Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:12, 9 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (7)[edit]
Created (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Protein Status Grid - Date: 23:12, 9 November 2007 (UTC)[edit]
Vebose Log - Date: 23:12, 9 November 2007 (UTC)[edit]
- INFO: Beginning work on AIFM1... {November 9, 2007 2:50:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AIFM1 image.jpg {November 9, 2007 2:50:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:50:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AIFM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gv4.
| PDB = {{PDB2|1gv4}}, {{PDB2|1m6i}}
| Name = Apoptosis-inducing factor, mitochondrion-associated, 1
| HGNCid = 8768
| Symbol = AIFM1
| AltSymbols =; AIF; MGC111425; PDCD8
| OMIM = 300169
| ECnumber =
| Homologene = 3100
| MGIid = 1349419
| GeneAtlas_image1 = PBB_GE_AIFM1_205512_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005792 |text = microsome}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0008630 |text = DNA damage response, signal transduction resulting in induction of apoptosis}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9131
| Hs_Ensembl = ENSG00000156709
| Hs_RefseqProtein = NP_004199
| Hs_RefseqmRNA = NM_004208
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 129091018
| Hs_GenLoc_end = 129127489
| Hs_Uniprot = O95831
| Mm_EntrezGene = 26926
| Mm_Ensembl = ENSMUSG00000036932
| Mm_RefseqmRNA = NM_012019
| Mm_RefseqProtein = NP_036149
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 44719571
| Mm_GenLoc_end = 44758053
| Mm_Uniprot = Q1L6K5
}}
}}
'''Apoptosis-inducing factor, mitochondrion-associated, 1''', also known as '''AIFM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9131| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Daugas E, Nochy D, Ravagnan L, ''et al.'' |title=Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. |journal=FEBS Lett. |volume=476 |issue= 3 |pages= 118-23 |year= 2000 |pmid= 10913597 |doi= }}
*{{cite journal | author=Ferri KF, Jacotot E, Blanco J, ''et al.'' |title=Mitochondrial control of cell death induced by HIV-1-encoded proteins. |journal=Ann. N. Y. Acad. Sci. |volume=926 |issue= |pages= 149-64 |year= 2001 |pmid= 11193032 |doi= }}
*{{cite journal | author=Candé C, Cohen I, Daugas E, ''et al.'' |title=Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. |journal=Biochimie |volume=84 |issue= 2-3 |pages= 215-22 |year= 2002 |pmid= 12022952 |doi= }}
*{{cite journal | author=Castedo M, Perfettini JL, Andreau K, ''et al.'' |title=Mitochondrial apoptosis induced by the HIV-1 envelope. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 19-28 |year= 2004 |pmid= 15033690 |doi= }}
*{{cite journal | author=Moon HS, Yang JS |title=Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells. |journal=Mol. Cells |volume=21 |issue= 1 |pages= 7-20 |year= 2006 |pmid= 16511342 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BACE2... {November 9, 2007 3:02:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BACE2 image.jpg {November 9, 2007 3:03:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:04:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BACE2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ewy.
| PDB = {{PDB2|2ewy}}
| Name = Beta-site APP-cleaving enzyme 2
| HGNCid = 934
| Symbol = BACE2
| AltSymbols =; AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
| OMIM = 605668
| ECnumber =
| Homologene = 22696
| MGIid = 1860440
| GeneAtlas_image1 = PBB_GE_BACE2_217867_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004194 |text = pepsin A activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0009049 |text = aspartic-type signal peptidase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006509 |text = membrane protein ectodomain proteolysis}} {{GNF_GO|id=GO:0009306 |text = protein secretion}} {{GNF_GO|id=GO:0016486 |text = peptide hormone processing}} {{GNF_GO|id=GO:0042985 |text = negative regulation of amyloid precursor protein biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 25825
| Hs_Ensembl = ENSG00000182240
| Hs_RefseqProtein = NP_036237
| Hs_RefseqmRNA = NM_012105
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 41462061
| Hs_GenLoc_end = 41569619
| Hs_Uniprot = Q9Y5Z0
| Mm_EntrezGene = 56175
| Mm_Ensembl = ENSMUSG00000040605
| Mm_RefseqmRNA = NM_019517
| Mm_RefseqProtein = NP_062390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 97461672
| Mm_GenLoc_end = 97543922
| Mm_Uniprot =
}}
}}
'''Beta-site APP-cleaving enzyme 2''', also known as '''BACE2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: BACE2 beta-site APP-cleaving enzyme 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25825| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C2... {November 9, 2007 2:27:35 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein C2 image.jpg {November 9, 2007 2:28:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:28:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i6q.
| PDB = {{PDB2|2i6q}}, {{PDB2|2i6s}}, {{PDB2|2odp}}, {{PDB2|2odq}}
| Name = Complement component 2
| HGNCid = 1248
| Symbol = C2
| AltSymbols =; CO2; DKFZp779M0311
| OMIM = 217000
| ECnumber =
| Homologene = 45
| MGIid = 88226
| GeneAtlas_image1 = PBB_GE_C2_203052_at_tn.png
| Function = {{GNF_GO|id=GO:0003813 |text = classical-complement-pathway C3/C5 convertase activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005603 |text = complement component C2 complex}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 717
| Hs_Ensembl = ENSG00000166278
| Hs_RefseqProtein = NP_000054
| Hs_RefseqmRNA = NM_000063
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 32030300
| Hs_GenLoc_end = 32048254
| Hs_Uniprot = P06681
| Mm_EntrezGene = 12263
| Mm_Ensembl = ENSMUSG00000024372
| Mm_RefseqmRNA = NM_013484
| Mm_RefseqProtein = NP_038512
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34470664
| Mm_GenLoc_end = 34490119
| Mm_Uniprot = O70350
}}
}}
'''Complement component 2''', also known as '''C2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Component C2 is part of the classical pathway of complement system. Activated C1 cleaves C2 into C2a and C2b. C2a leads to activation of C3. Deficiency of C2 has been reported to associated with certain autoimmune diseases.<ref>{{cite web | title = Entrez Gene: C2 complement component 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=717| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bartholomew WR, Shanahan TC |title=Complement components and receptors: deficiencies and disease associations. |journal=Immunol. Ser. |volume=52 |issue= |pages= 33-51 |year= 1991 |pmid= 2091785 |doi= }}
*{{cite journal | author=Campbell RD |title=The molecular genetics and polymorphism of C2 and factor B. |journal=Br. Med. Bull. |volume=43 |issue= 1 |pages= 37-49 |year= 1988 |pmid= 3315100 |doi= }}
*{{cite journal | author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213-30 |year= 1999 |pmid= 10072631 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD19... {November 9, 2007 2:28:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:29:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD19 molecule
| HGNCid = 1633
| Symbol = CD19
| AltSymbols =; B4; MGC12802
| OMIM = 107265
| ECnumber =
| Homologene = 1341
| MGIid = 88319
| GeneAtlas_image1 = PBB_GE_CD19_206398_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 930
| Hs_Ensembl = ENSG00000177455
| Hs_RefseqProtein = NP_001761
| Hs_RefseqmRNA = NM_001770
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 28850779
| Hs_GenLoc_end = 28858164
| Hs_Uniprot = P15391
| Mm_EntrezGene = 12478
| Mm_Ensembl = ENSMUSG00000030724
| Mm_RefseqmRNA = NM_009844
| Mm_RefseqProtein = NP_033974
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 126199599
| Mm_GenLoc_end = 126205984
| Mm_Uniprot = Q3TA95
}}
}}
'''CD19 molecule''', also known as '''CD19''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.<ref>{{cite web | title = Entrez Gene: CD19 CD19 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=930| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ishikawa H, Tsuyama N, Mahmoud MS, ''et al.'' |title=CD19 expression and growth inhibition of tumours in human multiple myeloma. |journal=Leuk. Lymphoma |volume=43 |issue= 3 |pages= 613-6 |year= 2003 |pmid= 12002767 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHAT... {November 9, 2007 2:29:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CHAT image.jpg {November 9, 2007 2:29:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:30:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CHAT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fy2.
| PDB = {{PDB2|2fy2}}, {{PDB2|2fy3}}, {{PDB2|2fy4}}, {{PDB2|2fy5}}
| Name = Choline acetyltransferase
| HGNCid = 1912
| Symbol = CHAT
| AltSymbols =; CMS1A; CMS1A2
| OMIM = 118490
| ECnumber =
| Homologene = 40693
| MGIid = 88392
| GeneAtlas_image1 = PBB_GE_CHAT_221197_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004102 |text = choline O-acetyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007274 |text = neuromuscular synaptic transmission}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007529 |text = establishment of synaptic specificity at neuromuscular junction}} {{GNF_GO|id=GO:0007622 |text = rhythmic behavior}} {{GNF_GO|id=GO:0007628 |text = adult walking behavior}} {{GNF_GO|id=GO:0016358 |text = dendrite development}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0042136 |text = neurotransmitter biosynthetic process}} {{GNF_GO|id=GO:0043179 |text = rhythmic excitation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1103
| Hs_Ensembl = ENSG00000070748
| Hs_RefseqProtein = NP_065574
| Hs_RefseqmRNA = NM_020549
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 50487147
| Hs_GenLoc_end = 50543156
| Hs_Uniprot = P28329
| Mm_EntrezGene = 12647
| Mm_Ensembl = ENSMUSG00000021919
| Mm_RefseqmRNA = NM_009891
| Mm_RefseqProtein = NP_034021
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 31237212
| Mm_GenLoc_end = 31294918
| Mm_Uniprot = Q8BQN4
}}
}}
'''Choline acetyltransferase''', also known as '''CHAT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.<ref>{{cite web | title = Entrez Gene: CHAT choline acetyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1103| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oda Y |title=Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. |journal=Pathol. Int. |volume=49 |issue= 11 |pages= 921-37 |year= 2000 |pmid= 10594838 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DFFA... {November 9, 2007 2:30:01 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DFFA image.jpg {November 9, 2007 2:30:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:30:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DFFA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iyr.
| PDB = {{PDB2|1iyr}}, {{PDB2|1koy}}
| Name = DNA fragmentation factor, 45kDa, alpha polypeptide
| HGNCid = 2772
| Symbol = DFFA
| AltSymbols =; DFF-45; DFF1; ICAD
| OMIM = 601882
| ECnumber =
| Homologene = 3240
| MGIid = 1196227
| GeneAtlas_image1 = PBB_GE_DFFA_203277_at_tn.png
| Function = {{GNF_GO|id=GO:0004537 |text = caspase-activated deoxyribonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1676
| Hs_Ensembl = ENSG00000160049
| Hs_RefseqProtein = NP_004392
| Hs_RefseqmRNA = NM_004401
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 10439166
| Hs_GenLoc_end = 10455200
| Hs_Uniprot = O00273
| Mm_EntrezGene = 13347
| Mm_Ensembl = ENSMUSG00000028974
| Mm_RefseqmRNA = NM_001025296
| Mm_RefseqProtein = NP_001020467
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 147947946
| Mm_GenLoc_end = 147964450
| Mm_Uniprot = Q8BQC7
}}
}}
'''DNA fragmentation factor, 45kDa, alpha polypeptide''', also known as '''DFFA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: DFFA DNA fragmentation factor, 45kDa, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1676| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakanuma Y, Tsuneyama K, Sasaki M, Harada K |title=Destruction of bile ducts in primary biliary cirrhosis. |journal=Baillière's best practice & research. Clinical gastroenterology |volume=14 |issue= 4 |pages= 549-70 |year= 2000 |pmid= 10976014 |doi= 10.1053/bega.2000.0103 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ECE1... {November 9, 2007 2:30:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:31:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_protein_box = yes
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin converting enzyme 1
| HGNCid = 3146
| Symbol = ECE1
| AltSymbols =; ECE
| OMIM = 600423
| ECnumber =
| Homologene = 1068
| MGIid = 1101357
| GeneAtlas_image1 = PBB_GE_ECE1_201750_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ECE1_201749_at_tn.png
| Function = {{GNF_GO|id=GO:0004245 |text = neprilysin activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016512 |text = endothelin-converting enzyme 1 activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1889
| Hs_Ensembl = ENSG00000117298
| Hs_RefseqProtein = NP_001388
| Hs_RefseqmRNA = NM_001397
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 21417664
| Hs_GenLoc_end = 21544584
| Hs_Uniprot = P42892
| Mm_EntrezGene = 230857
| Mm_Ensembl = ENSMUSG00000057530
| Mm_RefseqmRNA = XM_989734
| Mm_RefseqProtein = XP_994828
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 137134373
| Mm_GenLoc_end = 137237305
| Mm_Uniprot = Q3TUZ3
}}
}}
'''Endothelin converting enzyme 1''', also known as '''ECE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: ECE1 endothelin converting enzyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1889| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EEF1D... {November 9, 2007 2:31:50 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:32:47 PM PST}
- CREATED: Created new protein page: EEF1D {November 9, 2007 2:32:54 PM PST}
- INFO: Beginning work on GABRA1... {November 9, 2007 2:32:54 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:33:28 PM PST}
- CREATED: Created new protein page: GABRA1 {November 9, 2007 2:33:37 PM PST}
- INFO: Beginning work on GAD1... {November 9, 2007 2:33:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GAD1 image.jpg {November 9, 2007 2:34:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:35:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GAD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2okj.
| PDB = {{PDB2|2okj}}
| Name = Glutamate decarboxylase 1 (brain, 67kDa)
| HGNCid = 4092
| Symbol = GAD1
| AltSymbols =; FLJ45882; GAD; SCP
| OMIM = 605363
| ECnumber =
| Homologene = 635
| MGIid = 95632
| GeneAtlas_image1 = PBB_GE_GAD1_205278_at_tn.png
| GeneAtlas_image2 = PBB_GE_GAD1_206670_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GAD1_206669_at_tn.png
| Function = {{GNF_GO|id=GO:0004351 |text = glutamate decarboxylase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0012506 |text = vesicle membrane}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006540 |text = glutamate decarboxylation to succinate}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0018352 |text = protein-pyridoxal-5-phosphate linkage}} {{GNF_GO|id=GO:0019752 |text = carboxylic acid metabolic process}} {{GNF_GO|id=GO:0042136 |text = neurotransmitter biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2571
| Hs_Ensembl = ENSG00000128683
| Hs_RefseqProtein = NP_000808
| Hs_RefseqmRNA = NM_000817
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 171381318
| Hs_GenLoc_end = 171425907
| Hs_Uniprot = Q99259
| Mm_EntrezGene = 14415
| Mm_Ensembl = ENSMUSG00000070880
| Mm_RefseqmRNA = NM_008077
| Mm_RefseqProtein = NP_032103
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 70363052
| Mm_GenLoc_end = 70402856
| Mm_Uniprot = Q3TQ56
}}
}}
'''Glutamate decarboxylase 1 (brain, 67kDa)''', also known as '''GAD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.<ref>{{cite web | title = Entrez Gene: GAD1 glutamate decarboxylase 1 (brain, 67kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2571| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GAP43... {November 9, 2007 2:35:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:36:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth associated protein 43
| HGNCid = 4140
| Symbol = GAP43
| AltSymbols =; B-50; PP46
| OMIM = 162060
| ECnumber =
| Homologene = 1545
| MGIid = 95639
| GeneAtlas_image1 = PBB_GE_GAP43_216963_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GAP43_204471_at_tn.png
| Function = {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030424 |text = axon}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0007205 |text = protein kinase C activation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0010001 |text = glial cell differentiation}} {{GNF_GO|id=GO:0040008 |text = regulation of growth}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2596
| Hs_Ensembl = ENSG00000172020
| Hs_RefseqProtein = NP_002036
| Hs_RefseqmRNA = NM_002045
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 116824861
| Hs_GenLoc_end = 116922935
| Hs_Uniprot = P17677
| Mm_EntrezGene = 14432
| Mm_Ensembl = ENSMUSG00000047261
| Mm_RefseqmRNA = XM_994895
| Mm_RefseqProtein = XP_999989
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 42167776
| Mm_GenLoc_end = 42259983
| Mm_Uniprot = P06837
}}
}}
'''Growth associated protein 43''', also known as '''GAP43''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This encoded protein is considered a crucial component of an effective regenerative response in the nervous system.<ref>{{cite web | title = Entrez Gene: GAP43 growth associated protein 43| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2596| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLI3... {November 9, 2007 2:36:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:37:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)
| HGNCid = 4319
| Symbol = GLI3
| AltSymbols =; ACLS; GCPS; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV
| OMIM = 165240
| ECnumber =
| Homologene = 139
| MGIid = 95729
| GeneAtlas_image1 = PBB_GE_GLI3_205201_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0017053 |text = transcriptional repressor complex}}
| Process = {{GNF_GO|id=GO:0000060 |text = protein import into nucleus, translocation}} {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007224 |text = smoothened signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0048558 |text = embryonic gut morphogenesis}} {{GNF_GO|id=GO:0048663 |text = neuron fate commitment}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2737
| Hs_Ensembl = ENSG00000106571
| Hs_RefseqProtein = NP_000159
| Hs_RefseqmRNA = NM_000168
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 41970205
| Hs_GenLoc_end = 42229420
| Hs_Uniprot = P10071
| Mm_EntrezGene = 14634
| Mm_Ensembl = ENSMUSG00000021318
| Mm_RefseqmRNA = NM_008130
| Mm_RefseqProtein = NP_032156
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 15254867
| Mm_GenLoc_end = 15517860
| Mm_Uniprot = Q3TYX7
}}
}}
'''GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)''', also known as '''GLI3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.<ref>{{cite web | title = Entrez Gene: GLI3 GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2737| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLRX... {November 9, 2007 2:37:06 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GLRX image.jpg {November 9, 2007 2:42:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:42:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GLRX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b4q.
| PDB = {{PDB2|1b4q}}, {{PDB2|1jhb}}
| Name = Glutaredoxin (thioltransferase)
| HGNCid = 4330
| Symbol = GLRX
| AltSymbols =; GRX; GRX1; MGC117407
| OMIM = 600443
| ECnumber =
| Homologene = 37566
| MGIid = 2135625
| GeneAtlas_image1 = PBB_GE_GLRX_206662_at_tn.png
| GeneAtlas_image2 = PBB_GE_GLRX_209276_s_at_tn.png
| Function = {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015035 |text = protein disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0015038 |text = glutathione disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0047485 |text = protein N-terminus binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2745
| Hs_Ensembl = ENSG00000173221
| Hs_RefseqProtein = NP_002055
| Hs_RefseqmRNA = NM_002064
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 95175309
| Hs_GenLoc_end = 95184465
| Hs_Uniprot = P35754
| Mm_EntrezGene = 93692
| Mm_Ensembl = ENSMUSG00000021591
| Mm_RefseqmRNA = NM_053108
| Mm_RefseqProtein = NP_444338
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 76305916
| Mm_GenLoc_end = 76316153
| Mm_Uniprot = Q3U6L3
}}
}}
'''Glutaredoxin (thioltransferase)''', also known as '''GLRX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lou MF |title=Redox regulation in the lens. |journal=Progress in retinal and eye research |volume=22 |issue= 5 |pages= 657-82 |year= 2003 |pmid= 12892645 |doi= }}
*{{cite journal | author=Sykes MC, Mowbray AL, Jo H |title=Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death. |journal=Circ. Res. |volume=100 |issue= 2 |pages= 152-4 |year= 2007 |pmid= 17272816 |doi= 10.1161/01.RES.0000258171.08020.72 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HIST2H3C... {November 9, 2007 3:04:03 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST2H3C image.jpg {November 9, 2007 3:04:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:04:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HIST2H3C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1f66}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1u35}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2hue}}, {{PDB2|2io5}}, {{PDB2|2nzd}}
| Name = Histone cluster 2, H3c
| HGNCid = 20503
| Symbol = HIST2H3C
| AltSymbols =; H3; H3.2; H3/M; H3F2; H3FM; MGC9629; H3/n; H3/o
| OMIM = 142780
| ECnumber =
| Homologene = 79492
| MGIid = 2448355
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 126961
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001124743
| Hs_RefseqmRNA = XM_001124743
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 15077
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_886396
| Mm_RefseqProtein = XP_891489
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Histone cluster 2, H3c''', also known as '''HIST2H3C''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.<ref>{{cite web | title = Entrez Gene: HIST2H3C histone cluster 2, H3c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126961| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL24... {November 9, 2007 3:02:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:02:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin 24
| HGNCid = 11346
| Symbol = IL24
| AltSymbols =; C49A; FISP; IL-24; IL10B; MDA7; Mob-5; ST16; mda-7
| OMIM = 604136
| ECnumber =
| Homologene = 4991
| MGIid = 2135548
| GeneAtlas_image1 = PBB_GE_IL24_206569_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11009
| Hs_Ensembl = ENSG00000162892
| Hs_RefseqProtein = NP_006841
| Hs_RefseqmRNA = NM_006850
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 205137411
| Hs_GenLoc_end = 205144107
| Hs_Uniprot = Q13007
| Mm_EntrezGene = 93672
| Mm_Ensembl = ENSMUSG00000026420
| Mm_RefseqmRNA = NM_053095
| Mm_RefseqProtein = NP_444325
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 132709620
| Mm_GenLoc_end = 132714885
| Mm_Uniprot = Q925S4
}}
}}
'''Interleukin 24''', also known as '''IL24''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: IL24 interleukin 24| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11009| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sauane M, Gopalkrishnan RV, Sarkar D, ''et al.'' |title=MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. |journal=Cytokine Growth Factor Rev. |volume=14 |issue= 1 |pages= 35-51 |year= 2003 |pmid= 12485618 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LILRB1... {November 9, 2007 3:00:30 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LILRB1 image.jpg {November 9, 2007 3:01:29 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:01:54 PM PST}
- CREATED: Created new protein page: LILRB1 {November 9, 2007 3:02:01 PM PST}
- INFO: Beginning work on NPHS2... {November 9, 2007 2:47:53 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:48:26 PM PST}
- CREATED: Created new protein page: NPHS2 {November 9, 2007 2:48:33 PM PST}
- INFO: Beginning work on PIAS2... {November 9, 2007 2:48:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:50:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein inhibitor of activated STAT, 2
| HGNCid = 17311
| Symbol = PIAS2
| AltSymbols =; MGC102682; MIZ1; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4; miz
| OMIM = 603567
| ECnumber =
| Homologene = 20979
| MGIid = 1096566
| GeneAtlas_image1 = PBB_GE_PIAS2_37433_at_tn.png
| GeneAtlas_image2 = PBB_GE_PIAS2_214442_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PIAS2_214593_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019789 |text = SUMO ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0016925 |text = protein sumoylation}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9063
| Hs_Ensembl = ENSG00000078043
| Hs_RefseqProtein = XP_001129747
| Hs_RefseqmRNA = XM_001129747
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 42646058
| Hs_GenLoc_end = 42751464
| Hs_Uniprot = O75928
| Mm_EntrezGene = 17344
| Mm_Ensembl = ENSMUSG00000025423
| Mm_RefseqmRNA = XM_990156
| Mm_RefseqProtein = XP_995250
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 77301699
| Mm_GenLoc_end = 77357244
| Mm_Uniprot = Q3V3U5
}}
}}
'''Protein inhibitor of activated STAT, 2''', also known as '''PIAS2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cookson MR |title=Pathways to Parkinsonism. |journal=Neuron |volume=37 |issue= 1 |pages= 7-10 |year= 2003 |pmid= 12526767 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNAI1... {November 9, 2007 2:42:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:43:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Snail homolog 1 (Drosophila)
| HGNCid = 11128
| Symbol = SNAI1
| AltSymbols =; SLUGH2; SNA; SNAH; dJ710H13.1
| OMIM = 604238
| ECnumber =
| Homologene = 4363
| MGIid = 98330
| GeneAtlas_image1 = PBB_GE_SNAI1_219480_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6615
| Hs_Ensembl = ENSG00000124216
| Hs_RefseqProtein = NP_005976
| Hs_RefseqmRNA = NM_005985
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 48032934
| Hs_GenLoc_end = 48038825
| Hs_Uniprot = O95863
| Mm_EntrezGene = 20613
| Mm_Ensembl = ENSMUSG00000042821
| Mm_RefseqmRNA = NM_011427
| Mm_RefseqProtein = NP_035557
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 167229432
| Mm_GenLoc_end = 167234019
| Mm_Uniprot = Q4FK48
}}
}}
'''Snail homolog 1 (Drosophila)''', also known as '''SNAI1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.<ref>{{cite web | title = Entrez Gene: SNAI1 snail homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6615| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNCG... {November 9, 2007 2:43:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:43:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Synuclein, gamma (breast cancer-specific protein 1)
| HGNCid = 11141
| Symbol = SNCG
| AltSymbols =; SR; BCSG1
| OMIM = 602998
| ECnumber =
| Homologene = 2322
| MGIid = 1298397
| GeneAtlas_image1 = PBB_GE_SNCG_209877_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6623
| Hs_Ensembl = ENSG00000173267
| Hs_RefseqProtein = NP_003078
| Hs_RefseqmRNA = NM_003087
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 88708365
| Hs_GenLoc_end = 88712997
| Hs_Uniprot = O76070
| Mm_EntrezGene = 20618
| Mm_Ensembl = ENSMUSG00000023064
| Mm_RefseqmRNA = NM_011430
| Mm_RefseqProtein = NP_035560
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 33199367
| Mm_GenLoc_end = 33203752
| Mm_Uniprot = Q5GQ64
}}
}}
'''Synuclein, gamma (breast cancer-specific protein 1)''', also known as '''SNCG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.<ref>{{cite web | title = Entrez Gene: SNCG synuclein, gamma (breast cancer-specific protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6623| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=George JM |title=The synucleins. |journal=Genome Biol. |volume=3 |issue= 1 |pages= REVIEWS3002 |year= 2002 |pmid= 11806835 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SYP... {November 9, 2007 2:43:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:44:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Synaptophysin
| HGNCid = 11506
| Symbol = SYP
| AltSymbols =;
| OMIM = 313475
| ECnumber =
| Homologene = 2391
| MGIid = 98467
| GeneAtlas_image1 = PBB_GE_SYP_213200_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015485 |text = cholesterol binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0030285 |text = integral to synaptic vesicle membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0016188 |text = synaptic vesicle maturation}} {{GNF_GO|id=GO:0048499 |text = synaptic vesicle membrane organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6855
| Hs_Ensembl = ENSG00000102003
| Hs_RefseqProtein = NP_003170
| Hs_RefseqmRNA = NM_003179
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 48931201
| Hs_GenLoc_end = 48943606
| Hs_Uniprot = P08247
| Mm_EntrezGene = 20977
| Mm_Ensembl = ENSMUSG00000031144
| Mm_RefseqmRNA = NM_009305
| Mm_RefseqProtein = NP_033331
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 6795643
| Mm_GenLoc_end = 6810210
| Mm_Uniprot = Q62277
}}
}}
'''Synaptophysin''', also known as '''SYP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SYP synaptophysin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6855| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TCEB2... {November 9, 2007 2:44:23 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TCEB2 image.jpg {November 9, 2007 2:44:37 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:44:48 PM PST}
- CREATED: Created new protein page: TCEB2 {November 9, 2007 2:44:58 PM PST}
- INFO: Beginning work on TIAM1... {November 9, 2007 2:44:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TIAM1 image.jpg {November 9, 2007 2:45:50 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 2:46:00 PM PST}
- CREATED: Created new protein page: TIAM1 {November 9, 2007 2:46:08 PM PST}
- INFO: Beginning work on TJP2... {November 9, 2007 2:50:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TJP2 image.jpg {November 9, 2007 3:00:06 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:00:22 PM PST}
- CREATED: Created new protein page: TJP2 {November 9, 2007 3:00:30 PM PST}
- INFO: Beginning work on TMPO... {November 9, 2007 2:46:08 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 2:47:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 2:47:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TMPO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gjj.
| PDB = {{PDB2|1gjj}}, {{PDB2|1h9e}}, {{PDB2|1h9f}}
| Name = Thymopoietin
| HGNCid = 11875
| Symbol = TMPO
| AltSymbols =; TP; LAP2; CMD1T; MGC61508; PRO0868
| OMIM = 188380
| ECnumber =
| Homologene = 31144
| MGIid = 106920
| GeneAtlas_image1 = PBB_GE_TMPO_209753_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TMPO_209754_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TMPO_203432_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005521 |text = lamin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7112
| Hs_Ensembl = ENSG00000120802
| Hs_RefseqProtein = NP_001027454
| Hs_RefseqmRNA = NM_001032283
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 97433527
| Hs_GenLoc_end = 97468250
| Hs_Uniprot = P42167
| Mm_EntrezGene = 21917
| Mm_Ensembl = ENSMUSG00000019961
| Mm_RefseqmRNA = NM_001080129
| Mm_RefseqProtein = NP_001073598
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 90578420
| Mm_GenLoc_end = 90611277
| Mm_Uniprot = Q61033
}}
}}
'''Thymopoietin''', also known as '''TMPO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dechat T, Vlcek S, Foisner R |title=Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. |journal=J. Struct. Biol. |volume=129 |issue= 2-3 |pages= 335-45 |year= 2000 |pmid= 10806084 |doi= 10.1006/jsbi.2000.4212 }}
}}
{{refend}}
{{protein-stub}}
end log.
