Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 04:05, 26 November 2007 (UTC)[edit]
Proteins without matches (18)[edit]
Proteins with a High Potential Match (3)[edit]
Redirected Proteins (4)[edit]
Created (3)[edit]
Manual Inspection (Page not found) (18)[edit]
Updated (4)[edit]
Protein Status Grid - Date: 04:05, 26 November 2007 (UTC)[edit]
Vebose Log - Date: 04:05, 26 November 2007 (UTC)[edit]
- INFO: Beginning work on OPN1LW... {November 25, 2007 8:03:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:04:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)
| HGNCid = 9936
| Symbol = OPN1LW
| AltSymbols =; CBP; CBBM; RCP
| OMIM = 303900
| ECnumber =
| Homologene = 68064
| MGIid = 1097692
| GeneAtlas_image1 = PBB_GE_OPN1LW_221327_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0009881 |text = photoreceptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5956
| Hs_Ensembl = ENSG00000102076
| Hs_RefseqProtein = NP_064445
| Hs_RefseqmRNA = NM_020061
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153062934
| Hs_GenLoc_end = 153077699
| Hs_Uniprot = P04000
| Mm_EntrezGene = 14539
| Mm_Ensembl = ENSMUSG00000031394
| Mm_RefseqmRNA = NM_008106
| Mm_RefseqProtein = NP_032132
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70380184
| Mm_GenLoc_end = 70403476
| Mm_Uniprot = O35599
}}
}}
'''Opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)''', also known as '''OPN1LW''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPN1LW opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5956| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness.<ref name="entrez">{{cite web | title = Entrez Gene: OPN1LW opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5956| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Applebury ML, Hargrave PA |title=Molecular biology of the visual pigments. |journal=Vision Res. |volume=26 |issue= 12 |pages= 1881-95 |year= 1987 |pmid= 3303660 |doi= }}
*{{cite journal | author=Winderickx J, Lindsey DT, Sanocki E, ''et al.'' |title=Polymorphism in red photopigment underlies variation in colour matching. |journal=Nature |volume=356 |issue= 6368 |pages= 431-3 |year= 1992 |pmid= 1557123 |doi= 10.1038/356431a0 }}
*{{cite journal | author=Dietrich A, Korn B, Poustka A |title=Completion of the physical map of Xq28: the location of the gene for L1CAM on the human X chromosome. |journal=Mamm. Genome |volume=3 |issue= 3 |pages= 168-72 |year= 1992 |pmid= 1617223 |doi= }}
*{{cite journal | author=Arveiler B, Vincent A, Mandel JL |title=Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region. |journal=Genomics |volume=4 |issue= 4 |pages= 460-71 |year= 1989 |pmid= 2501212 |doi= }}
*{{cite journal | author=Nathans J, Thomas D, Hogness DS |title=Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. |journal=Science |volume=232 |issue= 4747 |pages= 193-202 |year= 1986 |pmid= 2937147 |doi= }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
*{{cite journal | author=Li ZY, Kljavin IJ, Milam AH |title=Rod photoreceptor neurite sprouting in retinitis pigmentosa. |journal=J. Neurosci. |volume=15 |issue= 8 |pages= 5429-38 |year= 1995 |pmid= 7643192 |doi= }}
*{{cite journal | author=Chen J, Tucker CL, Woodford B, ''et al.'' |title=The human blue opsin promoter directs transgene expression in short-wave cones and bipolar cells in the mouse retina. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2611-5 |year= 1994 |pmid= 8146162 |doi= }}
*{{cite journal | author=Nathans J, Maumenee IH, Zrenner E, ''et al.'' |title=Genetic heterogeneity among blue-cone monochromats. |journal=Am. J. Hum. Genet. |volume=53 |issue= 5 |pages= 987-1000 |year= 1993 |pmid= 8213841 |doi= }}
*{{cite journal | author=Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL |title=A new mechanism in blue cone monochromatism. |journal=Hum. Genet. |volume=98 |issue= 4 |pages= 403-8 |year= 1996 |pmid= 8792812 |doi= }}
*{{cite journal | author=Ferreira PA, Nakayama TA, Pak WL, Travis GH |title=Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. |journal=Nature |volume=383 |issue= 6601 |pages= 637-40 |year= 1996 |pmid= 8857542 |doi= 10.1038/383637a0 }}
*{{cite journal | author=Voegel JJ, Heine MJ, Tini M, ''et al.'' |title=The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. |journal=EMBO J. |volume=17 |issue= 2 |pages= 507-19 |year= 1998 |pmid= 9430642 |doi= 10.1093/emboj/17.2.507 }}
*{{cite journal | author=Zhao Z, Hewett-Emmett D, Li WH |title=Frequent gene conversion between human red and green opsin genes. |journal=J. Mol. Evol. |volume=46 |issue= 4 |pages= 494-6 |year= 1998 |pmid= 9541545 |doi= }}
*{{cite journal | author=Nakayama TA, Zhang W, Cowan A, Kung M |title=Mutagenesis studies of human red opsin: trp-281 is essential for proper folding and protein-retinal interactions. |journal=Biochemistry |volume=37 |issue= 50 |pages= 17487-94 |year= 1999 |pmid= 9860863 |doi= 10.1021/bi982077u }}
*{{cite journal | author=John SK, Smith JE, Aguirre GD, Milam AH |title=Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. |journal=Mol. Vis. |volume=6 |issue= |pages= 204-15 |year= 2000 |pmid= 11063754 |doi= }}
*{{cite journal | author=Ueyama H, Kuwayama S, Imai H, ''et al.'' |title=Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 205-9 |year= 2002 |pmid= 12051694 |doi= 10.1016/S0006-291X(02)00458-8 }}
*{{cite journal | author=Fitzgerald KA, Rowe DC, Barnes BJ, ''et al.'' |title=LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. |journal=J. Exp. Med. |volume=198 |issue= 7 |pages= 1043-55 |year= 2003 |pmid= 14517278 |doi= 10.1084/jem.20031023 }}
*{{cite journal | author=Long J, Wang G, Matsuura I, ''et al.'' |title=Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 1 |pages= 99-104 |year= 2004 |pmid= 14691252 |doi= 10.1073/pnas.0307598100 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPRM1... {November 25, 2007 7:44:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:45:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opioid receptor, mu 1
| HGNCid = 8156
| Symbol = OPRM1
| AltSymbols =; MOR1; KIAA0403; OPRM
| OMIM = 600018
| ECnumber =
| Homologene = 37368
| MGIid = 97441
| GeneAtlas_image1 = PBB_GE_OPRM1_211359_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004988 |text = mu-opioid receptor activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4988
| Hs_Ensembl = ENSG00000112038
| Hs_RefseqProtein = NP_000905
| Hs_RefseqmRNA = NM_000914
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 154402136
| Hs_GenLoc_end = 154609693
| Hs_Uniprot = P35372
| Mm_EntrezGene = 18390
| Mm_Ensembl = ENSMUSG00000000766
| Mm_RefseqmRNA = XM_001052051
| Mm_RefseqProtein = XP_001052051
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 3332431
| Mm_GenLoc_end = 3588035
| Mm_Uniprot = Q8CH75
}}
}}
'''Opioid receptor, mu 1''', also known as '''OPRM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPRM1 opioid receptor, mu 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4988| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Uhl GR, Sora I, Wang Z |title=The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 7752-5 |year= 1999 |pmid= 10393893 |doi= }}
*{{cite journal | author=Christie MJ, Connor M, Vaughan CW, ''et al.'' |title=Cellular actions of opioids and other analgesics: implications for synergism in pain relief. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 7 |pages= 520-3 |year= 2000 |pmid= 10874510 |doi= }}
*{{cite journal | author=Maneckjee R, Minna JD |title=Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 9 |pages= 3294-8 |year= 1990 |pmid= 2159143 |doi= }}
*{{cite journal | author=Chuang TK, Killam KF, Chuang LF, ''et al.'' |title=Mu opioid receptor gene expression in immune cells. |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 3 |pages= 922-30 |year= 1995 |pmid= 7488213 |doi= 10.1006/bbrc.1995.2709 }}
*{{cite journal | author=Mestek A, Hurley JH, Bye LS, ''et al.'' |title=The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C. |journal=J. Neurosci. |volume=15 |issue= 3 Pt 2 |pages= 2396-406 |year= 1995 |pmid= 7891175 |doi= }}
*{{cite journal | author=Wang JB, Johnson PS, Persico AM, ''et al.'' |title=Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. |journal=FEBS Lett. |volume=338 |issue= 2 |pages= 217-22 |year= 1994 |pmid= 7905839 |doi= }}
*{{cite journal | author=Bare LA, Mansson E, Yang D |title=Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain. |journal=FEBS Lett. |volume=354 |issue= 2 |pages= 213-6 |year= 1994 |pmid= 7957926 |doi= }}
*{{cite journal | author=Georgoussi Z, Carr C, Milligan G |title=Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 62-9 |year= 1993 |pmid= 8393523 |doi= }}
*{{cite journal | author=Massotte D, Baroche L, Simonin F, ''et al.'' |title=Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19987-92 |year= 1997 |pmid= 9242668 |doi= }}
*{{cite journal | author=Pak Y, O'Dowd BF, George SR |title=Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 24961-5 |year= 1997 |pmid= 9312100 |doi= }}
*{{cite journal | author=Koch T, Kroslak T, Mayer P, ''et al.'' |title=Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization. |journal=J. Neurochem. |volume=69 |issue= 4 |pages= 1767-70 |year= 1997 |pmid= 9326307 |doi= }}
*{{cite journal | author=Bergen AW, Kokoszka J, Peterson R, ''et al.'' |title=Mu opioid receptor gene variants: lack of association with alcohol dependence. |journal=Mol. Psychiatry |volume=2 |issue= 6 |pages= 490-4 |year= 1998 |pmid= 9399694 |doi= }}
*{{cite journal | author=Lee JW, Joshi S, Chan JS, Wong YH |title=Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. |journal=J. Neurochem. |volume=70 |issue= 5 |pages= 2203-11 |year= 1998 |pmid= 9572309 |doi= }}
*{{cite journal | author=Bond C, LaForge KS, Tian M, ''et al.'' |title=Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9608-13 |year= 1998 |pmid= 9689128 |doi= }}
*{{cite journal | author=Peckys D, Landwehrmeyer GB |title=Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study. |journal=Neuroscience |volume=88 |issue= 4 |pages= 1093-135 |year= 1999 |pmid= 10336124 |doi= }}
*{{cite journal | author=Fimiani C, Arcuri E, Santoni A, ''et al.'' |title=Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release. |journal=Cancer Lett. |volume=146 |issue= 1 |pages= 45-51 |year= 2000 |pmid= 10656608 |doi= }}
*{{cite journal | author=Pan YX, Xu J, Bolan E, ''et al.'' |title=Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F. |journal=FEBS Lett. |volume=466 |issue= 2-3 |pages= 337-40 |year= 2000 |pmid= 10682855 |doi= }}
*{{cite journal | author=Sander T, Berlin W, Gscheidel N, ''et al.'' |title=Genetic variation of the human mu-opioid receptor and susceptibility to idiopathic absence epilepsy. |journal=Epilepsy Res. |volume=39 |issue= 1 |pages= 57-61 |year= 2000 |pmid= 10690754 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1D2... {November 25, 2007 7:45:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:46:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily D, member 2
| HGNCid = 8183
| Symbol = OR1D2
| AltSymbols =; MGC119942; MGC119943; OLFR1; OR17-4
| OMIM = 164342
| ECnumber =
| Homologene = 37634
| MGIid = 3030246
| GeneAtlas_image1 = PBB_GE_OR1D2_221464_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4991
| Hs_Ensembl = ENSG00000184166
| Hs_RefseqProtein = NP_002539
| Hs_RefseqmRNA = NM_002548
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 2942102
| Hs_GenLoc_end = 2943040
| Hs_Uniprot = P34982
| Mm_EntrezGene = 258153
| Mm_Ensembl = ENSMUSG00000058275
| Mm_RefseqmRNA = NM_001011851
| Mm_RefseqProtein = NP_001011851
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74180866
| Mm_GenLoc_end = 74181804
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily D, member 2''', also known as '''OR1D2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J |title=Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. |journal=Brain Res. Mol. Brain Res. |volume=13 |issue= 1-2 |pages= 159-63 |year= 1992 |pmid= 1315913 |doi= }}
*{{cite journal | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal | author=Buck L, Axel R |title=A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. |journal=Cell |volume=65 |issue= 1 |pages= 175-87 |year= 1991 |pmid= 1840504 |doi= }}
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Schurmans S, Muscatelli F, Miot F, ''et al.'' |title=The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 3 |pages= 200-4 |year= 1993 |pmid= 8097991 |doi= }}
*{{cite journal | author=Nekrasova E, Sosinskaya A, Natochin M, ''et al.'' |title=Overexpression, solubilization and purification of rat and human olfactory receptors. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 28-37 |year= 1996 |pmid= 8665947 |doi= }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Spehr M, Gisselmann G, Poplawski A, ''et al.'' |title=Identification of a testicular odorant receptor mediating human sperm chemotaxis. |journal=Science |volume=299 |issue= 5615 |pages= 2054-8 |year= 2003 |pmid= 12663925 |doi= 10.1126/science.1080376 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR1F1... {November 25, 2007 7:46:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:47:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 1, subfamily F, member 1
| HGNCid = 8194
| Symbol = OR1F1
| AltSymbols =; OLFMF; OR16-36; OR16-37; OR16-88; OR16-89; OR16-90; OR1F10; OR1F13P; OR1F4; OR1F5; OR1F6; OR1F7; OR1F8; OR1F9; OR3-145; ORL1023
| OMIM = 603232
| ECnumber =
| Homologene = 69122
| MGIid =
| GeneAtlas_image1 = PBB_GE_OR1F1_221402_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4992
| Hs_Ensembl = ENSG00000168124
| Hs_RefseqProtein = NP_036492
| Hs_RefseqmRNA = NM_012360
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 3194248
| Hs_GenLoc_end = 3195189
| Hs_Uniprot = O43749
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 1, subfamily F, member 1''', also known as '''OR1F1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1F1 olfactory receptor, family 1, subfamily F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4992| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1F1 olfactory receptor, family 1, subfamily F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4992| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author= |title=A candidate gene for familial Mediterranean fever. The French FMF Consortium. |journal=Nat. Genet. |volume=17 |issue= 1 |pages= 25-31 |year= 1997 |pmid= 9288094 |doi= 10.1038/ng0997-25 }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Bernot A, Heilig R, Clepet C, ''et al.'' |title=A transcriptional Map of the FMF region. |journal=Genomics |volume=50 |issue= 2 |pages= 147-60 |year= 1998 |pmid= 9653642 |doi= }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR2C1... {November 25, 2007 7:47:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:47:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 2, subfamily C, member 1
| HGNCid = 8242
| Symbol = OR2C1
| AltSymbols =; MGC163200; MGC95444; OLFmf3; OR2C2P
| OMIM =
| ECnumber =
| Homologene = 7459
| MGIid = 106182
| GeneAtlas_image1 = PBB_GE_OR2C1_221460_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4993
| Hs_Ensembl = ENSG00000168158
| Hs_RefseqProtein = NP_036500
| Hs_RefseqmRNA = NM_012368
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 3345942
| Hs_GenLoc_end = 3346880
| Hs_Uniprot = O95371
| Mm_EntrezGene = 18312
| Mm_Ensembl = ENSMUSG00000059043
| Mm_RefseqmRNA = NM_008762
| Mm_RefseqProtein = NP_032788
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 3754203
| Mm_GenLoc_end = 3755141
| Mm_Uniprot = Q496W6
}}
}}
'''Olfactory receptor, family 2, subfamily C, member 1''', also known as '''OR2C1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4993| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4993| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Centola M, Chen X, Sood R, ''et al.'' |title=Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1172-91 |year= 1999 |pmid= 9847080 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR3A1... {November 25, 2007 7:47:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:48:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 1
| HGNCid = 8282
| Symbol = OR3A1
| AltSymbols =; OLFRA03; OR17-40; OR17-82; OR40
| OMIM =
| ECnumber =
| Homologene = 1915
| MGIid = 3030236
| GeneAtlas_image1 = PBB_GE_OR3A1_221353_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4994
| Hs_Ensembl = ENSG00000180090
| Hs_RefseqProtein = NP_002541
| Hs_RefseqmRNA = NM_002550
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3141679
| Hs_GenLoc_end = 3142626
| Hs_Uniprot = P47881
| Mm_EntrezGene = 258703
| Mm_Ensembl = ENSMUSG00000070379
| Mm_RefseqmRNA = NM_146708
| Mm_RefseqProtein = NP_666919
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 73971351
| Mm_GenLoc_end = 73972298
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 3, subfamily A, member 1''', also known as '''OR3A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Crowe ML, Perry BN, Connerton IF |title=Olfactory receptor-encoding genes and pseudogenes are expressed in humans. |journal=Gene |volume=169 |issue= 2 |pages= 247-9 |year= 1996 |pmid= 8647456 |doi= }}
*{{cite journal | author=Glusman G, Clifton S, Roe B, Lancet D |title=Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. |journal=Genomics |volume=37 |issue= 2 |pages= 147-60 |year= 1997 |pmid= 8921386 |doi= 10.1006/geno.1996.0536 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Jacquier V, Prummer M, Segura JM, ''et al.'' |title=Visualizing odorant receptor trafficking in living cells down to the single-molecule level. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 39 |pages= 14325-30 |year= 2006 |pmid= 16980412 |doi= 10.1073/pnas.0603942103 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR3A2... {November 25, 2007 7:48:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:49:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 2
| HGNCid = 8283
| Symbol = OR3A2
| AltSymbols =; OLFRA04; OR17-14; OR17-228; OR228
| OMIM =
| ECnumber =
| Homologene = 68262
| MGIid = 3030244
| GeneAtlas_image1 = PBB_GE_OR3A2_221386_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4995
| Hs_Ensembl = ENSG00000205813
| Hs_RefseqProtein = NP_002542
| Hs_RefseqmRNA = NM_002551
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 3128014
| Hs_GenLoc_end = 3236337
| Hs_Uniprot = P47893
| Mm_EntrezGene = 258702
| Mm_Ensembl = ENSMUSG00000063116
| Mm_RefseqmRNA = NM_146707
| Mm_RefseqProtein = NP_666918
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74150477
| Mm_GenLoc_end = 74151424
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 3, subfamily A, member 2''', also known as '''OR3A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4995| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4995| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi= }}
*{{cite journal | author=Glusman G, Clifton S, Roe B, Lancet D |title=Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. |journal=Genomics |volume=37 |issue= 2 |pages= 147-60 |year= 1997 |pmid= 8921386 |doi= 10.1006/geno.1996.0536 }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OXTR... {November 25, 2007 7:49:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:49:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oxytocin receptor
| HGNCid = 8529
| Symbol = OXTR
| AltSymbols =; OT-R
| OMIM = 167055
| ECnumber =
| Homologene = 20255
| MGIid = 109147
| GeneAtlas_image1 = PBB_GE_OXTR_206825_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004990 |text = oxytocin receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007595 |text = lactation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5021
| Hs_Ensembl = ENSG00000180914
| Hs_RefseqProtein = NP_000907
| Hs_RefseqmRNA = NM_000916
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 8765419
| Hs_GenLoc_end = 8786300
| Hs_Uniprot = P30559
| Mm_EntrezGene = 18430
| Mm_Ensembl = ENSMUSG00000049112
| Mm_RefseqmRNA = XM_001001627
| Mm_RefseqProtein = XP_001001627
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 112442851
| Mm_GenLoc_end = 112455574
| Mm_Uniprot = Q3UPP9
}}
}}
'''Oxytocin receptor''', also known as '''OXTR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OXTR oxytocin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5021| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.<ref name="entrez">{{cite web | title = Entrez Gene: OXTR oxytocin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5021| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kimura T, Ivell R |title=The oxytocin receptor. |journal=Results and problems in cell differentiation |volume=26 |issue= |pages= 135-68 |year= 1999 |pmid= 10453463 |doi= }}
*{{cite journal | author=Cassoni P, Sapino A, Marrocco T, ''et al.'' |title=Oxytocin and oxytocin receptors in cancer cells and proliferation. |journal=J. Neuroendocrinol. |volume=16 |issue= 4 |pages= 362-4 |year= 2004 |pmid= 15089975 |doi= 10.1111/j.0953-8194.2004.01165.x }}
*{{cite journal | author=Devost D, Zingg HH |title=Homo- and hetero-dimeric complex formations of the human oxytocin receptor. |journal=J. Neuroendocrinol. |volume=16 |issue= 4 |pages= 372-7 |year= 2004 |pmid= 15089977 |doi= 10.1111/j.0953-8194.2004.01188.x }}
*{{cite journal | author=Kimura T, Tanizawa O, Mori K, ''et al.'' |title=Structure and expression of a human oxytocin receptor. |journal=Nature |volume=356 |issue= 6369 |pages= 526-9 |year= 1992 |pmid= 1313946 |doi= 10.1038/356526a0 }}
*{{cite journal | author=Simmons CF, Clancy TE, Quan R, Knoll JH |title=The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. |journal=Genomics |volume=26 |issue= 3 |pages= 623-5 |year= 1995 |pmid= 7607693 |doi= }}
*{{cite journal | author=Inoue T, Kimura T, Azuma C, ''et al.'' |title=Structural organization of the human oxytocin receptor gene. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32451-6 |year= 1995 |pmid= 7798245 |doi= }}
*{{cite journal | author=Kjaer A, Knigge U, Warberg J |title=Histamine- and stress-induced prolactin secretion: importance of vasopressin V1- and V2-receptors. |journal=Eur. J. Endocrinol. |volume=131 |issue= 4 |pages= 391-7 |year= 1994 |pmid= 7921229 |doi= }}
*{{cite journal | author=Mayerhofer A, Sterzik K, Link H, ''et al.'' |title=Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells. |journal=J. Clin. Endocrinol. Metab. |volume=77 |issue= 5 |pages= 1209-14 |year= 1994 |pmid= 8077313 |doi= }}
*{{cite journal | author=Ito Y, Kobayashi T, Kimura T, ''et al.'' |title=Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies. |journal=Endocrinology |volume=137 |issue= 2 |pages= 773-9 |year= 1996 |pmid= 8593829 |doi= }}
*{{cite journal | author=Kimura T, Takemura M, Nomura S, ''et al.'' |title=Expression of oxytocin receptor in human pregnant myometrium. |journal=Endocrinology |volume=137 |issue= 2 |pages= 780-5 |year= 1996 |pmid= 8593830 |doi= }}
*{{cite journal | author=Gimpl G, Burger K, Fahrenholz F |title=Cholesterol as modulator of receptor function. |journal=Biochemistry |volume=36 |issue= 36 |pages= 10959-74 |year= 1997 |pmid= 9283088 |doi= 10.1021/bi963138w }}
*{{cite journal | author=Kimura T, Makino Y, Bathgate R, ''et al.'' |title=The role of N-terminal glycosylation in the human oxytocin receptor. |journal=Mol. Hum. Reprod. |volume=3 |issue= 11 |pages= 957-63 |year= 1998 |pmid= 9433921 |doi= }}
*{{cite journal | author=Kimura T |title=Regulation of the human oxytocin receptor in the uterus: a molecular approach. |journal=Hum. Reprod. Update |volume=4 |issue= 5 |pages= 615-24 |year= 1999 |pmid= 10027615 |doi= }}
*{{cite journal | author=Politowska E, Czaplewski C, Ciarkowski J |title=Molecular modeling of the oxytocin receptor/bioligand interactions. |journal=Acta Biochim. Pol. |volume=46 |issue= 3 |pages= 581-90 |year= 2000 |pmid= 10698266 |doi= }}
*{{cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229-37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200 }}
*{{cite journal | author=Novak JF, Judkins MB, Chernin MI, ''et al.'' |title=A plasmin-derived hexapeptide from the carboxyl end of osteocalcin counteracts oxytocin-mediated growth inhibition [corrected] of osteosarcoma cells. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3470-6 |year= 2000 |pmid= 10910058 |doi= }}
*{{cite journal | author=Oakley RH, Laporte SA, Holt JA, ''et al.'' |title=Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19452-60 |year= 2001 |pmid= 11279203 |doi= 10.1074/jbc.M101450200 }}
*{{cite journal | author=Wesley VJ, Hawtin SR, Howard HC, Wheatley M |title=Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. |journal=Biochemistry |volume=41 |issue= 16 |pages= 5086-92 |year= 2002 |pmid= 11955056 |doi= }}
*{{cite journal | author=Petersson M, Lagumdzija A, Stark A, Bucht E |title=Oxytocin stimulates proliferation of human osteoblast-like cells. |journal=Peptides |volume=23 |issue= 6 |pages= 1121-6 |year= 2003 |pmid= 12126740 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on P2RY1... {November 25, 2007 7:49:42 PM PST}
- REDIRECT: Protein Redirected to: P2RY1 {November 25, 2007 7:50:00 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:50:03 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:50:03 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:50:03 PM PST}
- UPDATED: Updated protein page: P2RY1 {November 25, 2007 7:50:08 PM PST}
- INFO: Beginning work on P2RY11... {November 25, 2007 7:52:15 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:52:53 PM PST}
- CREATED: Created new protein page: P2RY11 {November 25, 2007 7:53:03 PM PST}
- INFO: Beginning work on P2RY2... {November 25, 2007 7:50:08 PM PST}
- REDIRECT: Protein Redirected to: P2RY2 {November 25, 2007 7:50:30 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:50:32 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:50:32 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:50:32 PM PST}
- UPDATED: Updated protein page: P2RY2 {November 25, 2007 7:50:38 PM PST}
- INFO: Beginning work on P2RY4... {November 25, 2007 7:50:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:51:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pyrimidinergic receptor P2Y, G-protein coupled, 4
| HGNCid = 8542
| Symbol = P2RY4
| AltSymbols =; NRU; P2P; P2Y4; UNR
| OMIM = 300038
| ECnumber =
| Homologene = 20568
| MGIid = 1926594
| GeneAtlas_image1 = PBB_GE_P2RY4_221466_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045030 |text = UTP-activated nucleotide receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0030321 |text = transepithelial chloride transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5030
| Hs_Ensembl = ENSG00000186912
| Hs_RefseqProtein = NP_002556
| Hs_RefseqmRNA = NM_002565
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 69394745
| Hs_GenLoc_end = 69396339
| Hs_Uniprot = P51582
| Mm_EntrezGene = 57385
| Mm_Ensembl = ENSMUSG00000044359
| Mm_RefseqmRNA = NM_020621
| Mm_RefseqProtein = NP_065646
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 96792873
| Mm_GenLoc_end = 96797588
| Mm_Uniprot = Q0VBT7
}}
}}
'''Pyrimidinergic receptor P2Y, G-protein coupled, 4''', also known as '''P2RY4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5030| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5030| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nguyen T, Erb L, Weisman GA, ''et al.'' |title=Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 30845-8 |year= 1996 |pmid= 8537335 |doi= }}
*{{cite journal | author=Communi D, Pirotton S, Parmentier M, Boeynaems JM |title=Cloning and functional expression of a human uridine nucleotide receptor. |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 30849-52 |year= 1996 |pmid= 8537336 |doi= }}
*{{cite journal | author=Stam NJ, Klomp J, Van de Heuvel N, Olijve W |title=Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. |journal=FEBS Lett. |volume=384 |issue= 3 |pages= 260-4 |year= 1996 |pmid= 8617367 |doi= }}
*{{cite journal | author=Nicholas RA, Watt WC, Lazarowski ER, ''et al.'' |title=Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. |journal=Mol. Pharmacol. |volume=50 |issue= 2 |pages= 224-9 |year= 1996 |pmid= 8700127 |doi= }}
*{{cite journal | author=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 297-302 |year= 1997 |pmid= 9268704 |doi= 10.1006/bbrc.1997.7135 }}
*{{cite journal | author=Jin J, Dasari VR, Sistare FD, Kunapuli SP |title=Distribution of P2Y receptor subtypes on haematopoietic cells. |journal=Br. J. Pharmacol. |volume=123 |issue= 5 |pages= 789-94 |year= 1998 |pmid= 9535005 |doi= 10.1038/sj.bjp.0701665 }}
*{{cite journal | author=Brinson AE, Harden TK |title=Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11939-48 |year= 2001 |pmid= 11114308 |doi= 10.1074/jbc.M009909200 }}
*{{cite journal | author=Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B |title=Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. |journal=Eur. J. Pharmacol. |volume=416 |issue= 3 |pages= 197-202 |year= 2001 |pmid= 11290369 |doi= }}
*{{cite journal | author=Moore DJ, Chambers JK, Wahlin JP, ''et al.'' |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107-19 |year= 2001 |pmid= 11690642 |doi= }}
*{{cite journal | author=Idzko M, Dichmann S, Ferrari D, ''et al.'' |title=Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. |journal=Blood |volume=100 |issue= 3 |pages= 925-32 |year= 2002 |pmid= 12130504 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Burrell HE, Bowler WB, Gallagher JA, Sharpe GR |title=Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 440-7 |year= 2003 |pmid= 12603858 |doi= 10.1046/j.1523-1747.2003.12050.x }}
*{{cite journal | author=Kim SG, Soltysiak KA, Gao ZG, ''et al.'' |title=Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. |journal=Biochem. Pharmacol. |volume=65 |issue= 6 |pages= 923-31 |year= 2003 |pmid= 12623123 |doi= }}
*{{cite journal | author=Herold CL, Qi AD, Harden TK, Nicholas RA |title=Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11456-64 |year= 2004 |pmid= 14670966 |doi= 10.1074/jbc.M301734200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Cavaliere F, Nestola V, Amadio S, ''et al.'' |title=The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. |journal=Neurobiol. Dis. |volume=18 |issue= 1 |pages= 100-9 |year= 2005 |pmid= 15649700 |doi= 10.1016/j.nbd.2004.09.001 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on P2RY6... {November 25, 2007 7:51:26 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:52:06 PM PST}
- CREATED: Created new protein page: P2RY6 {November 25, 2007 7:52:15 PM PST}
- INFO: Beginning work on PPYR1... {November 25, 2007 7:53:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:53:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pancreatic polypeptide receptor 1
| HGNCid = 9329
| Symbol = PPYR1
| AltSymbols =; PP1; MGC116897; NPY4-R; NPY4R; Y4
| OMIM = 601790
| ECnumber =
| Homologene = 38119
| MGIid = 105374
| GeneAtlas_image1 = PBB_GE_PPYR1_210956_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001601 |text = peptide YY receptor activity}} {{GNF_GO|id=GO:0001602 |text = pancreatic polypeptide receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5540
| Hs_Ensembl = ENSG00000204174
| Hs_RefseqProtein = XP_001129329
| Hs_RefseqmRNA = XM_001129329
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 46503540
| Hs_GenLoc_end = 46508326
| Hs_Uniprot = P50391
| Mm_EntrezGene = 19065
| Mm_Ensembl = ENSMUSG00000048337
| Mm_RefseqmRNA = NM_008919
| Mm_RefseqProtein = NP_032945
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 32973084
| Mm_GenLoc_end = 32981581
| Mm_Uniprot = Q3UN46
}}
}}
'''Pancreatic polypeptide receptor 1''', also known as '''PPYR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPYR1 pancreatic polypeptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Keire DA, Bowers CW, Solomon TE, Reeve JR |title=Structure and receptor binding of PYY analogs. |journal=Peptides |volume=23 |issue= 2 |pages= 305-21 |year= 2002 |pmid= 11825645 |doi= }}
*{{cite journal | author=Balasubramaniam A |title=Clinical potentials of neuropeptide Y family of hormones. |journal=Am. J. Surg. |volume=183 |issue= 4 |pages= 430-4 |year= 2002 |pmid= 11975932 |doi= }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
*{{cite journal | author=Benaim G, Villalobo A |title=Phosphorylation of calmodulin. Functional implications. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3619-31 |year= 2002 |pmid= 12153558 |doi= }}
*{{cite journal | author=Lundell I, Blomqvist AG, Berglund MM, ''et al.'' |title=Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29123-8 |year= 1996 |pmid= 7493937 |doi= }}
*{{cite journal | author=Bard JA, Walker MW, Branchek TA, Weinshank RL |title=Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26762-5 |year= 1995 |pmid= 7592911 |doi= }}
*{{cite journal | author=Yan H, Yang J, Marasco J, ''et al.'' |title=Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4661-5 |year= 1996 |pmid= 8643460 |doi= }}
*{{cite journal | author=Kawabe T, Muslin AJ, Korsmeyer SJ |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. |journal=Nature |volume=385 |issue= 6615 |pages= 454-8 |year= 1997 |pmid= 9009195 |doi= 10.1038/385454a0 }}
*{{cite journal | author=Lutz CM, Richards JE, Scott KL, ''et al.'' |title=Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. |journal=Genomics |volume=46 |issue= 2 |pages= 287-90 |year= 1998 |pmid= 9417917 |doi= 10.1006/geno.1997.5024 }}
*{{cite journal | author=Darby K, Eyre HJ, Lapsys N, ''et al.'' |title=Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. |journal=Genomics |volume=46 |issue= 3 |pages= 513-5 |year= 1998 |pmid= 9441761 |doi= 10.1006/geno.1997.5071 }}
*{{cite journal | author=Hsieh-Wilson LC, Allen PB, Watanabe T, ''et al.'' |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. |journal=Biochemistry |volume=38 |issue= 14 |pages= 4365-73 |year= 1999 |pmid= 10194355 |doi= 10.1021/bi982900m }}
*{{cite journal | author=Smith FD, Oxford GS, Milgram SL |title=Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19894-900 |year= 1999 |pmid= 10391935 |doi= }}
*{{cite journal | author=Marx SO, Reiken S, Hisamatsu Y, ''et al.'' |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. |journal=Cell |volume=101 |issue= 4 |pages= 365-76 |year= 2000 |pmid= 10830164 |doi= }}
*{{cite journal | author=Connor JH, Weiser DC, Li S, ''et al.'' |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6841-50 |year= 2001 |pmid= 11564868 |doi= 10.1128/MCB.21.20.6841-6850.2001 }}
*{{cite journal | author=Cavadas C, Silva AP, Mosimann F, ''et al.'' |title=NPY regulates catecholamine secretion from human adrenal chromaffin cells. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 12 |pages= 5956-63 |year= 2001 |pmid= 11739470 |doi= }}
*{{cite journal | author=Cox HM, Tough IR |title=Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1505-12 |year= 2002 |pmid= 11906964 |doi= 10.1038/sj.bjp.0704604 }}
*{{cite journal | author=Wu DY, Tkachuck DC, Roberson RS, Schubach WH |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27706-15 |year= 2002 |pmid= 12016208 |doi= 10.1074/jbc.M200955200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTAFR... {November 25, 2007 7:53:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:54:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Platelet-activating factor receptor
| HGNCid = 9582
| Symbol = PTAFR
| AltSymbols =; PAFR
| OMIM = 173393
| ECnumber =
| Homologene = 20260
| MGIid = 106066
| GeneAtlas_image1 = PBB_GE_PTAFR_206278_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTAFR_211661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004992 |text = platelet activating factor receptor activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001816 |text = cytokine production}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5724
| Hs_Ensembl = ENSG00000169403
| Hs_RefseqProtein = NP_000943
| Hs_RefseqmRNA = NM_000952
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 28346264
| Hs_GenLoc_end = 28392971
| Hs_Uniprot = P25105
| Mm_EntrezGene = 19204
| Mm_Ensembl = ENSMUSG00000056529
| Mm_RefseqmRNA = XM_357441
| Mm_RefseqProtein = XP_357441
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 131836299
| Mm_GenLoc_end = 131852935
| Mm_Uniprot = Q62035
}}
}}
'''Platelet-activating factor receptor''', also known as '''PTAFR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTAFR platelet-activating factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5724| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PTAFR platelet-activating factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5724| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shukla SD |title=Platelet-activating factor receptor and signal transduction mechanisms. |journal=FASEB J. |volume=6 |issue= 6 |pages= 2296-301 |year= 1992 |pmid= 1312046 |doi= }}
*{{cite journal | author=Sugimoto T, Tsuchimochi H, McGregor CG, ''et al.'' |title=Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 617-24 |year= 1993 |pmid= 1281995 |doi= }}
*{{cite journal | author=Seyfried CE, Schweickart VL, Godiska R, Gray PW |title=The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. |journal=Genomics |volume=13 |issue= 3 |pages= 832-4 |year= 1992 |pmid= 1322356 |doi= }}
*{{cite journal | author=Kunz D, Gerard NP, Gerard C |title=The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9101-6 |year= 1992 |pmid= 1374385 |doi= }}
*{{cite journal | author=Ye RD, Prossnitz ER, Zou AH, Cochrane CG |title=Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 1 |pages= 105-11 |year= 1991 |pmid= 1656963 |doi= }}
*{{cite journal | author=Nakamura M, Honda Z, Izumi T, ''et al.'' |title=Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 20400-5 |year= 1991 |pmid= 1657923 |doi= }}
*{{cite journal | author=Haslam RJ, Williams KA, Davidson MM |title=Receptor-effector coupling in platelets: roles of guanine nucleotides. |journal=Adv. Exp. Med. Biol. |volume=192 |issue= |pages= 265-80 |year= 1986 |pmid= 3010668 |doi= }}
*{{cite journal | author=Valone FH |title=Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. |journal=Immunology |volume=52 |issue= 1 |pages= 169-74 |year= 1984 |pmid= 6325330 |doi= }}
*{{cite journal | author=Cundell DR, Gerard NP, Gerard C, ''et al.'' |title=Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. |journal=Nature |volume=377 |issue= 6548 |pages= 435-8 |year= 1995 |pmid= 7566121 |doi= 10.1038/377435a0 }}
*{{cite journal | author=Izumi T, Kishimoto S, Takano T, ''et al.'' |title=Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. |journal=Biochem. J. |volume=305 ( Pt 3) |issue= |pages= 829-35 |year= 1995 |pmid= 7848283 |doi= }}
*{{cite journal | author=Bito H, Honda Z, Nakamura M, Shimizu T |title=Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. |journal=Eur. J. Biochem. |volume=221 |issue= 1 |pages= 211-8 |year= 1994 |pmid= 8168510 |doi= }}
*{{cite journal | author=Chase PB, Halonen M, Regan JW |title=Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. |journal=Am. J. Respir. Cell Mol. Biol. |volume=8 |issue= 3 |pages= 240-4 |year= 1993 |pmid= 8383507 |doi= }}
*{{cite journal | author=Mutoh H, Bito H, Minami M, ''et al.'' |title=Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. |journal=FEBS Lett. |volume=322 |issue= 2 |pages= 129-34 |year= 1993 |pmid= 8387031 |doi= }}
*{{cite journal | author=Nakamura M, Honda Z, Matsumoto T, ''et al.'' |title=Isolation and properties of platelet-activating factor receptor cDNAs. |journal=Journal of lipid mediators |volume=6 |issue= 1-3 |pages= 163-8 |year= 1993 |pmid= 8395240 |doi= }}
*{{cite journal | author=Kishimoto S, Shimadzu W, Izumi T, ''et al.'' |title=Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils. |journal=J. Immunol. |volume=157 |issue= 9 |pages= 4126-32 |year= 1996 |pmid= 8892648 |doi= }}
*{{cite journal | author=Chase PB, Yang JM, Thompson FH, ''et al.'' |title=Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 205-7 |year= 1997 |pmid= 8978777 |doi= }}
*{{cite journal | author=Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J |title=Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. |journal=FEBS Lett. |volume=402 |issue= 2-3 |pages= 203-8 |year= 1997 |pmid= 9037196 |doi= }}
*{{cite journal | author=Ahmed A, Dearn S, Shams M, ''et al.'' |title=Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. |journal=FASEB J. |volume=12 |issue= 10 |pages= 831-43 |year= 1998 |pmid= 9657523 |doi= }}
*{{cite journal | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGDR... {November 25, 2007 7:54:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:55:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin D2 receptor (DP)
| HGNCid = 9591
| Symbol = PTGDR
| AltSymbols =; AS1; ASRT1; DP; MGC49004
| OMIM = 604687
| ECnumber =
| Homologene = 736
| MGIid = 102966
| GeneAtlas_image1 = PBB_GE_PTGDR_215894_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001785 |text = prostaglandin J receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004956 |text = prostaglandin D receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5729
| Hs_Ensembl = ENSG00000168229
| Hs_RefseqProtein = NP_000944
| Hs_RefseqmRNA = NM_000953
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 51804181
| Hs_GenLoc_end = 51813191
| Hs_Uniprot = Q13258
| Mm_EntrezGene = 19214
| Mm_Ensembl = ENSMUSG00000071489
| Mm_RefseqmRNA = NM_008962
| Mm_RefseqProtein = NP_032988
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 43773112
| Mm_GenLoc_end = 43781252
| Mm_Uniprot = Q8CCM3
}}
}}
'''Prostaglandin D2 receptor (DP)''', also known as '''PTGDR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGDR prostaglandin D2 receptor (DP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5729| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.<ref name="entrez">{{cite web | title = Entrez Gene: PTGDR prostaglandin D2 receptor (DP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5729| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Boyce JA |title=The role of mast cells in asthma. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 195-205 |year= 2004 |pmid= 12895603 |doi= }}
*{{cite journal | author=Chiba T, Kanda A, Ueki S, ''et al.'' |title=Possible novel receptor for PGD2 on human bronchial epithelial cells. |journal=Int. Arch. Allergy Immunol. |volume=143 Suppl 1 |issue= |pages= 23-7 |year= 2007 |pmid= 17541272 |doi= 10.1159/000101400 }}
*{{cite journal | author=Senior J, Sangha R, Baxter GS, ''et al.'' |title=In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium. |journal=Br. J. Pharmacol. |volume=107 |issue= 1 |pages= 215-21 |year= 1992 |pmid= 1422574 |doi= }}
*{{cite journal | author=Boie Y, Sawyer N, Slipetz DM, ''et al.'' |title=Molecular cloning and characterization of the human prostanoid DP receptor. |journal=J. Biol. Chem. |volume=270 |issue= 32 |pages= 18910-6 |year= 1995 |pmid= 7642548 |doi= }}
*{{cite journal | author=Ishikawa TO, Tamai Y, Rochelle JM, ''et al.'' |title=Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. |journal=Genomics |volume=32 |issue= 2 |pages= 285-8 |year= 1997 |pmid= 8833158 |doi= 10.1006/geno.1996.0118 }}
*{{cite journal | author=Kobayashi T, Ushikubi F, Narumiya S |title=Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24294-303 |year= 2000 |pmid= 10827082 |doi= 10.1074/jbc.M002437200 }}
*{{cite journal | author=Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM |title=The human prostanoid DP receptor stimulates mucin secretion in LS174T cells. |journal=Br. J. Pharmacol. |volume=131 |issue= 8 |pages= 1537-45 |year= 2001 |pmid= 11139429 |doi= 10.1038/sj.bjp.0703688 }}
*{{cite journal | author=Gervais FG, Cruz RP, Chateauneuf A, ''et al.'' |title=Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. |journal=J. Allergy Clin. Immunol. |volume=108 |issue= 6 |pages= 982-8 |year= 2002 |pmid= 11742277 |doi= 10.1067/mai.2001.119919 }}
*{{cite journal | author=Noguchi E, Shibasaki M, Kamioka M, ''et al.'' |title=New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. |journal=Clin. Exp. Allergy |volume=32 |issue= 1 |pages= 93-6 |year= 2002 |pmid= 12002745 |doi= }}
*{{cite journal | author=Hakonarson H, Bjornsdottir US, Halapi E, ''et al.'' |title=A major susceptibility gene for asthma maps to chromosome 14q24. |journal=Am. J. Hum. Genet. |volume=71 |issue= 3 |pages= 483-91 |year= 2002 |pmid= 12119603 |doi= }}
*{{cite journal | author=Iwasaki M, Nagata K, Takano S, ''et al.'' |title=Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. |journal=J. Invest. Dermatol. |volume=119 |issue= 3 |pages= 609-16 |year= 2002 |pmid= 12230502 |doi= 10.1046/j.1523-1747.2002.01862.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Moreland RB, Nehra A, Kim NN, ''et al.'' |title=Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle. |journal=Int. J. Impot. Res. |volume=14 |issue= 6 |pages= 446-52 |year= 2003 |pmid= 12494276 |doi= 10.1038/sj.ijir.3900900 }}
*{{cite journal | author=Faveeuw C, Gosset P, Bureau F, ''et al.'' |title=Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. |journal=Eur. J. Immunol. |volume=33 |issue= 4 |pages= 889-98 |year= 2003 |pmid= 12672054 |doi= 10.1002/eji.200323330 }}
*{{cite journal | author=Angeli V, Staumont D, Charbonnier AS, ''et al.'' |title=Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. |journal=J. Immunol. |volume=172 |issue= 6 |pages= 3822-9 |year= 2004 |pmid= 15004188 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Oguma T, Palmer LJ, Birben E, ''et al.'' |title=Role of prostanoid DP receptor variants in susceptibility to asthma. |journal=N. Engl. J. Med. |volume=351 |issue= 17 |pages= 1752-63 |year= 2004 |pmid= 15496624 |doi= 10.1056/NEJMoa031785 }}
*{{cite journal | author=Spik I, Brénuchon C, Angéli V, ''et al.'' |title=Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. |journal=J. Immunol. |volume=174 |issue= 6 |pages= 3703-8 |year= 2005 |pmid= 15749909 |doi= }}
*{{cite journal | author=Hirano Y, Shichijo M, Deguchi M, ''et al.'' |title=Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. |journal=Eur. J. Pharmacol. |volume=560 |issue= 1 |pages= 81-8 |year= 2007 |pmid= 17307163 |doi= 10.1016/j.ejphar.2007.01.003 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGER1... {November 25, 2007 7:55:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:56:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin E receptor 1 (subtype EP1), 42kDa
| HGNCid = 9593
| Symbol = PTGER1
| AltSymbols =; EP1
| OMIM = 176802
| ECnumber =
| Homologene = 738
| MGIid = 97793
| GeneAtlas_image1 = PBB_GE_PTGER1_214391_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTGER1_207650_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004957 |text = prostaglandin E receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5731
| Hs_Ensembl = ENSG00000160951
| Hs_RefseqProtein = NP_000946
| Hs_RefseqmRNA = NM_000955
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 14444279
| Hs_GenLoc_end = 14447174
| Hs_Uniprot = P34995
| Mm_EntrezGene = 19216
| Mm_Ensembl = ENSMUSG00000019464
| Mm_RefseqmRNA = NM_013641
| Mm_RefseqProtein = NP_038669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 86556973
| Mm_GenLoc_end = 86562860
| Mm_Uniprot = P35375
}}
}}
'''Prostaglandin E receptor 1 (subtype EP1), 42kDa''', also known as '''PTGER1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.<ref name="entrez">{{cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coleman RA, Smith WL, Narumiya S |title=International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. |journal=Pharmacol. Rev. |volume=46 |issue= 2 |pages= 205-29 |year= 1994 |pmid= 7938166 |doi= }}
*{{cite journal | author=Lee TY, Watanabe Y |title=A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems. |journal=Japanese heart journal |volume=16 |issue= 3 |pages= 243-56 |year= 1975 |pmid= 1160156 |doi= }}
*{{cite journal | author=Duncan AM, Anderson LL, Funk CD, ''et al.'' |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740-2 |year= 1995 |pmid= 7759114 |doi= }}
*{{cite journal | author=Funk CD, Furci L, FitzGerald GA, ''et al.'' |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767-72 |year= 1994 |pmid= 8253813 |doi= }}
*{{cite journal | author=Kurihara Y, Endo H, Kondo H |title=Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells. |journal=Inflamm. Res. |volume=50 |issue= 1 |pages= 1-5 |year= 2001 |pmid= 11235015 |doi= }}
*{{cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51-8 |year= 2002 |pmid= 11951086 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Matsuoka Y, Furuyashiki T, Bito H, ''et al.'' |title=Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4132-7 |year= 2003 |pmid= 12642666 |doi= 10.1073/pnas.0633341100 }}
*{{cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810-6 |year= 2003 |pmid= 12788892 |doi= }}
*{{cite journal | author=Kitamura T, Itoh M, Noda T, ''et al.'' |title=Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. |journal=Cancer Sci. |volume=94 |issue= 7 |pages= 618-21 |year= 2004 |pmid= 12841871 |doi= }}
*{{cite journal | author=Moreland RB, Kim N, Nehra A, ''et al.'' |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362-8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042 }}
*{{cite journal | author=Su JL, Shih JY, Yen ML, ''et al.'' |title=Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 554-64 |year= 2004 |pmid= 14744769 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Han C, Wu T |title=Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 24053-63 |year= 2005 |pmid= 15855163 |doi= 10.1074/jbc.M500562200 }}
*{{cite journal | author=Nicola C, Timoshenko AV, Dixon SJ, ''et al.'' |title=EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 8 |pages= 4736-46 |year= 2005 |pmid= 15886234 |doi= 10.1210/jc.2005-0413 }}
*{{cite journal | author=Han C, Michalopoulos GK, Wu T |title=Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. |journal=J. Cell. Physiol. |volume=207 |issue= 1 |pages= 261-70 |year= 2006 |pmid= 16331686 |doi= 10.1002/jcp.20560 }}
*{{cite journal | author=Durrenberger PF, Facer P, Casula MA, ''et al.'' |title=Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. |journal=BMC neurology |volume=6 |issue= |pages= 1 |year= 2006 |pmid= 16393343 |doi= 10.1186/1471-2377-6-1 }}
*{{cite journal | author=McGraw DW, Mihlbachler KA, Schwarb MR, ''et al.'' |title=Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. |journal=J. Clin. Invest. |volume=116 |issue= 5 |pages= 1400-9 |year= 2006 |pmid= 16670773 |doi= 10.1172/JCI25840 }}
*{{cite journal | author=Horita H, Kuroda E, Hachisuga T, ''et al.'' |title=Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo. |journal=Hum. Reprod. |volume=22 |issue= 7 |pages= 1801-9 |year= 2007 |pmid= 17525067 |doi= 10.1093/humrep/dem125 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGER2... {November 25, 2007 7:56:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:57:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin E receptor 2 (subtype EP2), 53kDa
| HGNCid = 9594
| Symbol = PTGER2
| AltSymbols =; EP2
| OMIM = 176804
| ECnumber =
| Homologene = 739
| MGIid = 97794
| GeneAtlas_image1 = PBB_GE_PTGER2_206631_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004957 |text = prostaglandin E receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5732
| Hs_Ensembl = ENSG00000125384
| Hs_RefseqProtein = NP_000947
| Hs_RefseqmRNA = NM_000956
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 51850863
| Hs_GenLoc_end = 51865062
| Hs_Uniprot = P43116
| Mm_EntrezGene = 19217
| Mm_Ensembl = ENSMUSG00000037759
| Mm_RefseqmRNA = NM_008964
| Mm_RefseqProtein = NP_032990
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 43910072
| Mm_GenLoc_end = 43925090
| Mm_Uniprot = Q3UW60
}}
}}
'''Prostaglandin E receptor 2 (subtype EP2), 53kDa''', also known as '''PTGER2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5732| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Duncan AM, Anderson LL, Funk CD, ''et al.'' |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740-2 |year= 1995 |pmid= 7759114 |doi= }}
*{{cite journal | author=Regan JW, Bailey TJ, Pepperl DJ, ''et al.'' |title=Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. |journal=Mol. Pharmacol. |volume=46 |issue= 2 |pages= 213-20 |year= 1994 |pmid= 8078484 |doi= }}
*{{cite journal | author=Bastien L, Sawyer N, Grygorczyk R, ''et al.'' |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873-7 |year= 1994 |pmid= 8163486 |doi= }}
*{{cite journal | author=An S, Yang J, Xia M, Goetzl EJ |title=Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 1 |pages= 263-70 |year= 1994 |pmid= 8250933 |doi= }}
*{{cite journal | author=Stillman BA, Breyer MD, Breyer RM |title=Importance of the extracellular domain for prostaglandin EP(2) receptor function. |journal=Mol. Pharmacol. |volume=56 |issue= 3 |pages= 545-51 |year= 1999 |pmid= 10462542 |doi= }}
*{{cite journal | author=Smock SL, Pan LC, Castleberry TA, ''et al.'' |title=Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype. |journal=Gene |volume=237 |issue= 2 |pages= 393-402 |year= 1999 |pmid= 10521663 |doi= }}
*{{cite journal | author=Desai S, April H, Nwaneshiudu C, Ashby B |title=Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1279-86 |year= 2001 |pmid= 11093764 |doi= }}
*{{cite journal | author=Duckworth N, Marshall K, Clayton JK |title=An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women. |journal=J. Endocrinol. |volume=172 |issue= 2 |pages= 263-9 |year= 2002 |pmid= 11834444 |doi= }}
*{{cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51-8 |year= 2002 |pmid= 11951086 |doi= }}
*{{cite journal | author=Takafuji VA, Evans A, Lynch KR, Roche JK |title=PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=66 |issue= 1 |pages= 71-81 |year= 2003 |pmid= 12051958 |doi= 10.1054/plef.2001.0299 }}
*{{cite journal | author=Scandella E, Men Y, Gillessen S, ''et al.'' |title=Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. |journal=Blood |volume=100 |issue= 4 |pages= 1354-61 |year= 2002 |pmid= 12149218 |doi= 10.1182/blood-2001-11-0017 }}
*{{cite journal | author=Okuyama T, Ishihara S, Sato H, ''et al.'' |title=Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines. |journal=J. Lab. Clin. Med. |volume=140 |issue= 2 |pages= 92-102 |year= 2002 |pmid= 12228765 |doi= }}
*{{cite journal | author=Konger RL, Scott GA, Landt Y, ''et al.'' |title=Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression. |journal=Am. J. Pathol. |volume=161 |issue= 6 |pages= 2065-78 |year= 2003 |pmid= 12466123 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Abulencia JP, Gaspard R, Healy ZR, ''et al.'' |title=Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28388-94 |year= 2003 |pmid= 12743126 |doi= 10.1074/jbc.M301378200 }}
*{{cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810-6 |year= 2003 |pmid= 12788892 |doi= }}
*{{cite journal | author=Sun HS, Hsiao KY, Hsu CC, ''et al.'' |title=Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. |journal=Endocrinology |volume=144 |issue= 9 |pages= 3934-42 |year= 2003 |pmid= 12933667 |doi= }}
*{{cite journal | author=Bradbury DA, Newton R, Zhu YM, ''et al.'' |title=Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49954-64 |year= 2004 |pmid= 14517215 |doi= 10.1074/jbc.M307964200 }}
*{{cite journal | author=Moreland RB, Kim N, Nehra A, ''et al.'' |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362-8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042 }}
*{{cite journal | author=Sugimoto Y, Nakato T, Kita A, ''et al.'' |title=A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11016-26 |year= 2004 |pmid= 14699136 |doi= 10.1074/jbc.M307404200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGER3... {November 25, 2007 7:57:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:00:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin E receptor 3 (subtype EP3)
| HGNCid = 9595
| Symbol = PTGER3
| AltSymbols =; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302
| OMIM = 176806
| ECnumber =
| Homologene = 22622
| MGIid = 97795
| GeneAtlas_image1 = PBB_GE_PTGER3_210375_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTGER3_210374_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTGER3_210831_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0004957 |text = prostaglandin E receptor activity}}
| Component = {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006351 |text = transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5733
| Hs_Ensembl = ENSG00000050628
| Hs_RefseqProtein = NP_000948
| Hs_RefseqmRNA = NM_000957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 71090624
| Hs_GenLoc_end = 71286079
| Hs_Uniprot = P43115
| Mm_EntrezGene = 19218
| Mm_Ensembl = ENSMUSG00000040016
| Mm_RefseqmRNA = NM_011196
| Mm_RefseqProtein = NP_035326
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 157502185
| Mm_GenLoc_end = 157580051
| Mm_Uniprot = P30557
}}
}}
'''Prostaglandin E receptor 3 (subtype EP3)''', also known as '''PTGER3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kotani M, Tanaka I, Ogawa Y, ''et al.'' |title=Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. |journal=Mol. Pharmacol. |volume=48 |issue= 5 |pages= 869-79 |year= 1995 |pmid= 7476918 |doi= }}
*{{cite journal | author=Duncan AM, Anderson LL, Funk CD, ''et al.'' |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740-2 |year= 1995 |pmid= 7759114 |doi= }}
*{{cite journal | author=Schmid A, Thierauch KH, Schleuning WD, Dinter H |title=Splice variants of the human EP3 receptor for prostaglandin E2. |journal=Eur. J. Biochem. |volume=228 |issue= 1 |pages= 23-30 |year= 1995 |pmid= 7883006 |doi= }}
*{{cite journal | author=An S, Yang J, So SW, ''et al.'' |title=Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. |journal=Biochemistry |volume=33 |issue= 48 |pages= 14496-502 |year= 1995 |pmid= 7981210 |doi= }}
*{{cite journal | author=Regan JW, Bailey TJ, Donello JE, ''et al.'' |title=Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini. |journal=Br. J. Pharmacol. |volume=112 |issue= 2 |pages= 377-85 |year= 1994 |pmid= 8075855 |doi= }}
*{{cite journal | author=Yang J, Xia M, Goetzl EJ, An S |title=Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 999-1006 |year= 1994 |pmid= 8117308 |doi= }}
*{{cite journal | author=Kunapuli SP, Fen Mao G, Bastepe M, ''et al.'' |title=Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells. |journal=Biochem. J. |volume=298 ( Pt 2) |issue= |pages= 263-7 |year= 1994 |pmid= 8135729 |doi= }}
*{{cite journal | author=Adam M, Boie Y, Rushmore TH, ''et al.'' |title=Cloning and expression of three isoforms of the human EP3 prostanoid receptor. |journal=FEBS Lett. |volume=338 |issue= 2 |pages= 170-4 |year= 1994 |pmid= 8307176 |doi= }}
*{{cite journal | author=Chang C, Negishi M, Nishigaki N, Ichikawa A |title=Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype. |journal=Biochem. J. |volume=322 ( Pt 2) |issue= |pages= 597-601 |year= 1997 |pmid= 9065782 |doi= }}
*{{cite journal | author=Kotani M, Tanaka I, Ogawa Y, ''et al.'' |title=Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). |journal=Genomics |volume=40 |issue= 3 |pages= 425-34 |year= 1997 |pmid= 9073510 |doi= 10.1006/geno.1996.4585 }}
*{{cite journal | author=Ushikubi F, Segi E, Sugimoto Y, ''et al.'' |title=Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. |journal=Nature |volume=395 |issue= 6699 |pages= 281-4 |year= 1998 |pmid= 9751056 |doi= 10.1038/26233 }}
*{{cite journal | author=Bhattacharya M, Peri K, Ribeiro-da-Silva A, ''et al.'' |title=Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15719-24 |year= 1999 |pmid= 10336471 |doi= }}
*{{cite journal | author=Liu J, Akahoshi T, Jiang S, ''et al.'' |title=Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3. |journal=J. Leukoc. Biol. |volume=68 |issue= 2 |pages= 187-93 |year= 2000 |pmid= 10947062 |doi= }}
*{{cite journal | author=Kurihara Y, Endo H, Kondo H |title=Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells. |journal=Inflamm. Res. |volume=50 |issue= 1 |pages= 1-5 |year= 2001 |pmid= 11235015 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Matsuoka Y, Furuyashiki T, Bito H, ''et al.'' |title=Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4132-7 |year= 2003 |pmid= 12642666 |doi= 10.1073/pnas.0633341100 }}
*{{cite journal | author=Wing DA, Goharkhay N, Hanna M, ''et al.'' |title=EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium. |journal=J. Soc. Gynecol. Investig. |volume=10 |issue= 3 |pages= 124-9 |year= 2003 |pmid= 12699873 |doi= }}
*{{cite journal | author=Abulencia JP, Gaspard R, Healy ZR, ''et al.'' |title=Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28388-94 |year= 2003 |pmid= 12743126 |doi= 10.1074/jbc.M301378200 }}
*{{cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810-6 |year= 2003 |pmid= 12788892 |doi= }}
*{{cite journal | author=Moreland RB, Kim N, Nehra A, ''et al.'' |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362-8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGER4... {November 25, 2007 8:00:35 PM PST}
- REDIRECT: Protein Redirected to: PTGER4 {November 25, 2007 8:00:52 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:00:55 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 8:00:55 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:00:55 PM PST}
- UPDATED: Updated protein page: PTGER4 {November 25, 2007 8:01:00 PM PST}
- INFO: Beginning work on PTGFR... {November 25, 2007 8:01:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:01:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin F receptor (FP)
| HGNCid = 9600
| Symbol = PTGFR
| AltSymbols =; FP; MGC120498; MGC46203
| OMIM = 600563
| ECnumber =
| Homologene = 741
| MGIid = 97796
| GeneAtlas_image1 = PBB_GE_PTGFR_207177_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004958 |text = prostaglandin F receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007567 |text = parturition}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5737
| Hs_Ensembl = ENSG00000122420
| Hs_RefseqProtein = NP_000950
| Hs_RefseqmRNA = NM_000959
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 78542156
| Hs_GenLoc_end = 78778022
| Hs_Uniprot = P43088
| Mm_EntrezGene = 19220
| Mm_Ensembl = ENSMUSG00000028036
| Mm_RefseqmRNA = NM_008966
| Mm_RefseqProtein = NP_032992
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 151737371
| Mm_GenLoc_end = 151774818
| Mm_Uniprot = Q60I90
}}
}}
'''Prostaglandin F receptor (FP)''', also known as '''PTGFR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGFR prostaglandin F receptor (FP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PTGFR prostaglandin F receptor (FP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Duncan AM, Anderson LL, Funk CD, ''et al.'' |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740-2 |year= 1995 |pmid= 7759114 |doi= }}
*{{cite journal | author=Lake S, Gullberg H, Wahlqvist J, ''et al.'' |title=Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. |journal=FEBS Lett. |volume=355 |issue= 3 |pages= 317-25 |year= 1995 |pmid= 7988697 |doi= }}
*{{cite journal | author=Bastien L, Sawyer N, Grygorczyk R, ''et al.'' |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873-7 |year= 1994 |pmid= 8163486 |doi= }}
*{{cite journal | author=Funk CD, Furci L, FitzGerald GA, ''et al.'' |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767-72 |year= 1994 |pmid= 8253813 |doi= }}
*{{cite journal | author=Abramovitz M, Boie Y, Nguyen T, ''et al.'' |title=Cloning and expression of a cDNA for the human prostanoid FP receptor. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2632-6 |year= 1994 |pmid= 8300593 |doi= }}
*{{cite journal | author=Sugimoto Y, Yamasaki A, Segi E, ''et al.'' |title=Failure of parturition in mice lacking the prostaglandin F receptor. |journal=Science |volume=277 |issue= 5326 |pages= 681-3 |year= 1997 |pmid= 9235889 |doi= }}
*{{cite journal | author=Kunapuli P, Lawson JA, Rokach J, FitzGerald GA |title=Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27147-54 |year= 1997 |pmid= 9341156 |doi= }}
*{{cite journal | author=Betz R, Lagercrantz J, Kedra D, ''et al.'' |title=Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 2 |pages= 413-6 |year= 1999 |pmid= 9918852 |doi= 10.1006/bbrc.1998.9827 }}
*{{cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51-8 |year= 2002 |pmid= 11951086 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Neuschäfer-Rube F, Engemaier E, Koch S, ''et al.'' |title=Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 443-9 |year= 2003 |pmid= 12519077 |doi= 10.1042/BJ20021429 }}
*{{cite journal | author=Zaragoza DB, Wilson R, Eyster K, Olson DM |title=Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene. |journal=Biochim. Biophys. Acta |volume=1676 |issue= 2 |pages= 193-202 |year= 2004 |pmid= 14746914 |doi= }}
*{{cite journal | author=Sales KJ, Milne SA, Williams AR, ''et al.'' |title=Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 986-93 |year= 2004 |pmid= 14764825 |doi= }}
*{{cite journal | author=Vielhauer GA, Fujino H, Regan JW |title=Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. |journal=Arch. Biochem. Biophys. |volume=421 |issue= 2 |pages= 175-85 |year= 2004 |pmid= 14984197 |doi= }}
*{{cite journal | author=Jin P, Fu GK, Wilson AD, ''et al.'' |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566-71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 }}
*{{cite journal | author=Sugino N, Karube-Harada A, Taketani T, ''et al.'' |title=Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation. |journal=J. Reprod. Dev. |volume=50 |issue= 2 |pages= 215-25 |year= 2004 |pmid= 15118249 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Scott G, Jacobs S, Leopardi S, ''et al.'' |title=Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation. |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 407-16 |year= 2005 |pmid= 15748887 |doi= 10.1016/j.yexcr.2004.11.016 }}
*{{cite journal | author=Mandal AK, Ray R, Zhang Z, ''et al.'' |title=Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32897-904 |year= 2005 |pmid= 16061484 |doi= 10.1074/jbc.M502375200 }}
*{{cite journal | author=Hébert RL, Carmosino M, Saito O, ''et al.'' |title=Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 35028-37 |year= 2005 |pmid= 16096282 |doi= 10.1074/jbc.M505852200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTGIR... {November 25, 2007 8:01:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:02:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin I2 (prostacyclin) receptor (IP)
| HGNCid = 9602
| Symbol = PTGIR
| AltSymbols =; IP; MGC102830; PRIPR
| OMIM = 600022
| ECnumber =
| Homologene = 7496
| MGIid = 99535
| GeneAtlas_image1 = PBB_GE_PTGIR_206187_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5739
| Hs_Ensembl = ENSG00000160013
| Hs_RefseqProtein = NP_000951
| Hs_RefseqmRNA = NM_000960
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 51815566
| Hs_GenLoc_end = 51820194
| Hs_Uniprot = P43119
| Mm_EntrezGene = 19222
| Mm_Ensembl = ENSMUSG00000043017
| Mm_RefseqmRNA = NM_008967
| Mm_RefseqProtein = NP_032993
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 16065012
| Mm_GenLoc_end = 16069427
| Mm_Uniprot = Q3U4F1
}}
}}
'''Prostaglandin I2 (prostacyclin) receptor (IP)''', also known as '''PTGIR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5739| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.<ref name="entrez">{{cite web | title = Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5739| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coleman RA, Smith WL, Narumiya S |title=International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. |journal=Pharmacol. Rev. |volume=46 |issue= 2 |pages= 205-29 |year= 1994 |pmid= 7938166 |doi= }}
*{{cite journal | author=Rauvala H, Peng HB |title=HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts. |journal=Prog. Neurobiol. |volume=52 |issue= 2 |pages= 127-44 |year= 1997 |pmid= 9185236 |doi= }}
*{{cite journal | author=Smyth EM, FitzGerald GA |title=Human prostacyclin receptor. |journal=Vitam. Horm. |volume=65 |issue= |pages= 149-65 |year= 2003 |pmid= 12481546 |doi= }}
*{{cite journal | author=Boie Y, Rushmore TH, Darmon-Goodwin A, ''et al.'' |title=Cloning and expression of a cDNA for the human prostanoid IP receptor. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12173-8 |year= 1994 |pmid= 7512962 |doi= }}
*{{cite journal | author=Katsuyama M, Sugimoto Y, Namba T, ''et al.'' |title=Cloning and expression of a cDNA for the human prostacyclin receptor. |journal=FEBS Lett. |volume=344 |issue= 1 |pages= 74-8 |year= 1994 |pmid= 7514139 |doi= }}
*{{cite journal | author=Ogawa Y, Tanaka I, Inoue M, ''et al.'' |title=Structural organization and chromosomal assignment of the human prostacyclin receptor gene. |journal=Genomics |volume=27 |issue= 1 |pages= 142-8 |year= 1995 |pmid= 7665161 |doi= }}
*{{cite journal | author=Duncan AM, Anderson LL, Funk CD, ''et al.'' |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740-2 |year= 1995 |pmid= 7759114 |doi= }}
*{{cite journal | author=Nakagawa O, Tanaka I, Usui T, ''et al.'' |title=Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. |journal=Circulation |volume=90 |issue= 4 |pages= 1643-7 |year= 1994 |pmid= 7923647 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Sasaki Y, Takahashi T, Tanaka I, ''et al.'' |title=Expression of prostacyclin receptor in human megakaryocytes. |journal=Blood |volume=90 |issue= 3 |pages= 1039-46 |year= 1997 |pmid= 9242534 |doi= }}
*{{cite journal | author=Fisch A, Tobusch K, Veit K, ''et al.'' |title=Prostacyclin receptor desensitization is a reversible phenomenon in human platelets. |journal=Circulation |volume=96 |issue= 3 |pages= 756-60 |year= 1997 |pmid= 9264479 |doi= }}
*{{cite journal | author=Smyth EM, Li WH, FitzGerald GA |title=Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23258-66 |year= 1998 |pmid= 9722557 |doi= }}
*{{cite journal | author=Kömhoff M, Lesener B, Nakao K, ''et al.'' |title=Localization of the prostacyclin receptor in human kidney. |journal=Kidney Int. |volume=54 |issue= 6 |pages= 1899-908 |year= 1999 |pmid= 9853255 |doi= 10.1046/j.1523-1755.1998.00213.x }}
*{{cite journal | author=Hayes JS, Lawler OA, Walsh MT, Kinsella BT |title=The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23707-18 |year= 1999 |pmid= 10446129 |doi= }}
*{{cite journal | author=Smyth EM, Austin SC, Reilly MP, FitzGerald GA |title=Internalization and sequestration of the human prostacyclin receptor. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32037-45 |year= 2000 |pmid= 10889200 |doi= 10.1074/jbc.M003873200 }}
*{{cite journal | author=Lawler OA, Miggin SM, Kinsella BT |title=Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33596-607 |year= 2001 |pmid= 11443126 |doi= 10.1074/jbc.M104434200 }}
*{{cite journal | author=Zhang Z, Austin SC, Smyth EM |title=Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction. |journal=Mol. Pharmacol. |volume=60 |issue= 3 |pages= 480-7 |year= 2001 |pmid= 11502878 |doi= }}
*{{cite journal | author=Fortier I, Patry C, Lora M, ''et al.'' |title=Immunohistochemical localization of the prostacyclin receptor (IP) human bone. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=65 |issue= 2 |pages= 79-83 |year= 2001 |pmid= 11545623 |doi= 10.1054/plef.2001.0292 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTHR1... {November 25, 2007 8:02:14 PM PST}
- REDIRECT: Protein Redirected to: PTHR1 {November 25, 2007 8:02:37 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:02:39 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 8:02:39 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:02:39 PM PST}
- UPDATED: Updated protein page: PTHR1 {November 25, 2007 8:02:45 PM PST}
- INFO: Beginning work on PTHR2... {November 25, 2007 8:02:45 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:03:22 PM PST}
- CREATED: Created new protein page: PTHR2 {November 25, 2007 8:03:32 PM PST}
- INFO: Beginning work on TAS2R38... {November 25, 2007 7:54:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:54:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Taste receptor, type 2, member 38
| HGNCid = 9584
| Symbol = TAS2R38
| AltSymbols =; PTC; T2R61
| OMIM = 607751
| ECnumber =
| Homologene = 47976
| MGIid = 2681306
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5726
| Hs_Ensembl = ENSG00000183609
| Hs_RefseqProtein = NP_789787
| Hs_RefseqmRNA = NM_176817
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 141318957
| Hs_GenLoc_end = 141319958
| Hs_Uniprot = P59533
| Mm_EntrezGene = 387513
| Mm_Ensembl = ENSMUSG00000058250
| Mm_RefseqmRNA = NM_001001451
| Mm_RefseqProtein = NP_001001451
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 40541922
| Mm_GenLoc_end = 40542917
| Mm_Uniprot = A0PK79
}}
}}
'''Taste receptor, type 2, member 38''', also known as '''TAS2R38''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R38 taste receptor, type 2, member 38| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5726| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1-4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200 }}
*{{cite journal | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366-71 |year= 2002 |pmid= 12139982 |doi= }}
*{{cite journal | author=Kim UK, Drayna D |title=Genetics of individual differences in bitter taste perception: lessons from the PTC gene. |journal=Clin. Genet. |volume=67 |issue= 4 |pages= 275-80 |year= 2005 |pmid= 15733260 |doi= 10.1111/j.1399-0004.2004.00361.x }}
*{{cite journal | author=Anne-Spence M, Falk CT, Neiswanger K, ''et al.'' |title=Estimating the recombination frequency for the PTC-Kell linkage. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 183-6 |year= 1984 |pmid= 6745938 |doi= }}
*{{cite journal | author=Bufe B, Hofmann T, Krautwurst D, ''et al.'' |title=The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. |journal=Nat. Genet. |volume=32 |issue= 3 |pages= 397-401 |year= 2002 |pmid= 12379855 |doi= 10.1038/ng1014 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zhang Y, Hoon MA, Chandrashekar J, ''et al.'' |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293-301 |year= 2003 |pmid= 12581520 |doi= }}
*{{cite journal | author=Conte C, Ebeling M, Marcuz A, ''et al.'' |title=Identification and characterization of human taste receptor genes belonging to the TAS2R family. |journal=Cytogenet. Genome Res. |volume=98 |issue= 1 |pages= 45-53 |year= 2003 |pmid= 12584440 |doi= 10.1159/000068546 }}
*{{cite journal | author=Kim UK, Jorgenson E, Coon H, ''et al.'' |title=Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. |journal=Science |volume=299 |issue= 5610 |pages= 1221-5 |year= 2003 |pmid= 12595690 |doi= 10.1126/science.1080190 }}
*{{cite journal | author=Drayna D, Coon H, Kim UK, ''et al.'' |title=Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. |journal=Hum. Genet. |volume=112 |issue= 5-6 |pages= 567-72 |year= 2003 |pmid= 12624758 |doi= 10.1007/s00439-003-0911-y }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Wooding S, Kim UK, Bamshad MJ, ''et al.'' |title=Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. |journal=Am. J. Hum. Genet. |volume=74 |issue= 4 |pages= 637-46 |year= 2004 |pmid= 14997422 |doi= 10.1086/383092 }}
*{{cite journal | author=Pronin AN, Tang H, Connor J, Keung W |title=Identification of ligands for two human bitter T2R receptors. |journal=Chem. Senses |volume=29 |issue= 7 |pages= 583-93 |year= 2005 |pmid= 15337684 |doi= 10.1093/chemse/bjh064 }}
*{{cite journal | author=Prodi DA, Drayna D, Forabosco P, ''et al.'' |title=Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. |journal=Chem. Senses |volume=29 |issue= 8 |pages= 697-702 |year= 2005 |pmid= 15466815 |doi= 10.1093/chemse/bjh074 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432-6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027 }}
*{{cite journal | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313-26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523 }}
}}
{{refend}}
{{protein-stub}}
end log.
