Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 07:14, 7 November 2007 (UTC)[edit]
Proteins without matches (14)[edit]
Proteins with a High Potential Match (11)[edit]
Created (4)[edit]
Manual Inspection (Page not found) (21)[edit]
Protein Status Grid - Date: 07:14, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 07:14, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on AKT2... {November 6, 2007 10:49:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AKT2 image.jpg {November 6, 2007 10:50:17 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 10:50:33 PM PST}
- CREATED: Created new protein page: AKT2 {November 6, 2007 10:50:40 PM PST}
- INFO: Beginning work on CANX... {November 6, 2007 10:50:40 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CANX image.jpg {November 6, 2007 10:51:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:51:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CANX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jhn.
| PDB = {{PDB2|1jhn}}
| Name = Calnexin
| HGNCid = 1473
| Symbol = CANX
| AltSymbols =; CNX; FLJ26570; IP90; P90
| OMIM = 114217
| ECnumber =
| Homologene = 1324
| MGIid = 88261
| GeneAtlas_image1 = PBB_GE_CANX_208852_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CANX_208853_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0009306 |text = protein secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 821
| Hs_Ensembl = ENSG00000127022
| Hs_RefseqProtein = NP_001019820
| Hs_RefseqmRNA = NM_001024649
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 179058536
| Hs_GenLoc_end = 179091243
| Hs_Uniprot = P27824
| Mm_EntrezGene = 12330
| Mm_Ensembl = ENSMUSG00000020368
| Mm_RefseqmRNA = NM_007597
| Mm_RefseqProtein = NP_031623
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 50137886
| Mm_GenLoc_end = 50169014
| Mm_Uniprot = Q3TXE5
}}
}}
'''Calnexin''', also known as '''CANX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.<ref>{{cite web | title = Entrez Gene: CANX calnexin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=821| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kleizen B, Braakman I |title=Protein folding and quality control in the endoplasmic reticulum. |journal=Curr. Opin. Cell Biol. |volume=16 |issue= 4 |pages= 343-9 |year= 2005 |pmid= 15261665 |doi= 10.1016/j.ceb.2004.06.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCL4... {November 6, 2007 11:06:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCL4 image.jpg {November 6, 2007 11:06:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:07:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCL4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hum.
| PDB = {{PDB2|1hum}}, {{PDB2|1hun}}, {{PDB2|1je4}}, {{PDB2|2ffk}}, {{PDB2|2fin}}
| Name = Chemokine (C-C motif) ligand 4
| HGNCid = 10630
| Symbol = CCL4
| AltSymbols =; SCYA2; ACT2; AT744.1; G-26; LAG1; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP1B; SCYA4
| OMIM = 182284
| ECnumber =
| Homologene = 48153
| MGIid = 98261
| GeneAtlas_image1 = PBB_GE_CCL4_204103_at_tn.png
| Function = {{GNF_GO|id=GO:0004716 |text = receptor signaling protein tyrosine kinase activity}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007163 |text = establishment and/or maintenance of cell polarity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6351
| Hs_Ensembl = ENSG00000129277
| Hs_RefseqProtein = NP_002975
| Hs_RefseqmRNA = NM_002984
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 31455333
| Hs_GenLoc_end = 31457127
| Hs_Uniprot = P13236
| Mm_EntrezGene = 20303
| Mm_Ensembl = ENSMUSG00000018930
| Mm_RefseqmRNA = NM_013652
| Mm_RefseqProtein = NP_038680
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 83478782
| Mm_GenLoc_end = 83480875
| Mm_Uniprot = Q5QNV9
}}
}}
'''Chemokine (C-C motif) ligand 4''', also known as '''CCL4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Menten P, Wuyts A, Van Damme J |title=Macrophage inflammatory protein-1. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 6 |pages= 455-81 |year= 2003 |pmid= 12401480 |doi= }}
*{{cite journal | author=Muthumani K, Desai BM, Hwang DS, ''et al.'' |title=HIV-1 Vpr and anti-inflammatory activity. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 239-47 |year= 2004 |pmid= 15142381 |doi= 10.1089/104454904773819824 }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL4A5... {November 6, 2007 10:51:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:52:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 5 (Alport syndrome)
| HGNCid = 2207
| Symbol = COL4A5
| AltSymbols =; ASLN; ATS; CA54; MGC42377
| OMIM = 303630
| ECnumber =
| Homologene = 22422
| MGIid = 88456
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1287
| Hs_Ensembl = ENSG00000188153
| Hs_RefseqProtein = NP_000486
| Hs_RefseqmRNA = NM_000495
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 107569810
| Hs_GenLoc_end = 107827431
| Hs_Uniprot = P29400
| Mm_EntrezGene = 12830
| Mm_Ensembl = ENSMUSG00000031274
| Mm_RefseqmRNA = XM_623033
| Mm_RefseqProtein = XP_623033
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 136721787
| Mm_GenLoc_end = 136935548
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 5 (Alport syndrome)''', also known as '''COL4A5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Three transcript variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: COL4A5 collagen, type IV, alpha 5 (Alport syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1287| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lemmink HH, Schröder CH, Monnens LA, Smeets HJ |title=The clinical spectrum of type IV collagen mutations. |journal=Hum. Mutat. |volume=9 |issue= 6 |pages= 477-99 |year= 1997 |pmid= 9195222 |doi= 10.1002/(SICI)1098-1004(1997)9:6<477::AID-HUMU1>3.0.CO;2-# }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL7A1... {November 6, 2007 10:52:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:52:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)
| HGNCid = 2214
| Symbol = COL7A1
| AltSymbols =; EBD1; EBDCT; EBR1
| OMIM = 120120
| ECnumber =
| Homologene = 73
| MGIid = 88462
| GeneAtlas_image1 = PBB_GE_COL7A1_204136_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL7A1_217312_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005590 |text = collagen type VII}} {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1294
| Hs_Ensembl = ENSG00000114270
| Hs_RefseqProtein = NP_000085
| Hs_RefseqmRNA = NM_000094
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 48576510
| Hs_GenLoc_end = 48607704
| Hs_Uniprot = Q02388
| Mm_EntrezGene = 12836
| Mm_Ensembl = ENSMUSG00000025650
| Mm_RefseqmRNA = NM_007738
| Mm_RefseqProtein = NP_031764
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 108810682
| Mm_GenLoc_end = 108841157
| Mm_Uniprot =
}}
}}
'''Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)''', also known as '''COL7A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.<ref>{{cite web | title = Entrez Gene: COL7A1 collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1294| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mecklenbeck S, Hammami-Hauasli N, Höpfner B, ''et al.'' |title=Clustering of COL7A1 mutations in exon 73: implications for mutation analysis in dystrophic epidermolysis bullosa. |journal=J. Invest. Dermatol. |volume=112 |issue= 3 |pages= 398-400 |year= 1999 |pmid= 10084325 |doi= 10.1046/j.1523-1747.1999.00518.x }}
*{{cite journal | author=Dang N, Klingberg S, Marr P, Murrell DF |title=Review of collagen VII sequence variants found in Australasian patients with dystrophic epidermolysis bullosa reveals nine novel COL7A1 variants. |journal=J. Dermatol. Sci. |volume=46 |issue= 3 |pages= 169-78 |year= 2007 |pmid= 17425959 |doi= 10.1016/j.jdermsci.2007.02.006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F11... {November 6, 2007 10:54:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein F11 image.jpg {November 6, 2007 10:54:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:54:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_F11_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xx9.
| PDB = {{PDB2|1xx9}}, {{PDB2|1xxd}}, {{PDB2|1xxf}}, {{PDB2|1zhm}}, {{PDB2|1zhp}}, {{PDB2|1zhr}}, {{PDB2|1zjd}}, {{PDB2|1zlr}}, {{PDB2|1zmj}}, {{PDB2|1zml}}, {{PDB2|1zmn}}, {{PDB2|1zom}}, {{PDB2|1zpb}}, {{PDB2|1zpc}}, {{PDB2|1zpz}}, {{PDB2|1zrk}}, {{PDB2|1zsj}}, {{PDB2|1zsk}}, {{PDB2|1zsl}}, {{PDB2|1ztj}}, {{PDB2|1ztk}}, {{PDB2|1ztl}}, {{PDB2|2f83}}, {{PDB2|2fda}}
| Name = Coagulation factor XI (plasma thromboplastin antecedent)
| HGNCid = 3529
| Symbol = F11
| AltSymbols =; FXI; MGC141891
| OMIM = 264900
| ECnumber =
| Homologene = 86654
| MGIid = 99481
| GeneAtlas_image1 = PBB_GE_F11_206610_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003803 |text = coagulation factor IXa activity}} {{GNF_GO|id=GO:0003805 |text = coagulation factor XIa activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2160
| Hs_Ensembl = ENSG00000088926
| Hs_RefseqProtein = NP_062505
| Hs_RefseqmRNA = NM_019559
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 187424272
| Hs_GenLoc_end = 187446928
| Hs_Uniprot = P03951
| Mm_EntrezGene = 109821
| Mm_Ensembl = ENSMUSG00000031645
| Mm_RefseqmRNA = NM_028066
| Mm_RefseqProtein = NP_082342
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 46739987
| Mm_GenLoc_end = 46760848
| Mm_Uniprot = Q9DAT3
}}
}}
'''Coagulation factor XI (plasma thromboplastin antecedent)''', also known as '''F11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.<ref>{{cite web | title = Entrez Gene: F11 coagulation factor XI (plasma thromboplastin antecedent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2160| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gailani D, Zivelin A, Sinha D, Walsh PN |title=Do platelets synthesize factor XI? |journal=J. Thromb. Haemost. |volume=2 |issue= 10 |pages= 1709-12 |year= 2005 |pmid= 15456479 |doi= 10.1111/j.1538-7836.2004.00935.x }}
*{{cite journal | author=Dossenbach-Glaninger A, Hopmeier P |title=Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency. |journal=Blood Coagul. Fibrinolysis |volume=16 |issue= 4 |pages= 231-8 |year= 2005 |pmid= 15870541 |doi= }}
*{{cite journal | author=Seligsohn U |title=Factor XI in haemostasis and thrombosis: past, present and future. |journal=Thromb. Haemost. |volume=98 |issue= 1 |pages= 84-9 |year= 2007 |pmid= 17597996 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GCG... {November 6, 2007 10:54:45 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 10:55:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:55:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GCG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d0r.
| PDB = {{PDB2|1d0r}}, {{PDB2|1gcn}}, {{PDB2|1kx6}}, {{PDB2|2g49}}
| Name = Glucagon
| HGNCid = 4191
| Symbol = GCG
| AltSymbols =; GLP1; GLP2; GRPP
| OMIM = 138030
| ECnumber =
| Homologene = 1553
| MGIid = 95674
| GeneAtlas_image1 = PBB_GE_GCG_206422_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050796 |text = regulation of insulin secretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2641
| Hs_Ensembl = ENSG00000115263
| Hs_RefseqProtein = NP_002045
| Hs_RefseqmRNA = NM_002054
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 162708779
| Hs_GenLoc_end = 162713934
| Hs_Uniprot = P01275
| Mm_EntrezGene = 14526
| Mm_Ensembl = ENSMUSG00000000394
| Mm_RefseqmRNA = NM_008100
| Mm_RefseqProtein = NP_032126
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 62275369
| Mm_GenLoc_end = 62284489
| Mm_Uniprot = P55095
}}
}}
'''Glucagon''', also known as '''GCG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.<ref>{{cite web | title = Entrez Gene: GCG glucagon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2641| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kieffer TJ, Habener JF |title=The glucagon-like peptides. |journal=Endocr. Rev. |volume=20 |issue= 6 |pages= 876-913 |year= 2000 |pmid= 10605628 |doi= }}
*{{cite journal | author=Drucker DJ |title=Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. |journal=Mol. Endocrinol. |volume=17 |issue= 2 |pages= 161-71 |year= 2003 |pmid= 12554744 |doi= }}
*{{cite journal | author=Jeppesen PB |title=Clinical significance of GLP-2 in short-bowel syndrome. |journal=J. Nutr. |volume=133 |issue= 11 |pages= 3721-4 |year= 2004 |pmid= 14608103 |doi= }}
*{{cite journal | author=Brubaker PL, Anini Y |title=Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. |journal=Can. J. Physiol. Pharmacol. |volume=81 |issue= 11 |pages= 1005-12 |year= 2004 |pmid= 14719035 |doi= 10.1139/y03-107 }}
*{{cite journal | author=Baggio LL, Drucker DJ |title=Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2. |journal=Best Pract. Res. Clin. Endocrinol. Metab. |volume=18 |issue= 4 |pages= 531-54 |year= 2005 |pmid= 15533774 |doi= 10.1016/j.beem.2004.08.001 }}
*{{cite journal | author=Holz GG, Chepurny OG |title=Diabetes outfoxed by GLP-1? |journal=Sci. STKE |volume=2005 |issue= 268 |pages= pe2 |year= 2006 |pmid= 15671479 |doi= 10.1126/stke.2682005pe2 }}
*{{cite journal | author=Dunning BE, Foley JE, Ahrén B |title=Alpha cell function in health and disease: influence of glucagon-like peptide-1. |journal=Diabetologia |volume=48 |issue= 9 |pages= 1700-13 |year= 2006 |pmid= 16132964 |doi= 10.1007/s00125-005-1878-0 }}
*{{cite journal | author=Gautier JF, Fetita S, Sobngwi E, Salaün-Martin C |title=Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. |journal=Diabetes Metab. |volume=31 |issue= 3 Pt 1 |pages= 233-42 |year= 2005 |pmid= 16142014 |doi= }}
*{{cite journal | author=De León DD, Crutchlow MF, Ham JY, Stoffers DA |title=Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 5-6 |pages= 845-59 |year= 2006 |pmid= 16202636 |doi= 10.1016/j.biocel.2005.07.011 }}
*{{cite journal | author=Beglinger C, Degen L |title=Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY? |journal=Physiol. Behav. |volume=89 |issue= 4 |pages= 460-4 |year= 2007 |pmid= 16828127 |doi= 10.1016/j.physbeh.2006.05.048 }}
*{{cite journal | author=Stephens JW, Bain SC |title=Safety and adverse effects associated with GLP-1 analogues. |journal=Expert opinion on drug safety |volume=6 |issue= 4 |pages= 417-22 |year= 2007 |pmid= 17688385 |doi= 10.1517/14740338.6.4.417 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GCK... {November 6, 2007 10:55:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GCK image.jpg {November 6, 2007 10:56:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:56:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GCK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v4s.
| PDB = {{PDB2|1v4s}}, {{PDB2|1v4t}}
| Name = Glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
| HGNCid = 4195
| Symbol = GCK
| AltSymbols =; GK; GLK; HHF3; HK4; HKIV; HXKP; MODY2
| OMIM = 138079
| ECnumber =
| Homologene = 55440
| MGIid = 1270854
| GeneAtlas_image1 = PBB_GE_GCK_211167_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004340 |text = glucokinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005536 |text = glucose binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0032024 |text = positive regulation of insulin secretion}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}} {{GNF_GO|id=GO:0045721 |text = negative regulation of gluconeogenesis}} {{GNF_GO|id=GO:0045725 |text = positive regulation of glycogen biosynthetic process}} {{GNF_GO|id=GO:0051594 |text = detection of glucose}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2645
| Hs_Ensembl = ENSG00000106633
| Hs_RefseqProtein = NP_000153
| Hs_RefseqmRNA = NM_000162
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 44150395
| Hs_GenLoc_end = 44195563
| Hs_Uniprot = P35557
| Mm_EntrezGene = 103988
| Mm_Ensembl = ENSMUSG00000041798
| Mm_RefseqmRNA = NM_010292
| Mm_RefseqProtein = NP_034422
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 5800826
| Mm_GenLoc_end = 5850084
| Mm_Uniprot = Q5SVI5
}}
}}
'''Glucokinase (hexokinase 4, maturity onset diabetes of the young 2)''', also known as '''GCK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).<ref>{{cite web | title = Entrez Gene: GCK glucokinase (hexokinase 4, maturity onset diabetes of the young 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2645| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Permutt MA, Chiu KC, Tanizawa Y |title=Glucokinase and NIDDM. A candidate gene that paid off. |journal=Diabetes |volume=41 |issue= 11 |pages= 1367-72 |year= 1992 |pmid= 1397713 |doi= }}
*{{cite journal | author=Gerbitz KD, Gempel K, Brdiczka D |title=Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. |journal=Diabetes |volume=45 |issue= 2 |pages= 113-26 |year= 1996 |pmid= 8549853 |doi= }}
*{{cite journal | author=Foster JD, Pederson BA, Nordlie RC |title=Glucose-6-phosphatase structure, regulation, and function: an update. |journal=Proc. Soc. Exp. Biol. Med. |volume=215 |issue= 4 |pages= 314-32 |year= 1997 |pmid= 9270716 |doi= }}
*{{cite journal | author=Postic C, Shiota M, Magnuson MA |title=Cell-specific roles of glucokinase in glucose homeostasis. |journal=Recent Prog. Horm. Res. |volume=56 |issue= |pages= 195-217 |year= 2001 |pmid= 11237213 |doi= }}
*{{cite journal | author=Gloyn AL |title=Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. |journal=Hum. Mutat. |volume=22 |issue= 5 |pages= 353-62 |year= 2004 |pmid= 14517946 |doi= 10.1002/humu.10277 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on H2AFX... {November 6, 2007 10:57:28 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein H2AFX image.jpg {November 6, 2007 10:58:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:58:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_H2AFX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = H2A histone family, member X
| HGNCid = 4739
| Symbol = H2AFX
| AltSymbols =; H2A.X; H2A/X; H2AX
| OMIM = 601772
| ECnumber =
| Homologene = 68227
| MGIid = 102688
| GeneAtlas_image1 = PBB_GE_H2AFX_205436_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_H2AFX_212525_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005657 |text = replication fork}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0000724 |text = double-strand break repair via homologous recombination}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3014
| Hs_Ensembl = ENSG00000188486
| Hs_RefseqProtein = NP_002096
| Hs_RefseqmRNA = NM_002105
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 118469799
| Hs_GenLoc_end = 118471369
| Hs_Uniprot = P16104
| Mm_EntrezGene = 15270
| Mm_Ensembl = ENSMUSG00000049932
| Mm_RefseqmRNA = NM_010436
| Mm_RefseqProtein = NP_034566
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 44085689
| Mm_GenLoc_end = 44087066
| Mm_Uniprot = P27661
}}
}}
'''H2A histone family, member X''', also known as '''H2AFX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.<ref>{{cite web | title = Entrez Gene: H2AFX H2A histone family, member X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3014| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Redon C, Pilch D, Rogakou E, ''et al.'' |title=Histone H2A variants H2AX and H2AZ. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 2 |pages= 162-9 |year= 2002 |pmid= 11893489 |doi= }}
*{{cite journal | author=Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A |title=H2AX: the histone guardian of the genome. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 959-67 |year= 2005 |pmid= 15279782 |doi= 10.1016/j.dnarep.2004.03.024 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HBEGF... {November 6, 2007 10:52:57 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HBEGF image.jpg {November 6, 2007 10:53:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:54:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HBEGF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xdt.
| PDB = {{PDB2|1xdt}}
| Name = Heparin-binding EGF-like growth factor
| HGNCid = 3059
| Symbol = HBEGF
| AltSymbols =; DTR; DTS; DTSF; HEGFL
| OMIM = 126150
| ECnumber =
| Homologene = 1466
| MGIid = 96070
| GeneAtlas_image1 = PBB_GE_HBEGF_38037_at_tn.png
| GeneAtlas_image2 = PBB_GE_HBEGF_203821_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005154 |text = epidermal growth factor receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0035313 |text = wound healing, spreading of epidermal cells}} {{GNF_GO|id=GO:0048661 |text = positive regulation of smooth muscle cell proliferation}} {{GNF_GO|id=GO:0051549 |text = positive regulation of keratinocyte migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1839
| Hs_Ensembl = ENSG00000113070
| Hs_RefseqProtein = NP_001936
| Hs_RefseqmRNA = NM_001945
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 139692615
| Hs_GenLoc_end = 139706359
| Hs_Uniprot = Q99075
| Mm_EntrezGene = 15200
| Mm_Ensembl = ENSMUSG00000024486
| Mm_RefseqmRNA = NM_010415
| Mm_RefseqProtein = NP_034545
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 36630906
| Mm_GenLoc_end = 36641748
| Mm_Uniprot = Q5FW64
}}
}}
'''Heparin-binding EGF-like growth factor''', also known as '''HBEGF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IRS2... {November 6, 2007 11:12:27 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 11:13:19 PM PST}
- CREATED: Created new protein page: IRS2 {November 6, 2007 11:13:27 PM PST}
- INFO: Beginning work on JAK1... {November 6, 2007 10:59:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:59:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Janus kinase 1 (a protein tyrosine kinase)
| HGNCid = 6190
| Symbol = JAK1
| AltSymbols =; JAK1A; JAK1B
| OMIM = 147795
| ECnumber =
| Homologene = 1678
| MGIid = 96628
| GeneAtlas_image1 = PBB_GE_JAK1_201648_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004718 |text = Janus kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3716
| Hs_Ensembl = ENSG00000162434
| Hs_RefseqProtein = NP_002218
| Hs_RefseqmRNA = NM_002227
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 65071500
| Hs_GenLoc_end = 65204775
| Hs_Uniprot = P23458
| Mm_EntrezGene = 16451
| Mm_Ensembl = ENSMUSG00000028530
| Mm_RefseqmRNA = NM_146145
| Mm_RefseqProtein = NP_666257
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 100650299
| Mm_GenLoc_end = 100763214
| Mm_Uniprot = Q3TI10
}}
}}
'''Janus kinase 1 (a protein tyrosine kinase)''', also known as '''JAK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.<ref>{{cite web | title = Entrez Gene: JAK1 Janus kinase 1 (a protein tyrosine kinase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3716| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Donnelly RP, Dickensheets H, Finbloom DS |title=The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 6 |pages= 563-73 |year= 1999 |pmid= 10433356 |doi= 10.1089/107999099313695 }}
*{{cite journal | author=Carter-Su C, Rui L, Stofega MR |title=SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. |journal=Recent Prog. Horm. Res. |volume=55 |issue= |pages= 293-311 |year= 2000 |pmid= 11036942 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KPNA1... {November 6, 2007 10:59:51 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KPNA1 image.jpg {November 6, 2007 11:01:16 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 11:01:32 PM PST}
- CREATED: Created new protein page: KPNA1 {November 6, 2007 11:01:39 PM PST}
- INFO: Beginning work on MBP... {November 6, 2007 11:02:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:03:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myelin basic protein
| HGNCid = 6925
| Symbol = MBP
| AltSymbols =; MGC99675
| OMIM = 159430
| ECnumber =
| Homologene = 1788
| MGIid = 96925
| GeneAtlas_image1 = PBB_GE_MBP_207323_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MBP_209072_at_tn.png
| Function = {{GNF_GO|id=GO:0019911 |text = structural constituent of myelin sheath}}
| Component =
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0042552 |text = myelination}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4155
| Hs_Ensembl = ENSG00000197971
| Hs_RefseqProtein = NP_001020252
| Hs_RefseqmRNA = NM_001025081
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 72819778
| Hs_GenLoc_end = 72973762
| Hs_Uniprot = P02686
| Mm_EntrezGene = 17196
| Mm_Ensembl = ENSMUSG00000041607
| Mm_RefseqmRNA = NM_001025245
| Mm_RefseqProtein = NP_001020416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 82609551
| Mm_GenLoc_end = 82720065
| Mm_Uniprot = P04370
}}
}}
'''Myelin basic protein''', also known as '''MBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.<ref>{{cite web | title = Entrez Gene: MBP myelin basic protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4155| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MSH6... {November 6, 2007 10:56:24 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MSH6 image.jpg {November 6, 2007 10:57:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:57:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MSH6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gfu.
| PDB = {{PDB2|2gfu}}, {{PDB2|2o8b}}, {{PDB2|2o8c}}, {{PDB2|2o8d}}, {{PDB2|2o8e}}, {{PDB2|2o8f}}
| Name = MutS homolog 6 (E. coli)
| HGNCid = 7329
| Symbol = MSH6
| AltSymbols =; GTBP; HNPCC5; HSAP
| OMIM = 600678
| ECnumber =
| Homologene = 149
| MGIid = 1343961
| GeneAtlas_image1 = PBB_GE_MSH6_202911_at_tn.png
| GeneAtlas_image2 = PBB_GE_MSH6_211450_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000400 |text = four-way junction DNA binding}} {{GNF_GO|id=GO:0000701 |text = purine-specific mismatch base pair DNA N-glycosylase activity}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015444 |text = magnesium-importing ATPase activity}} {{GNF_GO|id=GO:0032137 |text = guanine/thymine mispair binding}} {{GNF_GO|id=GO:0032139 |text = dinucleotide insertion or deletion binding}} {{GNF_GO|id=GO:0032142 |text = single guanine insertion binding}} {{GNF_GO|id=GO:0032143 |text = single thymine insertion binding}} {{GNF_GO|id=GO:0032357 |text = oxidized purine DNA binding}} {{GNF_GO|id=GO:0032405 |text = MutLalpha complex binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043531 |text = ADP binding}} {{GNF_GO|id=GO:0045027 |text = DNA end binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0032301 |text = MutSalpha complex}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0006298 |text = mismatch repair}} {{GNF_GO|id=GO:0008340 |text = determination of adult life span}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0009411 |text = response to UV}} {{GNF_GO|id=GO:0016446 |text = somatic hypermutation of immunoglobulin genes}} {{GNF_GO|id=GO:0016447 |text = somatic recombination of immunoglobulin gene segments}} {{GNF_GO|id=GO:0032026 |text = response to magnesium ion}} {{GNF_GO|id=GO:0045910 |text = negative regulation of DNA recombination}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2956
| Hs_Ensembl = ENSG00000116062
| Hs_RefseqProtein = NP_000170
| Hs_RefseqmRNA = NM_000179
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 47863725
| Hs_GenLoc_end = 47887588
| Hs_Uniprot = P52701
| Mm_EntrezGene = 17688
| Mm_Ensembl = ENSMUSG00000005370
| Mm_RefseqmRNA = NM_010830
| Mm_RefseqProtein = NP_034960
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 87883410
| Mm_GenLoc_end = 87899389
| Mm_Uniprot = Q61061
}}
}}
'''MutS homolog 6 (E. coli)''', also known as '''MSH6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYCN... {November 6, 2007 11:03:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:04:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
| HGNCid = 7559
| Symbol = MYCN
| AltSymbols =; MODED; N-myc; NMYC; ODED
| OMIM = 164840
| ECnumber =
| Homologene = 3922
| MGIid = 97357
| GeneAtlas_image1 = PBB_GE_MYCN_209757_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYCN_209756_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MYCN_211377_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4613
| Hs_Ensembl = ENSG00000134323
| Hs_RefseqProtein = NP_005369
| Hs_RefseqmRNA = NM_005378
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 15998134
| Hs_GenLoc_end = 16004579
| Hs_Uniprot = P04198
| Mm_EntrezGene = 18109
| Mm_Ensembl = ENSMUSG00000037169
| Mm_RefseqmRNA = NM_008709
| Mm_RefseqProtein = NP_032735
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 12962079
| Mm_GenLoc_end = 12967694
| Mm_Uniprot = Q3UII1
}}
}}
'''V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)''', also known as '''MYCN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.<ref>{{cite web | title = Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4613| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1-14 |year= 2001 |pmid= 11602341 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCAM1... {November 6, 2007 11:04:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCAM1 image.jpg {November 6, 2007 11:05:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:05:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCAM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1epf.
| PDB = {{PDB2|1epf}}, {{PDB2|1lwr}}, {{PDB2|1qz1}}, {{PDB2|2e3v}}, {{PDB2|2haz}}, {{PDB2|2ncm}}, {{PDB2|3ncm}}
| Name = Neural cell adhesion molecule 1
| HGNCid = 7656
| Symbol = NCAM1
| AltSymbols =; CD56; MSK39; NCAM
| OMIM = 116930
| ECnumber =
| Homologene = 40754
| MGIid = 97281
| GeneAtlas_image1 = PBB_GE_NCAM1_212843_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCAM1_209968_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4684
| Hs_Ensembl = ENSG00000149294
| Hs_RefseqProtein = NP_000606
| Hs_RefseqmRNA = NM_000615
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 112578307
| Hs_GenLoc_end = 112653781
| Hs_Uniprot = P13591
| Mm_EntrezGene = 17967
| Mm_Ensembl = ENSMUSG00000039542
| Mm_RefseqmRNA = NM_001081445
| Mm_RefseqProtein = NP_001074914
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 49257298
| Mm_GenLoc_end = 49322170
| Mm_Uniprot = O08909
}}
}}
'''Neural cell adhesion molecule 1''', also known as '''NCAM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rutishauser U, Acheson A, Hall AK, ''et al.'' |title=The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. |journal=Science |volume=240 |issue= 4848 |pages= 53-7 |year= 1988 |pmid= 3281256 |doi= }}
*{{cite journal | author=Rønn LC, Hartz BP, Bock E |title=The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. |journal=Exp. Gerontol. |volume=33 |issue= 7-8 |pages= 853-64 |year= 1999 |pmid= 9951628 |doi= }}
*{{cite journal | author=Zeromski J, Nyczak E, Dyszkiewicz W |title=Significance of cell adhesion molecules, CD56/NCAM in particular, in human tumor growth and spreading. |journal=Folia Histochem. Cytobiol. |volume=39 Suppl 2 |issue= |pages= 36-7 |year= 2002 |pmid= 11820619 |doi= }}
*{{cite journal | author=Itoh K, Kamiguchi H |title=[Neural cell adhesion molecules in lipid microdomains] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 338-43 |year= 2002 |pmid= 11915324 |doi= }}
*{{cite journal | author=Sahara N, Takeshita A |title=Prognostic significance of surface markers expressed in multiple myeloma: CD56 and other antigens. |journal=Leuk. Lymphoma |volume=45 |issue= 1 |pages= 61-5 |year= 2004 |pmid= 15061198 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCL... {November 6, 2007 11:05:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCL image.jpg {November 6, 2007 11:05:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:06:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fc8.
| PDB = {{PDB2|2fc8}}, {{PDB2|2fc9}}
| Name = Nucleolin
| HGNCid = 7667
| Symbol = NCL
| AltSymbols =; C23; FLJ45706
| OMIM = 164035
| ECnumber =
| Homologene = 21821
| MGIid =
| GeneAtlas_image1 = PBB_GE_NCL_200610_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005938 |text = cell cortex}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4691
| Hs_Ensembl = ENSG00000115053
| Hs_RefseqProtein = NP_005372
| Hs_RefseqmRNA = NM_005381
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 232027704
| Hs_GenLoc_end = 232037449
| Hs_Uniprot = P19338
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nucleolin''', also known as '''NCL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.<ref>{{cite web | title = Entrez Gene: NCL nucleolin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4691| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tuteja R, Tuteja N |title=Nucleolin: a multifunctional major nucleolar phosphoprotein. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 6 |pages= 407-36 |year= 1999 |pmid= 9918513 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SFTPA1... {November 6, 2007 11:07:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:07:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Surfactant, pulmonary-associated protein A1
| HGNCid = 10798
| Symbol = SFTPA1
| AltSymbols =; PSAP; COLEC4; MGC133365; PSPA; SFTP1; SP-A; SP-A1; SFTPA1
| OMIM = 178630
| ECnumber =
| Homologene = 88721
| MGIid =
| Function = {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0050828 |text = regulation of liquid surface tension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6435
| Hs_Ensembl =
| Hs_RefseqProtein = NP_005402
| Hs_RefseqmRNA = NM_005411
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Surfactant, pulmonary-associated protein A1''', also known as '''SFTPA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lu J |title=Collectins: collectors of microorganisms for the innate immune system. |journal=Bioessays |volume=19 |issue= 6 |pages= 509-18 |year= 1997 |pmid= 9204768 |doi= 10.1002/bies.950190610 }}
*{{cite journal | author=Floros J, Hoover RR |title=Genetics of the hydrophilic surfactant proteins A and D. |journal=Biochim. Biophys. Acta |volume=1408 |issue= 2-3 |pages= 312-22 |year= 1999 |pmid= 9813381 |doi= }}
*{{cite journal | author=Khubchandani KR, Snyder JM |title=Surfactant protein A (SP-A): the alveolus and beyond. |journal=FASEB J. |volume=15 |issue= 1 |pages= 59-69 |year= 2001 |pmid= 11149893 |doi= 10.1096/fj.00-0318rev }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMAD7... {November 6, 2007 11:01:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:02:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SMAD family member 7
| HGNCid = 6773
| Symbol = SMAD7
| AltSymbols =; MADH7; FLJ16482; MADH8
| OMIM = 602932
| ECnumber =
| Homologene = 4314
| MGIid = 1100518
| GeneAtlas_image1 = PBB_GE_SMAD7_204790_at_tn.png
| Function = {{GNF_GO|id=GO:0005076 |text = receptor signaling protein serine/threonine kinase signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030617 |text = transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4092
| Hs_Ensembl = ENSG00000101665
| Hs_RefseqProtein = NP_005895
| Hs_RefseqmRNA = NM_005904
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 44700222
| Hs_GenLoc_end = 44731079
| Hs_Uniprot = O15105
| Mm_EntrezGene = 17131
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_986975
| Mm_RefseqProtein = XP_992069
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''SMAD family member 7''', also known as '''SMAD7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Massagué J |title=TGF-beta signal transduction. |journal=Annu. Rev. Biochem. |volume=67 |issue= |pages= 753-91 |year= 1998 |pmid= 9759503 |doi= 10.1146/annurev.biochem.67.1.753 }}
*{{cite journal | author=Verschueren K, Huylebroeck D |title=Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 187-99 |year= 2000 |pmid= 10647776 |doi= }}
*{{cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5-13 |year= 2000 |pmid= 10708948 |doi= }}
*{{cite journal | author=Miyazono K |title=TGF-beta signaling by Smad proteins. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 15-22 |year= 2000 |pmid= 10708949 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFPI... {November 6, 2007 11:07:38 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TFPI image.jpg {November 6, 2007 11:08:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:08:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TFPI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1adz.
| PDB = {{PDB2|1adz}}, {{PDB2|1irh}}, {{PDB2|1tfx}}
| Name = Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
| HGNCid = 11760
| Symbol = TFPI
| AltSymbols =; TFI; EPI; LACI
| OMIM = 152310
| ECnumber =
| Homologene = 4579
| MGIid = 1095418
| GeneAtlas_image1 = PBB_GE_TFPI_209676_at_tn.png
| GeneAtlas_image2 = PBB_GE_TFPI_210664_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TFPI_210665_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0030414 |text = protease inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7035
| Hs_Ensembl = ENSG00000003436
| Hs_RefseqProtein = NP_001027452
| Hs_RefseqmRNA = NM_001032281
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 188039530
| Hs_GenLoc_end = 188127410
| Hs_Uniprot = P10646
| Mm_EntrezGene = 21788
| Mm_Ensembl = ENSMUSG00000027082
| Mm_RefseqmRNA = NM_011576
| Mm_RefseqProtein = NP_035706
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84233699
| Mm_GenLoc_end = 84275013
| Mm_Uniprot = O54819
}}
}}
'''Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)''', also known as '''TFPI''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.<ref>{{cite web | title = Entrez Gene: TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7035| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Broze GJ, Girard TJ, Novotny WF |title=Regulation of coagulation by a multivalent Kunitz-type inhibitor. |journal=Biochemistry |volume=29 |issue= 33 |pages= 7539-46 |year= 1991 |pmid= 2271516 |doi= }}
*{{cite journal | author=McVey JH |title=Tissue factor pathway. |journal=Baillieres Best Pract. Res. Clin. Haematol. |volume=12 |issue= 3 |pages= 361-72 |year= 2000 |pmid= 10856975 |doi= }}
*{{cite journal | author=Bajaj MS, Birktoft JJ, Steer SA, Bajaj SP |title=Structure and biology of tissue factor pathway inhibitor. |journal=Thromb. Haemost. |volume=86 |issue= 4 |pages= 959-72 |year= 2002 |pmid= 11686353 |doi= }}
*{{cite journal | author=Witt I |title=[Tissue factor pathway inhibitor: biochemistry, molecular biology, physiology and physiopathology] |journal=Hamostaseologie |volume=22 |issue= 2 |pages= 30-5 |year= 2002 |pmid= 12193974 |doi= 10.1267/Hamo02020071 }}
*{{cite journal | author=Lwaleed BA, Bass PS |title=Tissue factor pathway inhibitor: structure, biology and involvement in disease. |journal=J. Pathol. |volume=208 |issue= 3 |pages= 327-39 |year= 2006 |pmid= 16261634 |doi= 10.1002/path.1871 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNC... {November 6, 2007 10:58:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNC image.jpg {November 6, 2007 10:59:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 10:59:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ten.
| PDB = {{PDB2|1ten}}
| Name = Tenascin C (hexabrachion)
| HGNCid = 5318
| Symbol = TNC
| AltSymbols =; HXB; TN
| OMIM = 187380
| ECnumber =
| Homologene = 55636
| MGIid = 101922
| GeneAtlas_image1 = PBB_GE_TNC_201645_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007528 |text = neuromuscular junction development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3371
| Hs_Ensembl = ENSG00000041982
| Hs_RefseqProtein = NP_002151
| Hs_RefseqmRNA = NM_002160
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 116822634
| Hs_GenLoc_end = 116920260
| Hs_Uniprot = P24821
| Mm_EntrezGene = 21923
| Mm_Ensembl = ENSMUSG00000028364
| Mm_RefseqmRNA = NM_011607
| Mm_RefseqProtein = NP_035737
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 63446149
| Mm_GenLoc_end = 63533177
| Mm_Uniprot = Q80YX0
}}
}}
'''Tenascin C (hexabrachion)''', also known as '''TNC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Imanaka-Yoshida K, Hiroe M, Yoshida T |title=Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling. |journal=Histol. Histopathol. |volume=19 |issue= 2 |pages= 517-25 |year= 2004 |pmid= 15024713 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UCP2... {November 6, 2007 11:08:57 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 11:10:02 PM PST}
- CREATED: Created new protein page: UCP2 {November 6, 2007 11:10:09 PM PST}
- INFO: Beginning work on VTN... {November 6, 2007 11:10:09 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein VTN image.jpg {November 6, 2007 11:10:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:10:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VTN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oc0.
| PDB = {{PDB2|1oc0}}, {{PDB2|1s4g}}, {{PDB2|1ssu}}
| Name = Vitronectin
| HGNCid = 12724
| Symbol = VTN
| AltSymbols =; V75; VN; VNT
| OMIM = 193190
| ECnumber =
| Homologene = 532
| MGIid = 98940
| GeneAtlas_image1 = PBB_GE_VTN_204534_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7448
| Hs_Ensembl = ENSG00000109072
| Hs_RefseqProtein = NP_000629
| Hs_RefseqmRNA = NM_000638
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 23718425
| Hs_GenLoc_end = 23721844
| Hs_Uniprot = P04004
| Mm_EntrezGene = 22370
| Mm_Ensembl = ENSMUSG00000017344
| Mm_RefseqmRNA = NM_011707
| Mm_RefseqProtein = NP_035837
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 78315315
| Mm_GenLoc_end = 78318518
| Mm_Uniprot = Q5SYG4
}}
}}
'''Vitronectin''', also known as '''VTN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.<ref>{{cite web | title = Entrez Gene: VTN vitronectin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7448| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schroeck F, Arroyo de Prada N, Sperl S, ''et al.'' |title=Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin (Vn): mapping the binding sites on PAI-1 and Vn. |journal=Biol. Chem. |volume=383 |issue= 7-8 |pages= 1143-9 |year= 2003 |pmid= 12437099 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on YWHAE... {November 6, 2007 11:10:58 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAE image.jpg {November 6, 2007 11:12:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:12:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YWHAE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2br9.
| PDB = {{PDB2|2br9}}
| Name = Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
| HGNCid = 12851
| Symbol = YWHAE
| AltSymbols =; MDCR; MDS; KCIP-1; 14-3-3E; FLJ45465
| OMIM = 605066
| ECnumber =
| Homologene = 38223
| MGIid = 894689
| GeneAtlas_image1 = PBB_GE_YWHAE_210317_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YWHAE_210996_s_at_tn.png
| Function = {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7531
| Hs_Ensembl = ENSG00000108953
| Hs_RefseqProtein = XP_001126863
| Hs_RefseqmRNA = XM_001126863
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 1194558
| Hs_GenLoc_end = 1250231
| Hs_Uniprot = P62258
| Mm_EntrezGene = 22627
| Mm_Ensembl = ENSMUSG00000020849
| Mm_RefseqmRNA = NM_009536
| Mm_RefseqProtein = NP_033562
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 75549134
| Mm_GenLoc_end = 75582033
| Mm_Uniprot = Q3V453
}}
}}
'''Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide''', also known as '''YWHAE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.<ref>{{cite web | title = Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7531| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
}}
{{refend}}
{{protein-stub}}
end log.
