Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 08:39, 7 November 2007 (UTC)
[edit]Proteins without matches (12)
[edit]Proteins with a High Potential Match (13)
[edit]Manual Inspection (Page not found) (18)
[edit]
Protein Status Grid - Date: 08:39, 7 November 2007 (UTC)
[edit]Vebose Log - Date: 08:39, 7 November 2007 (UTC)
[edit]- INFO: Beginning work on ACTN1... {November 7, 2007 12:12:52 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACTN1 image.jpg {November 7, 2007 12:14:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:14:11 AM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACTN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1sjj.
| PDB = {{PDB2|1sjj}}, {{PDB2|2eyi}}, {{PDB2|2eyn}}
| Name = Actinin, alpha 1
| HGNCid = 163
| Symbol = ACTN1
| AltSymbols =; FLJ40884
| OMIM = 102575
| ECnumber =
| Homologene = 55553
| MGIid = 2137706
| GeneAtlas_image1 = PBB_GE_ACTN1_208636_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACTN1_208637_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ACTN1_211160_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017166 |text = vinculin binding}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0030018 |text = Z disc}} {{GNF_GO|id=GO:0031143 |text = pseudopodium}}
| Process = {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0048041 |text = focal adhesion formation}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}} {{GNF_GO|id=GO:0051271 |text = negative regulation of cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 87
| Hs_Ensembl = ENSG00000072110
| Hs_RefseqProtein = NP_001093
| Hs_RefseqmRNA = NM_001102
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 68410793
| Hs_GenLoc_end = 68515747
| Hs_Uniprot = P12814
| Mm_EntrezGene = 109711
| Mm_Ensembl = ENSMUSG00000015143
| Mm_RefseqmRNA = NM_134156
| Mm_RefseqProtein = NP_598917
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 81086385
| Mm_GenLoc_end = 81179156
| Mm_Uniprot = A1BN54
}}
}}
'''Actinin, alpha 1''', also known as '''ACTN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.<ref>{{cite web | title = Entrez Gene: ACTN1 actinin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=87| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
*{{cite journal | author=Menko S, Philp N, Veneziale B, Walker J |title=Integrins and development: how might these receptors regulate differentiation of the lens. |journal=Ann. N. Y. Acad. Sci. |volume=842 |issue= |pages= 36-41 |year= 1998 |pmid= 9599291 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADAM17... {November 7, 2007 12:31:22 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:32:37 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:32:54 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADAM17_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bkc.
| PDB = {{PDB2|1bkc}}, {{PDB2|1zxc}}, {{PDB2|2a8h}}, {{PDB2|2ddf}}, {{PDB2|2fv5}}, {{PDB2|2fv9}}, {{PDB2|2i47}}
| Name = ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
| HGNCid = 195
| Symbol = ADAM17
| AltSymbols =; CD156b; MGC71942; TACE; cSVP
| OMIM = 603639
| ECnumber =
| Homologene = 2395
| MGIid = 1096335
| GeneAtlas_image1 = PBB_GE_ADAM17_205746_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADAM17_205745_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ADAM17_213532_at_tn.png
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6868
| Hs_Ensembl = ENSG00000151694
| Hs_RefseqProtein = NP_003174
| Hs_RefseqmRNA = NM_003183
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 9546066
| Hs_GenLoc_end = 9613368
| Hs_Uniprot = P78536
| Mm_EntrezGene = 11491
| Mm_Ensembl = ENSMUSG00000052593
| Mm_RefseqmRNA = NM_009615
| Mm_RefseqProtein = NP_033745
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 21569999
| Mm_GenLoc_end = 21620083
| Mm_Uniprot = Q3UEC0
}}
}}
'''ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)''', also known as '''ADAM17''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.<ref>{{cite web | title = Entrez Gene: ADAM17 ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6868| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Black RA |title=Tumor necrosis factor-alpha converting enzyme. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 1 |pages= 1-5 |year= 2002 |pmid= 11733179 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADORA2A... {November 7, 2007 12:14:11 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:14:45 AM PST}
- CREATED: Created new protein page: ADORA2A {November 7, 2007 12:14:51 AM PST}
- INFO: Beginning work on APOC3... {November 7, 2007 12:14:51 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:15:24 AM PST}
- CREATED: Created new protein page: APOC3 {November 7, 2007 12:15:31 AM PST}
- INFO: Beginning work on ARSA... {November 7, 2007 12:15:31 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ARSA image.jpg {November 7, 2007 12:16:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:16:14 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ARSA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1auk.
| PDB = {{PDB2|1auk}}, {{PDB2|1e1z}}, {{PDB2|1e2s}}, {{PDB2|1e33}}, {{PDB2|1e3c}}, {{PDB2|1n2k}}, {{PDB2|1n2l}}
| Name = Arylsulfatase A
| HGNCid = 713
| Symbol = ARSA
| AltSymbols =; MLD
| OMIM = 607574
| ECnumber =
| Homologene = 20138
| MGIid = 88077
| GeneAtlas_image1 = PBB_GE_ARSA_204443_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004065 |text = arylsulfatase activity}} {{GNF_GO|id=GO:0004098 |text = cerebroside-sulfatase activity}} {{GNF_GO|id=GO:0008484 |text = sulfuric ester hydrolase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000299 |text = integral to membrane of membrane fraction}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007339 |text = binding of sperm to zona pellucida}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 410
| Hs_Ensembl = ENSG00000100299
| Hs_RefseqProtein = NP_000478
| Hs_RefseqmRNA = NM_000487
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 49410316
| Hs_GenLoc_end = 49413442
| Hs_Uniprot = P15289
| Mm_EntrezGene = 11883
| Mm_Ensembl = ENSMUSG00000022620
| Mm_RefseqmRNA = NM_009713
| Mm_RefseqProtein = NP_033843
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 89300257
| Mm_GenLoc_end = 89305192
| Mm_Uniprot = Q9DC66
}}
}}
'''Arylsulfatase A''', also known as '''ARSA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene.<ref>{{cite web | title = Entrez Gene: ARSA arylsulfatase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=410| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Narahara K, Takahashi Y, Murakami M, ''et al.'' |title=Terminal 22q deletion associated with a partial deficiency of arylsulphatase A. |journal=J. Med. Genet. |volume=29 |issue= 6 |pages= 432-3 |year= 1992 |pmid= 1352356 |doi= }}
*{{cite journal | author=Gieselmann V, Zlotogora J, Harris A, ''et al.'' |title=Molecular genetics of metachromatic leukodystrophy. |journal=Hum. Mutat. |volume=4 |issue= 4 |pages= 233-42 |year= 1995 |pmid= 7866401 |doi= 10.1002/humu.1380040402 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AVPR2... {November 7, 2007 12:16:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:17:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)
| HGNCid = 897
| Symbol = AVPR2
| AltSymbols =; ADHR; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; V2R
| OMIM = 300538
| ECnumber =
| Homologene = 20064
| MGIid = 88123
| GeneAtlas_image1 = PBB_GE_AVPR2_208111_at_tn.png
| GeneAtlas_image2 = PBB_GE_AVPR2_208108_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0007599 |text = hemostasis}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 554
| Hs_Ensembl = ENSG00000126895
| Hs_RefseqProtein = NP_000045
| Hs_RefseqmRNA = NM_000054
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152823383
| Hs_GenLoc_end = 152825834
| Hs_Uniprot = P30518
| Mm_EntrezGene = 12000
| Mm_Ensembl = ENSMUSG00000031390
| Mm_RefseqmRNA = NM_019404
| Mm_RefseqProtein = NP_062277
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70126278
| Mm_GenLoc_end = 70147147
| Mm_Uniprot = Q3KNZ4
}}
}}
'''Arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)''', also known as '''AVPR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The human AVPR2 locus encodes the vasopressin receptor, type 2, also known as the V2 receptor, located in cytogenetic band Xq28. The gene's three exons and two introns are contained within 2.1 kilobases. The L1CAM gene lies some 29 kb centromeric to AVPR2, and the C1 gene immediately teleomeric. Both are apparently transcribed in opposite orientation to AVPR2 (see NID g1302657). The AVPR2 protein product belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and it couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.<ref>{{cite web | title = Entrez Gene: AVPR2 arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=554| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Birnbaumer M |title=The V2 vasopressin receptor mutations and fluid homeostasis. |journal=Cardiovasc. Res. |volume=51 |issue= 3 |pages= 409-15 |year= 2001 |pmid= 11476731 |doi= }}
*{{cite journal | author=Ishikawa SE |title=[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2] |journal=Nippon Rinsho |volume=60 |issue= 2 |pages= 350-5 |year= 2002 |pmid= 11857925 |doi= }}
*{{cite journal | author=Thibonnier M, Coles P, Thibonnier A, Shoham M |title=Molecular pharmacology and modeling of vasopressin receptors. |journal=Prog. Brain Res. |volume=139 |issue= |pages= 179-96 |year= 2002 |pmid= 12436935 |doi= }}
*{{cite journal | author=Bichet DG |title=Nephrogenic diabetes insipidus. |journal=Advances in chronic kidney disease |volume=13 |issue= 2 |pages= 96-104 |year= 2006 |pmid= 16580609 |doi= 10.1053/j.ackd.2006.01.006 }}
*{{cite journal | author=Robben JH, Knoers NV, Deen PM |title=Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F257-70 |year= 2006 |pmid= 16825342 |doi= 10.1152/ajprenal.00491.2005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAMP... {November 7, 2007 12:17:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:17:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cathelicidin antimicrobial peptide
| HGNCid = 1472
| Symbol = CAMP
| AltSymbols =; CAP18; FALL-39; FALL39; HSD26; LL37
| OMIM = 600474
| ECnumber =
| Homologene = 3206
| MGIid = 108443
| GeneAtlas_image1 = PBB_GE_CAMP_210244_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 820
| Hs_Ensembl = ENSG00000164047
| Hs_RefseqProtein = NP_004336
| Hs_RefseqmRNA = NM_004345
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 48239866
| Hs_GenLoc_end = 48241979
| Hs_Uniprot = P49913
| Mm_EntrezGene = 12796
| Mm_Ensembl = ENSMUSG00000038357
| Mm_RefseqmRNA = NM_009921
| Mm_RefseqProtein = NP_034051
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 109704793
| Mm_GenLoc_end = 109706855
| Mm_Uniprot = Q0VB78
}}
}}
'''Cathelicidin antimicrobial peptide''', also known as '''CAMP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cathelicidin antimicrobial protein is an antimicrobial protein found in specific granules of polymorphonuclear leukocytes (PMNs).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CAMP cathelicidin antimicrobial peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=820| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lehrer RI, Ganz T |title=Cathelicidins: a family of endogenous antimicrobial peptides. |journal=Curr. Opin. Hematol. |volume=9 |issue= 1 |pages= 18-22 |year= 2002 |pmid= 11753073 |doi= }}
*{{cite journal | author=Niyonsaba F, Hirata M, Ogawa H, Nagaoka I |title=Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. |journal=Current drug targets. Inflammation and allergy |volume=2 |issue= 3 |pages= 224-31 |year= 2003 |pmid= 14561157 |doi= }}
*{{cite journal | author=van Wetering S, Tjabringa GS, Hiemstra PS |title=Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells. |journal=J. Leukoc. Biol. |volume=77 |issue= 4 |pages= 444-50 |year= 2005 |pmid= 15591123 |doi= 10.1189/jlb.0604367 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD9... {November 7, 2007 12:17:52 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:18:38 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD9 molecule
| HGNCid = 1709
| Symbol = CD9
| AltSymbols =; 5H9; BA2; BTCC-1; DRAP-27; GIG2; MIC3; MRP-1; P24; TSPAN29
| OMIM = 143030
| ECnumber =
| Homologene = 20420
| MGIid = 88348
| GeneAtlas_image1 = PBB_GE_CD9_201005_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007342 |text = fusion of sperm to egg plasma membrane}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030913 |text = paranodal junction assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 928
| Hs_Ensembl = ENSG00000010278
| Hs_RefseqProtein = NP_001760
| Hs_RefseqmRNA = NM_001769
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 6179134
| Hs_GenLoc_end = 6217686
| Hs_Uniprot = P21926
| Mm_EntrezGene = 12527
| Mm_Ensembl = ENSMUSG00000030342
| Mm_RefseqmRNA = NM_007657
| Mm_RefseqProtein = NP_031683
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 125425885
| Mm_GenLoc_end = 125460379
| Mm_Uniprot = P40240
}}
}}
'''CD9 molecule''', also known as '''CD9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.<ref>{{cite web | title = Entrez Gene: CD9 CD9 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=928| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1-4 |year= 1991 |pmid= 1879540 |doi= }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHRNA7... {November 7, 2007 12:18:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:18:51 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 7
| HGNCid = 1960
| Symbol = CHRNA7
| AltSymbols =; NACHRA7
| OMIM = 118511
| ECnumber =
| Homologene = 593
| MGIid = 99779
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1139
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001127577
| Hs_RefseqmRNA = XM_001127577
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 11441
| Mm_Ensembl = ENSMUSG00000030525
| Mm_RefseqmRNA = NM_007390
| Mm_RefseqProtein = NP_031416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 62977642
| Mm_GenLoc_end = 63091519
| Mm_Uniprot = Q53YJ9
}}
}}
'''Cholinergic receptor, nicotinic, alpha 7''', also known as '''CHRNA7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.<ref>{{cite web | title = Entrez Gene: CHRNA7 cholinergic receptor, nicotinic, alpha 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1139| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Green WN, Millar NS |title=Ion-channel assembly. |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280-7 |year= 1995 |pmid= 7571003 |doi= }}
*{{cite journal | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue= |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal | author=Gallowitsch-Puerta M, Tracey KJ |title=Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor. |journal=Ann. N. Y. Acad. Sci. |volume=1062 |issue= |pages= 209-19 |year= 2006 |pmid= 16461803 |doi= 10.1196/annals.1358.024 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CR1... {November 7, 2007 12:18:51 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CR1 image.jpg {November 7, 2007 12:20:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:20:17 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gkg.
| PDB = {{PDB2|1gkg}}, {{PDB2|1gkn}}, {{PDB2|1ppq}}
| Name = Complement component (3b/4b) receptor 1 (Knops blood group)
| HGNCid = 2334
| Symbol = CR1
| AltSymbols =; C3BR; CD35; KN
| OMIM = 120620
| ECnumber =
| Homologene = 55474
| MGIid =
| GeneAtlas_image1 = PBB_GE_CR1_206244_at_tn.png
| GeneAtlas_image2 = PBB_GE_CR1_208488_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CR1_217552_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004877 |text = complement component C3b receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1378
| Hs_Ensembl = ENSG00000203710
| Hs_RefseqProtein = XP_001126036
| Hs_RefseqmRNA = XM_001126036
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 205736125
| Hs_GenLoc_end = 205880615
| Hs_Uniprot = P17927
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement component (3b/4b) receptor 1 (Knops blood group)''', also known as '''CR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.<ref>{{cite web | title = Entrez Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1378| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ahearn JM, Fearon DT |title=Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). |journal=Adv. Immunol. |volume=46 |issue= |pages= 183-219 |year= 1989 |pmid= 2551147 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRKL... {November 7, 2007 12:20:18 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CRKL image.jpg {November 7, 2007 12:20:50 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:20:58 AM PST}
- CREATED: Created new protein page: CRKL {November 7, 2007 12:21:05 AM PST}
- INFO: Beginning work on DLG1... {November 7, 2007 12:21:05 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DLG1 image.jpg {November 7, 2007 12:22:34 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:22:52 AM PST}
- CREATED: Created new protein page: DLG1 {November 7, 2007 12:22:59 AM PST}
- INFO: Beginning work on ETV6... {November 7, 2007 12:22:59 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ETV6 image.jpg {November 7, 2007 12:23:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:23:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ETV6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ji7.
| PDB = {{PDB2|1ji7}}, {{PDB2|1lky}}, {{PDB2|2dao}}
| Name = Ets variant gene 6 (TEL oncogene)
| HGNCid = 3495
| Symbol = ETV6
| AltSymbols =; TEL; TEL/ABL
| OMIM = 600618
| ECnumber =
| Homologene = 37560
| MGIid = 109336
| GeneAtlas_image1 = PBB_GE_ETV6_205585_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2120
| Hs_Ensembl = ENSG00000139083
| Hs_RefseqProtein = NP_001978
| Hs_RefseqmRNA = NM_001987
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 11694055
| Hs_GenLoc_end = 11939588
| Hs_Uniprot = P41212
| Mm_EntrezGene = 14011
| Mm_Ensembl = ENSMUSG00000030199
| Mm_RefseqmRNA = NM_007961
| Mm_RefseqProtein = NP_031987
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 134091327
| Mm_GenLoc_end = 134235851
| Mm_Uniprot = Q3U037
}}
}}
'''Ets variant gene 6 (TEL oncogene)''', also known as '''ETV6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.<ref>{{cite web | title = Entrez Gene: ETV6 ets variant gene 6 (TEL oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2120| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Keung YK, Beaty M, Steward W, ''et al.'' |title=Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature. |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 2 |pages= 139-42 |year= 2003 |pmid= 12505259 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRIN2A... {November 7, 2007 12:23:49 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GRIN2A image.jpg {November 7, 2007 12:24:20 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:24:33 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRIN2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2a5s.
| PDB = {{PDB2|2a5s}}, {{PDB2|2a5t}}
| Name = Glutamate receptor, ionotropic, N-methyl D-aspartate 2A
| HGNCid = 4585
| Symbol = GRIN2A
| AltSymbols =; NMDAR2A; NR2A
| OMIM = 138253
| ECnumber =
| Homologene = 645
| MGIid = 95820
| GeneAtlas_image1 = PBB_GE_GRIN2A_206534_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004970 |text = ionotropic glutamate receptor activity}} {{GNF_GO|id=GO:0004972 |text = N-methyl-D-aspartate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042734 |text = presynaptic membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007215 |text = glutamate signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0048167 |text = regulation of synaptic plasticity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2903
| Hs_Ensembl = ENSG00000183454
| Hs_RefseqProtein = NP_000824
| Hs_RefseqmRNA = NM_000833
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 9764507
| Hs_GenLoc_end = 10181769
| Hs_Uniprot = Q12879
| Mm_EntrezGene = 14811
| Mm_Ensembl = ENSMUSG00000059003
| Mm_RefseqmRNA = XM_988553
| Mm_RefseqProtein = XP_993647
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 9491382
| Mm_GenLoc_end = 9906111
| Mm_Uniprot = P35436
}}
}}
'''Glutamate receptor, ionotropic, N-methyl D-aspartate 2A''', also known as '''GRIN2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).<ref>{{cite web | title = Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2903| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL5... {November 7, 2007 12:24:33 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL5 image.jpg {November 7, 2007 12:25:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:25:17 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hul.
| PDB = {{PDB2|1hul}}
| Name = Interleukin 5 (colony-stimulating factor, eosinophil)
| HGNCid = 6016
| Symbol = IL5
| AltSymbols =; EDF; IL-5; TRF
| OMIM = 147850
| ECnumber =
| Homologene = 679
| MGIid = 96557
| GeneAtlas_image1 = PBB_GE_IL5_207952_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005137 |text = interleukin-5 receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3567
| Hs_Ensembl = ENSG00000113525
| Hs_RefseqProtein = NP_000870
| Hs_RefseqmRNA = NM_000879
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 131905035
| Hs_GenLoc_end = 131907113
| Hs_Uniprot = P05113
| Mm_EntrezGene = 16191
| Mm_Ensembl = ENSMUSG00000036117
| Mm_RefseqmRNA = NM_010558
| Mm_RefseqProtein = NP_034688
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53564217
| Mm_GenLoc_end = 53568526
| Mm_Uniprot = Q05A89
}}
}}
'''Interleukin 5 (colony-stimulating factor, eosinophil)''', also known as '''IL5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.<ref>{{cite web | title = Entrez Gene: IL5 interleukin 5 (colony-stimulating factor, eosinophil)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3567| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Broide DH, Hoffman H, Sriramarao P |title=Genes that regulate eosinophilic inflammation. |journal=Am. J. Hum. Genet. |volume=65 |issue= 2 |pages= 302-7 |year= 1999 |pmid= 10417272 |doi= }}
*{{cite journal | author=Martinez-Moczygemba M, Huston DP |title=Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. |journal=J. Allergy Clin. Immunol. |volume=112 |issue= 4 |pages= 653-65; quiz 666 |year= 2003 |pmid= 14564341 |doi= 10.1016/S0091 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL8RA... {November 7, 2007 12:25:17 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:26:10 AM PST}
- CREATED: Created new protein page: IL8RA {November 7, 2007 12:26:16 AM PST}
- INFO: Beginning work on INHA... {November 7, 2007 12:26:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:26:46 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibin, alpha
| HGNCid = 6065
| Symbol = INHA
| AltSymbols =;
| OMIM = 147380
| ECnumber =
| Homologene = 1652
| MGIid = 96569
| GeneAtlas_image1 = PBB_GE_INHA_210141_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0017106 |text = activin inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0043512 |text = inhibin A complex}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009605 |text = response to external stimulus}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042326 |text = negative regulation of phosphorylation}} {{GNF_GO|id=GO:0042541 |text = hemoglobin biosynthetic process}} {{GNF_GO|id=GO:0045077 |text = negative regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0045578 |text = negative regulation of B cell differentiation}} {{GNF_GO|id=GO:0045650 |text = negative regulation of macrophage differentiation}} {{GNF_GO|id=GO:0046881 |text = positive regulation of follicle-stimulating hormone secretion}} {{GNF_GO|id=GO:0046882 |text = negative regulation of follicle-stimulating hormone secretion}} {{GNF_GO|id=GO:0051726 |text = regulation of cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3623
| Hs_Ensembl = ENSG00000123999
| Hs_RefseqProtein = NP_002182
| Hs_RefseqmRNA = NM_002191
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 220145161
| Hs_GenLoc_end = 220148679
| Hs_Uniprot = P05111
| Mm_EntrezGene = 16322
| Mm_Ensembl = ENSMUSG00000032968
| Mm_RefseqmRNA = NM_010564
| Mm_RefseqProtein = NP_034694
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 75390225
| Mm_GenLoc_end = 75393502
| Mm_Uniprot = Q6GTG7
}}
}}
'''Inhibin, alpha''', also known as '''INHA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.<ref>{{cite web | title = Entrez Gene: INHA inhibin, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3623| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mellor SL, Richards MG, Pedersen JS, ''et al.'' |title=Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 3 |pages= 969-75 |year= 1998 |pmid= 9506758 |doi= }}
*{{cite journal | author=Munz B, Hübner G, Tretter Y, ''et al.'' |title=A novel role of activin in inflammation and repair. |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187-93 |year= 1999 |pmid= 10320815 |doi= }}
*{{cite journal | author=Welt C, Sidis Y, Keutmann H, Schneyer A |title=Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 9 |pages= 724-52 |year= 2002 |pmid= 12324653 |doi= }}
*{{cite journal | author=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis. |journal=Stem Cells |volume=20 |issue= 6 |pages= 493-500 |year= 2003 |pmid= 12456957 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT5... {November 7, 2007 12:26:46 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:27:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)
| HGNCid = 6442
| Symbol = KRT5
| AltSymbols =; CK5; DDD; EBS2; K5; KRT5A
| OMIM = 148040
| ECnumber =
| Homologene = 55461
| MGIid = 96702
| GeneAtlas_image1 = PBB_GE_KRT5_201820_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3852
| Hs_Ensembl = ENSG00000186081
| Hs_RefseqProtein = NP_000415
| Hs_RefseqmRNA = NM_000424
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 51194628
| Hs_GenLoc_end = 51200347
| Hs_Uniprot = P13647
| Mm_EntrezGene = 110308
| Mm_Ensembl = ENSMUSG00000061527
| Mm_RefseqmRNA = NM_027011
| Mm_RefseqProtein = NP_081287
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101535104
| Mm_GenLoc_end = 101540925
| Mm_Uniprot = Q32P04
}}
}}
'''Keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)''', also known as '''KRT5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.<ref>{{cite web | title = Entrez Gene: KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3852| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schuilenga-Hut PH, Vlies P, Jonkman MF, ''et al.'' |title=Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations. |journal=Hum. Mutat. |volume=21 |issue= 4 |pages= 447 |year= 2003 |pmid= 12655565 |doi= 10.1002/humu.9124 }}
*{{cite journal | author=Seibert JA, Boone JM |title=X-ray imaging physics for nuclear medicine technologists. Part 2: X-ray interactions and image formation. |journal=Journal of nuclear medicine technology |volume=33 |issue= 1 |pages= 3-18 |year= 2005 |pmid= 15731015 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCOR2... {November 7, 2007 12:35:23 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCOR2 image.jpg {November 7, 2007 12:36:51 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:37:13 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCOR2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xc5.
| PDB = {{PDB2|1xc5}}
| Name = Nuclear receptor co-repressor 2
| HGNCid = 7673
| Symbol = NCOR2
| AltSymbols =; CTG26; TNRC14; TRAC1; SMRT; SMRTE; SMRTE-tau; TRAC-1
| OMIM = 600848
| ECnumber =
| Homologene = 31370
| MGIid = 1337080
| GeneAtlas_image1 = PBB_GE_NCOR2_207760_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOR2_208888_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOR2_208889_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9612
| Hs_Ensembl = ENSG00000196498
| Hs_RefseqProtein = NP_001070729
| Hs_RefseqmRNA = NM_001077261
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 123374915
| Hs_GenLoc_end = 123545750
| Hs_Uniprot = Q9Y618
| Mm_EntrezGene = 20602
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011424
| Mm_RefseqProtein = NP_035554
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nuclear receptor co-repressor 2''', also known as '''NCOR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OTC... {November 7, 2007 12:27:23 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein OTC image.jpg {November 7, 2007 12:27:57 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:28:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OTC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c9y.
| PDB = {{PDB2|1c9y}}, {{PDB2|1ep9}}, {{PDB2|1fb5}}, {{PDB2|1fvo}}, {{PDB2|1oth}}
| Name = Ornithine carbamoyltransferase
| HGNCid = 8512
| Symbol = OTC
| AltSymbols =; OCTD; MGC129967; MGC129968; MGC138856
| OMIM = 300461
| ECnumber =
| Homologene = 446
| MGIid = 97448
| GeneAtlas_image1 = PBB_GE_OTC_207200_at_tn.png
| Function = {{GNF_GO|id=GO:0004585 |text = ornithine carbamoyltransferase activity}} {{GNF_GO|id=GO:0016597 |text = amino acid binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0005759 |text = mitochondrial matrix}} {{GNF_GO|id=GO:0009348 |text = ornithine carbamoyltransferase complex}}
| Process = {{GNF_GO|id=GO:0000050 |text = urea cycle}} {{GNF_GO|id=GO:0006526 |text = arginine biosynthetic process}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5009
| Hs_Ensembl = ENSG00000036473
| Hs_RefseqProtein = NP_000522
| Hs_RefseqmRNA = NM_000531
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 38096302
| Hs_GenLoc_end = 38165553
| Hs_Uniprot = P00480
| Mm_EntrezGene = 18416
| Mm_Ensembl = ENSMUSG00000031173
| Mm_RefseqmRNA = NM_008769
| Mm_RefseqProtein = NP_032795
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 9409318
| Mm_GenLoc_end = 9477983
| Mm_Uniprot = Q543H3
}}
}}
'''Ornithine carbamoyltransferase''', also known as '''OTC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.<ref>{{cite web | title = Entrez Gene: OTC ornithine carbamoyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5009| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tuchman M, Plante RJ |title=Mutations and polymorphisms in the human ornithine transcarbamylase gene: mutation update addendum. |journal=Hum. Mutat. |volume=5 |issue= 4 |pages= 293-5 |year= 1995 |pmid= 7627182 |doi= 10.1002/humu.1380050404 }}
*{{cite journal | author=Tuchman M |title=Mutations and polymorphisms in the human ornithine transcarbamylase gene. |journal=Hum. Mutat. |volume=2 |issue= 3 |pages= 174-8 |year= 1993 |pmid= 8364586 |doi= 10.1002/humu.1380020304 }}
*{{cite journal | author=Matsuda I, Tanase S |title=The ornithine transcarbamylase (OTC) gene: mutations in 50 Japanese families with OTC deficiency. |journal=Am. J. Med. Genet. |volume=71 |issue= 4 |pages= 378-83 |year= 1997 |pmid= 9286441 |doi= }}
*{{cite journal | author=Wakabayashi Y |title=Tissue-selective expression of enzymes of arginine synthesis. |journal=Current opinion in clinical nutrition and metabolic care |volume=1 |issue= 4 |pages= 335-9 |year= 1999 |pmid= 10565370 |doi= }}
*{{cite journal | author=Tuchman M, Jaleel N, Morizono H, ''et al.'' |title=Mutations and polymorphisms in the human ornithine transcarbamylase gene. |journal=Hum. Mutat. |volume=19 |issue= 2 |pages= 93-107 |year= 2002 |pmid= 11793468 |doi= 10.1002/humu.10035 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POU2F1... {November 7, 2007 12:28:16 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POU2F1 image.jpg {November 7, 2007 12:29:00 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:29:12 AM PST}
- CREATED: Created new protein page: POU2F1 {November 7, 2007 12:29:18 AM PST}
- INFO: Beginning work on PRKAR2A... {November 7, 2007 12:29:18 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRKAR2A image.jpg {November 7, 2007 12:30:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:30:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKAR2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1l6e.
| PDB = {{PDB2|1l6e}}, {{PDB2|1r2a}}, {{PDB2|2drn}}, {{PDB2|2h9r}}, {{PDB2|2hwn}}, {{PDB2|2izx}}, {{PDB2|2izy}}
| Name = Protein kinase, cAMP-dependent, regulatory, type II, alpha
| HGNCid = 9391
| Symbol = PRKAR2A
| AltSymbols =; MGC3606; PKR2; PRKAR2
| OMIM = 176910
| ECnumber =
| Homologene = 3064
| MGIid = 108025
| GeneAtlas_image1 = PBB_GE_PRKAR2A_204842_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKAR2A_204843_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRKAR2A_213052_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0030552 |text = cAMP binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5576
| Hs_Ensembl = ENSG00000114302
| Hs_RefseqProtein = NP_004148
| Hs_RefseqmRNA = NM_004157
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 48762099
| Hs_GenLoc_end = 48860274
| Hs_Uniprot = P13861
| Mm_EntrezGene = 19087
| Mm_Ensembl = ENSMUSG00000032601
| Mm_RefseqmRNA = NM_008924
| Mm_RefseqProtein = NP_032950
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 108549547
| Mm_GenLoc_end = 108606747
| Mm_Uniprot = Q8K1M3
}}
}}
'''Protein kinase, cAMP-dependent, regulatory, type II, alpha''', also known as '''PRKAR2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).<ref>{{cite web | title = Entrez Gene: PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5576| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cho-Chung YS, Nesterova MV |title=Tumor reversion: protein kinase A isozyme switching. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 76-86 |year= 2006 |pmid= 16394127 |doi= 10.1196/annals.1359.014 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTH... {November 7, 2007 12:30:41 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PTH image.jpg {November 7, 2007 12:31:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:31:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bwx.
| PDB = {{PDB2|1bwx}}, {{PDB2|1et1}}, {{PDB2|1fvy}}, {{PDB2|1hph}}, {{PDB2|1hpy}}, {{PDB2|1zwa}}, {{PDB2|1zwb}}, {{PDB2|1zwc}}, {{PDB2|1zwd}}, {{PDB2|1zwe}}, {{PDB2|1zwf}}, {{PDB2|1zwg}}
| Name = Parathyroid hormone
| HGNCid = 9606
| Symbol = PTH
| AltSymbols =;
| OMIM = 168450
| ECnumber =
| Homologene = 266
| MGIid = 97799
| GeneAtlas_image1 = PBB_GE_PTH_206977_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0008628 |text = induction of apoptosis by hormones}} {{GNF_GO|id=GO:0045453 |text = bone resorption}} {{GNF_GO|id=GO:0046058 |text = cAMP metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5741
| Hs_Ensembl = ENSG00000152266
| Hs_RefseqProtein = NP_000306
| Hs_RefseqmRNA = NM_000315
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 13470178
| Hs_GenLoc_end = 13474143
| Hs_Uniprot = P01270
| Mm_EntrezGene = 19226
| Mm_Ensembl = ENSMUSG00000059077
| Mm_RefseqmRNA = NM_020623
| Mm_RefseqProtein = NP_065648
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 113176759
| Mm_GenLoc_end = 113179753
| Mm_Uniprot =
}}
}}
'''Parathyroid hormone''', also known as '''PTH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH).<ref>{{cite web | title = Entrez Gene: PTH parathyroid hormone| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5741| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Drüeke TB, Massy ZA |title=Advanced oxidation protein products, parathyroid hormone and vascular calcification in uremia. |journal=Blood Purif. |volume=20 |issue= 5 |pages= 494-7 |year= 2003 |pmid= 12207101 |doi= }}
*{{cite journal | author=Parfitt AM |title=Parathyroid hormone and periosteal bone expansion. |journal=J. Bone Miner. Res. |volume=17 |issue= 10 |pages= 1741-3 |year= 2003 |pmid= 12369776 |doi= }}
*{{cite journal | author=Martin TJ |title=Does bone resorption inhibition affect the anabolic response to parathyroid hormone? |journal=Trends Endocrinol. Metab. |volume=15 |issue= 2 |pages= 49-50 |year= 2004 |pmid= 15080150 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on THRA... {November 7, 2007 12:32:54 AM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 12:33:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:34:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THRA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nav.
| PDB = {{PDB2|1nav}}, {{PDB2|2h77}}, {{PDB2|2h79}}
| Name = Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
| HGNCid = 11796
| Symbol = THRA
| AltSymbols =; AR7; EAR7; ERB-T-1; ERBA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; c-ERBA-1
| OMIM = 190120
| ECnumber =
| Homologene = 37747
| MGIid = 98742
| GeneAtlas_image1 = PBB_GE_THRA_35846_at_tn.png
| GeneAtlas_image2 = PBB_GE_THRA_204100_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7067
| Hs_Ensembl = ENSG00000126351
| Hs_RefseqProtein = NP_003241
| Hs_RefseqmRNA = NM_003250
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35472686
| Hs_GenLoc_end = 35503644
| Hs_Uniprot = P10827
| Mm_EntrezGene = 21833
| Mm_Ensembl = ENSMUSG00000058756
| Mm_RefseqmRNA = XM_994382
| Mm_RefseqProtein = XP_999476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98557963
| Mm_GenLoc_end = 98585094
| Mm_Uniprot = Q80Y90
}}
}}
'''Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)''', also known as '''THRA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7067| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Forrest D, Reh TA, Rüsch A |title=Neurodevelopmental control by thyroid hormone receptors. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 1 |pages= 49-56 |year= 2002 |pmid= 11861164 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TJP1... {November 7, 2007 12:34:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TJP1 image.jpg {November 7, 2007 12:35:03 AM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 12:35:17 AM PST}
- CREATED: Created new protein page: TJP1 {November 7, 2007 12:35:23 AM PST}
end log.
