User:Mr. Ibrahem/Pegcetacoplan
 | |
| Clinical data | |
|---|---|
| Trade names | Empaveli, Aspaveli |
| Other names | APL-2 |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category |
|
| Routes of administration | Subcutaneous |
| Drug class | Complement inhibitor |
| Legal status | |
| Legal status | |
| Chemical and physical data | |
| Formula | C170H248N50O47S4 |
| Molar mass | 3872.40 g·mol−1 |
Pegcetacoplan, sold under the brand name Empaveli among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH).[2][4] Specifically it is used in adults who continue to have low red blood cells despite taking a medicine called a C5 inhibitor.[4] It is given by gradual injection under the skin.[4]
Common side effects include injection-site reactions, infections, diarrhea, abdominal pain, respiratory tract infection, viral infection, tiredness, and fever.[2] Safety in pregnancy is unclear.[2] Use requires people being vaccinated.[4] It works by binding to and inhibiting complement protein C3.[4]
Pegcetacoplan was approved for medical use in the United States and Europe in 2021.[2][4] In the United Kingdom it costs the NHS about £24,800 for 4 weeks.[5] In the United States this amount costs about 37,000 USD.[6]
References[edit]
- ^ a b "Empaveli APMDS". Therapeutic Goods Administration (TGA). 17 February 2022. Retrieved 20 February 2022.
- ^ a b c d e f g h "Empaveli- pegcetacoplan injection, solution". DailyMed. Archived from the original on 13 July 2021. Retrieved 13 July 2021.
- ^ "FDA approves new treatment for adults with serious rare blood disease". U.S. Food and Drug Administration (FDA). 14 May 2021. Archived from the original on 14 May 2021. Retrieved 14 May 2021.
This article incorporates text from this source, which is in the public domain.
- ^ a b c d e f g h "Aspaveli EPAR". European Medicines Agency (EMA). Archived from the original on 17 December 2021. Retrieved 18 December 2021.
- ^ "Pegcetacoplan". SPS - Specialist Pharmacy Service. 12 March 2019. Archived from the original on 16 October 2021. Retrieved 30 October 2022.
- ^ "Empaveli Prices, Coupons, Copay & Patient Assistance". Drugs.com. Archived from the original on 25 May 2022. Retrieved 30 October 2022.
