Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 00:23, 7 November 2007 (UTC)[edit]
Proteins without matches (16)[edit]
Proteins with a High Potential Match (9)[edit]
Created (5)[edit]
Manual Inspection (Page not found) (20)[edit]
Protein Status Grid - Date: 00:23, 7 November 2007 (UTC)[edit]
Vebose Log - Date: 00:23, 7 November 2007 (UTC)[edit]
- INFO: Beginning work on ANGPT2... {November 6, 2007 3:27:47 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ANGPT2 image.jpg {November 6, 2007 3:32:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 3:32:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ANGPT2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z3s.
| PDB = {{PDB2|1z3s}}, {{PDB2|1z3u}}, {{PDB2|2gy7}}
| Name = Angiopoietin 2
| HGNCid = 485
| Symbol = ANGPT2
| AltSymbols =; AGPT2; ANG2
| OMIM = 601922
| ECnumber =
| Homologene = 22401
| MGIid = 1202890
| GeneAtlas_image1 = PBB_GE_ANGPT2_211148_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ANGPT2_205572_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 285
| Hs_Ensembl = ENSG00000091879
| Hs_RefseqProtein = NP_001138
| Hs_RefseqmRNA = NM_001147
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 6344580
| Hs_GenLoc_end = 6408338
| Hs_Uniprot = O15123
| Mm_EntrezGene = 11601
| Mm_Ensembl = ENSMUSG00000031465
| Mm_RefseqmRNA = NM_007426
| Mm_RefseqProtein = NP_031452
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 18691314
| Mm_GenLoc_end = 18741528
| Mm_Uniprot = O35608
}}
}}
'''Angiopoietin 2''', also known as '''ANGPT2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1<ref>{{cite web | title = Entrez Gene: ANGPT2 angiopoietin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on APOH... {November 6, 2007 3:32:22 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein APOH image.jpg {November 6, 2007 3:32:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 3:33:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APOH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c1z.
| PDB = {{PDB2|1c1z}}, {{PDB2|1g4f}}, {{PDB2|1g4g}}, {{PDB2|1qub}}
| Name = Apolipoprotein H (beta-2-glycoprotein I)
| HGNCid = 616
| Symbol = APOH
| AltSymbols =; B2G1; BG
| OMIM = 138700
| ECnumber =
| Homologene = 26
| MGIid = 88058
| GeneAtlas_image1 = PBB_GE_APOH_205216_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 350
| Hs_Ensembl = ENSG00000091583
| Hs_RefseqProtein = NP_000033
| Hs_RefseqmRNA = NM_000042
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 61638577
| Hs_GenLoc_end = 61655974
| Hs_Uniprot = P02749
| Mm_EntrezGene = 11818
| Mm_Ensembl = ENSMUSG00000000049
| Mm_RefseqmRNA = NM_013475
| Mm_RefseqProtein = NP_038503
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 108211381
| Mm_GenLoc_end = 108230485
| Mm_Uniprot = Q6LAL7
}}
}}
'''Apolipoprotein H (beta-2-glycoprotein I)''', also known as '''APOH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.<ref>{{cite web | title = Entrez Gene: APOH apolipoprotein H (beta-2-glycoprotein I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=350| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miyakis S, Giannakopoulos B, Krilis SA |title=Beta 2 glycoprotein I--function in health and disease. |journal=Thromb. Res. |volume=114 |issue= 5-6 |pages= 335-46 |year= 2005 |pmid= 15507263 |doi= 10.1016/j.thromres.2004.07.017 }}
*{{cite journal | author=Kuwana M |title=Beta2-glycoprotein I: antiphospholipid syndrome and T-cell reactivity. |journal=Thromb. Res. |volume=114 |issue= 5-6 |pages= 347-55 |year= 2005 |pmid= 15507264 |doi= 10.1016/j.thromres.2004.06.029 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BAD... {November 6, 2007 3:33:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 3:34:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2-antagonist of cell death
| HGNCid = 936
| Symbol = BAD
| AltSymbols =; BBC2; BCL2L8
| OMIM = 603167
| ECnumber =
| Homologene = 3189
| MGIid = 1096330
| GeneAtlas_image1 = PBB_GE_BAD_1861_at_tn.png
| GeneAtlas_image2 = PBB_GE_BAD_209364_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}}
| Process = {{GNF_GO|id=GO:0006007 |text = glucose catabolic process}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045579 |text = positive regulation of B cell differentiation}} {{GNF_GO|id=GO:0045582 |text = positive regulation of T cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 572
| Hs_Ensembl = ENSG00000002330
| Hs_RefseqProtein = NP_004313
| Hs_RefseqmRNA = NM_004322
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 63793878
| Hs_GenLoc_end = 63808740
| Hs_Uniprot = Q92934
| Mm_EntrezGene = 12015
| Mm_Ensembl = ENSMUSG00000024959
| Mm_RefseqmRNA = NM_007522
| Mm_RefseqProtein = NP_031548
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 7008905
| Mm_GenLoc_end = 7018937
| Mm_Uniprot = Q3TFU7
}}
}}
'''BCL2-antagonist of cell death''', also known as '''BAD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.<ref>{{cite web | title = Entrez Gene: BAD BCL2-antagonist of cell death| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=572| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, ''et al.'' |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141-51 |year= 2004 |pmid= 15078178 |doi= }}
*{{cite journal | author=Jiang P, Du W, Wu M |title=p53 and Bad: remote strangers become close friends. |journal=Cell Res. |volume=17 |issue= 4 |pages= 283-5 |year= 2007 |pmid= 17404594 |doi= 10.1038/cr.2007.19 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CA2... {November 6, 2007 3:34:04 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CA2 image.jpg {November 6, 2007 3:34:42 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 3:35:05 PM PST}
- CREATED: Created new protein page: CA2 {November 6, 2007 3:35:18 PM PST}
- INFO: Beginning work on CDC25C... {November 6, 2007 3:35:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 3:36:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell division cycle 25 homolog C (S. pombe)
| HGNCid = 1727
| Symbol = CDC25C
| AltSymbols =; CDC25
| OMIM = 157680
| ECnumber =
| Homologene = 1356
| MGIid = 88350
| GeneAtlas_image1 = PBB_GE_CDC25C_205167_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC25C_217010_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0000087 |text = M phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}} {{GNF_GO|id=GO:0007089 |text = traversing start control point of mitotic cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 995
| Hs_Ensembl = ENSG00000158402
| Hs_RefseqProtein = NP_001781
| Hs_RefseqmRNA = NM_001790
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 137649168
| Hs_GenLoc_end = 137701943
| Hs_Uniprot = P30307
| Mm_EntrezGene = 12532
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009860
| Mm_RefseqProtein = NP_033990
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cell division cycle 25 homolog C (S. pombe)''', also known as '''CDC25C''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.<ref>{{cite web | title = Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=995| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53-63 |year= 1997 |pmid= 9141461 |doi= }}
*{{cite journal | author=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue= |pages= 107-14 |year= 2000 |pmid= 10740819 |doi= }}
*{{cite journal | author=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249-60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43-51 |year= 2005 |pmid= 15638722 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ERBB3... {November 6, 2007 3:36:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ERBB3 image.jpg {November 6, 2007 3:37:15 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 3:38:17 PM PST}
- CREATED: Created new protein page: ERBB3 {November 6, 2007 3:38:26 PM PST}
- INFO: Beginning work on FURIN... {November 6, 2007 4:09:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FURIN image.jpg {November 6, 2007 4:10:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:10:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FURIN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p8j.
| PDB = {{PDB2|1p8j}}
| Name = Furin (paired basic amino acid cleaving enzyme)
| HGNCid = 8568
| Symbol = FURIN
| AltSymbols =; FUR; PACE; PCSK3; SPC1
| OMIM = 136950
| ECnumber =
| Homologene = 1930
| MGIid = 97513
| GeneAtlas_image1 = PBB_GE_FURIN_201945_at_tn.png
| Function = {{GNF_GO|id=GO:0004276 |text = furin activity}} {{GNF_GO|id=GO:0004289 |text = subtilase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030140 |text = trans-Golgi network transport vesicle}}
| Process = {{GNF_GO|id=GO:0006465 |text = signal peptide processing}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5045
| Hs_Ensembl = ENSG00000140564
| Hs_RefseqProtein = NP_002560
| Hs_RefseqmRNA = NM_002569
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 89212889
| Hs_GenLoc_end = 89227691
| Hs_Uniprot = P09958
| Mm_EntrezGene = 18550
| Mm_Ensembl = ENSMUSG00000030530
| Mm_RefseqmRNA = XM_980423
| Mm_RefseqProtein = XP_985517
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 80262709
| Mm_GenLoc_end = 80276275
| Mm_Uniprot = Q6GTN6
}}
}}
'''Furin (paired basic amino acid cleaving enzyme)''', also known as '''FURIN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.<ref>{{cite web | title = Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5045| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakayama K |title=Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. |journal=Biochem. J. |volume=327 ( Pt 3) |issue= |pages= 625-35 |year= 1998 |pmid= 9599222 |doi= }}
*{{cite journal | author=Bassi DE, Mahloogi H, Klein-Szanto AJ |title=The proprotein convertases furin and PACE4 play a significant role in tumor progression. |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 63-9 |year= 2000 |pmid= 10900462 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNB2L1... {November 6, 2007 4:21:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:21:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
| HGNCid = 4399
| Symbol = GNB2L1
| AltSymbols =; Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1
| OMIM = 176981
| ECnumber =
| Homologene = 4446
| MGIid = 101849
| Function = {{GNF_GO|id=GO:0005080 |text = protein kinase C binding}} {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007205 |text = protein kinase C activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10399
| Hs_Ensembl =
| Hs_RefseqProtein = NP_006089
| Hs_RefseqmRNA = NM_006098
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14694
| Mm_Ensembl = ENSMUSG00000020372
| Mm_RefseqmRNA = NM_008143
| Mm_RefseqProtein = NP_032169
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 48643783
| Mm_GenLoc_end = 48649857
| Mm_Uniprot = Q3THP0
}}
}}
'''Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1''', also known as '''GNB2L1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Liu YV, Semenza GL |title=RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. |journal=Cell Cycle |volume=6 |issue= 6 |pages= 656-9 |year= 2007 |pmid= 17361105 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HLA-DQA1... {November 6, 2007 3:38:26 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HLA-DQA1 image.jpg {November 6, 2007 3:39:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 3:58:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HLA-DQA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jk8.
| PDB = {{PDB2|1jk8}}, {{PDB2|1s9v}}, {{PDB2|1uvq}}
| Name = Major histocompatibility complex, class II, DQ alpha 1
| HGNCid = 4942
| Symbol = HLA-DQA1
| AltSymbols =; GSE; CD; CELIAC1; DQ-A1; FLJ27088; FLJ27328; HLA DQA1; HLA-DQA
| OMIM = 146880
| ECnumber =
| Homologene = 7750
| MGIid = 95895
| GeneAtlas_image1 = PBB_GE_HLA-DQA1_212671_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HLA-DQA1_213831_at_tn.png
| GeneAtlas_image3 = PBB_GE_HLA-DQA1_203290_at_tn.png
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3117
| Hs_Ensembl = ENSG00000196735
| Hs_RefseqProtein = XP_001134217
| Hs_RefseqmRNA = XM_001134217
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32713112
| Hs_GenLoc_end = 32719345
| Hs_Uniprot = P01907
| Mm_EntrezGene = 14960
| Mm_Ensembl = ENSMUSG00000036594
| Mm_RefseqmRNA = NM_010378
| Mm_RefseqProtein = NP_034508
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33891095
| Mm_GenLoc_end = 33896139
| Mm_Uniprot = Q3TB90
}}
}}
'''Major histocompatibility complex, class II, DQ alpha 1''', also known as '''HLA-DQA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.<ref>{{cite web | title = Entrez Gene: HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3117| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schmidt H, Williamson D, Ashley-Koch A |title=HLA-DR15 haplotype and multiple sclerosis: a HuGE review. |journal=Am. J. Epidemiol. |volume=165 |issue= 10 |pages= 1097-109 |year= 2007 |pmid= 17329717 |doi= 10.1093/aje/kwk118 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IKBKG... {November 6, 2007 4:17:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:19:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
| HGNCid = 5961
| Symbol = IKBKG
| AltSymbols =; IP; FIP-3; FIP3; Fip3p; IKK-gamma; IP1; IP2; NEMO
| OMIM = 300248
| ECnumber =
| Homologene = 2698
| MGIid = 1338074
| GeneAtlas_image1 = PBB_GE_IKBKG_36004_at_tn.png
| GeneAtlas_image2 = PBB_GE_IKBKG_209929_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0008385 |text = IkappaB kinase complex}} {{GNF_GO|id=GO:0044444 |text = cytoplasmic part}}
| Process = {{GNF_GO|id=GO:0001782 |text = B cell homeostasis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8517
| Hs_Ensembl = ENSG00000073009
| Hs_RefseqProtein = NP_003630
| Hs_RefseqmRNA = NM_003639
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153423653
| Hs_GenLoc_end = 153446455
| Hs_Uniprot = Q9Y6K9
| Mm_EntrezGene = 16151
| Mm_Ensembl = ENSMUSG00000004221
| Mm_RefseqmRNA = NM_010547
| Mm_RefseqProtein = NP_034677
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70677332
| Mm_GenLoc_end = 70704240
| Mm_Uniprot = Q3UG24
}}
}}
'''Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma''', also known as '''IKBKG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8517| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL12B... {November 6, 2007 4:00:14 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL12B image.jpg {November 6, 2007 4:00:49 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 4:01:22 PM PST}
- CREATED: Created new protein page: IL12B {November 6, 2007 4:01:37 PM PST}
- INFO: Beginning work on IL6ST... {November 6, 2007 3:58:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL6ST image.jpg {November 6, 2007 3:59:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:00:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL6ST_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bj8.
| PDB = {{PDB2|1bj8}}, {{PDB2|1bqu}}, {{PDB2|1i1r}}, {{PDB2|1p9m}}, {{PDB2|1pvh}}
| Name = Interleukin 6 signal transducer (gp130, oncostatin M receptor)
| HGNCid = 6021
| Symbol = IL6ST
| AltSymbols =; CD130; CDw130; GP130; GP130-RAPS; IL6R-beta
| OMIM = 600694
| ECnumber =
| Homologene = 1645
| MGIid = 96560
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004915 |text = interleukin-6 receptor activity}} {{GNF_GO|id=GO:0004924 |text = oncostatin-M receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008593 |text = regulation of Notch signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3572
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002175
| Hs_RefseqmRNA = NM_002184
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16195
| Mm_Ensembl = ENSMUSG00000021756
| Mm_RefseqmRNA = NM_010560
| Mm_RefseqProtein = NP_034690
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 113584987
| Mm_GenLoc_end = 113627719
| Mm_Uniprot = Q3TDT5
}}
}}
'''Interleukin 6 signal transducer (gp130, oncostatin M receptor)''', also known as '''IL6ST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3572| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGA4... {November 6, 2007 4:01:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:03:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
| HGNCid = 6140
| Symbol = ITGA4
| AltSymbols =; CD49D; IA4; MGC90518
| OMIM = 192975
| ECnumber =
| Homologene = 37364
| MGIid = 96603
| GeneAtlas_image1 = PBB_GE_ITGA4_213416_at_tn.png
| GeneAtlas_image2 = PBB_GE_ITGA4_205884_at_tn.png
| GeneAtlas_image3 = PBB_GE_ITGA4_205885_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001974 |text = blood vessel remodeling}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3676
| Hs_Ensembl = ENSG00000115232
| Hs_RefseqProtein = NP_000876
| Hs_RefseqmRNA = NM_000885
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 182029864
| Hs_GenLoc_end = 182110711
| Hs_Uniprot = P13612
| Mm_EntrezGene = 16401
| Mm_Ensembl = ENSMUSG00000027009
| Mm_RefseqmRNA = NM_010576
| Mm_RefseqProtein = NP_034706
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 79056339
| Mm_GenLoc_end = 79133962
| Mm_Uniprot = Q78E20
}}
}}
'''Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)''', also known as '''ITGA4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.<ref>{{cite web | title = Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3676| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Humphries MJ, Sheridan J, Mould AP, Newham P |title=Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design. |journal=Ciba Found. Symp. |volume=189 |issue= |pages= 177-91; discussion 191-9 |year= 1995 |pmid= 7587632 |doi= }}
*{{cite journal | author=Oostendorp RA, Dörmer P |title=VLA-4-mediated interactions between normal human hematopoietic progenitors and stromal cells. |journal=Leuk. Lymphoma |volume=24 |issue= 5-6 |pages= 423-35 |year= 1997 |pmid= 9086434 |doi= }}
*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390-6 |year= 1999 |pmid= 9789327 |doi= }}
*{{cite journal | author=Rose DM, Han J, Ginsberg MH |title=Alpha4 integrins and the immune response. |journal=Immunol. Rev. |volume=186 |issue= |pages= 118-24 |year= 2003 |pmid= 12234367 |doi= }}
*{{cite journal | author=O'Connor P |title=Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis. |journal=Expert opinion on biological therapy |volume=7 |issue= 1 |pages= 123-36 |year= 2007 |pmid= 17150024 |doi= 10.1517/14712598.7.1.123 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGAL... {November 6, 2007 4:03:28 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ITGAL image.jpg {November 6, 2007 4:04:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:04:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGAL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cqp.
| PDB = {{PDB2|1cqp}}, {{PDB2|1dgq}}, {{PDB2|1lfa}}, {{PDB2|1mjn}}, {{PDB2|1mq8}}, {{PDB2|1mq9}}, {{PDB2|1mqa}}, {{PDB2|1rd4}}, {{PDB2|1t0p}}, {{PDB2|1xdd}}, {{PDB2|1xdg}}, {{PDB2|1xuo}}, {{PDB2|1zon}}, {{PDB2|1zoo}}, {{PDB2|1zop}}, {{PDB2|2ica}}, {{PDB2|2o7n}}
| Name = Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
| HGNCid = 6148
| Symbol = ITGAL
| AltSymbols =; CD11A; LFA-1; LFA1A
| OMIM = 153370
| ECnumber =
| Homologene = 1666
| MGIid = 96606
| GeneAtlas_image1 = PBB_GE_ITGAL_213475_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3683
| Hs_Ensembl = ENSG00000005844
| Hs_RefseqProtein = NP_002200
| Hs_RefseqmRNA = NM_002209
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 30391551
| Hs_GenLoc_end = 30441772
| Hs_Uniprot = P20701
| Mm_EntrezGene = 16408
| Mm_Ensembl = ENSMUSG00000030830
| Mm_RefseqmRNA = NM_008400
| Mm_RefseqProtein = NP_032426
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 127087558
| Mm_GenLoc_end = 127124876
| Mm_Uniprot = Q3T9N8
}}
}}
'''Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)''', also known as '''ITGAL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.<ref>{{cite web | title = Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3683| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lub M, van Kooyk Y, Figdor CG |title=Ins and outs of LFA-1. |journal=Immunol. Today |volume=16 |issue= 10 |pages= 479-83 |year= 1995 |pmid= 7576051 |doi= }}
*{{cite journal | author=Dickeson SK, Santoro SA |title=Ligand recognition by the I domain-containing integrins. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 6 |pages= 556-66 |year= 1998 |pmid= 9676575 |doi= }}
*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390-6 |year= 1999 |pmid= 9789327 |doi= }}
*{{cite journal | author=Giblin PA, Lemieux RM |title=LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics. |journal=Curr. Pharm. Des. |volume=12 |issue= 22 |pages= 2771-95 |year= 2006 |pmid= 16918410 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCNJ11... {November 6, 2007 4:04:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:05:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 11
| HGNCid = 6257
| Symbol = KCNJ11
| AltSymbols =; BIR; HHF2; IKATP; KIR6.2; MGC133230; PHHI; TNDM3
| OMIM = 600937
| ECnumber =
| Homologene = 441
| MGIid = 107501
| Function = {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0015272 |text = ATP-activated inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3767
| Hs_Ensembl = ENSG00000187486
| Hs_RefseqProtein = NP_000516
| Hs_RefseqmRNA = NM_000525
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 17365042
| Hs_GenLoc_end = 17366214
| Hs_Uniprot = Q14654
| Mm_EntrezGene = 16514
| Mm_Ensembl = ENSMUSG00000070561
| Mm_RefseqmRNA = NM_010602
| Mm_RefseqProtein = NP_034732
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 45966767
| Mm_GenLoc_end = 45967939
| Mm_Uniprot = Q8CCI6
}}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 11''', also known as '''KCNJ11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM).<ref>{{cite web | title = Entrez Gene: KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3767| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Aguilar-Bryan L, Bryan J |title=Molecular biology of adenosine triphosphate-sensitive potassium channels. |journal=Endocr. Rev. |volume=20 |issue= 2 |pages= 101-35 |year= 1999 |pmid= 10204114 |doi= }}
*{{cite journal | author=Meissner T, Beinbrech B, Mayatepek E |title=Congenital hyperinsulinism: molecular basis of a heterogeneous disease. |journal=Hum. Mutat. |volume=13 |issue= 5 |pages= 351-61 |year= 1999 |pmid= 10338089 |doi= 10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO;2-R }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
*{{cite journal | author=Gloyn AL, Siddiqui J, Ellard S |title=Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. |journal=Hum. Mutat. |volume=27 |issue= 3 |pages= 220-31 |year= 2006 |pmid= 16416420 |doi= 10.1002/humu.20292 }}
*{{cite journal | author=Flechtner I, de Lonlay P, Polak M |title=Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences. |journal=Diabetes Metab. |volume=32 |issue= 6 |pages= 569-80 |year= 2007 |pmid= 17296510 |doi= 10.1016/S1262-3636(07)70311-7 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KNG1... {November 6, 2007 4:05:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:07:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kininogen 1
| HGNCid = 6383
| Symbol = KNG1
| AltSymbols =; BDK; KNG
| OMIM = 228960
| ECnumber =
| Homologene = 88343
| MGIid = 3027157
| GeneAtlas_image1 = PBB_GE_KNG1_206054_at_tn.png
| GeneAtlas_image2 = PBB_GE_KNG1_217512_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0030146 |text = diuresis}} {{GNF_GO|id=GO:0030147 |text = natriuresis}} {{GNF_GO|id=GO:0030195 |text = negative regulation of blood coagulation}} {{GNF_GO|id=GO:0042311 |text = vasodilation}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3827
| Hs_Ensembl = ENSG00000113889
| Hs_RefseqProtein = NP_000884
| Hs_RefseqmRNA = NM_000893
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 187917814
| Hs_GenLoc_end = 187944435
| Hs_Uniprot = P01042
| Mm_EntrezGene = 385643
| Mm_Ensembl = ENSMUSG00000060459
| Mm_RefseqmRNA = XM_989028
| Mm_RefseqProtein = XP_994122
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 22902680
| Mm_GenLoc_end = 22944351
| Mm_Uniprot =
}}
}}
'''Kininogen 1''', also known as '''KNG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Iarovaia GA |title=[Kallikrein-kinin system: novel facts and concepts (literature review)] |journal=Vopr. Med. Khim. |volume=47 |issue= 1 |pages= 20-42 |year= 2001 |pmid= 11385996 |doi= }}
*{{cite journal | author=Matthews KW, Mueller-Ortiz SL, Wetsel RA |title=Carboxypeptidase N: a pleiotropic regulator of inflammation. |journal=Mol. Immunol. |volume=40 |issue= 11 |pages= 785-93 |year= 2004 |pmid= 14687935 |doi= }}
*{{cite journal | author=Scharfstein J, Schmitz V, Svensjö E, ''et al.'' |title=Kininogens coordinate adaptive immunity through the proteolytic release of bradykinin, an endogenous danger signal driving dendritic cell maturation. |journal=Scand. J. Immunol. |volume=66 |issue= 2-3 |pages= 128-36 |year= 2007 |pmid= 17635790 |doi= 10.1111/j.1365-3083.2007.01983.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MC1R... {November 6, 2007 4:07:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:07:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
| HGNCid = 6929
| Symbol = MC1R
| AltSymbols =; MGC14337; MSH-R
| OMIM = 155555
| ECnumber =
| Homologene = 1789
| MGIid = 99456
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004980 |text = melanocyte stimulating hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0015630 |text = microtubule cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009650 |text = UV protection}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4157
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002377
| Hs_RefseqmRNA = NM_002386
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 17199
| Mm_Ensembl = ENSMUSG00000074037
| Mm_RefseqmRNA = NM_008559
| Mm_RefseqProtein = NP_032585
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 126293586
| Mm_GenLoc_end = 126294846
| Mm_Uniprot = Q75NA2
}}
}}
'''Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)''', also known as '''MC1R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.<ref>{{cite web | title = Entrez Gene: MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4157| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Venter JC |title=Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. |journal=J. Pharm. Pharmacol. |volume=45 Suppl 1 |issue= |pages= 355-60 |year= 1993 |pmid= 8098743 |doi= }}
*{{cite journal | author=Abdel-Malek Z, Suzuki I, Tada A, ''et al.'' |title=The melanocortin-1 receptor and human pigmentation. |journal=Ann. N. Y. Acad. Sci. |volume=885 |issue= |pages= 117-33 |year= 2000 |pmid= 10816645 |doi= }}
*{{cite journal | author=Rees JL |title=The melanocortin 1 receptor (MC1R): more than just red hair. |journal=Pigment Cell Res. |volume=13 |issue= 3 |pages= 135-40 |year= 2000 |pmid= 10885670 |doi= }}
*{{cite journal | author=Sturm RA, Duffy DL, Box NF, ''et al.'' |title=The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. |journal=Pigment Cell Res. |volume=16 |issue= 3 |pages= 266-72 |year= 2004 |pmid= 12753400 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCK1... {November 6, 2007 4:07:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCK1 image.jpg {November 6, 2007 4:09:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:09:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NCK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ci8.
| PDB = {{PDB2|2ci8}}, {{PDB2|2ci9}}, {{PDB2|2cub}}
| Name = NCK adaptor protein 1
| HGNCid = 7664
| Symbol = NCK1
| AltSymbols =; MGC12668; NCK; NCKalpha
| OMIM = 600508
| ECnumber =
| Homologene = 38148
| MGIid = 109601
| GeneAtlas_image1 = PBB_GE_NCK1_204725_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCK1_211063_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008093 |text = cytoskeletal adaptor activity}} {{GNF_GO|id=GO:0030159 |text = receptor signaling complex scaffold activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0012506 |text = vesicle membrane}}
| Process = {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007172 |text = signal complex assembly}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030032 |text = lamellipodium biogenesis}} {{GNF_GO|id=GO:0030838 |text = positive regulation of actin filament polymerization}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4690
| Hs_Ensembl = ENSG00000158092
| Hs_RefseqProtein = NP_006144
| Hs_RefseqmRNA = NM_006153
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 138063763
| Hs_GenLoc_end = 138150657
| Hs_Uniprot = P16333
| Mm_EntrezGene = 17973
| Mm_Ensembl = ENSMUSG00000032475
| Mm_RefseqmRNA = NM_010878
| Mm_RefseqProtein = NP_035008
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 100304355
| Mm_GenLoc_end = 100355405
| Mm_Uniprot =
}}
}}
'''NCK adaptor protein 1''', also known as '''NCK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS.<ref>{{cite web | title = Entrez Gene: NCK1 NCK adaptor protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4690| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Iwata S, Ohashi Y, Kamiguchi K, Morimoto C |title=Beta 1-integrin-mediated cell signaling in T lymphocytes. |journal=J. Dermatol. Sci. |volume=23 |issue= 2 |pages= 75-86 |year= 2000 |pmid= 10808124 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PECAM1... {November 6, 2007 4:10:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:12:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Platelet/endothelial cell adhesion molecule (CD31 antigen)
| HGNCid = 8823
| Symbol = PECAM1
| AltSymbols =; CD31; PECAM-1
| OMIM = 173445
| ECnumber =
| Homologene = 47925
| MGIid = 97537
| GeneAtlas_image1 = PBB_GE_PECAM1_208982_at_tn.png
| GeneAtlas_image2 = PBB_GE_PECAM1_208981_at_tn.png
| GeneAtlas_image3 = PBB_GE_PECAM1_208983_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008037 |text = cell recognition}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0042060 |text = wound healing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5175
| Hs_Ensembl = ENSG00000198802
| Hs_RefseqProtein = NP_000433
| Hs_RefseqmRNA = NM_000442
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59754404
| Hs_GenLoc_end = 59794504
| Hs_Uniprot = P16284
| Mm_EntrezGene = 18613
| Mm_Ensembl = ENSMUSG00000020717
| Mm_RefseqmRNA = NM_001032378
| Mm_RefseqProtein = NP_001027550
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106470307
| Mm_GenLoc_end = 106566718
| Mm_Uniprot = Q8CAW4
}}
}}
'''Platelet/endothelial cell adhesion molecule (CD31 antigen)''', also known as '''PECAM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jackson DE |title=The unfolding tale of PECAM-1. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 7-14 |year= 2003 |pmid= 12681475 |doi= }}
*{{cite journal | author=Newman PJ, Newman DK |title=Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 953-64 |year= 2004 |pmid= 12689916 |doi= 10.1161/01.ATV.0000071347.69358.D9 }}
*{{cite journal | author=Ilan N, Madri JA |title=PECAM-1: old friend, new partners. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 5 |pages= 515-24 |year= 2004 |pmid= 14519385 |doi= }}
*{{cite journal | author=Wong MX, Jackson DE |title=Regulation of B cell activation by PECAM-1: implications for the development of autoimmune disorders. |journal=Curr. Pharm. Des. |volume=10 |issue= 2 |pages= 155-61 |year= 2004 |pmid= 14754395 |doi= }}
*{{cite journal | author=Kalinowska A, Losy J |title=PECAM-1, a key player in neuroinflammation. |journal=Eur. J. Neurol. |volume=13 |issue= 12 |pages= 1284-90 |year= 2007 |pmid= 17116209 |doi= 10.1111/j.1468-1331.2006.01640.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPS6KA1... {November 6, 2007 4:12:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:13:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 1
| HGNCid = 10430
| Symbol = RPS6KA1
| AltSymbols =; HU-1; MAPKAPK1A; RSK; RSK1; S6K-alpha 1
| OMIM = 601684
| ECnumber =
| Homologene = 55703
| MGIid = 104558
| GeneAtlas_image1 = PBB_GE_RPS6KA1_203379_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6195
| Hs_Ensembl = ENSG00000117676
| Hs_RefseqProtein = NP_001006666
| Hs_RefseqmRNA = NM_001006665
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 26728836
| Hs_GenLoc_end = 26774108
| Hs_Uniprot = Q15418
| Mm_EntrezGene = 20111
| Mm_Ensembl = ENSMUSG00000003644
| Mm_RefseqmRNA = NM_009097
| Mm_RefseqProtein = NP_033123
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 133119370
| Mm_GenLoc_end = 133159860
| Mm_Uniprot = Q3TIM6
}}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 1''', also known as '''RPS6KA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SOCS3... {November 6, 2007 4:19:09 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SOCS3 image.jpg {November 6, 2007 4:20:12 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 4:20:45 PM PST}
- CREATED: Created new protein page: SOCS3 {November 6, 2007 4:21:00 PM PST}
- INFO: Beginning work on SPARC... {November 6, 2007 4:13:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SPARC image.jpg {November 6, 2007 4:14:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:14:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPARC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bmo.
| PDB = {{PDB2|1bmo}}, {{PDB2|1nub}}, {{PDB2|1sra}}
| Name = Secreted protein, acidic, cysteine-rich (osteonectin)
| HGNCid = 11219
| Symbol = SPARC
| AltSymbols =; ON
| OMIM = 182120
| ECnumber =
| Homologene = 31132
| MGIid = 98373
| GeneAtlas_image1 = PBB_GE_SPARC_200665_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPARC_212667_at_tn.png
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005604 |text = basement membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6678
| Hs_Ensembl = ENSG00000113140
| Hs_RefseqProtein = NP_003109
| Hs_RefseqmRNA = NM_003118
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 151021212
| Hs_GenLoc_end = 151046710
| Hs_Uniprot = P09486
| Mm_EntrezGene = 20692
| Mm_Ensembl = ENSMUSG00000018593
| Mm_RefseqmRNA = XM_990025
| Mm_RefseqProtein = XP_995119
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 55237924
| Mm_GenLoc_end = 55263289
| Mm_Uniprot = Q3TXI6
}}
}}
'''Secreted protein, acidic, cysteine-rich (osteonectin)''', also known as '''SPARC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SPARC secreted protein, acidic, cysteine-rich (osteonectin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6678| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yan Q, Sage EH |title=SPARC, a matricellular glycoprotein with important biological functions. |journal=J. Histochem. Cytochem. |volume=47 |issue= 12 |pages= 1495-506 |year= 1999 |pmid= 10567433 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SRF... {November 6, 2007 4:14:25 PM PST}
- UPLOAD: Added new Image to wiki:
{November 6, 2007 4:15:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:15:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SRF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hbx.
| PDB = {{PDB2|1hbx}}, {{PDB2|1k6o}}, {{PDB2|1srs}}
| Name = Serum response factor (c-fos serum response element-binding transcription factor)
| HGNCid = 11291
| Symbol = SRF
| AltSymbols =; MCM1
| OMIM = 600589
| ECnumber =
| Homologene = 31135
| MGIid = 106658
| GeneAtlas_image1 = PBB_GE_SRF_202401_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SRF_202400_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001947 |text = heart looping}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0046716 |text = muscle maintenance}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6722
| Hs_Ensembl = ENSG00000112658
| Hs_RefseqProtein = NP_003122
| Hs_RefseqmRNA = NM_003131
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 43246898
| Hs_GenLoc_end = 43257219
| Hs_Uniprot = P11831
| Mm_EntrezGene = 20807
| Mm_Ensembl = ENSMUSG00000015605
| Mm_RefseqmRNA = NM_020493
| Mm_RefseqProtein = NP_065239
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 46010028
| Mm_GenLoc_end = 46019351
| Mm_Uniprot = Q9JM73
}}
}}
'''Serum response factor (c-fos serum response element-binding transcription factor)''', also known as '''SRF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).<ref>{{cite web | title = Entrez Gene: SRF serum response factor (c-fos serum response element-binding transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6722| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miano JM |title=Serum response factor: toggling between disparate programs of gene expression. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 6 |pages= 577-93 |year= 2004 |pmid= 12788374 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on STX1A... {November 6, 2007 4:15:40 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein STX1A image.jpg {November 6, 2007 4:16:16 PM PST}
- CREATE: Found no pages, creating new page. {November 6, 2007 4:16:34 PM PST}
- CREATED: Created new protein page: STX1A {November 6, 2007 4:16:44 PM PST}
- INFO: Beginning work on UBB... {November 6, 2007 4:16:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein UBB image.jpg {November 6, 2007 4:17:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 4:17:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UBB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aar.
| PDB = {{PDB2|1aar}}, {{PDB2|1cmx}}, {{PDB2|1d3z}}, {{PDB2|1f9j}}, {{PDB2|1fxt}}, {{PDB2|1g6j}}, {{PDB2|1gjz}}, {{PDB2|1nbf}}, {{PDB2|1ogw}}, {{PDB2|1otr}}, {{PDB2|1p3q}}, {{PDB2|1q0w}}, {{PDB2|1q5w}}, {{PDB2|1s1q}}, {{PDB2|1sif}}, {{PDB2|1tbe}}, {{PDB2|1ubi}}, {{PDB2|1ubq}}, {{PDB2|1ud7}}, {{PDB2|1uzx}}, {{PDB2|1v80}}, {{PDB2|1v81}}, {{PDB2|1wr1}}, {{PDB2|1wr6}}, {{PDB2|1wrd}}, {{PDB2|1xd3}}, {{PDB2|1xqq}}, {{PDB2|1yd8}}, {{PDB2|1yiw}}, {{PDB2|1yj1}}, {{PDB2|1yx5}}, {{PDB2|1yx6}}, {{PDB2|1zgu}}, {{PDB2|2ayo}}, {{PDB2|2bgf}}, {{PDB2|2c7m}}, {{PDB2|2c7n}}, {{PDB2|2d3g}}, {{PDB2|2den}}, {{PDB2|2dx5}}, {{PDB2|2fcm}}, {{PDB2|2fcn}}, {{PDB2|2fcq}}, {{PDB2|2fcs}}, {{PDB2|2fid}}, {{PDB2|2fif}}, {{PDB2|2fuh}}, {{PDB2|2g3q}}, {{PDB2|2g45}}, {{PDB2|2gbj}}, {{PDB2|2gbk}}, {{PDB2|2gbm}}, {{PDB2|2gbn}}, {{PDB2|2gbr}}, {{PDB2|2gmi}}, {{PDB2|2hd5}}, {{PDB2|2hth}}, {{PDB2|2ibi}}, {{PDB2|2j7q}}, {{PDB2|2nr2}}, {{PDB2|2o6v}}, {{PDB2|2oob}}
| Name = Ubiquitin B
| HGNCid = 12463
| Symbol = UBB
| AltSymbols =; FLJ25987; MGC8385
| OMIM = 191339
| ECnumber =
| Homologene = 75104
| MGIid =
| GeneAtlas_image1 = PBB_GE_UBB_200633_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7314
| Hs_Ensembl = ENSG00000170315
| Hs_RefseqProtein = NP_061828
| Hs_RefseqmRNA = NM_018955
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 16225092
| Hs_GenLoc_end = 16226779
| Hs_Uniprot = P62988
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ubiquitin B''', also known as '''UBB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.<ref>{{cite web | title = Entrez Gene: UBB ubiquitin B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7314| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Conaway RC, Brower CS, Conaway JW |title=Emerging roles of ubiquitin in transcription regulation. |journal=Science |volume=296 |issue= 5571 |pages= 1254-8 |year= 2002 |pmid= 12016299 |doi= 10.1126/science.1067466 }}
*{{cite journal | author=Murphey RK, Godenschwege TA |title=New roles for ubiquitin in the assembly and function of neuronal circuits. |journal=Neuron |volume=36 |issue= 1 |pages= 5-8 |year= 2002 |pmid= 12367500 |doi= }}
*{{cite journal | author=Mazzé FM, Degrève L |title=The role of viral and cellular proteins in the budding of human immunodeficiency virus. |journal=Acta Virol. |volume=50 |issue= 2 |pages= 75-85 |year= 2006 |pmid= 16808324 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
