User:John03815/DHRS7B

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DHRS7B

Short-chain dehydrogenase reductase (SDR) family member 7B (DHRS7B) is a gene found on chromosome 17p11.2 and encodes a protein predicted to function in steroid hormone regulation.^[1]^[2]^[3] DHRS7B can also be referred to as DKFZp566O084, MGC8916, SDR32C1, and CGI-93 [2].^[1]

Gene Features

DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses, within its protein sequence, characteristic features of an SDR. The following table identifies sequences in the protein and corresponding function.^[4]

Sequence	Function
"VVV"	Valine-rich region, unknown function
"TGXXXGXG"	NADP binding site
"NXXG"	Possible active site motif
"DXXD"	Adenine ring pocket motif
"GXXXXXSS"	Possible active site motif
"SXYXXXK"	Catalytic site, with upstream serine residue
"LXNNXG"	Conserved region, unknown function

Gene Expression

Tissue expression in humans has been predicted for DHRS7B using microarrays. Gene expression is observed strongly in the testes, uterus, and intestine. There is moderate expression in the brain, pancreas, breast, and ovaries. Finally, there is little to no expression in circulating blood, bladder, and lymphatic tissues (spleen, thymus, and tonsil).

File:BIOI image1 microarray.png

Homology

Genus/Species	Common Name	Accession #	Sequence Length	Sequence Identity	Sequence Similarity	Notes
Homo sapiens	Human	NP_056325.2 [3]	325 aa	100%	100%	DHRS7B
Pan troglodytes	Chimpanzee	XP_511344.2 [4]	325 aa	99%	99%	Mammal
Pongo abelli	Sumatran orangutan	NP_001127381 [5]	325 aa	99%	99%	Mammal
Mustela putorius furo	Domestic ferret	AER97198 [6]	345 aa	88%	94%	Mammal
Canis familiaris	Dog	XP_536670 [7]	325 aa	87%	94%	Mammal
Gallus gallus	Chicken	XP_414804 [8]	309 aa	73%	87%	Bird
Anolis carolinensis	Lizard	XP_003226576 [9]	309 aa	68%	85%	Reptile
Salmo salar	Salmon	ACM08861 [10]	310 aa	64%	85%	Fish
Xenopus (silurana) tropicalis	Western clawed frog	NP_001072246 [11]	309 aa	68%	84%	Amphibia
Drosophila melanogaster	Fruit fly	NP_651717 [12]	326 aa	45%	63%	Insect
Stongylocentrotus purpuratus	Purple sea urchin	XP_790920 [13]	344aa	34%	50%	Invertebrate
Saccharomyces cerevisiae S288C	Yeast	NP_013953 [14]	267 aa	33%	49%	Fungi

Disease

DHRS7B has been identified in the Smith-Magenis Syndrome region, a genetic developmental disorder linked to a deletion in chromosome 17p11.2.^[3] In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated.^[5] CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. Additionally, it acts as an adhesion molecule for leukocytes on peripheral lymphoid organs and inflammation sites. CD24 is associated with B-cells, epithelial cells, and dendritic cells, functioning as an adhesion molecule and shown to enhance a tumor cell's capability of metastasizing.^[6]

References

^ ^a ^b "Genecards: DHRS7B Gene protein-coding GIFtS 47".
^ Tannin G, Agarwal A, Monder C, New M, White P (Sept 1991). "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization". Biological Chem. 266 (25): 16653–58. doi:10.1016/S0021-9258(18)55351-5. {{cite journal}}: Check date values in: |date= (help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
^ ^a ^b "NCBI (National Center for Biotechnology Information)". {{cite web}}: Missing or empty |url= (help); Text "[1]" ignored (help) Cite error: The named reference "NCBI" was defined multiple times with different content (see the help page).
^ "GeneNote".
^ Honeth G, Bendahl P, Ringner M, Saal L, Gruvberger-Saal S, Lovgren K, Brabau D, Ferno M, Borg A, Hegardt C (June 2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503. PMID 18559090.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ Kindt T, Goldsby R, Osborne B (2007). Immunology. W.H. Freeman and Company, New York. pp. Appendix A, 3–4.{{cite book}}: CS1 maint: multiple names: authors list (link)

[Genecards-1] "Genecards: DHRS7B Gene protein-coding GIFtS 47".

[Tannin,_G._1991-2] Tannin G, Agarwal A, Monder C, New M, White P (Sept 1991). "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization". Biological Chem. 266 (25): 16653–58. doi:10.1016/S0021-9258(18)55351-5. {{cite journal}}: Check date values in: |date= (help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)

[NCBI-3] "NCBI (National Center for Biotechnology Information)". {{cite web}}: Missing or empty |url= (help); Text "[1]" ignored (help) Cite error: The named reference "NCBI" was defined multiple times with different content (see the help page).

[GeneNote-4] "GeneNote".

[Breast_Cancer_Research-5] Honeth G, Bendahl P, Ringner M, Saal L, Gruvberger-Saal S, Lovgren K, Brabau D, Ferno M, Borg A, Hegardt C (June 2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503. PMID 18559090.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

[Immunology-6] Kindt T, Goldsby R, Osborne B (2007). Immunology. W.H. Freeman and Company, New York. pp. Appendix A, 3–4.{{cite book}}: CS1 maint: multiple names: authors list (link)

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