User:Orsini.M1/sandbox

Welcome to your sandbox!

Link to Project Resource Page

This is a place to practice clicking the "edit" button and practice adding references (via the citation button).
Chronic lymphocytic leukemia is super super cool, is you know.^[1]
Chronic lymphocytic leukemia is a topic of importance for medical intervention and care.^[2]

Note: You will be emailing your assignment # 3 directly to your tutor, however, please paste a version here that excludes your personal information. This will allow us to support your efforts on Wikipedia prior to editing "live" in the article.

Edits to Signs and Symptoms - Accounting for SLL

Proposed Changes

Current Writing

“CLL is, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). This subtype, termed chronic lymphocytic leukemia/small lymphocyte lymphoma MBL (CLL/SLL MBL) is an asymptomatic, indolent, and chronic disorder in which individuals exhibit an increase in the number of circulating B-cell lymphocytes. These B-cells are abnormal: they are monoclonal, i.e. produced by a single ancestral B-cell, and have some of the same cell marker proteins, chromosome abnormalities, and gene mutations found in CLL.”

Proposed Edit

“CLL can be grouped with Small lymphocytic lymphoma (SLL) as one disease with two clinical presentations.^[3] Wherein, with CLL, diseased cells propagate from within the bone marrow, in SLL they grow propagate within the lymphatic tissue.^[3] CLL and SLL are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). This subtype, termed chronic lymphocytic leukemia/small lymphocyte lymphoma MBL (CLL/SLL MBL) is an asymptomatic, indolent, and chronic disorder in which individuals exhibit an increase in the number of circulating B-cell lymphocytes. These B-cells are abnormal: they are monoclonal, i.e. produced by a single ancestral B-cell, and have some of the same cell marker proteins, chromosome abnormalities, and gene mutations found in CLL.”

Rational

Within the Signs and Symptoms section of the CLL Wikipedia article, small lymphocytic lymphoma (SLL) is referenced without an explanation as to what it is. This could be potentially confusing to readers as they try to understand this section of the article. To make this easier to understand, what SLL is and how it relates to CLL was elucidated.
- Sentence 1 - An introduction is provided to SLL, with the express purpose of explaining why it is relevant to CLL. The reference used for this change is a review article comparing and contrasting the different clinical presentations of CLL and SLL.
- Sentence 2 - Further explanation is provided on the major difference between SLL and CLL—the tissues from which they propagate. The same reference is used as above.
Together, these sentences act to provide a simple explanation of SLL and its relation to CLL without taking the focus of the paragraph—and the article as a whole—off of CLL.

Area of Controversy

The edits being made are uncontroversial as the relationship between CLL and SLL are well described in the literature.

Critique of Source

The chosen source is a review article published within a relevant peer-reviewed journal (Expert Review of Hematology) with a modest impact factor (2.57 in 2019). This supports the reliability of the source as a reference. Moreover, the source is considered recent as per Wikipedia's guidelines as it was published in 2016. Though no funding was received for this particular publication, it is important to note that the authors disclosed having relationships with industry. Considering relationships with industry are unlikely to alter the classification and biological comparison between CLL and SLL, it is unlikely for this to have a material effect on the validity of the proposed changes. No other biases were noted.

Article Improvements

This will also be covered on Nov 23rd in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
Talk Page Template: Wikipedia:CARL Medical Editing Initiative/Fall 2020/Talk Page Template

^ Kipps, Thomas J.; Stevenson, Freda K.; Wu, Catherine J.; Croce, Carlo M.; Packham, Graham; Wierda, William G.; O’Brien, Susan; Gribben, John; Rai, Kanti (2017-01-19). "Chronic lymphocytic leukaemia". Nature reviews. Disease primers. 3: 16096. doi:10.1038/nrdp.2016.96. ISSN 2056-676X. PMC 5336551. PMID 28102226.
^ Rai, Kanti R.; Jain, Preetesh (2016-03). "Chronic lymphocytic leukemia (CLL)-Then and now". American Journal of Hematology. 91 (3): 330–340. doi:10.1002/ajh.24282. ISSN 1096-8652. PMID 26690614. {{cite journal}}: Check date values in: |date= (help)
^ ^a ^b Tees, Michael T.; Flinn, Ian W. (2017-02). "Chronic lymphocytic leukemia and small lymphocytic lymphoma: two faces of the same disease". Expert Review of Hematology. 10 (2): 137–146. doi:10.1080/17474086.2017.1270203. ISSN 1747-4094. PMID 27936980. {{cite journal}}: Check date values in: |date= (help)