Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 02:15, 8 November 2007 (UTC)
[edit]Proteins without matches (20)
[edit]Proteins with a High Potential Match (5)
[edit]Manual Inspection (Page not found) (18)
[edit]
Protein Status Grid - Date: 02:15, 8 November 2007 (UTC)
[edit]Vebose Log - Date: 02:15, 8 November 2007 (UTC)
[edit]- INFO: Beginning work on ACE2... {November 7, 2007 6:06:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACE2 image.jpg {November 7, 2007 6:07:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:07:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACE2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r42.
| PDB = {{PDB2|1r42}}, {{PDB2|1r4l}}, {{PDB2|2ajf}}
| Name = Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
| HGNCid = 13557
| Symbol = ACE2
| AltSymbols =; ACEH; DKFZP434A014
| OMIM = 300335
| ECnumber =
| Homologene = 41448
| MGIid = 1917258
| GeneAtlas_image1 = PBB_GE_ACE2_219962_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACE2_222257_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001618 |text = viral receptor activity}} {{GNF_GO|id=GO:0004180 |text = carboxypeptidase activity}} {{GNF_GO|id=GO:0004246 |text = peptidyl-dipeptidase A activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0046718 |text = entry of virus into host cell}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 59272
| Hs_Ensembl = ENSG00000130234
| Hs_RefseqProtein = NP_068576
| Hs_RefseqmRNA = NM_021804
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 15489077
| Hs_GenLoc_end = 15530199
| Hs_Uniprot = Q9BYF1
| Mm_EntrezGene = 70008
| Mm_Ensembl = ENSMUSG00000015405
| Mm_RefseqmRNA = NM_027286
| Mm_RefseqProtein = NP_081562
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 159484737
| Mm_GenLoc_end = 159532523
| Mm_Uniprot = Q3URC9
}}
}}
'''Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2''', also known as '''ACE2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This protein catalyzes the cleavage of angiotensin I into angiotensin 1-9. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility.<ref>{{cite web | title = Entrez Gene: ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59272| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Turner AJ, Tipnis SR, Guy JL, ''et al.'' |title=ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. |journal=Can. J. Physiol. Pharmacol. |volume=80 |issue= 4 |pages= 346-53 |year= 2002 |pmid= 12025971 |doi= }}
*{{cite journal | author=Turner AJ, Hiscox JA, Hooper NM |title=ACE2: from vasopeptidase to SARS virus receptor. |journal=Trends Pharmacol. Sci. |volume=25 |issue= 6 |pages= 291-4 |year= 2004 |pmid= 15165741 |doi= 10.1016/j.tips.2004.04.001 }}
*{{cite journal | author=Katovich MJ, Grobe JL, Huentelman M, Raizada MK |title=Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. |journal=Exp. Physiol. |volume=90 |issue= 3 |pages= 299-305 |year= 2005 |pmid= 15640278 |doi= 10.1113/expphysiol.2004.028522 }}
*{{cite journal | author=Ferrario CM, Trask AJ, Jessup JA |title=Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=289 |issue= 6 |pages= H2281-90 |year= 2006 |pmid= 16055515 |doi= 10.1152/ajpheart.00618.2005 }}
*{{cite journal | author=Jia HP, Look DC, Hickey M, ''et al.'' |title=Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. |journal=Adv. Exp. Med. Biol. |volume=581 |issue= |pages= 479-84 |year= 2006 |pmid= 17037581 |doi= }}
*{{cite journal | author=Lazartigues E, Feng Y, Lavoie JL |title=The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1231-45 |year= 2007 |pmid= 17504232 |doi= }}
*{{cite journal | author=Raizada MK, Ferreira AJ |title=ACE2: a new target for cardiovascular disease therapeutics. |journal=J. Cardiovasc. Pharmacol. |volume=50 |issue= 2 |pages= 112-9 |year= 2007 |pmid= 17703127 |doi= 10.1097/FJC.0b013e3180986219 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ACPP... {November 7, 2007 5:43:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACPP image.jpg {November 7, 2007 5:44:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:44:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACPP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cvi.
| PDB = {{PDB2|1cvi}}, {{PDB2|1nd5}}, {{PDB2|1nd6}}, {{PDB2|2hpa}}
| Name = Acid phosphatase, prostate
| HGNCid = 125
| Symbol = ACPP
| AltSymbols =; ACP-3; ACP3; PAP
| OMIM = 171790
| ECnumber =
| Homologene = 55552
| MGIid = 1928480
| GeneAtlas_image1 = PBB_GE_ACPP_204393_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003993 |text = acid phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 55
| Hs_Ensembl = ENSG00000014257
| Hs_RefseqProtein = NP_001090
| Hs_RefseqmRNA = NM_001099
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 133518941
| Hs_GenLoc_end = 133569831
| Hs_Uniprot = P15309
| Mm_EntrezGene = 56318
| Mm_Ensembl = ENSMUSG00000032561
| Mm_RefseqmRNA = NM_019807
| Mm_RefseqProtein = NP_062781
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 104146585
| Mm_GenLoc_end = 104196067
| Mm_Uniprot =
}}
}}
'''Acid phosphatase, prostate''', also known as '''ACPP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Prostatic acid phosphatase precursor catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. ACPP is synthesized under androgen regulation and secreted by the epithelial cells of the prostrate gland. Sequence comparison has indicated the presence of several polymorphisms. ACPP undergoes alternative splicing in the 3' UTR.<ref>{{cite web | title = Entrez Gene: ACPP acid phosphatase, prostate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ostrowski WS, Kuciel R |title=Human prostatic acid phosphatase: selected properties and practical applications. |journal=Clin. Chim. Acta |volume=226 |issue= 2 |pages= 121-9 |year= 1994 |pmid= 7923807 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADH1B... {November 7, 2007 5:44:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ADH1B image.jpg {November 7, 2007 5:45:12 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:45:22 PM PST}
- CREATED: Created new protein page: ADH1B {November 7, 2007 5:45:31 PM PST}
- INFO: Beginning work on CCL20... {November 7, 2007 6:04:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCL20 image.jpg {November 7, 2007 6:04:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:04:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCL20_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m8a.
| PDB = {{PDB2|1m8a}}, {{PDB2|2hci}}
| Name = Chemokine (C-C motif) ligand 20
| HGNCid = 10619
| Symbol = CCL20
| AltSymbols =; CKb4; LARC; MIP-3a; MIP3A; SCYA20; ST38
| OMIM = 601960
| ECnumber =
| Homologene = 3375
| MGIid = 1329031
| GeneAtlas_image1 = PBB_GE_CCL20_205476_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6364
| Hs_Ensembl = ENSG00000115009
| Hs_RefseqProtein = NP_004582
| Hs_RefseqmRNA = NM_004591
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 228386814
| Hs_GenLoc_end = 228390494
| Hs_Uniprot = P78556
| Mm_EntrezGene = 20297
| Mm_Ensembl = ENSMUSG00000026166
| Mm_RefseqmRNA = NM_016960
| Mm_RefseqProtein = NP_058656
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 82995806
| Mm_GenLoc_end = 83005701
| Mm_Uniprot = Q54AI7
}}
}}
'''Chemokine (C-C motif) ligand 20''', also known as '''CCL20''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL17A1... {November 7, 2007 5:45:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:46:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type XVII, alpha 1
| HGNCid = 2194
| Symbol = COL17A1
| AltSymbols =; BA16H23.2; BP180; BPAG2; KIAA0204; LAD-1
| OMIM = 113811
| ECnumber =
| Homologene = 7276
| MGIid = 88450
| GeneAtlas_image1 = PBB_GE_COL17A1_204636_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030056 |text = hemidesmosome}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1308
| Hs_Ensembl = ENSG00000065618
| Hs_RefseqProtein = NP_570134
| Hs_RefseqmRNA = NM_130778
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 105781034
| Hs_GenLoc_end = 105835750
| Hs_Uniprot = Q9UMD9
| Mm_EntrezGene = 12821
| Mm_Ensembl = ENSMUSG00000025064
| Mm_RefseqmRNA = NM_007732
| Mm_RefseqProtein = NP_031758
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 47699673
| Mm_GenLoc_end = 47745405
| Mm_Uniprot = Q08AT3
}}
}}
'''Collagen, type XVII, alpha 1''', also known as '''COL17A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.<ref>{{cite web | title = Entrez Gene: COL17A1 collagen, type XVII, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1308| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRYAA... {November 7, 2007 5:46:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:46:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Crystallin, alpha A
| HGNCid = 2388
| Symbol = CRYAA
| AltSymbols =; CRYA1; HSPB4
| OMIM = 123580
| ECnumber =
| Homologene = 48053
| MGIid = 88515
| GeneAtlas_image1 = PBB_GE_CRYAA_210199_at_tn.png
| Function = {{GNF_GO|id=GO:0005212 |text = structural constituent of eye lens}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000072 |text = M phase specific microtubule process}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1409
| Hs_Ensembl = ENSG00000160202
| Hs_RefseqProtein = NP_000385
| Hs_RefseqmRNA = NM_000394
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 43462210
| Hs_GenLoc_end = 43465982
| Hs_Uniprot = P02489
| Mm_EntrezGene = 12954
| Mm_Ensembl = ENSMUSG00000024041
| Mm_RefseqmRNA = NM_013501
| Mm_RefseqProtein = NP_038529
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 31406661
| Mm_GenLoc_end = 31410057
| Mm_Uniprot = Q546L9
}}
}}
'''Crystallin, alpha A''', also known as '''CRYAA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).<ref>{{cite web | title = Entrez Gene: CRYAA crystallin, alpha A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1409| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Derham BK, Harding JJ |title=Alpha-crystallin as a molecular chaperone. |journal=Progress in retinal and eye research |volume=18 |issue= 4 |pages= 463-509 |year= 1999 |pmid= 10217480 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSF3R... {November 7, 2007 5:46:56 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CSF3R image.jpg {November 7, 2007 5:47:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:47:49 PM PST}
- CREATED: Created new protein page: CSF3R {November 7, 2007 5:47:56 PM PST}
- INFO: Beginning work on GADD45A... {November 7, 2007 5:47:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:48:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth arrest and DNA-damage-inducible, alpha
| HGNCid = 4095
| Symbol = GADD45A
| AltSymbols =; DDIT1; GADD45
| OMIM = 126335
| ECnumber =
| Homologene = 1449
| MGIid = 107799
| GeneAtlas_image1 = PBB_GE_GADD45A_203725_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1647
| Hs_Ensembl = ENSG00000116717
| Hs_RefseqProtein = NP_001915
| Hs_RefseqmRNA = NM_001924
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 67923332
| Hs_GenLoc_end = 67926609
| Hs_Uniprot = P24522
| Mm_EntrezGene = 13197
| Mm_Ensembl = ENSMUSG00000036390
| Mm_RefseqmRNA = NM_007836
| Mm_RefseqProtein = NP_031862
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 66964674
| Mm_GenLoc_end = 66966985
| Mm_Uniprot = Q3UMH6
}}
}}
'''Growth arrest and DNA-damage-inducible, alpha''', also known as '''GADD45A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.<ref>{{cite web | title = Entrez Gene: GADD45A growth arrest and DNA-damage-inducible, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1647| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hildesheim J, Fornace AJ |title=Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. |journal=Clin. Cancer Res. |volume=8 |issue= 8 |pages= 2475-9 |year= 2003 |pmid= 12171872 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GGT1... {November 7, 2007 5:48:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:49:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gamma-glutamyltransferase 1
| HGNCid = 4250
| Symbol = GGT1
| AltSymbols =; CD224; D22S672; D22S732; GGT; GTG; MGC96892; MGC96904; MGC96963
| OMIM = 231950
| ECnumber =
| Homologene = 68450
| MGIid = 95706
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003840 |text = gamma-glutamyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006750 |text = glutathione biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2678
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001027536
| Hs_RefseqmRNA = NM_001032364
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14598
| Mm_Ensembl = ENSMUSG00000006345
| Mm_RefseqmRNA = NM_008116
| Mm_RefseqProtein = NP_032142
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 75012380
| Mm_GenLoc_end = 75029906
| Mm_Uniprot = Q4FK56
}}
}}
'''Gamma-glutamyltransferase 1''', also known as '''GGT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.<ref>{{cite web | title = Entrez Gene: GGT1 gamma-glutamyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2678| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chikhi N, Holic N, Guellaen G, Laperche Y |title=Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species. |journal=Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |volume=122 |issue= 4 |pages= 367-80 |year= 1999 |pmid= 10392451 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on H3F3A... {November 7, 2007 5:49:06 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein H3F3A image.jpg {November 7, 2007 5:49:27 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:49:43 PM PST}
- CREATED: Created new protein page: H3F3A {November 7, 2007 5:49:54 PM PST}
- INFO: Beginning work on KCNMA1... {November 7, 2007 5:49:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:51:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium large conductance calcium-activated channel, subfamily M, alpha member 1
| HGNCid = 6284
| Symbol = KCNMA1
| AltSymbols =; BKTM; DKFZp686K1437; KCa1.1; MGC71881; MaxiK; SAKCA; SLO; SLO-ALPHA
| OMIM = 600150
| ECnumber =
| Homologene = 1693
| MGIid = 99923
| GeneAtlas_image1 = PBB_GE_KCNMA1_221583_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNMA1_221584_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_KCNMA1_214921_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015269 |text = calcium-activated potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3778
| Hs_Ensembl = ENSG00000156113
| Hs_RefseqProtein = NP_001014797
| Hs_RefseqmRNA = NM_001014797
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 78307361
| Hs_GenLoc_end = 79068359
| Hs_Uniprot = Q12791
| Mm_EntrezGene = 16531
| Mm_Ensembl = ENSMUSG00000063142
| Mm_RefseqmRNA = NM_010610
| Mm_RefseqProtein = NP_034740
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 22077983
| Mm_GenLoc_end = 22792677
| Mm_Uniprot = Q3TSL8
}}
}}
'''Potassium large conductance calcium-activated channel, subfamily M, alpha member 1''', also known as '''KCNMA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3778| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Magleby KL |title=Gating mechanism of BK (Slo1) channels: so near, yet so far. |journal=J. Gen. Physiol. |volume=121 |issue= 2 |pages= 81-96 |year= 2003 |pmid= 12566537 |doi= }}
*{{cite journal | author=Wei AD, Gutman GA, Aldrich R, ''et al.'' |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463-72 |year= 2006 |pmid= 16382103 |doi= 10.1124/pr.57.4.9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCNQ2... {November 7, 2007 5:51:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:53:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium voltage-gated channel, KQT-like subfamily, member 2
| HGNCid = 6296
| Symbol = KCNQ2
| AltSymbols =; BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1
| OMIM = 602235
| ECnumber =
| Homologene = 26174
| MGIid = 1309503
| GeneAtlas_image1 = PBB_GE_KCNQ2_210508_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNQ2_211486_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_KCNQ2_205737_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3785
| Hs_Ensembl = ENSG00000075043
| Hs_RefseqProtein = NP_004509
| Hs_RefseqmRNA = NM_004518
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 61502007
| Hs_GenLoc_end = 61574437
| Hs_Uniprot = O43526
| Mm_EntrezGene = 16536
| Mm_Ensembl = ENSMUSG00000016346
| Mm_RefseqmRNA = NM_001003824
| Mm_RefseqProtein = NP_001003824
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 181004987
| Mm_GenLoc_end = 181064662
| Mm_Uniprot = Q9Z351
}}
}}
'''Potassium voltage-gated channel, KQT-like subfamily, member 2''', also known as '''KCNQ2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3785| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAD2L1... {November 7, 2007 5:53:14 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MAD2L1 image.jpg {November 7, 2007 5:53:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:54:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MAD2L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1duj.
| PDB = {{PDB2|1duj}}, {{PDB2|1go4}}, {{PDB2|1klq}}, {{PDB2|1s2h}}
| Name = MAD2 mitotic arrest deficient-like 1 (yeast)
| HGNCid = 6763
| Symbol = MAD2L1
| AltSymbols =; HSMAD2; MAD2
| OMIM = 601467
| ECnumber =
| Homologene = 1768
| MGIid = 1860374
| GeneAtlas_image1 = PBB_GE_MAD2L1_203362_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005816 |text = spindle pole body}}
| Process = {{GNF_GO|id=GO:0000070 |text = mitotic sister chromatid segregation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007094 |text = mitotic cell cycle spindle assembly checkpoint}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4085
| Hs_Ensembl = ENSG00000164109
| Hs_RefseqProtein = NP_002349
| Hs_RefseqmRNA = NM_002358
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 121200029
| Hs_GenLoc_end = 121207411
| Hs_Uniprot = Q13257
| Mm_EntrezGene = 56150
| Mm_Ensembl = ENSMUSG00000029910
| Mm_RefseqmRNA = NM_019499
| Mm_RefseqProtein = NP_062372
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 66465046
| Mm_GenLoc_end = 66470571
| Mm_Uniprot = Q3TV93
}}
}}
'''MAD2 mitotic arrest deficient-like 1 (yeast)''', also known as '''MAD2L1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.<ref>{{cite web | title = Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4085| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MCM7... {November 7, 2007 5:54:06 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:55:08 PM PST}
- CREATED: Created new protein page: MCM7 {November 7, 2007 5:55:15 PM PST}
- INFO: Beginning work on NEDD4... {November 7, 2007 5:55:15 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:55:53 PM PST}
- CREATED: Created new protein page: NEDD4 {November 7, 2007 5:56:00 PM PST}
- INFO: Beginning work on OPA1... {November 7, 2007 5:56:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:57:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Optic atrophy 1 (autosomal dominant)
| HGNCid = 8140
| Symbol = OPA1
| AltSymbols =; FLJ12460; KIAA0567; NPG; NTG; largeG
| OMIM = 605290
| ECnumber =
| Homologene = 14618
| MGIid = 1921393
| GeneAtlas_image1 = PBB_GE_OPA1_212213_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_OPA1_212214_at_tn.png
| GeneAtlas_image3 = PBB_GE_OPA1_214306_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0005758 |text = mitochondrial intermembrane space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030061 |text = mitochondrial crista}} {{GNF_GO|id=GO:0030425 |text = dendrite}}
| Process = {{GNF_GO|id=GO:0000266 |text = mitochondrial fission}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007007 |text = inner mitochondrial membrane organization and biogenesis}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008053 |text = mitochondrial fusion}} {{GNF_GO|id=GO:0019896 |text = axon transport of mitochondrion}} {{GNF_GO|id=GO:0045768 |text = positive regulation of anti-apoptosis}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4976
| Hs_Ensembl = ENSG00000198836
| Hs_RefseqProtein = NP_056375
| Hs_RefseqmRNA = NM_015560
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 194793806
| Hs_GenLoc_end = 194898009
| Hs_Uniprot = O60313
| Mm_EntrezGene = 74143
| Mm_Ensembl = ENSMUSG00000038084
| Mm_RefseqmRNA = XM_001000561
| Mm_RefseqProtein = XP_001000561
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 29499089
| Mm_GenLoc_end = 29572237
| Mm_Uniprot = P58281
}}
}}
'''Optic atrophy 1 (autosomal dominant)''', also known as '''OPA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Eight transcript variants encoding different isoforms, resulting from alternative splicing of exon 4 and two novel exons named 4b and 5b, have been reported for this gene.<ref>{{cite web | title = Entrez Gene: OPA1 optic atrophy 1 (autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4976| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Olichon A, Guillou E, Delettre C, ''et al.'' |title=Mitochondrial dynamics and disease, OPA1. |journal=Biochim. Biophys. Acta |volume=1763 |issue= 5-6 |pages= 500-9 |year= 2006 |pmid= 16737747 |doi= 10.1016/j.bbamcr.2006.04.003 }}
*{{cite journal | author=Pawlikowska P, Orzechowski A |title=[Role of transmembrane GTPases in mitochondrial morphology and activity] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 53-9 |year= 2007 |pmid= 17718388 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PGF... {November 7, 2007 5:58:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PGF image.jpg {November 7, 2007 5:58:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:59:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PGF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rv6.
| PDB = {{PDB2|1rv6}}
| Name = Placental growth factor, vascular endothelial growth factor-related protein
| HGNCid = 8893
| Symbol = PGF
| AltSymbols =; PLGF; PlGF-2
| OMIM = 601121
| ECnumber =
| Homologene = 1978
| MGIid = 105095
| GeneAtlas_image1 = PBB_GE_PGF_209652_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PGF_215179_x_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5228
| Hs_Ensembl = ENSG00000119630
| Hs_RefseqProtein = NP_002623
| Hs_RefseqmRNA = NM_002632
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 74479162
| Hs_GenLoc_end = 74492220
| Hs_Uniprot = P49763
| Mm_EntrezGene = 18654
| Mm_Ensembl = ENSMUSG00000004791
| Mm_RefseqmRNA = NM_008827
| Mm_RefseqProtein = NP_032853
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 86058457
| Mm_GenLoc_end = 86066066
| Mm_Uniprot = Q544A5
}}
}}
'''Placental growth factor, vascular endothelial growth factor-related protein''', also known as '''PGF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luttun A, Tjwa M, Carmeliet P |title=Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. |journal=Ann. N. Y. Acad. Sci. |volume=979 |issue= |pages= 80-93 |year= 2003 |pmid= 12543719 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PIGR... {November 7, 2007 5:59:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PIGR image.jpg {November 7, 2007 5:59:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:59:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PIGR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xed.
| PDB = {{PDB2|1xed}}, {{PDB2|2ocw}}
| Name = Polymeric immunoglobulin receptor
| HGNCid = 8968
| Symbol = PIGR
| AltSymbols =; MGC125361; MGC125362
| OMIM = 173880
| ECnumber =
| Homologene = 1984
| MGIid = 103080
| GeneAtlas_image1 = PBB_GE_PIGR_204213_at_tn.png
| Function = {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0009306 |text = protein secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5284
| Hs_Ensembl = ENSG00000162896
| Hs_RefseqProtein = NP_002635
| Hs_RefseqmRNA = NM_002644
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 205168486
| Hs_GenLoc_end = 205186434
| Hs_Uniprot = P01833
| Mm_EntrezGene = 18703
| Mm_Ensembl = ENSMUSG00000026417
| Mm_RefseqmRNA = NM_011082
| Mm_RefseqProtein = NP_035212
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 132654297
| Mm_GenLoc_end = 132866011
| Mm_Uniprot = Q8R544
}}
}}
'''Polymeric immunoglobulin receptor''', also known as '''PIGR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PIGR polymeric immunoglobulin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5284| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kaetzel CS |title=The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. |journal=Immunol. Rev. |volume=206 |issue= |pages= 83-99 |year= 2005 |pmid= 16048543 |doi= 10.1111/j.0105-2896.2005.00278.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PLCG2... {November 7, 2007 5:59:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:00:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phospholipase C, gamma 2 (phosphatidylinositol-specific)
| HGNCid = 9066
| Symbol = PLCG2
| AltSymbols =;
| OMIM = 600220
| ECnumber =
| Homologene = 55671
| MGIid = 97616
| GeneAtlas_image1 = PBB_GE_PLCG2_204613_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5336
| Hs_Ensembl = ENSG00000197943
| Hs_RefseqProtein = NP_002652
| Hs_RefseqmRNA = NM_002661
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 80370408
| Hs_GenLoc_end = 80549399
| Hs_Uniprot = P16885
| Mm_EntrezGene = 234779
| Mm_Ensembl = ENSMUSG00000034330
| Mm_RefseqmRNA = NM_172285
| Mm_RefseqProtein = NP_758489
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 120384268
| Mm_GenLoc_end = 120521119
| Mm_Uniprot =
}}
}}
'''Phospholipase C, gamma 2 (phosphatidylinositol-specific)''', also known as '''PLCG2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5336| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fruman DA, Satterthwaite AB, Witte ON |title=Xid-like phenotypes: a B cell signalosome takes shape. |journal=Immunity |volume=13 |issue= 1 |pages= 1-3 |year= 2000 |pmid= 10933389 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PLTP... {November 7, 2007 6:00:27 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:01:09 PM PST}
- CREATED: Created new protein page: PLTP {November 7, 2007 6:01:16 PM PST}
- INFO: Beginning work on PSMD4... {November 7, 2007 6:01:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMD4 image.jpg {November 7, 2007 6:02:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:02:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMD4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p9c.
| PDB = {{PDB2|1p9c}}, {{PDB2|1p9d}}, {{PDB2|1uel}}, {{PDB2|1yx4}}, {{PDB2|1yx5}}, {{PDB2|1yx6}}
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
| HGNCid = 9561
| Symbol = PSMD4
| AltSymbols =; ASF; AF-1; AF; MCB1; Rpn10; S5A; pUB-R5
| OMIM = 601648
| ECnumber =
| Homologene = 55691
| MGIid = 1201670
| GeneAtlas_image1 = PBB_GE_PSMD4_200882_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMD4_210460_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PSMD4_211609_x_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5710
| Hs_Ensembl = ENSG00000159352
| Hs_RefseqProtein = NP_002801
| Hs_RefseqmRNA = NM_002810
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 149493803
| Hs_GenLoc_end = 149506579
| Hs_Uniprot = P55036
| Mm_EntrezGene = 19185
| Mm_Ensembl = ENSMUSG00000005625
| Mm_RefseqmRNA = NM_008951
| Mm_RefseqProtein = NP_032977
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 95118218
| Mm_GenLoc_end = 95122172
| Mm_Uniprot = Q3ULG4
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4''', also known as '''PSMD4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.<ref>{{cite web | title = Entrez Gene: PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5710| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAB5A... {November 7, 2007 6:02:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAB5A image.jpg {November 7, 2007 6:03:43 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:03:53 PM PST}
- CREATED: Created new protein page: RAB5A {November 7, 2007 6:04:00 PM PST}
- INFO: Beginning work on SERPINA5... {November 7, 2007 5:57:15 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SERPINA5 image.jpg {November 7, 2007 5:57:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:58:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINA5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lq8.
| PDB = {{PDB2|1lq8}}, {{PDB2|2hi9}}, {{PDB2|2ol2}}
| Name = Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
| HGNCid = 8723
| Symbol = SERPINA5
| AltSymbols =; PAI3; PCI; PLANH3; PROCI
| OMIM = 601841
| ECnumber =
| Homologene = 20159
| MGIid = 107817
| GeneAtlas_image1 = PBB_GE_SERPINA5_209443_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0032190 |text = acrosin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007342 |text = fusion of sperm to egg plasma membrane}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5104
| Hs_Ensembl = ENSG00000188488
| Hs_RefseqProtein = NP_000615
| Hs_RefseqmRNA = NM_000624
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 94123453
| Hs_GenLoc_end = 94129204
| Hs_Uniprot = P05154
| Mm_EntrezGene = 268591
| Mm_Ensembl = ENSMUSG00000041550
| Mm_RefseqmRNA = NM_172953
| Mm_RefseqProtein = NP_766541
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 104502163
| Mm_GenLoc_end = 104507187
| Mm_Uniprot = Q5BKQ8
}}
}}
'''Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5''', also known as '''SERPINA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Suzuki K, Hayashi T |title=cis-elements required for expression of human protein C inhibitor gene in HepG2 cells and its androgen-dependent expression in rat reproductive organs. |journal=Semin. Thromb. Hemost. |volume=26 |issue= 1 |pages= 75-83 |year= 2000 |pmid= 10805286 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SIRT1... {November 7, 2007 6:05:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:06:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
| HGNCid = 14929
| Symbol = SIRT1
| AltSymbols =; SIR2L1
| OMIM = 604479
| ECnumber =
| Homologene = 56556
| MGIid = 2135607
| GeneAtlas_image1 = PBB_GE_SIRT1_218878_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003950 |text = NAD+ ADP-ribosyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017136 |text = NAD-dependent histone deacetylase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005677 |text = chromatin silencing complex}}
| Process = {{GNF_GO|id=GO:0001542 |text = ovulation (sensu Mammalia)}} {{GNF_GO|id=GO:0006342 |text = chromatin silencing}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007519 |text = striated muscle development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016575 |text = histone deacetylation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23411
| Hs_Ensembl = ENSG00000096717
| Hs_RefseqProtein = NP_036370
| Hs_RefseqmRNA = NM_012238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 69314433
| Hs_GenLoc_end = 69348153
| Hs_Uniprot = Q96EB6
| Mm_EntrezGene = 93759
| Mm_Ensembl = ENSMUSG00000020063
| Mm_RefseqmRNA = XM_975350
| Mm_RefseqProtein = XP_980444
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 62714364
| Mm_GenLoc_end = 62734366
| Mm_Uniprot = Q3USJ2
}}
}}
'''Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)''', also known as '''SIRT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.<ref>{{cite web | title = Entrez Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23411| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPINK1... {November 7, 2007 6:04:57 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SPINK1 image.jpg {November 7, 2007 6:05:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:05:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPINK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cgi.
| PDB = {{PDB2|1cgi}}, {{PDB2|1cgj}}, {{PDB2|1hpt}}
| Name = Serine peptidase inhibitor, Kazal type 1
| HGNCid = 11244
| Symbol = SPINK1
| AltSymbols =; PCTT; PSTI; Spink3; TATI
| OMIM = 167790
| ECnumber =
| Homologene = 68300
| MGIid = 106202
| GeneAtlas_image1 = PBB_GE_SPINK1_206239_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6690
| Hs_Ensembl = ENSG00000164266
| Hs_RefseqProtein = NP_003113
| Hs_RefseqmRNA = NM_003122
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 147184339
| Hs_GenLoc_end = 147191453
| Hs_Uniprot = P00995
| Mm_EntrezGene = 20730
| Mm_Ensembl = ENSMUSG00000024503
| Mm_RefseqmRNA = NM_009258
| Mm_RefseqProtein = NP_033284
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 43853416
| Mm_GenLoc_end = 43862528
| Mm_Uniprot = P09036
}}
}}
'''Serine peptidase inhibitor, Kazal type 1''', also known as '''SPINK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marchbank T, Freeman TC, Playford RJ |title=Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair. |journal=Digestion |volume=59 |issue= 3 |pages= 167-74 |year= 1998 |pmid= 9643675 |doi= }}
*{{cite journal | author=Pfützer RH, Whitcomb DC |title=SPINK1 mutations are associated with multiple phenotypes. |journal=Pancreatology |volume=1 |issue= 5 |pages= 457-60 |year= 2002 |pmid= 12120224 |doi= }}
*{{cite journal | author=Schneider A |title=Serine protease inhibitor kazal type 1 mutations and pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 61-78 |year= 2005 |pmid= 15749232 |doi= 10.1016/j.cll.2004.12.005 }}
*{{cite journal | author=Cohn JA, Mitchell RM, Jowell PS |title=The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 79-100 |year= 2005 |pmid= 15749233 |doi= 10.1016/j.cll.2004.12.007 }}
*{{cite journal | author=Kandula L, Whitcomb DC, Lowe ME |title=Genetic issues in pediatric pancreatitis. |journal=Current gastroenterology reports |volume=8 |issue= 3 |pages= 248-53 |year= 2006 |pmid= 16764792 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
