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |issue= |pages= 708-17 |year= 2006 |pmid= 16146763 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAF9... {November 9, 2007 1:50:21 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TAF9 image.jpg {November 9, 2007 1:51:11 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:51:53 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TAF9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rkb.
| PDB = {{PDB2|1rkb}}
| Name = TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
| HGNCid = 11542
| Symbol = TAF9
| AltSymbols =; AD-004; AK6; CGI-137; CINAP; CIP; MGC1603; MGC3647; MGC5067; MGC:1603; MGC:3647; MGC:5067; TAF2G; TAFII31; TAFII32; TAFIID32
| OMIM = 600822
| ECnumber =
| Homologene = 39986
| MGIid = 1888697
| GeneAtlas_image1 = PBB_GE_TAF9_203893_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAF9_202168_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004017 |text = adenylate kinase activity}} {{GNF_GO|id=GO:0004765 |text = shikimate kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019201 |text = nucleotide kinase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005669 |text = transcription factor TFIID complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6880
| Hs_Ensembl = ENSG00000085231
| Hs_RefseqProtein = NP_001015891
| Hs_RefseqmRNA = NM_001015891
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c5_H2
| Hs_GenLoc_start = 69107684
| Hs_GenLoc_end = 69125972
| Hs_Uniprot = Q9Y3D8
| Mm_EntrezGene = 108143
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_001015889
| Mm_RefseqProtein = NP_001015889
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa''', also known as '''TAF9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6880| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TLN1... {November 9, 2007 1:51:53 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TLN1 image.jpg {November 9, 2007 1:52:29 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:52:43 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TLN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mix.
| PDB = {{PDB2|1mix}}, {{PDB2|1miz}}, {{PDB2|1mk7}}, {{PDB2|1mk9}}, {{PDB2|1sj7}}, {{PDB2|1sj8}}, {{PDB2|1u89}}, {{PDB2|1y19}}, {{PDB2|2b0h}}, {{PDB2|2g35}}, {{PDB2|2h7d}}, {{PDB2|2h7e}}
| Name = Talin 1
| HGNCid = 11845
| Symbol = TLN1
| AltSymbols =; ILWEQ; TLN; KIAA1027
| OMIM = 186745
| ECnumber =
| Homologene = 21267
| MGIid = 1099832
| GeneAtlas_image1 = PBB_GE_TLN1_203254_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017166 |text = vinculin binding}} {{GNF_GO|id=GO:0030274 |text = LIM domain binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007016 |text = cytoskeletal anchoring}} {{GNF_GO|id=GO:0007043 |text = intercellular junction assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7094
| Hs_Ensembl = ENSG00000137076
| Hs_RefseqProtein = NP_006280
| Hs_RefseqmRNA = NM_006289
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 35687336
| Hs_GenLoc_end = 35722369
| Hs_Uniprot = Q9Y490
| Mm_EntrezGene = 21894
| Mm_Ensembl = ENSMUSG00000028465
| Mm_RefseqmRNA = NM_011602
| Mm_RefseqProtein = NP_035732
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 43552618
| Mm_GenLoc_end = 43583522
| Mm_Uniprot = Q0V930
}}
}}
'''Talin 1''', also known as '''TLN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.<ref>{{cite web | title = Entrez Gene: TLN1 talin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7094| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luna EJ, Hitt AL |title=Cytoskeleton--plasma membrane interactions. |journal=Science |volume=258 |issue= 5084 |pages= 955-64 |year= 1992 |pmid= 1439807 |doi= }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal | author=Critchley DR |title=Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 5 |pages= 831-6 |year= 2005 |pmid= 15494027 |doi= 10.1042/BST0320831 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPSAB1... {November 9, 2007 1:52:43 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TPSAB1 image.jpg {November 9, 2007 1:55:02 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:55:19 AM PST}
- CREATED: Created new protein page: TPSAB1 {November 9, 2007 1:55:26 AM PST}
- INFO: Beginning work on TXNRD1... {November 9, 2007 1:55:26 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TXNRD1 image.jpg {November 9, 2007 1:55:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:55:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TXNRD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h6v.
| PDB = {{PDB2|1h6v}}, {{PDB2|2cfy}}
| Name = Thioredoxin reductase 1
| HGNCid = 12437
| Symbol = TXNRD1
| AltSymbols =; TR; TR1; GRIM-12; MGC9145; TRXR1; TXNR
| OMIM = 601112
| ECnumber =
| Homologene = 55733
| MGIid = 1354175
| Function = {{GNF_GO|id=GO:0004791 |text = thioredoxin-disulfide reductase activity}} {{GNF_GO|id=GO:0008430 |text = selenium binding}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016654 |text = oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7296
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003321
| Hs_RefseqmRNA = NM_003330
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 50493
| Mm_Ensembl = ENSMUSG00000020250
| Mm_RefseqmRNA = NM_001042513
| Mm_RefseqProtein = NP_001035978
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 82304448
| Mm_GenLoc_end = 82325844
| Mm_Uniprot = Q3UEB7
}}
}}
'''Thioredoxin reductase 1''', also known as '''TXNRD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.<ref>{{cite web | title = Entrez Gene: TXNRD1 thioredoxin reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7296| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
