User:Mr. Ibrahem/Anagrelide

From Wikipedia, the free encyclopedia
Mr. Ibrahem/Anagrelide
Clinical data
Trade namesAgrylin, Xagrid, others
AHFS/Drugs.comMonograph
MedlinePlusa601020
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
Drug classAntithrombotic[1]
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver, partially through CYP1A2
Elimination half-life1.3 hours
ExcretionUrine (<1%)
Identifiers
  • 6,7-dichloro-1,5-dihydroimidazo
    (2,1-b)quinazolin-2(3H)-one
Chemical and physical data
FormulaC10H7Cl2N3O
Molar mass256.09 g·mol−1
3D model (JSmol)
  • Clc1ccc3c(c1Cl)CN2/C(=N\C(=O)C2)N3
  • InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16) checkY
  • Key:OTBXOEAOVRKTNQ-UHFFFAOYSA-N checkY
  (verify)

Anagrelide, sold under the brand name Agrylin among others, is a medication used to treat high platelets in essential thrombocytosis or other myeloproliferative disorders.[2] It is used when other treatments are not effective or tolerated.[3] It is taken by mouth.[3]

Common side effects may include headache, palpitations, diarrhea, weakness, swelling, nausea, shortness of breath, itchiness, and heart burn.[2] Other side effects may include arrhythmias, QT prolongation, bleeding, and interstitial nephritis.[1] Safety in pregnancy is unclear, with evidence of harm in other animals.[2] It is an antithrombotic.[1]

Anagrelide was approved for medical use in the United States in 1997 and Europe in 2004.[4][5] It is available as a generic medication.[3] In the United Kingdom 100 pills of 500 micrograms costs the NHS about £400 as of 2021.[3] This amount in the United States costs about 52 USD.[6]

References[edit]

  1. ^ a b c "Anagrelide". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Retrieved 14 January 2022.
  2. ^ a b c d e "Anagrelide Monograph for Professionals". Drugs.com. Archived from the original on 25 February 2021. Retrieved 14 January 2022.
  3. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1079. ISBN 978-0857114105.
  4. ^ "DailyMed - ANAGRELIDE capsule". dailymed.nlm.nih.gov. Archived from the original on 24 March 2021. Retrieved 14 January 2022.
  5. ^ "Xagrid". Archived from the original on 6 May 2021. Retrieved 14 January 2022.
  6. ^ "Anagrelide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 January 2022.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Anagrelide&oldid=1102043907"