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Edestin[edit]

Edestin, (also known as Edistin) is a highly-digestible, hexameric legumin protein with six subunits[1], and a seed storage protein, with a molecular weight of 310 kDa. This protein is primarily found in hemp seeds.[2] Edestin is a globular protein (biologically active) as opposed to fibrous protein (structural). Though the human body can manufacture globular proteins from any protein source, it is much more efficient for the body to make globulins from locally digestible globular proteins.

Edestin has the unique ability to stimulate the manufacturing process of antibodies against invasive agents and contains a low aggravatory phosphor content (kidney ailments, etc.).

Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins, and Gamma globulins) are long peptide chains, precursors for biological proteins essential for life. Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing:

  • hormones (which regulate all the body processes),
  • hemoglobin (which transports oxygen, carbon dioxide, and nitric oxide),
  • enzymes (which catalyze and control biochemical reactions),
  • antibodies (immunoglobulins which fend off invading bacteria, viruses, and other pathogens, as well as toxins or antigens as they enter the body).

Edestin can also be broken down to edestan.

Hemp Seeds[edit]

It has been discovered that there are seven cDNAs encoding edestin in Cannabis sativa L., the sequences are distinguished by globulin characteristic. There is a type 1 and type 2 of edestin that are both used in process of the development of hemp seeds. Edestin has been used to help the nutritional quality of plant consumption. [3] Hemp seeds are considered to be fruits from hemp plants[4], and can be used in several different methods: medicine, food, fiber, or psychotic drugs.[5]

Commercial hemp seeds (for human consumption) contain an average 30-35% protein, of which 60-80% is edestin (the remainder being albumin).[6] A particular strain of Korean hemp, Cheungsam, because it contains 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, has been suggested for utilization as "a superior antioxidative nutrient".[7]

Article body[edit]

References[edit]

  1. ^ Patel, Samit; Cudney, Robert; McPherson, Alexander (1994-01-07). "Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp". Journal of Molecular Biology. 235 (1): 361–363. doi:10.1016/S0022-2836(05)80040-3. ISSN 0022-2836.
  2. ^ Patel, Samit; Cudney, Robert; McPherson, Alexander (27 July 1993). "Crystallographic Characterization and Molecular Symmetry of Edestin, a Legumin from Hemp" (PDF). escholarship.org.
  3. ^ Docimo, Teresa; Caruso, Immacolata; Ponzoni, Elena; Mattana, Monica; Galasso, Incoronata (2014-11-01). "Molecular characterization of edestin gene family in Cannabis sativa L." Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. ISSN 0981-9428.
  4. ^ Bhandwale, Guruprasad (July 2021). Pujari, Sourabh; Kadam, Pradnya; Mantri, Shivani; Kulkarni, Poorva (eds.). "Evolutionary study of Edestin Protein in Cannabis Sativa L" (PDF). www.irjet.net. Retrieved July 2021. {{cite web}}: Check date values in: |access-date= (help); Missing |editor1= (help)
  5. ^ Docimo, Teresa; Caruso, Immacolata; Ponzoni, Elena; Mattana, Monica; Galasso, Incoronata (2014-11-01). "Molecular characterization of edestin gene family in Cannabis sativa L." Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. ISSN 0981-9428.
  6. ^ Galasso, Incoronata (2016), "Variability in Seed Traits in a Collection of Cannabis sativa L. Genotypes", Frontiers in Plant Science, 7: 688, doi:10.3389/fpls.2016.00688, PMC 4873519, PMID 27242881
  7. ^ Kim, Jum-Ji (2011), "Isolation and Characterization of Edestin from Cheungsam Hempseed", Journal of Applied Biological Chemistry, 54 (2): 84–88, doi:10.3839/jabc.2011.015