Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 08:13, 9 November 2007 (UTC)[edit]
Proteins without matches (19)[edit]
Proteins with a High Potential Match (6)[edit]
Created (6)[edit]
Manual Inspection (Page not found) (19)[edit]
Protein Status Grid - Date: 08:13, 9 November 2007 (UTC)[edit]
Vebose Log - Date: 08:13, 9 November 2007 (UTC)[edit]
- INFO: Beginning work on ACVR2A... {November 8, 2007 11:43:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACVR2A image.jpg {November 8, 2007 11:43:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:44:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACVR2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bte.
| PDB = {{PDB2|1bte}}, {{PDB2|1lx5}}, {{PDB2|2goo}}
| Name = Activin A receptor, type IIA
| HGNCid = 173
| Symbol = ACVR2A
| AltSymbols =; ACTRII; ACVR2
| OMIM = 102581
| ECnumber =
| Homologene = 20391
| MGIid = 102806
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0017002 |text = activin receptor activity}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0048186 |text = inhibin beta-A binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0045648 |text = positive regulation of erythrocyte differentiation}} {{GNF_GO|id=GO:0048276 |text = gastrulation (sensu Vertebrata)}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 92
| Hs_Ensembl = ENSG00000121989
| Hs_RefseqProtein = NP_001607
| Hs_RefseqmRNA = NM_001616
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 148319067
| Hs_GenLoc_end = 148404863
| Hs_Uniprot = P27037
| Mm_EntrezGene = 11480
| Mm_Ensembl = ENSMUSG00000052155
| Mm_RefseqmRNA = NM_007396
| Mm_RefseqProtein = NP_031422
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 48636166
| Mm_GenLoc_end = 48724172
| Mm_Uniprot = Q8BRV4
}}
}}
'''Activin A receptor, type IIA''', also known as '''ACVR2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.<ref>{{cite web | title = Entrez Gene: ACVR2A activin A receptor, type IIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317-23 |year= 2002 |pmid= 12032389 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BEST1... {November 8, 2007 11:58:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:59:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bestrophin 1
| HGNCid = 12703
| Symbol = BEST1
| AltSymbols =; BMD; BEST; TU15B; VMD2
| OMIM = 607854
| ECnumber =
| Homologene = 37895
| MGIid = 1346332
| GeneAtlas_image1 = PBB_GE_BEST1_207671_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005254 |text = chloride channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7439
| Hs_Ensembl = ENSG00000167995
| Hs_RefseqProtein = NP_004174
| Hs_RefseqmRNA = NM_004183
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 61474408
| Hs_GenLoc_end = 61488509
| Hs_Uniprot = O76090
| Mm_EntrezGene = 24115
| Mm_Ensembl = ENSMUSG00000037418
| Mm_RefseqmRNA = XM_980943
| Mm_RefseqProtein = XP_986037
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 10052219
| Mm_GenLoc_end = 10064259
| Mm_Uniprot = O88870
}}
}}
'''Bestrophin 1''', also known as '''BEST1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=White K, Marquardt A, Weber BH |title=VMD2 mutations in vitelliform macular dystrophy (Best disease) and other maculopathies. |journal=Hum. Mutat. |volume=15 |issue= 4 |pages= 301-8 |year= 2000 |pmid= 10737974 |doi= 10.1002/(SICI)1098-1004(200004)15:4<301::AID-HUMU1>3.0.CO;2-N }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD3D... {November 8, 2007 11:44:05 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD3D image.jpg {November 8, 2007 11:44:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:44:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD3D_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xiw.
| PDB = {{PDB2|1xiw}}
| Name = CD3d molecule, delta (CD3-TCR complex)
| HGNCid = 1673
| Symbol = CD3D
| AltSymbols =; CD3-DELTA; T3D
| OMIM = 186790
| ECnumber =
| Homologene = 585
| MGIid = 88331
| GeneAtlas_image1 = PBB_GE_CD3D_213539_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042105 |text = alpha-beta T cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0045059 |text = positive thymic T cell selection}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 915
| Hs_Ensembl = ENSG00000167286
| Hs_RefseqProtein = NP_000723
| Hs_RefseqmRNA = NM_000732
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 117715001
| Hs_GenLoc_end = 117718669
| Hs_Uniprot = P04234
| Mm_EntrezGene = 12500
| Mm_Ensembl = ENSMUSG00000032094
| Mm_RefseqmRNA = NM_013487
| Mm_RefseqProtein = NP_038515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 44732876
| Mm_GenLoc_end = 44737418
| Mm_Uniprot = A0N8K9
}}
}}
'''CD3d molecule, delta (CD3-TCR complex)''', also known as '''CD3D''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Balk SP, Polischuk JE, Probert C, ''et al.'' |title=Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. |journal=Int. Immunol. |volume=7 |issue= 8 |pages= 1237-41 |year= 1996 |pmid= 7495730 |doi= }}
*{{cite journal | author=Li CJ |title=Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference. |journal=J. Cell. Physiol. |volume=209 |issue= 3 |pages= 695-700 |year= 2007 |pmid= 17001685 |doi= 10.1002/jcp.20817 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COMP... {November 8, 2007 11:45:56 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein COMP image.jpg {November 8, 2007 11:46:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:46:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COMP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fbm.
| PDB = {{PDB2|1fbm}}, {{PDB2|1mz9}}, {{PDB2|1vdf}}
| Name = Cartilage oligomeric matrix protein
| HGNCid = 2227
| Symbol = COMP
| AltSymbols =; MED; EDM1; EPD1; MGC131819; MGC149768; PSACH; THBS5
| OMIM = 600310
| ECnumber =
| Homologene = 74
| MGIid = 88469
| GeneAtlas_image1 = PBB_GE_COMP_205713_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1311
| Hs_Ensembl = ENSG00000105664
| Hs_RefseqProtein = NP_000086
| Hs_RefseqmRNA = NM_000095
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 18754584
| Hs_GenLoc_end = 18763114
| Hs_Uniprot = P49747
| Mm_EntrezGene = 12845
| Mm_Ensembl = ENSMUSG00000031849
| Mm_RefseqmRNA = NM_016685
| Mm_RefseqProtein = NP_057894
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 73302547
| Mm_GenLoc_end = 73311055
| Mm_Uniprot = A1A557
}}
}}
'''Cartilage oligomeric matrix protein''', also known as '''COMP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).<ref>{{cite web | title = Entrez Gene: COMP cartilage oligomeric matrix protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1311| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Unger S, Hecht JT |title=Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments. |journal=Am. J. Med. Genet. |volume=106 |issue= 4 |pages= 244-50 |year= 2002 |pmid= 11891674 |doi= }}
*{{cite journal | author=Liu C |title=Transcriptional mechanism of COMP gene expression and chondrogenesis. |journal=Journal of musculoskeletal & neuronal interactions |volume=5 |issue= 4 |pages= 340-1 |year= 2006 |pmid= 16340129 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSTA... {November 8, 2007 11:46:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CSTA image.jpg {November 8, 2007 11:47:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:47:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSTA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cyu.
| PDB = {{PDB2|1cyu}}, {{PDB2|1cyv}}, {{PDB2|1dvc}}, {{PDB2|1dvd}}, {{PDB2|1gd3}}, {{PDB2|1gd4}}, {{PDB2|1n9j}}, {{PDB2|1nb3}}, {{PDB2|1nb5}}
| Name = Cystatin A (stefin A)
| HGNCid = 2481
| Symbol = CSTA
| AltSymbols =; STF1; STFA
| OMIM = 184600
| ECnumber =
| Homologene = 3819
| MGIid = 3524930
| GeneAtlas_image1 = PBB_GE_CSTA_204971_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0001533 |text = cornified envelope}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0018149 |text = peptide cross-linking}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1475
| Hs_Ensembl = ENSG00000121552
| Hs_RefseqProtein = NP_005204
| Hs_RefseqmRNA = NM_005213
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 123526701
| Hs_GenLoc_end = 123543501
| Hs_Uniprot = P01040
| Mm_EntrezGene = 209294
| Mm_Ensembl = ENSMUSG00000034362
| Mm_RefseqmRNA = NM_001033239
| Mm_RefseqProtein = NP_001028411
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 36039245
| Mm_GenLoc_end = 36050490
| Mm_Uniprot = P56567
}}
}}
'''Cystatin A (stefin A)''', also known as '''CSTA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.<ref>{{cite web | title = Entrez Gene: CSTA cystatin A (stefin A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1475| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Järvinen M, Rinne A, Hopsu-Havu VK |title=Human cystatins in normal and diseased tissues--a review. |journal=Acta Histochem. |volume=82 |issue= 1 |pages= 5-18 |year= 1988 |pmid= 3122506 |doi= }}
*{{cite journal | author=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5-12 |year= 1997 |pmid= 9007972 |doi= }}
*{{cite journal | author=Kos J, Lah TT |title=Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). |journal=Oncol. Rep. |volume=5 |issue= 6 |pages= 1349-61 |year= 1998 |pmid= 9769367 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTSC... {November 8, 2007 11:44:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CTSC image.jpg {November 8, 2007 11:45:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:45:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTSC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k3b.
| PDB = {{PDB2|1k3b}}, {{PDB2|2djf}}, {{PDB2|2djg}}
| Name = Cathepsin C
| HGNCid = 2528
| Symbol = CTSC
| AltSymbols =; CPPI; DPP1; DPPI; HMS; JP; JPD; PALS; PLS
| OMIM = 602365
| ECnumber =
| Homologene = 1373
| MGIid = 109553
| GeneAtlas_image1 = PBB_GE_CTSC_201487_at_tn.png
| Function = {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004214 |text = dipeptidyl-peptidase I activity}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1075
| Hs_Ensembl = ENSG00000109861
| Hs_RefseqProtein = NP_001805
| Hs_RefseqmRNA = NM_001814
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 87666421
| Hs_GenLoc_end = 87710586
| Hs_Uniprot = P53634
| Mm_EntrezGene = 13032
| Mm_Ensembl = ENSMUSG00000030560
| Mm_RefseqmRNA = NM_009982
| Mm_RefseqProtein = NP_034112
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 88153327
| Mm_GenLoc_end = 88186080
| Mm_Uniprot = Q3TIF1
}}
}}
'''Cathepsin C''', also known as '''CTSC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CTSC cathepsin C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1075| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DAPK1... {November 8, 2007 11:47:35 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DAPK1 image.jpg {November 8, 2007 11:48:29 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:48:41 PM PST}
- CREATED: Created new protein page: DAPK1 {November 8, 2007 11:48:48 PM PST}
- INFO: Beginning work on EDG1... {November 8, 2007 11:48:48 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 11:49:30 PM PST}
- CREATED: Created new protein page: EDG1 {November 8, 2007 11:49:40 PM PST}
- INFO: Beginning work on ERCC5... {November 8, 2007 11:49:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:50:20 PM PST}
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
| HGNCid = 3437
| Symbol = ERCC5
| AltSymbols =; ERCM2; UVDR; XPG; XPGC
| OMIM = 133530
| ECnumber =
| Homologene = 37265
| MGIid = 103582
| GeneAtlas_image1 = PBB_GE_ERCC5_202414_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0004518 |text = nuclease activity}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004520 |text = endodeoxyribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006283 |text = transcription-coupled nucleotide-excision repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2073
| Hs_Ensembl = ENSG00000134899
| Hs_RefseqProtein = NP_000114
| Hs_RefseqmRNA = NM_000123
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 102295195
| Hs_GenLoc_end = 102326346
| Hs_Uniprot = P28715
| Mm_EntrezGene = 22592
| Mm_Ensembl = ENSMUSG00000026048
| Mm_RefseqmRNA = NM_011729
| Mm_RefseqProtein = NP_035859
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 44092393
| Mm_GenLoc_end = 44125806
| Mm_Uniprot = Q3TPQ3
}}
}}
'''Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))''', also known as '''ERCC5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined.<ref>{{cite web | title = Entrez Gene: ERCC5 excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2073| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miura M |title=Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair. |journal=J. Radiat. Res. |volume=40 |issue= 1 |pages= 1-12 |year= 1999 |pmid= 10408173 |doi= }}
*{{cite journal | author=Cleaver JE, Thompson LH, Richardson AS, States JC |title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. |journal=Hum. Mutat. |volume=14 |issue= 1 |pages= 9-22 |year= 1999 |pmid= 10447254 |doi= 10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAP3K14... {November 9, 2007 12:01:26 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:02:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 14
| HGNCid = 6853
| Symbol = MAP3K14
| AltSymbols =; FTDCR1B; HS; HSNIK; NIK
| OMIM = 604655
| ECnumber =
| Homologene = 2940
| MGIid = 1858204
| GeneAtlas_image1 = PBB_GE_MAP3K14_205192_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9020
| Hs_Ensembl = ENSG00000006062
| Hs_RefseqProtein = NP_003945
| Hs_RefseqmRNA = NM_003954
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 40696278
| Hs_GenLoc_end = 40750148
| Hs_Uniprot = Q99558
| Mm_EntrezGene = 53859
| Mm_Ensembl = ENSMUSG00000020941
| Mm_RefseqmRNA = NM_016896
| Mm_RefseqProtein = NP_058592
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 103035854
| Mm_GenLoc_end = 103083835
| Mm_Uniprot = Q544K4
}}
}}
'''Mitogen-activated protein kinase kinase kinase 14''', also known as '''MAP3K14''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.<ref>{{cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PINK1... {November 9, 2007 12:04:33 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:05:26 AM PST}
- CREATED: Created new protein page: PINK1 {November 9, 2007 12:05:33 AM PST}
- INFO: Beginning work on PSMC4... {November 8, 2007 11:50:20 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMC4 image.jpg {November 8, 2007 11:50:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:50:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMC4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dvw.
| PDB = {{PDB2|2dvw}}
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 4
| HGNCid = 9551
| Symbol = PSMC4
| AltSymbols =; MGC13687; MGC23214; MGC8570; MIP224; S6; TBP7
| OMIM = 602707
| ECnumber =
| Homologene = 4744
| MGIid = 1346093
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5704
| Hs_Ensembl =
| Hs_RefseqProtein = NP_006494
| Hs_RefseqmRNA = NM_006503
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 23996
| Mm_Ensembl = ENSMUSG00000030603
| Mm_RefseqmRNA = NM_011874
| Mm_RefseqProtein = NP_036004
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 27750473
| Mm_GenLoc_end = 27758829
| Mm_Uniprot = Q3TFA5
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 4''', also known as '''PSMC4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5704| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMD7... {November 8, 2007 11:50:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:51:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)
| HGNCid = 9565
| Symbol = PSMD7
| AltSymbols =; S12; P40; MOV34
| OMIM = 157970
| ECnumber =
| Homologene = 2104
| MGIid = 1351511
| GeneAtlas_image1 = PBB_GE_PSMD7_201705_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMD7_gnf1h06716_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005838 |text = proteasome regulatory particle (sensu Eukaryota)}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5713
| Hs_Ensembl = ENSG00000103035
| Hs_RefseqProtein = NP_002802
| Hs_RefseqmRNA = NM_002811
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 72888182
| Hs_GenLoc_end = 72897685
| Hs_Uniprot = P51665
| Mm_EntrezGene = 17463
| Mm_Ensembl = ENSMUSG00000039067
| Mm_RefseqmRNA = NM_010817
| Mm_RefseqProtein = NP_034947
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 110469510
| Mm_GenLoc_end = 110477611
| Mm_Uniprot = P26516
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)''', also known as '''PSMD7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.<ref>{{cite web | title = Entrez Gene: PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5713| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGIR... {November 8, 2007 11:51:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:52:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin I2 (prostacyclin) receptor (IP)
| HGNCid = 9602
| Symbol = PTGIR
| AltSymbols =; IP; MGC102830; PRIPR
| OMIM = 600022
| ECnumber =
| Homologene = 7496
| MGIid = 99535
| GeneAtlas_image1 = PBB_GE_PTGIR_206187_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5739
| Hs_Ensembl = ENSG00000160013
| Hs_RefseqProtein = NP_000951
| Hs_RefseqmRNA = NM_000960
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 51815566
| Hs_GenLoc_end = 51820194
| Hs_Uniprot = P43119
| Mm_EntrezGene = 19222
| Mm_Ensembl = ENSMUSG00000043017
| Mm_RefseqmRNA = NM_008967
| Mm_RefseqProtein = NP_032993
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 16065012
| Mm_GenLoc_end = 16069427
| Mm_Uniprot = Q3U4F1
}}
}}
'''Prostaglandin I2 (prostacyclin) receptor (IP)''', also known as '''PTGIR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.<ref>{{cite web | title = Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5739| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coleman RA, Smith WL, Narumiya S |title=International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. |journal=Pharmacol. Rev. |volume=46 |issue= 2 |pages= 205-29 |year= 1994 |pmid= 7938166 |doi= }}
*{{cite journal | author=Rauvala H, Peng HB |title=HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts. |journal=Prog. Neurobiol. |volume=52 |issue= 2 |pages= 127-44 |year= 1997 |pmid= 9185236 |doi= }}
*{{cite journal | author=Smyth EM, FitzGerald GA |title=Human prostacyclin receptor. |journal=Vitam. Horm. |volume=65 |issue= |pages= 149-65 |year= 2003 |pmid= 12481546 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAB27A... {November 8, 2007 11:52:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:54:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAB27A, member RAS oncogene family
| HGNCid = 9766
| Symbol = RAB27A
| AltSymbols =; GS2; HsT18676; MGC117246; RAB27; RAM
| OMIM = 603868
| ECnumber =
| Homologene = 3069
| MGIid = 1861441
| GeneAtlas_image1 = PBB_GE_RAB27A_209514_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB27A_209515_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAB27A_210951_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0030425 |text = dendrite}} {{GNF_GO|id=GO:0042470 |text = melanosome}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0051875 |text = pigment granule localization}} {{GNF_GO|id=GO:0051904 |text = pigment granule transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5873
| Hs_Ensembl = ENSG00000069974
| Hs_RefseqProtein = NP_004571
| Hs_RefseqmRNA = NM_004580
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 53283094
| Hs_GenLoc_end = 53369293
| Hs_Uniprot = P51159
| Mm_EntrezGene = 11891
| Mm_Ensembl = ENSMUSG00000032202
| Mm_RefseqmRNA = XM_988908
| Mm_RefseqProtein = XP_994002
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 72841997
| Mm_GenLoc_end = 72894724
| Mm_Uniprot = Q544U7
}}
}}
'''RAB27A, member RAS oncogene family''', also known as '''RAB27A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.<ref>{{cite web | title = Entrez Gene: RAB27A RAB27A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5873| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RALA... {November 8, 2007 11:54:12 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RALA image.jpg {November 8, 2007 11:54:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:55:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RALA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u8y.
| PDB = {{PDB2|1u8y}}, {{PDB2|1u8z}}, {{PDB2|1u90}}, {{PDB2|1uad}}, {{PDB2|1zc3}}, {{PDB2|1zc4}}, {{PDB2|2a78}}, {{PDB2|2a9k}}, {{PDB2|2bov}}
| Name = V-ral simian leukemia viral oncogene homolog A (ras related)
| HGNCid = 9839
| Symbol = RALA
| AltSymbols =; MGC48949; RAL
| OMIM = 179550
| ECnumber =
| Homologene = 3942
| MGIid = 1927243
| GeneAtlas_image1 = PBB_GE_RALA_214435_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5898
| Hs_Ensembl = ENSG00000006451
| Hs_RefseqProtein = NP_005393
| Hs_RefseqmRNA = NM_005402
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 39629687
| Hs_GenLoc_end = 39714240
| Hs_Uniprot = P11233
| Mm_EntrezGene = 56044
| Mm_Ensembl = ENSMUSG00000008859
| Mm_RefseqmRNA = XM_985790
| Mm_RefseqProtein = XP_990884
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 17665717
| Mm_GenLoc_end = 17729359
| Mm_Uniprot = Q9CXY0
}}
}}
'''V-ral simian leukemia viral oncogene homolog A (ras related)''', also known as '''RALA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.<ref>{{cite web | title = Entrez Gene: RALA v-ral simian leukemia viral oncogene homolog A (ras related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5898| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RBP4... {November 8, 2007 11:55:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RBP4 image.jpg {November 8, 2007 11:55:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:55:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RBP4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aqb.
| PDB = {{PDB2|1aqb}}, {{PDB2|1brp}}, {{PDB2|1brq}}, {{PDB2|1erb}}, {{PDB2|1fel}}, {{PDB2|1fem}}, {{PDB2|1fen}}, {{PDB2|1hbp}}, {{PDB2|1hbq}}, {{PDB2|1jyd}}, {{PDB2|1jyj}}, {{PDB2|1kt3}}, {{PDB2|1kt4}}, {{PDB2|1kt5}}, {{PDB2|1kt6}}, {{PDB2|1kt7}}, {{PDB2|1qab}}, {{PDB2|1rbp}}, {{PDB2|1rlb}}
| Name = Retinol binding protein 4, plasma
| HGNCid = 9922
| Symbol = RBP4
| AltSymbols =;
| OMIM = 180250
| ECnumber =
| Homologene = 4908
| MGIid = 97879
| GeneAtlas_image1 = PBB_GE_RBP4_219140_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0016918 |text = retinal binding}} {{GNF_GO|id=GO:0019841 |text = retinol binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5950
| Hs_Ensembl = ENSG00000138207
| Hs_RefseqProtein = NP_006735
| Hs_RefseqmRNA = NM_006744
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 95341434
| Hs_GenLoc_end = 95351491
| Hs_Uniprot = P02753
| Mm_EntrezGene = 19662
| Mm_Ensembl = ENSMUSG00000024990
| Mm_RefseqmRNA = XM_993476
| Mm_RefseqProtein = XP_998570
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 38181773
| Mm_GenLoc_end = 38190392
| Mm_Uniprot = Q3TF08
}}
}}
'''Retinol binding protein 4, plasma''', also known as '''RBP4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.<ref>{{cite web | title = Entrez Gene: RBP4 retinol binding protein 4, plasma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5950| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Newcomer ME, Ong DE |title=Plasma retinol binding protein: structure and function of the prototypic lipocalin. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 57-64 |year= 2000 |pmid= 11058747 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100A10... {November 8, 2007 11:55:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein S100A10 image.jpg {November 8, 2007 11:57:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:57:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4p.
| PDB = {{PDB2|1a4p}}, {{PDB2|1bt6}}
| Name = S100 calcium binding protein A10
| HGNCid = 10487
| Symbol = S100A10
| AltSymbols =; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; MGC111133; P11; p10
| OMIM = 114085
| ECnumber =
| Homologene = 2228
| MGIid = 1339468
| GeneAtlas_image1 = PBB_GE_S100A10_200872_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6281
| Hs_Ensembl = ENSG00000197747
| Hs_RefseqProtein = NP_002957
| Hs_RefseqmRNA = NM_002966
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 150222015
| Hs_GenLoc_end = 150233490
| Hs_Uniprot = P60903
| Mm_EntrezGene = 20194
| Mm_Ensembl = ENSMUSG00000041959
| Mm_RefseqmRNA = NM_009112
| Mm_RefseqProtein = NP_033138
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 93640568
| Mm_GenLoc_end = 93650047
| Mm_Uniprot = Q3TC45
}}
}}
'''S100 calcium binding protein A10''', also known as '''S100A10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis.<ref>{{cite web | title = Entrez Gene: S100A10 S100 calcium binding protein A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6281| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Kwon M, MacLeod TJ, Zhang Y, Waisman DM |title=S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. |journal=Front. Biosci. |volume=10 |issue= |pages= 300-25 |year= 2006 |pmid= 15574370 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SCNN1A... {November 8, 2007 11:57:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 11:58:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sodium channel, nonvoltage-gated 1 alpha
| HGNCid = 10599
| Symbol = SCNN1A
| AltSymbols =; ENaCa; ENaCalpha; FLJ21883; SCNEA; SCNN1
| OMIM = 600228
| ECnumber =
| Homologene = 811
| MGIid = 101782
| GeneAtlas_image1 = PBB_GE_SCNN1A_203453_at_tn.png
| GeneAtlas_image2 = PBB_GE_SCNN1A_215026_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015280 |text = amiloride-sensitive sodium channel activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6337
| Hs_Ensembl = ENSG00000111319
| Hs_RefseqProtein = NP_001029
| Hs_RefseqmRNA = NM_001038
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 6326276
| Hs_GenLoc_end = 6354976
| Hs_Uniprot = P37088
| Mm_EntrezGene = 20276
| Mm_Ensembl = ENSMUSG00000030340
| Mm_RefseqmRNA = XM_982260
| Mm_RefseqProtein = XP_987354
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 125287329
| Mm_GenLoc_end = 125310559
| Mm_Uniprot = Q3USG4
}}
}}
'''Sodium channel, nonvoltage-gated 1 alpha''', also known as '''SCNN1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Edelheit O, Hanukoglu I, Gizewska M, ''et al.'' |title=Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism. |journal=Clin. Endocrinol. (Oxf) |volume=62 |issue= 5 |pages= 547-53 |year= 2005 |pmid= 15853823 |doi= 10.1111/j.1365-2265.2005.02255.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPRY2... {November 9, 2007 12:02:53 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:03:26 AM PST}
- CREATED: Created new protein page: SPRY2 {November 9, 2007 12:03:33 AM PST}
- INFO: Beginning work on STUB1... {November 9, 2007 12:03:33 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein STUB1 image.jpg {November 9, 2007 12:04:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:04:33 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STUB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2c2l.
| PDB = {{PDB2|2c2l}}, {{PDB2|2c2v}}
| Name = STIP1 homology and U-box containing protein 1
| HGNCid = 11427
| Symbol = STUB1
| AltSymbols =; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1
| OMIM = 607207
| ECnumber =
| Homologene = 4281
| MGIid = 1891731
| GeneAtlas_image1 = PBB_GE_STUB1_217934_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0030544 |text = Hsp70 protein binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0051879 |text = Hsp90 protein binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0031371 |text = ubiquitin conjugating enzyme complex}}
| Process = {{GNF_GO|id=GO:0000209 |text = protein polyubiquitination}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0030579 |text = ubiquitin-dependent SMAD protein catabolic process}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0051604 |text = protein maturation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10273
| Hs_Ensembl = ENSG00000103266
| Hs_RefseqProtein = NP_005852
| Hs_RefseqmRNA = NM_005861
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 670116
| Hs_GenLoc_end = 672768
| Hs_Uniprot = Q9UNE7
| Mm_EntrezGene = 56424
| Mm_Ensembl = ENSMUSG00000039615
| Mm_RefseqmRNA = NM_019719
| Mm_RefseqProtein = NP_062693
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 25558234
| Mm_GenLoc_end = 25560961
| Mm_Uniprot = Q3TYJ0
}}
}}
'''STIP1 homology and U-box containing protein 1''', also known as '''STUB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Patterson C |title=A new gun in town: the U box is a ubiquitin ligase domain. |journal=Sci. STKE |volume=2002 |issue= 116 |pages= PE4 |year= 2002 |pmid= 11805346 |doi= 10.1126/stke.2002.116.pe4 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFSF13... {November 9, 2007 12:01:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:01:26 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor (ligand) superfamily, member 13
| HGNCid = 11928
| Symbol = TNFSF13
| AltSymbols =; APRIL; CD256; TALL2; TRDL-1; UNQ383/PRO715; ligand
| OMIM = 604472
| ECnumber =
| Homologene = 56971
| MGIid = 1916833
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0048298 |text = positive regulation of isotype switching to IgA isotypes}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8741
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003799
| Hs_RefseqmRNA = NM_003808
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 69583
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_023517
| Mm_RefseqProtein = NP_076006
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tumor necrosis factor (ligand) superfamily, member 13''', also known as '''TNFSF13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8741| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bossen C, Schneider P |title=BAFF, APRIL and their receptors: structure, function and signaling. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 263-75 |year= 2007 |pmid= 16914324 |doi= 10.1016/j.smim.2006.04.006 }}
*{{cite journal | author=Tangye SG, Bryant VL, Cuss AK, Good KL |title=BAFF, APRIL and human B cell disorders. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 305-17 |year= 2007 |pmid= 16916610 |doi= 10.1016/j.smim.2006.04.004 }}
*{{cite journal | author=Treml LS, Crowley JE, Cancro MP |title=BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 297-304 |year= 2007 |pmid= 16919470 |doi= 10.1016/j.smim.2006.07.001 }}
*{{cite journal | author=Mackay F, Leung H |title=The role of the BAFF/APRIL system on T cell function. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 284-9 |year= 2007 |pmid= 16931039 |doi= 10.1016/j.smim.2006.04.005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRIM28... {November 9, 2007 12:02:05 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:02:45 AM PST}
- CREATED: Created new protein page: TRIM28 {November 9, 2007 12:02:53 AM PST}
- INFO: Beginning work on XRCC4... {November 8, 2007 11:59:06 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein XRCC4 image.jpg {November 9, 2007 12:00:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:00:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_XRCC4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fu1.
| PDB = {{PDB2|1fu1}}, {{PDB2|1ik9}}
| Name = X-ray repair complementing defective repair in Chinese hamster cells 4
| HGNCid = 12831
| Symbol = XRCC4
| AltSymbols =;
| OMIM = 194363
| ECnumber =
| Homologene = 2555
| MGIid = 1333799
| GeneAtlas_image1 = PBB_GE_XRCC4_205072_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_XRCC4_205071_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_XRCC4_210813_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006303 |text = double-strand break repair via nonhomologous end joining}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7518
| Hs_Ensembl = ENSG00000152422
| Hs_RefseqProtein = NP_003392
| Hs_RefseqmRNA = NM_003401
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 82409073
| Hs_GenLoc_end = 82685333
| Hs_Uniprot = Q13426
| Mm_EntrezGene = 108138
| Mm_Ensembl = ENSMUSG00000021615
| Mm_RefseqmRNA = NM_028012
| Mm_RefseqProtein = NP_082288
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 90323160
| Mm_GenLoc_end = 90563768
| Mm_Uniprot = Q924T3
}}
}}
'''X-ray repair complementing defective repair in Chinese hamster cells 4''', also known as '''XRCC4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.<ref>{{cite web | title = Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7518| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lieber MR |title=The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. |journal=Genes Cells |volume=4 |issue= 2 |pages= 77-85 |year= 1999 |pmid= 10320474 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YWHAG... {November 9, 2007 12:00:23 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAG image.jpg {November 9, 2007 12:00:43 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 12:00:54 AM PST}
- CREATED: Created new protein page: YWHAG {November 9, 2007 12:01:01 AM PST}
end log.
