User:Cboursnell/Sandbox/ABG transport
| ABG_transport | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:PDB NULL EBI.jpg | |||||||||
| Identifiers | |||||||||
| Symbol | ABG_transport | ||||||||
| Pfam | PF03806 | ||||||||
| Pfam clan | CL0182 | ||||||||
| InterPro | IPR004697 | ||||||||
| TCDB | 2.A.68 | ||||||||
| |||||||||
The p-aminobenzoyl-glutamate transporter family includes two putative transporters, the AbgT protein of Escherichia coli and MtrF of Neisseria gonorrhoeae. AbgT expression is apparently cryptic in wild type cells, but when present on a high copy number plasmid, or when expressed at higher levels due to mutation, it allows utilization of p-aminobenzoyl-glutamate as a source of p-aminobenzoate for p-aminobenzoate auxotrophs.[1] p-Aminobenzoate is a constituent of, and a precursor for, the biosynthesis of folic acid. It is not currently known if AbgT is naturally involved in transporting p-aminobenzoyl-glutamate, or if it only becomes involved when under altered regulation. MtrF is an inner membrane protein which, together with the MtrCDE efflux pump, is required for high-level resistance to hydrophobic antimicrobial agents in N. gonorrhoeae.[2] Its role in this process is not known, but it has been suggested that it may be a component of the efflux pump which is dispensible for basal activity, but required for high-level activity.[3]
References[edit]
- ^ Hussein MJ, Green JM, Nichols BP (December 1998). "Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli". J. Bacteriol. 180 (23): 6260–6268. doi:10.1128/JB.180.23.6260-6268.1998. PMC 107711. PMID 9829935.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Veal WL, Shafer WM (January 2003). "Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae". J. Antimicrob. Chemother. 51 (1): 27–37. doi:10.1093/jac/dkg031. PMID 12493784.
{{cite journal}}: CS1 maint: date and year (link) - ^ Folster JP, Shafer WM (June 2005). "Regulation of mtrF expression in Neisseria gonorrhoeae and its role in high-level antimicrobial resistance". J. Bacteriol. 187 (11): 3713–3720. doi:10.1128/JB.187.11.3713-3720.2005. PMC 1112036. PMID 15901695.
{{cite journal}}: CS1 maint: date and year (link)