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Protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene.[1] Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.

Gene

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KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597[2] . Its mRNA has 2683 bp[1] . The gene has these neighbors on chromosome 9:

Gene Neighbor
HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding[3].
C9orf147: Chromosome 9 open reading frame 147 has an unknown function[4] .
C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability[5] .
SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding[6] .


Homology

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Genus and Species

Common Name

Accession Number

Seq. Length

Seq. Identity

Seq. Similarity

Pan troglodytes

Chimpanzee

XM_528391

7945 bp

99 %

99 %

Mus musculus

Mouse

BAC38268

719 a

97 %

98 %

Callithrix jacchus

Common marmoset

XM_002743204

2346bp

97 %

82%

Pongo abelii

Sumatran Orangutan

XM_002820112

1120bp

96 %

4 %

Sus scrofa

Wild boar

XM_003122070

2502 bp

93 %

81 %

Ailuropoda melanoleuca

Giant Panda

XM_002925938

2151 bp

85 %

91 %

Nomascus leucogenys

White cheeked gibbon

XM_003263945

950 bp

93 %

5 %

Oryctolagus cuniculus

European rabbit

XM_002707990

2223 bp

93 %

43 %

Loxodonta africana

African bush elephant

XM_003407521

2388 bp

93 %

80 %

Cricetulus griseus

chinese hamster

XM_003505508

2534 bp

92 %

42 %

Equus caballus

Horse

XM_001916302

2536 bp

91 %

93 %

Bos taurus

Cow

XM_876102.5

2480 bp

91 %

81 %

Rattus norvegicus

Rat

XM_002726532

1364 bp

91 %

36 %

Cavia porcellus

Guinea pig

XM_003463791

2217 bp

91 %

43 %

Monodelphis domestica

Opossum

XM_001375976

2217 bp

78 %

41 %

Branchiostoma floridae

Lancelet

XP_002611438

719 a

29 %

48 %

Amphimedon queenslandica

Sponge

XP_003390994

388 a

25 %

48 %

Acyrthosiphon pisum

Pea aphid

XP_001943720

1197 aa

24 %

43 %

Oikopleura dioica

Chordate

CBY34656

629 a

22 %

43 %

Ciona intestinalis

Vase tunicate

XP_002125964

1004 aa

23 %

43 %

Xenopus (silurana) tropicalis

Western Clawed frog

AAI61073

679 a

23 %

43 %

Halocynthia roretzi

Sea pineapple

BAB40645

980 a

23 %

45 %

Protein

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KIAA1958 is comprised of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375[7] . Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.

KIAA1958 predicted phosphorylated sites

Structure

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PELE on SDSC Biology WorkBench is is supercomputer that is able to predict secondary structure of the KIAA1958 protein[8]. According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.

Expression

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KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST[9] . The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors[9] . Data from NCBI GEO Profile [10] shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells[11] . KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells[11] and both the embryonic stem cell and the pluripotent stem cell[11] .

Interactions

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There is no known proof that KIAA1958 interacts with any other proteins at this time[12] .

References

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  1. ^ a b "Homo sapiens KIAA1958 (KIAA1958), mRNA". NCBI. Retrieved 20 April 2012.
  2. ^ "Homo sapiens gene KIAA1958, encoding KIAA1958". AceView. Retrieved 19 April 2012.
  3. ^ "Q6YN16 (HSDL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot". UniProt. Retrieved 1 May 2012.
  4. ^ "Homo sapiens gene C9orf147, encoding chromosome 9 open reading frame 147". AceView. Retrieved 1 May 2012.
  5. ^ "Q9NRY2 (SOSSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  6. ^ "Q5VWJ9 (SNX30_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  7. ^ "Biology WorkBench". SDSC. Retrieved 3 May 2012.
  8. ^ "Biology Workbench". Retrieved 28 April 2012. {{cite web}}: Unknown parameter |Publisher= ignored (|publisher= suggested) (help)
  9. ^ a b "Unigene EST profile". Unigene. Retrieved 8 May 2012.
  10. ^ "Geo Profiles". Retrieved 28 April 2012. {{cite web}}: Unknown parameter |Publisher= ignored (|publisher= suggested) (help)
  11. ^ a b c "Gene Expression Profiles". Embl-Ebi. Retrieved 8 May 2012.
  12. ^ "Protein Interactions". String. Retrieved 7 May 2012.

Further Reading

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Olsen, JV (3). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 3. 127 (3): 635–48. Retrieved 7 May 2012. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)