Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 22:43, 7 November 2007 (UTC)
[edit]Proteins without matches (16)
[edit]Proteins with a High Potential Match (9)
[edit]Manual Inspection (Page not found) (20)
[edit]
Protein Status Grid - Date: 22:43, 7 November 2007 (UTC)
[edit]Vebose Log - Date: 22:43, 7 November 2007 (UTC)
[edit]- INFO: Beginning work on ADRA2A... {November 7, 2007 2:08:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ADRA2A image.jpg {November 7, 2007 2:08:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:09:07 PM PST}
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{{PBB_Controls
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADRA2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hll.
| PDB = {{PDB2|1hll}}, {{PDB2|1ho9}}, {{PDB2|1hod}}, {{PDB2|1hof}}
| Name = Adrenergic, alpha-2A-, receptor
| HGNCid = 281
| Symbol = ADRA2A
| AltSymbols =; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
| OMIM = 104210
| ECnumber =
| Homologene = 47944
| MGIid = 87934
| GeneAtlas_image1 = PBB_GE_ADRA2A_209869_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004935 |text = adrenoceptor activity}} {{GNF_GO|id=GO:0004938 |text = alpha2-adrenergic receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0042596 |text = fear response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 150
| Hs_Ensembl = ENSG00000150594
| Hs_RefseqProtein = NP_000672
| Hs_RefseqmRNA = NM_000681
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 112826911
| Hs_GenLoc_end = 112830655
| Hs_Uniprot = P08913
| Mm_EntrezGene = 11551
| Mm_Ensembl = ENSMUSG00000033717
| Mm_RefseqmRNA = XM_974141
| Mm_RefseqProtein = XP_979235
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 54098574
| Mm_GenLoc_end = 54102292
| Mm_Uniprot = Q1HL33
}}
}}
'''Adrenergic, alpha-2A-, receptor''', also known as '''ADRA2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.<ref>{{cite web | title = Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=150| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AICDA... {November 7, 2007 2:34:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:35:09 PM PST}
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{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Activation-induced cytidine deaminase
| HGNCid = 13203
| Symbol = AICDA
| AltSymbols =; ARP2; AID; CDA2; HIGM2
| OMIM = 605257
| ECnumber =
| Homologene = 7623
| MGIid = 1342279
| GeneAtlas_image1 = PBB_GE_AICDA_219841_at_tn.png
| Function = {{GNF_GO|id=GO:0004126 |text = cytidine deaminase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 57379
| Hs_Ensembl = ENSG00000111732
| Hs_RefseqProtein = NP_065712
| Hs_RefseqmRNA = NM_020661
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 8648147
| Hs_GenLoc_end = 8650880
| Hs_Uniprot = Q9GZX7
| Mm_EntrezGene = 11628
| Mm_Ensembl = ENSMUSG00000040627
| Mm_RefseqmRNA = NM_009645
| Mm_RefseqProtein = NP_033775
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 122519432
| Mm_GenLoc_end = 122529799
| Mm_Uniprot = Q546Y8
}}
}}
'''Activation-induced cytidine deaminase''', also known as '''AICDA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wedekind JE, Dance GS, Sowden MP, Smith HC |title=Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. |journal=Trends Genet. |volume=19 |issue= 4 |pages= 207-16 |year= 2003 |pmid= 12683974 |doi= }}
*{{cite journal | author=Bransteitter R, Sneeden JL, Allen S, ''et al.'' |title=First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 16833-6 |year= 2006 |pmid= 16624806 |doi= 10.1074/jbc.R600006200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C4A... {November 7, 2007 2:09:07 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:10:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:11:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hzf.
| PDB = {{PDB2|1hzf}}
| Name = Complement component 4A (Rodgers blood group)
| HGNCid = 1323
| Symbol = C4A
| AltSymbols =; C4; C4A2; C4A3; C4A4; C4A6; C4B; C4S; CO4; CPAMD2; RG; C4A; C4A13; C4A91; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CPAMD3
| OMIM = 120810
| ECnumber =
| Homologene = 36030
| MGIid = 88228
| GeneAtlas_image1 = PBB_GE_C4A_208451_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_C4A_214428_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006956 |text = complement activation}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 720
| Hs_Ensembl = ENSG00000204319
| Hs_RefseqProtein = NP_009224
| Hs_RefseqmRNA = NM_007293
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32090517
| Hs_GenLoc_end = 32111174
| Hs_Uniprot = P0C0L4
| Mm_EntrezGene = 12268
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001002697
| Mm_RefseqProtein = XP_001002697
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement component 4A (Rodgers blood group)''', also known as '''C4A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.<ref>{{cite web | title = Entrez Gene: C4A complement component 4A (Rodgers blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=720| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hugli TE |title=Biochemistry and biology of anaphylatoxins. |journal=Complement |volume=3 |issue= 3 |pages= 111-27 |year= 1987 |pmid= 3542363 |doi= }}
*{{cite journal | author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213-30 |year= 1999 |pmid= 10072631 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAPN1... {November 7, 2007 2:11:03 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CAPN1 image.jpg {November 7, 2007 2:11:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:11:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CAPN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zcm.
| PDB = {{PDB2|1zcm}}, {{PDB2|2ary}}
| Name = Calpain 1, (mu/I) large subunit
| HGNCid = 1476
| Symbol = CAPN1
| AltSymbols =; CANP; CANPL1; muCANP; muCL
| OMIM = 114220
| ECnumber =
| Homologene = 3800
| MGIid = 88263
| GeneAtlas_image1 = PBB_GE_CAPN1_200752_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004198 |text = calpain activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 823
| Hs_Ensembl = ENSG00000014216
| Hs_RefseqProtein = NP_005177
| Hs_RefseqmRNA = NM_005186
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 64705792
| Hs_GenLoc_end = 64736048
| Hs_Uniprot = P07384
| Mm_EntrezGene = 12333
| Mm_Ensembl = ENSMUSG00000024942
| Mm_RefseqmRNA = NM_007600
| Mm_RefseqProtein = NP_031626
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 5988546
| Mm_GenLoc_end = 6015163
| Mm_Uniprot = Q3TB79
}}
}}
'''Calpain 1, (mu/I) large subunit''', also known as '''CAPN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.<ref>{{cite web | title = Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=823| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Suzuki K, Sorimachi H, Yoshizawa T, ''et al.'' |title=Calpain: novel family members, activation, and physiologic function. |journal=Biol. Chem. Hoppe-Seyler |volume=376 |issue= 9 |pages= 523-9 |year= 1996 |pmid= 8561910 |doi= }}
*{{cite journal | author=Huang Y, Wang KK |title=The calpain family and human disease. |journal=Trends in molecular medicine |volume=7 |issue= 8 |pages= 355-62 |year= 2001 |pmid= 11516996 |doi= }}
*{{cite journal | author=Goll DE, Thompson VF, Li H, ''et al.'' |title=The calpain system. |journal=Physiol. Rev. |volume=83 |issue= 3 |pages= 731-801 |year= 2003 |pmid= 12843408 |doi= 10.1152/physrev.00029.2002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAV3... {November 7, 2007 2:11:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:12:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Caveolin 3
| HGNCid = 1529
| Symbol = CAV3
| AltSymbols =; VIP21; LGMD1C; MGC126100; MGC126101; MGC126129; VIP-21
| OMIM = 601253
| ECnumber =
| Homologene = 7255
| MGIid = 107570
| GeneAtlas_image1 = PBB_GE_CAV3_208204_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016010 |text = dystrophin-associated glycoprotein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016599 |text = caveolar membrane}}
| Process = {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 859
| Hs_Ensembl = ENSG00000182533
| Hs_RefseqProtein = NP_001225
| Hs_RefseqmRNA = NM_001234
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 8750253
| Hs_GenLoc_end = 8763451
| Hs_Uniprot = P56539
| Mm_EntrezGene = 12391
| Mm_Ensembl = ENSMUSG00000062694
| Mm_RefseqmRNA = XM_973503
| Mm_RefseqProtein = XP_978597
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 112425278
| Mm_GenLoc_end = 112438649
| Mm_Uniprot = Q9EPR3
}}
}}
'''Caveolin 3''', also known as '''CAV3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.<ref>{{cite web | title = Entrez Gene: CAV3 caveolin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=859| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Figarella-Branger D, Pouget J, Bernard R, ''et al.'' |title=Limb-girdle muscular dystrophy in a 71-year-old woman with an R27Q mutation in the CAV3 gene. |journal=Neurology |volume=61 |issue= 4 |pages= 562-4 |year= 2004 |pmid= 12939441 |doi= }}
*{{cite journal | author=Woodman SE, Sotgia F, Galbiati F, ''et al.'' |title=Caveolinopathies: mutations in caveolin-3 cause four distinct autosomal dominant muscle diseases. |journal=Neurology |volume=62 |issue= 4 |pages= 538-43 |year= 2005 |pmid= 14981167 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCNH... {November 7, 2007 2:14:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCNH image.jpg {November 7, 2007 2:14:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:14:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCNH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jkw.
| PDB = {{PDB2|1jkw}}, {{PDB2|1kxu}}
| Name = Cyclin H
| HGNCid = 1594
| Symbol = CCNH
| AltSymbols =; CAK; p34; p37
| OMIM = 601953
| ECnumber =
| Homologene = 946
| MGIid = 1913921
| GeneAtlas_image1 = PBB_GE_CCNH_204093_at_tn.png
| Function = {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 902
| Hs_Ensembl = ENSG00000134480
| Hs_RefseqProtein = NP_001230
| Hs_RefseqmRNA = NM_001239
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 86725838
| Hs_GenLoc_end = 86744592
| Hs_Uniprot = P51946
| Mm_EntrezGene = 66671
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_023243
| Mm_RefseqProtein = NP_075732
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cyclin H''', also known as '''CCNH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.<ref>{{cite web | title = Entrez Gene: CCNH cyclin H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=902| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDH5... {November 7, 2007 2:14:56 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:15:27 PM PST}
- CREATED: Created new protein page: CDH5 {November 7, 2007 2:15:34 PM PST}
- INFO: Beginning work on CX3CR1... {November 7, 2007 2:15:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:16:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-X3-C motif) receptor 1
| HGNCid = 2558
| Symbol = CX3CR1
| AltSymbols =; CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28
| OMIM = 601470
| ECnumber =
| Homologene = 20350
| MGIid = 1333815
| GeneAtlas_image1 = PBB_GE_CX3CR1_205898_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1524
| Hs_Ensembl = ENSG00000168329
| Hs_RefseqProtein = NP_001328
| Hs_RefseqmRNA = NM_001337
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 39279989
| Hs_GenLoc_end = 39298190
| Hs_Uniprot = P49238
| Mm_EntrezGene = 13051
| Mm_Ensembl = ENSMUSG00000052336
| Mm_RefseqmRNA = XM_983192
| Mm_RefseqProtein = XP_988286
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 119750314
| Mm_GenLoc_end = 119916981
| Mm_Uniprot = Q543X3
}}
}}
'''Chemokine (C-X3-C motif) receptor 1''', also known as '''CX3CR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173-83 |year= 2002 |pmid= 11818437 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EIF2S1... {November 7, 2007 2:16:26 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EIF2S1 image.jpg {November 7, 2007 2:17:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:18:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EIF2S1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kl9.
| PDB = {{PDB2|1kl9}}, {{PDB2|1q8k}}
| Name = Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
| HGNCid = 3265
| Symbol = EIF2S1
| AltSymbols =; EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A
| OMIM = 603907
| ECnumber =
| Homologene = 3020
| MGIid = 95299
| GeneAtlas_image1 = PBB_GE_EIF2S1_201142_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF2S1_201143_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_EIF2S1_201144_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005844 |text = polysome}} {{GNF_GO|id=GO:0005850 |text = eukaryotic translation initiation factor 2 complex}} {{GNF_GO|id=GO:0005851 |text = eukaryotic translation initiation factor 2B complex}}
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}} {{GNF_GO|id=GO:0043558 |text = regulation of translation initiation in response to stress}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1965
| Hs_Ensembl = ENSG00000134001
| Hs_RefseqProtein = NP_004085
| Hs_RefseqmRNA = NM_004094
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 66896787
| Hs_GenLoc_end = 66922986
| Hs_Uniprot = P05198
| Mm_EntrezGene = 13665
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_026114
| Mm_RefseqProtein = NP_080390
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa''', also known as '''EIF2S1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1965| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hershey JW |title=Translational control in mammalian cells. |journal=Annu. Rev. Biochem. |volume=60 |issue= |pages= 717-55 |year= 1991 |pmid= 1883206 |doi= 10.1146/annurev.bi.60.070191.003441 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FCGR3A... {November 7, 2007 2:18:05 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FCGR3A image.jpg {November 7, 2007 2:18:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:18:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FCGR3A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e4j.
| PDB = {{PDB2|1e4j}}, {{PDB2|1e4k}}, {{PDB2|1fnl}}, {{PDB2|1iis}}, {{PDB2|1iix}}, {{PDB2|1t83}}, {{PDB2|1t89}}
| Name = Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
| HGNCid = 3619
| Symbol = FCGR3A
| AltSymbols =; CD16; CD16a; FCG3; FCGR3; IGFR3
| OMIM = 146740
| ECnumber =
| Homologene = 477
| MGIid = 2179523
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0019864 |text = IgG binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2214
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001133750
| Hs_RefseqmRNA = XM_001133750
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 246256
| Mm_Ensembl = ENSMUSG00000059089
| Mm_RefseqmRNA = NM_144559
| Mm_RefseqProtein = NP_653142
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 172855601
| Mm_GenLoc_end = 172866436
| Mm_Uniprot =
}}
}}
'''Fc fragment of IgG, low affinity IIIa, receptor (CD16a)''', also known as '''FCGR3A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLB1... {November 7, 2007 2:18:36 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:19:06 PM PST}
- CREATED: Created new protein page: GLB1 {November 7, 2007 2:19:13 PM PST}
- INFO: Beginning work on HMGA2... {November 7, 2007 2:31:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:32:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = High mobility group AT-hook 2
| HGNCid = 5009
| Symbol = HMGA2
| AltSymbols =; BABL; HMGI-C; HMGIC; LIPO
| OMIM = 600698
| ECnumber =
| Homologene = 2602
| MGIid = 101761
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003680 |text = AT DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006325 |text = establishment and/or maintenance of chromatin architecture}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8091
| Hs_Ensembl = ENSG00000149948
| Hs_RefseqProtein = NP_003474
| Hs_RefseqmRNA = NM_003483
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 64504507
| Hs_GenLoc_end = 64595566
| Hs_Uniprot =
| Mm_EntrezGene = 15364
| Mm_Ensembl = ENSMUSG00000056758
| Mm_RefseqmRNA = NM_010441
| Mm_RefseqProtein = NP_034571
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 119865724
| Mm_GenLoc_end = 119879123
| Mm_Uniprot = Q6NSP9
}}
}}
'''High mobility group AT-hook 2''', also known as '''HMGA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: HMGA2 high mobility group AT-hook 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8091| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pedeutour F, Ligon AH, Morton CC |title=[Genetics of uterine leiomyomata] |journal=Bulletin du cancer |volume=86 |issue= 11 |pages= 920-8 |year= 1999 |pmid= 10586108 |doi= }}
*{{cite journal | author=Reeves R, Beckerbauer L |title=HMGI/Y proteins: flexible regulators of transcription and chromatin structure. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 13-29 |year= 2001 |pmid= 11406267 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLRK1... {November 7, 2007 2:33:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KLRK1 image.jpg {November 7, 2007 2:34:01 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:34:20 PM PST}
- CREATED: Created new protein page: KLRK1 {November 7, 2007 2:34:26 PM PST}
- INFO: Beginning work on NR1I2... {November 7, 2007 2:32:14 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NR1I2 image.jpg {November 7, 2007 2:33:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:33:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1I2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ilg.
| PDB = {{PDB2|1ilg}}, {{PDB2|1ilh}}, {{PDB2|1m13}}, {{PDB2|1nrl}}, {{PDB2|1skx}}, {{PDB2|2o9i}}
| Name = Nuclear receptor subfamily 1, group I, member 2
| HGNCid = 7968
| Symbol = NR1I2
| AltSymbols =; SAR; PAR1; PAR2; PRR; BXR; ONR1; PAR; PARq; PXR; SXR
| OMIM = 603065
| ECnumber =
| Homologene = 40757
| MGIid = 1337040
| GeneAtlas_image1 = PBB_GE_NR1I2_207202_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR1I2_207203_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8856
| Hs_Ensembl = ENSG00000144852
| Hs_RefseqProtein = NP_003880
| Hs_RefseqmRNA = NM_003889
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 120984236
| Hs_GenLoc_end = 121020021
| Hs_Uniprot = O75469
| Mm_EntrezGene = 18171
| Mm_Ensembl = ENSMUSG00000022809
| Mm_RefseqmRNA = NM_010936
| Mm_RefseqProtein = NP_035066
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 38167590
| Mm_GenLoc_end = 38214062
| Mm_Uniprot = Q0P525
}}
}}
'''Nuclear receptor subfamily 1, group I, member 2''', also known as '''NR1I2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.<ref>{{cite web | title = Entrez Gene: NR1I2 nuclear receptor subfamily 1, group I, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8856| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Watkins RE, Noble SM, Redinbo MR |title=Structural insights into the promiscuity and function of the human pregnane X receptor. |journal=Current opinion in drug discovery & development |volume=5 |issue= 1 |pages= 150-8 |year= 2002 |pmid= 11865669 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NUP98... {November 7, 2007 2:19:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NUP98 image.jpg {November 7, 2007 2:20:07 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:20:19 PM PST}
- CREATED: Created new protein page: NUP98 {November 7, 2007 2:20:26 PM PST}
- INFO: Beginning work on PSMB8... {November 7, 2007 2:20:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:21:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
| HGNCid = 9545
| Symbol = PSMB8
| AltSymbols =; D6S216; D6S216E; LMP7; MGC1491; RING10
| OMIM = 177046
| ECnumber =
| Homologene = 56499
| MGIid = 1346527
| GeneAtlas_image1 = PBB_GE_PSMB8_209040_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5696
| Hs_Ensembl = ENSG00000204264
| Hs_RefseqProtein = NP_004150
| Hs_RefseqmRNA = NM_004159
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32916471
| Hs_GenLoc_end = 32920690
| Hs_Uniprot = P28062
| Mm_EntrezGene = 16913
| Mm_Ensembl = ENSMUSG00000024338
| Mm_RefseqmRNA = NM_010724
| Mm_RefseqProtein = NP_034854
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33808583
| Mm_GenLoc_end = 33811657
| Mm_Uniprot = P28063
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)''', also known as '''PSMB8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.<ref>{{cite web | title = Entrez Gene: PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5696| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RHCE... {November 7, 2007 2:21:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:24:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Rh blood group, CcEe antigens
| HGNCid = 10008
| Symbol = RHCE
| AltSymbols =; RHC; CD240CE; MGC103977; RH; RH30A; RHE; RHIXB; RHPI; Rh4; RhIVb(J); RhVI; RhVIII; CD240D; DIIIc; RH30; RHCED; RHDVA(TT); RHDel; RHPII; RHXIII; RhDCw; RhII; RhK562-II; RhPI
| OMIM = 111700
| ECnumber =
| Homologene = 7918
| MGIid = 1202882
| GeneAtlas_image1 = PBB_GE_RHCE_215819_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RHCE_216317_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_RHCE_210429_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6006
| Hs_Ensembl = ENSG00000188672
| Hs_RefseqProtein = XP_001130486
| Hs_RefseqmRNA = XM_001130486
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 25561328
| Hs_GenLoc_end = 25629270
| Hs_Uniprot = P18577
| Mm_EntrezGene = 19746
| Mm_Ensembl = ENSMUSG00000028825
| Mm_RefseqmRNA = NM_011270
| Mm_RefseqProtein = NP_035400
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 134136660
| Mm_GenLoc_end = 134168248
| Mm_Uniprot =
}}
}}
'''Rh blood group, CcEe antigens''', also known as '''RHCE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Alternative splicing of this gene results in four transcript variants encoding four different isoforms.<ref>{{cite web | title = Entrez Gene: RHCE Rh blood group, CcEe antigens| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6006| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Agre P, Cartron JP |title=Molecular biology of the Rh antigens. |journal=Blood |volume=78 |issue= 3 |pages= 551-63 |year= 1991 |pmid= 1907207 |doi= }}
*{{cite journal | author=Avent ND, Reid ME |title=The Rh blood group system: a review. |journal=Blood |volume=95 |issue= 2 |pages= 375-87 |year= 2000 |pmid= 10627438 |doi= }}
*{{cite journal | author=Flegel WA, Wagner FF |title=Molecular genetics of RH. |journal=Vox Sang. |volume=78 Suppl 2 |issue= |pages= 109-15 |year= 2000 |pmid= 10938938 |doi= }}
*{{cite journal | author=Wagner FF, Flegel WA |title=Review: the molecular basis of the Rh blood group phenotypes. |journal=Immunohematology / American Red Cross |volume=20 |issue= 1 |pages= 23-36 |year= 2004 |pmid= 15373666 |doi= }}
*{{cite journal | author=Callebaut I, Dulin F, Bertrand O, ''et al.'' |title=Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 70-84 |year= 2006 |pmid= 16584906 |doi= 10.1016/j.tracli.2006.02.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RUNX1T1... {November 7, 2007 2:12:37 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RUNX1T1 image.jpg {November 7, 2007 2:13:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:14:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RUNX1T1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wq6.
| PDB = {{PDB2|1wq6}}, {{PDB2|2dj8}}, {{PDB2|2h7b}}
| Name = Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
| HGNCid = 1535
| Symbol = RUNX1T1
| AltSymbols =; AML1T1; CBFA2T1; CDR; ETO; MGC2796; MTG8; MTG8b; ZMYND2
| OMIM = 133435
| ECnumber =
| Homologene = 3801
| MGIid = 104793
| GeneAtlas_image1 = PBB_GE_RUNX1T1_205529_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RUNX1T1_205528_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RUNX1T1_216831_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0051101 |text = regulation of DNA binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 862
| Hs_Ensembl = ENSG00000079102
| Hs_RefseqProtein = NP_004340
| Hs_RefseqmRNA = NM_004349
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 93040328
| Hs_GenLoc_end = 93176619
| Hs_Uniprot = Q06455
| Mm_EntrezGene = 12395
| Mm_Ensembl = ENSMUSG00000006586
| Mm_RefseqmRNA = XM_975417
| Mm_RefseqProtein = XP_980511
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 13670583
| Mm_GenLoc_end = 13818712
| Mm_Uniprot = Q61909
}}
}}
'''Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)''', also known as '''RUNX1T1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ferrara F, Del Vecchio L |title=Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity. |journal=Haematologica |volume=87 |issue= 3 |pages= 306-19 |year= 2002 |pmid= 11869944 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPTAN1... {November 7, 2007 2:24:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SPTAN1 image.jpg {November 7, 2007 2:24:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:25:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPTAN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aey.
| PDB = {{PDB2|1aey}}, {{PDB2|1aj3}}, {{PDB2|1bk2}}, {{PDB2|1cun}}, {{PDB2|1e6g}}, {{PDB2|1e6h}}, {{PDB2|1e7o}}, {{PDB2|1h8k}}, {{PDB2|1hd3}}, {{PDB2|1m8m}}, {{PDB2|1pwt}}, {{PDB2|1qkw}}, {{PDB2|1qkx}}, {{PDB2|1shg}}, {{PDB2|1u06}}, {{PDB2|1u4q}}, {{PDB2|1u5p}}, {{PDB2|1uue}}, {{PDB2|2cdt}}, {{PDB2|2f2v}}, {{PDB2|2f2w}}, {{PDB2|2f2x}}, {{PDB2|2fot}}, {{PDB2|2jm8}}, {{PDB2|2jm9}}, {{PDB2|2jma}}, {{PDB2|2nuz}}
| Name = Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
| HGNCid = 11273
| Symbol = SPTAN1
| AltSymbols =; (ALPHA)II-SPECTRIN; FLJ44613
| OMIM = 182810
| ECnumber =
| Homologene = 2353
| MGIid = 98386
| GeneAtlas_image1 = PBB_GE_SPTAN1_208611_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPTAN1_215235_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0008091 |text = spectrin}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0051016 |text = barbed-end actin filament capping}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6709
| Hs_Ensembl = ENSG00000197694
| Hs_RefseqProtein = NP_003118
| Hs_RefseqmRNA = NM_003127
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 130354690
| Hs_GenLoc_end = 130435762
| Hs_Uniprot = Q13813
| Mm_EntrezGene = 20740
| Mm_Ensembl = ENSMUSG00000057738
| Mm_RefseqmRNA = XM_001000210
| Mm_RefseqProtein = XP_001000210
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 29787686
| Mm_GenLoc_end = 29853457
| Mm_Uniprot = Q3URW8
}}
}}
'''Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)''', also known as '''SPTAN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chow CW |title=Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 195-206 |year= 1999 |pmid= 10579058 |doi= }}
*{{cite journal | author=Hayashi Y, Arakaki R, Ishimaru N |title=The role of caspase cascade on the development of primary Sjögren's syndrome. |journal=J. Med. Invest. |volume=50 |issue= 1-2 |pages= 32-8 |year= 2003 |pmid= 12630566 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TACR1... {November 7, 2007 2:25:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:25:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tachykinin receptor 1
| HGNCid = 11526
| Symbol = TACR1
| AltSymbols =; SPR; NK1R; NKIR; TAC1R
| OMIM = 162323
| ECnumber =
| Homologene = 20288
| MGIid = 98475
| GeneAtlas_image1 = PBB_GE_TACR1_208049_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TACR1_210637_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004995 |text = tachykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007217 |text = tachykinin signaling pathway}} {{GNF_GO|id=GO:0007638 |text = mechanosensory behavior}} {{GNF_GO|id=GO:0009582 |text = detection of abiotic stimulus}} {{GNF_GO|id=GO:0048265 |text = response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6869
| Hs_Ensembl = ENSG00000115353
| Hs_RefseqProtein = NP_001049
| Hs_RefseqmRNA = NM_001058
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 75129738
| Hs_GenLoc_end = 75279781
| Hs_Uniprot = P25103
| Mm_EntrezGene = 21336
| Mm_Ensembl = ENSMUSG00000030043
| Mm_RefseqmRNA = NM_009313
| Mm_RefseqProtein = NP_033339
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 82368133
| Mm_GenLoc_end = 82525757
| Mm_Uniprot = Q3V353
}}
}}
'''Tachykinin receptor 1''', also known as '''TACR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. This receptor is also involved in the mediation of phosphatidylinositol metabolism of substance P.<ref>{{cite web | title = Entrez Gene: TACR1 tachykinin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6869| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Burcher E |title=The study of tachykinin receptors. |journal=Clin. Exp. Pharmacol. Physiol. |volume=16 |issue= 6 |pages= 539-43 |year= 1989 |pmid= 2548782 |doi= }}
*{{cite journal | author=Kowall NW, Quigley BJ, Krause JE, ''et al.'' |title=Substance P and substance P receptor histochemistry in human neurodegenerative diseases. |journal=Regul. Pept. |volume=46 |issue= 1-2 |pages= 174-85 |year= 1993 |pmid= 7692486 |doi= }}
*{{cite journal | author=Patacchini R, Maggi CA |title=Peripheral tachykinin receptors as targets for new drugs. |journal=Eur. J. Pharmacol. |volume=429 |issue= 1-3 |pages= 13-21 |year= 2002 |pmid= 11698023 |doi= }}
*{{cite journal | author=Saito R, Takano Y, Kamiya HO |title=Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. |journal=J. Pharmacol. Sci. |volume=91 |issue= 2 |pages= 87-94 |year= 2003 |pmid= 12686752 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFAP2A... {November 7, 2007 2:25:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:27:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
| HGNCid = 11742
| Symbol = TFAP2A
| AltSymbols =; AP-2; AP-2alpha; AP2TF; TFAP2
| OMIM = 107580
| ECnumber =
| Homologene = 2421
| MGIid = 104671
| GeneAtlas_image1 = PBB_GE_TFAP2A_204653_at_tn.png
| GeneAtlas_image2 = PBB_GE_TFAP2A_204654_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TFAP2A_210669_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007398 |text = ectoderm development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7020
| Hs_Ensembl = ENSG00000137203
| Hs_RefseqProtein = NP_001027451
| Hs_RefseqmRNA = NM_001032280
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 10504906
| Hs_GenLoc_end = 10527824
| Hs_Uniprot = P05549
| Mm_EntrezGene = 21418
| Mm_Ensembl = ENSMUSG00000021359
| Mm_RefseqmRNA = NM_011547
| Mm_RefseqProtein = NP_035677
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 40726649
| Mm_GenLoc_end = 40745894
| Mm_Uniprot = Q3UL09
}}
}}
'''Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)''', also known as '''TFAP2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7020| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPM1... {November 7, 2007 2:27:23 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TPM1 image.jpg {November 7, 2007 2:28:53 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:29:09 PM PST}
- CREATED: Created new protein page: TPM1 {November 7, 2007 2:29:16 PM PST}
- INFO: Beginning work on TPM3... {November 7, 2007 2:29:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TPM3 image.jpg {November 7, 2007 2:29:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:30:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TPM3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mv4.
| PDB = {{PDB2|1mv4}}, {{PDB2|2g9j}}, {{PDB2|2tma}}
| Name = Tropomyosin 3
| HGNCid = 12012
| Symbol = TPM3
| AltSymbols =; NEM1; TRK; FLJ41118; MGC14582; MGC3261; MGC72094; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TPMsk3; hscp30
| OMIM = 191030
| ECnumber =
| Homologene = 77475
| MGIid =
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005862 |text = muscle thin filament tropomyosin}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7170
| Hs_Ensembl = ENSG00000143549
| Hs_RefseqProtein = NP_001036816
| Hs_RefseqmRNA = NM_001043351
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 152395457
| Hs_GenLoc_end = 152431233
| Hs_Uniprot = P06753
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tropomyosin 3''', also known as '''TPM3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: TPM3 tropomyosin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7170| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lees-Miller JP, Helfman DM |title=The molecular basis for tropomyosin isoform diversity. |journal=Bioessays |volume=13 |issue= 9 |pages= 429-37 |year= 1992 |pmid= 1796905 |doi= 10.1002/bies.950130902 }}
*{{cite journal | author=Pittenger MF, Kazzaz JA, Helfman DM |title=Functional properties of non-muscle tropomyosin isoforms. |journal=Curr. Opin. Cell Biol. |volume=6 |issue= 1 |pages= 96-104 |year= 1994 |pmid= 8167032 |doi= }}
*{{cite journal | author=Gunning P, Weinberger R, Jeffrey P |title=Actin and tropomyosin isoforms in morphogenesis. |journal=Anat. Embryol. |volume=195 |issue= 4 |pages= 311-5 |year= 1997 |pmid= 9108196 |doi= }}
*{{cite journal | author=Gunning PW, Schevzov G, Kee AJ, Hardeman EC |title=Tropomyosin isoforms: divining rods for actin cytoskeleton function. |journal=Trends Cell Biol. |volume=15 |issue= 6 |pages= 333-41 |year= 2006 |pmid= 15953552 |doi= 10.1016/j.tcb.2005.04.007 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPO... {November 7, 2007 2:30:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:30:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thyroid peroxidase
| HGNCid = 12015
| Symbol = TPO
| AltSymbols =; MSA; TPX
| OMIM = 606765
| ECnumber =
| Homologene = 461
| MGIid = 98813
| GeneAtlas_image1 = PBB_GE_TPO_210342_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004447 |text = iodide peroxidase activity}} {{GNF_GO|id=GO:0004601 |text = peroxidase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006590 |text = thyroid hormone generation}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0042446 |text = hormone biosynthetic process}} {{GNF_GO|id=GO:0042744 |text = hydrogen peroxide catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7173
| Hs_Ensembl = ENSG00000115705
| Hs_RefseqProtein = NP_000538
| Hs_RefseqmRNA = NM_000547
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 1396240
| Hs_GenLoc_end = 1525506
| Hs_Uniprot = P07202
| Mm_EntrezGene = 22018
| Mm_Ensembl = ENSMUSG00000020673
| Mm_RefseqmRNA = XM_975183
| Mm_RefseqProtein = XP_980277
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 30640711
| Mm_GenLoc_end = 30718661
| Mm_Uniprot = Q4FZJ9
}}
}}
'''Thyroid peroxidase''', also known as '''TPO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined.<ref>{{cite web | title = Entrez Gene: TPO thyroid peroxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7173| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Asakawa H |title=[Thyroid peroxidase (TPO) gene and pathogenic TPO mutation] |journal=Nippon Rinsho |volume=52 |issue= 4 |pages= 864-8 |year= 1994 |pmid= 8196171 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YES1... {November 7, 2007 2:30:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YES1 image.jpg {November 7, 2007 2:31:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:31:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YES1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hda.
| PDB = {{PDB2|2hda}}, {{PDB2|2hwo}}, {{PDB2|2hwp}}, {{PDB2|2oiq}}
| Name = V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
| HGNCid = 12841
| Symbol = YES1
| AltSymbols =; HsT441; P61-YES; Yes; c-yes
| OMIM = 164880
| ECnumber =
| Homologene = 55900
| MGIid = 99147
| GeneAtlas_image1 = PBB_GE_YES1_202933_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YES1_202932_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7525
| Hs_Ensembl = ENSG00000176105
| Hs_RefseqProtein = NP_005424
| Hs_RefseqmRNA = NM_005433
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 711747
| Hs_GenLoc_end = 802547
| Hs_Uniprot = P07947
| Mm_EntrezGene = 22612
| Mm_Ensembl = ENSMUSG00000014932
| Mm_RefseqmRNA = NM_009535
| Mm_RefseqProtein = NP_033561
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 32887814
| Mm_GenLoc_end = 32963638
| Mm_Uniprot = Q3TJI7
}}
}}
'''V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1''', also known as '''YES1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.<ref>{{cite web | title = Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7525| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Brickell PM |title=The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. |journal=Critical reviews in oncogenesis |volume=3 |issue= 4 |pages= 401-46 |year= 1992 |pmid= 1384720 |doi= }}
*{{cite journal | author=Toyoshima K, Semba K, Nishizawa M, ''et al.'' |title=Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family. |journal=Int. Symp. Princess Takamatsu Cancer Res. Fund |volume=17 |issue= |pages= 11-20 |year= 1988 |pmid= 3332005 |doi= }}
*{{cite journal | author=Sudol M, Chen HI, Bougeret C, ''et al.'' |title=Characterization of a novel protein-binding module--the WW domain. |journal=FEBS Lett. |volume=369 |issue= 1 |pages= 67-71 |year= 1995 |pmid= 7641887 |doi= }}
*{{cite journal | author=Summy JM, Sudol M, Eck MJ, ''et al.'' |title=Specificity in signaling by c-Yes. |journal=Front. Biosci. |volume=8 |issue= |pages= s185-205 |year= 2004 |pmid= 12456296 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
