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User:Mr. Ibrahem/Bempedoic acid

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Mr. Ibrahem/Bempedoic acid
Clinical data
Trade namesNexletol, Nilemdo
Other namesESP-55016, ETC-1002
AHFS/Drugs.comMonograph
MedlinePlusa620020
License data
Pregnancy
category
  • Contraindicated
Routes of
administration		By mouth
Drug classAdenosine triphosphate-citrate lyase blocker[1]
Legal status
Legal status
Pharmacokinetic data
Protein binding99.3%[3]
MetabolismGlucuronidation
Elimination half-life21±11 hrs
Excretion70% urine, 30% feces
Identifiers
  • 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
Chemical and physical data
FormulaC19H36O5
Molar mass344.492 g·mol−1
3D model (JSmol)
  • CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
  • InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
  • Key:HYHMLYSLQUKXKP-UHFFFAOYSA-N

Bempedoic acid, sold under the brand name Nexletol among others, is a medication used to treat high cholesterol.[3][1] It is unclear if it effects life expectancy or disability as of 2021.[3] It is used together with a statin.[1] It is taken by mouth.[3]

Common side effects include high uric acid, pain in arms or legs, and [low red blood cells]].[1] Other side effects may include liver problems and tendon rupture.[3] Use in pregnancy may harm the baby.[3] It works by blocking an enzyme in the liver called adenosine triphosphate-citrate lyase, which is involved in making cholesterol.[1]

Bempedoic acid was approved for medical use in the United States and Europe in 2020.[1][3] In the United Kingdom 4 weeks of medication costs the NHS about £55 as of 2021.[4] This amount in the United States costs about 360 USD.[5] It is also available as the combination of bempedoic acid/ezetimibe.[6]

References[edit]

  1. ^ a b c d e f g h i j "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  2. ^ "Nilemdo 180mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 4 September 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.
  3. ^ a b c d e f g h "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.
  4. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 221. ISBN 978-0857114105.
  5. ^ "Nexletol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 January 2022.
  6. ^ "Bempedoic Acid Monograph for Professionals". Drugs.com. Retrieved 9 January 2022.
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